NOAEL Studies Cosmetic Ingredient

Propyl Acetate NOAEL Studies

INCI: PROPYL ACETATE

CAS: 109-60-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =900 mg/kg bw/day Rat oral: gavage 90 days subchronic EFSA FEEDAP - 2013 - OutputID 2209 - body weight - systemic - Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species - doi:10.2903/j.efsa.2013.3169
NTP_ICE_acute_inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 32 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=3357; Record_ID=acute_inhalation_2927; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID6021901; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=32; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14329/7/3/3/?documentUUID=97c5e164-522f-413f-8c5f-963c0c080aab; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021901
NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =9370 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_858; row=10090; data_type=In Vivo; mixture=Chemical; chemical_name=Propyl acetate; preferred_name=Propyl acetate; dtxsid=DTXSID6021901; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021901; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =9800 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_859; row=10091; data_type=In Vivo; mixture=Chemical; chemical_name=Propyl acetate; preferred_name=Propyl acetate; dtxsid=DTXSID6021901; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021901; source_file=acute_oral.xlsx
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_DOE_Protective_Action_Criteria LEL =71013.1 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=DOE Protective Action Criteria:15519066:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c8e414ea4efbc415a7992fa4fd22f92b
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral - developmental GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb6f9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7186/7/9/3?documentUUID=18232417-9d35-4dcb-9b66-b6b9b14abb73; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15820618:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4a8b682e6464a631bdebd2c0547155e3
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =900 mg/kg bw/day Rat oral subchronic; 90 days subchronic LONG_REF=EFSA FEEDAP (2013). Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species. doi:10.2903/j.efsa.2013.3169.; TITLE=Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2013.3169; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15622398:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c0cd2b26b59f00b6f0256fd175329e6f
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL local =420 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634382:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6567d74a772b53f29631ffea094141d4
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 4AWM8C91G6 UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"4AWM8C91G6"}
openFDA substances FDA UNII substance identifier 4AWM8C91G6 UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"4AWM8C91G6"}
openFDA substances FDA UNII substance identifier 4AWM8C91G6 UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"4AWM8C91G6"}
openFDA substances FDA UNII substance identifier 4AWM8C91G6 UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"4AWM8C91G6"}