NOAEL Studies Cosmetic Ingredient

Propionic Acid NOAEL Studies

INCI: PROPIONIC ACID

CAS: 79-09-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 200 mg/kg bw/day rat oral 730 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1500 mg/kg bw/day rat oral 168 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2000 mg/kg bw/day rat oral 84 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 4000 mg/kg bw/day rat oral 27 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 4800 mg/kg bw/day syrian hamster oral 7 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 6000 mg/kg bw/day mouse oral 7 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_acute_inhalation 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 >4.9 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=4619; Record_ID=acute_inhalation_1767; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8025961; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=4.9; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8025961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8025961
NTP_ICE_acute_inhalation LC50 >19.7 mg/L - Inhalation Duration=1 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=4621; Record_ID=acute_inhalation_873; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8025961; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=19.7; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14128/7/3/3/?documentUUID=4d21af17-e367-45de-a0ae-aecfcc000428; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8025961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8025961
NTP_ICE_acute_inhalation LC50 >20 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=4620; Record_ID=acute_inhalation_876; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID8025961; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=20; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14128/7/3/3/?documentUUID=0e4efb49-e8f8-4986-8668-3ce943bcb7a3; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8025961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8025961
NTP_ICE_acute_oral 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >400 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_10438; row=13835; data_type=In Vivo; mixture=Chemical; chemical_name=Propionic acid; preferred_name=Propionic acid; dtxsid=DTXSID8025961; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8025961; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8025961; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =2600 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10440; row=13836; data_type=In Vivo; mixture=Chemical; chemical_name=Propionic acid; preferred_name=Propionic acid; dtxsid=DTXSID8025961; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8025961; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8025961; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =4300 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_10442; row=13834; data_type=In Vivo; mixture=Chemical; chemical_name=Propionic acid; preferred_name=Propionic acid; dtxsid=DTXSID8025961; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8025961; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8025961; source_file=acute_oral.xlsx
NTP_ICE_skin_irritation 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_irritation Breakthrough Time 19.19 min - Dermal - In Vitro; Corrositex sheet=Data_invitro; excel_row=5160; Record_ID=skin_irritation_invitro_136; Data_Type=In Vitro; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8025961; Assay=Corrositex; Endpoint=Breakthrough Time; Response=19.19; Response_Unit=min; Reference=ICCVAM 1999; Not available; ntp.niehs.nih.gov/iccvam/docs/dermal_docs/corprrep.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8025961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8025961
NTP_ICE_skin_irritation Breakthrough Time 37.78 min - Dermal - In Vitro; Corrositex sheet=Data_invitro; excel_row=5162; Record_ID=skin_irritation_invitro_138; Data_Type=In Vitro; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8025961; Assay=Corrositex; Endpoint=Breakthrough Time; Response=37.78; Response_Unit=min; Reference=ICCVAM 1999; Not available; ntp.niehs.nih.gov/iccvam/docs/dermal_docs/corprrep.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8025961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8025961
NTP_ICE_skin_irritation Viability (240 minutes) 3.9 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=5166; Record_ID=skin_irritation_invitro_2301; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8025961; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=3.9; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8025961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8025961
NTP_ICE_skin_irritation Viability (240 minutes) 9.3 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=5168; Record_ID=skin_irritation_invitro_2305; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8025961; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=9.30; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8025961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8025961
NTP_ICE_skin_irritation Viability (3 minutes) 3.2 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=5155; Record_ID=skin_irritation_invitro_2301; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8025961; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=3.2; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8025961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8025961
NTP_ICE_skin_irritation Viability (3 minutes) 5.5 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=5156; Record_ID=skin_irritation_invitro_2303; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8025961; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=5.5; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8025961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8025961
NTP_ICE_skin_irritation Viability (3 minutes) 5.8 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=5157; Record_ID=skin_irritation_invitro_2305; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8025961; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=5.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8025961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8025961
NTP_ICE_skin_irritation Viability (60 minutes) 2.5 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=5158; Record_ID=skin_irritation_invitro_2301; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8025961; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=2.5; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8025961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8025961
NTP_ICE_skin_irritation Viability (60 minutes) 4.3 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=5154; Record_ID=skin_irritation_invitro_2305; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8025961; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=4.3; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8025961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8025961
NTP_ICE_skin_irritation Viability (60 minutes) 11.8 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=5159; Record_ID=skin_irritation_invitro_2303; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8025961; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=11.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8025961; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8025961
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_DOE_Protective_Action_Criteria LEL =87865.1 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2023; ORIGINAL_YEAR=2023; STUDY_GROUP=DOE Protective Action Criteria:15519039:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_09bd5ab192be69b5e40d3d1331a5c4cb
ToxValDB_ECOTOX 17 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =0.0045 mmol Rat injection acute; 0.0104 days acute LONG_REF=Neurosci. Lett.408(2): 151-154 Rigo,F.K., L. Pasquetti, C.R.M. Malfatti, M.R. Fighera, R.C. Coelho, C.Z. Petri, and C.F. Mello Propionic Acid Induces Convulsions and Protein Carbonylation in Rats 2006; TITLE=Propionic Acid Induces Convulsions and Protein Carbonylation in Rats; AUTHOR=Rigo,F.K., L. Pasquetti, C.R.M. Malfatti, M.R. Fighera, R.C. Coelho, C.Z. Petri, and C.F. Mello; DOI=10.1016/j.neulet.2006.08.075; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101662; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594373_15594374_15604066:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=07151c07e6c6188bf4382ee481a9f518
ToxValDB_ECOTOX LOEL =0.006 mmol Rat injection acute; 0.0104 days acute LONG_REF=Neurosci. Lett.408(2): 151-154 Rigo,F.K., L. Pasquetti, C.R.M. Malfatti, M.R. Fighera, R.C. Coelho, C.Z. Petri, and C.F. Mello Propionic Acid Induces Convulsions and Protein Carbonylation in Rats 2006; TITLE=Propionic Acid Induces Convulsions and Protein Carbonylation in Rats; AUTHOR=Rigo,F.K., L. Pasquetti, C.R.M. Malfatti, M.R. Fighera, R.C. Coelho, C.Z. Petri, and C.F. Mello; DOI=10.1016/j.neulet.2006.08.075; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101662; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Intoxication: Convulsions; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594373_15594374_15604066:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3e37c00d115653ec33f157d8eb810f07
ToxValDB_ECOTOX LOEL =0.1 mM European Rabbit environmental short-term; 5 days developmental LONG_REF=Biol. Reprod.20(2): 323-332 Kane,M.T. Fatty Acids as Energy Sources for Culture of One-Cell Rabbit Ova to Viable Morulae 1979; TITLE=Fatty Acids as Energy Sources for Culture of One-Cell Rabbit Ova to Viable Morulae; AUTHOR=Kane,M.T.; DOI=10.1095/biolreprod20.2.323; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=101665; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Development: Blastocyst stage; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15594461:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7ffc9b5aa34421861f7d41230de660ba
ToxValDB_ECOTOX LOEL =0.6 % Rat oral short-term; 21 days short-term LONG_REF=Toxicology38(1): 103-117 Rodrigues,C., E. Lok, E. Nera, F. Iverson, D. Page, K. Karpinski, and D.B. Clayson Short-Term Effects of Various Phenols and Acids on the Fischer 344 Male Rat Forestomach Epithelium 1986; TITLE=Short-Term Effects of Various Phenols and Acids on the Fischer 344 Male Rat Forestomach Epithelium; AUTHOR=Rodrigues,C., E. Lok, E. Nera, F. Iverson, D. Page, K. Karpinski, and D.B. Clayson; DOI=10.1016/0300-483x(86)90176-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=101597; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Histology: Proliferation; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15601420:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d41beb99c1066ec7539c511f4f581955
ToxValDB_ECOTOX LOEL =0.93 umol/g org Rat injection short-term; 12 days short-term LONG_REF=Neurochem. Int.33(1): 75-82 De Mattos-Dutra,A., M.S. De Freitas, C.S.F. Lisboa, R. Pessoa-Pureur, and M. Wajner Effects of Acute and Chronic Administration of Methylmalonic and Propionic Acids on the In Vitro Incorporation of 32P into Cytoskeletal Proteins from Cerebral Cortex of Young Rats 1998; TITLE=Effects of Acute and Chronic Administration of Methylmalonic and Propionic Acids on the In Vitro Incorporation of 32P into Cytoskeletal Proteins from Cerebral Cortex of Young Rats; AUTHOR=De Mattos-Dutra,A., M.S. De Freitas, C.S.F. Lisboa, R. Pessoa-Pureur, and M. Wajner; DOI=10.1016/s0197-0186(05)80011-7; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101587; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Biochemistry: Phosphorylation of proteins; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595673_15595674:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b04c5deaee3f60981ee282c5b75bc722
ToxValDB_ECOTOX LOEL =4 % diet Rat oral chronic; 91 days chronic LONG_REF=Ph.D.Thesis, Temple University, Philadelphia, PA:155 p. McLaughlin,J.E. Relationship of Propionic Acid-Induced Cell Proliferation and Inflammation in Rat Forestomach 1994; TITLE=Relationship of Propionic Acid-Induced Cell Proliferation and Inflammation in Rat Forestomach; AUTHOR=McLaughlin,J.E.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=103756; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595699_15595700:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fd84c8ef629e91751b23f0b1d8bed812
ToxValDB_ECOTOX LOEL <=8 ul/g Rat injection short-term; 22 days short-term LONG_REF=J. Neurol. Sci.158(2): 121-124 Brusque,A.M., S.T. Terracciano, F.U. Fontella, C. Vargas, C.G. Da Silva, A.T. Wyse, V.M.T. Trindade, C.M.D. Wannmacher, Chronic Administration of Propionic Acid Reduces Ganglioside N-Acetylneuraminic Acid Concentration in Cerebellum of Young Rats 1998; TITLE=Chronic Administration of Propionic Acid Reduces Ganglioside N-Acetylneuraminic Acid Concentration in Cerebellum of Young Rats; AUTHOR=Brusque,A.M., S.T. Terracciano, F.U. Fontella, C. Vargas, C.G. Da Silva, A.T. Wyse, V.M.T. Trindade, C.M.D. Wannmacher,; DOI=10.1016/s0022-510x(98)00109-9; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101586; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Biochemistry: Neuraminic acid; STUDY_GROUP=ECOTOX:15610749:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ce59cd278bf241e7de62ed5e2805e642
ToxValDB_ECOTOX LOEL =100 mM Rat injection acute; 1 days acute LONG_REF=Nutr. Res.13(2): 209-217 Ebihara,K., T. Miyada, and A. Nakajima Hypocholesterolemic Effect of Cecally Infused Propionic Acid in Rats Fed a Cholesterol-Free, Casein Diet 1993; TITLE=Hypocholesterolemic Effect of Cecally Infused Propionic Acid in Rats Fed a Cholesterol-Free, Casein Diet; AUTHOR=Ebihara,K., T. Miyada, and A. Nakajima; DOI=10.1016/S0271-5317(05)80442-7; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=101589; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Biochemistry: Cholesterol; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15596247:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=cedb1cb3aa4c99c077362dca5d65bec8
ToxValDB_ECOTOX LOEL =40000 ppm Rat oral short-term; 7 days short-term LONG_REF=Food Chem. Toxicol.29(6): 367-371 Harrison,P.T.C., P. Grasso, and V. Badescu Early Changes in the Forestomach of Rats, Mice and Hamsters Exposed to Dietary Propionic and Butyric Acid 1991; TITLE=Early Changes in the Forestomach of Rats, Mice and Hamsters Exposed to Dietary Propionic and Butyric Acid; AUTHOR=Harrison,P.T.C., P. Grasso, and V. Badescu; DOI=10.1016/0278-6915(91)90075-i; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=101593; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Histology: Vacuolization; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15594945:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b0a0f3b85811d50ad83e4eb20b6908fe
ToxValDB_ECOTOX NOEL =0.002 mmol Rat injection acute; 0.0104 days acute LONG_REF=Neurosci. Lett.408(2): 151-154 Rigo,F.K., L. Pasquetti, C.R.M. Malfatti, M.R. Fighera, R.C. Coelho, C.Z. Petri, and C.F. Mello Propionic Acid Induces Convulsions and Protein Carbonylation in Rats 2006; TITLE=Propionic Acid Induces Convulsions and Protein Carbonylation in Rats; AUTHOR=Rigo,F.K., L. Pasquetti, C.R.M. Malfatti, M.R. Fighera, R.C. Coelho, C.Z. Petri, and C.F. Mello; DOI=10.1016/j.neulet.2006.08.075; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101662; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Intoxication: Convulsions; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594373_15594374_15604066:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d06912de2b3df86d1c63f420b542d6c5
ToxValDB_ECOTOX NOEL =0.4 % diet Rat oral chronic; 91 days chronic LONG_REF=Ph.D.Thesis, Temple University, Philadelphia, PA:155 p. McLaughlin,J.E. Relationship of Propionic Acid-Induced Cell Proliferation and Inflammation in Rat Forestomach 1994; TITLE=Relationship of Propionic Acid-Induced Cell Proliferation and Inflammation in Rat Forestomach; AUTHOR=McLaughlin,J.E.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=103756; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595699_15595700:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=803cceca15b07923d5dd36191130aff6
ToxValDB_ECOTOX NOEL =0.8 ul/g Rat injection short-term; 22 days short-term LONG_REF=Metab. Brain Dis.17(2): 93-102 Trindade,V.M.T., A.M. Brusque, J.R. Raasch, L.F. Pettenuzzo, H.P. Rocha, C.M.D. Wannmacher, and M. Wajner Ganglioside Alterations in the Central Nervous System of Rats Chronically Injected with Methylmalonic and Propionic Acids 2002; TITLE=Ganglioside Alterations in the Central Nervous System of Rats Chronically Injected with Methylmalonic and Propionic Acids; AUTHOR=Trindade,V.M.T., A.M. Brusque, J.R. Raasch, L.F. Pettenuzzo, H.P. Rocha, C.M.D. Wannmacher, and M. Wajner; DOI=10.1023/A:1015464028616; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101660; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598380_15610736_15610769:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0b57ecf5bd4ffa4b4a33098b1370a6b1
ToxValDB_ECOTOX NOEL =1.68 mmol/kg Rat injection short-term; 15 days short-term LONG_REF=Neuroreport9(8): 1719-1721 Wyse,A.T.S., A.M. Brusque, C.G. Silva, E.L. Streck, M. Wajner, and C.M.D. Wannmacher Inhibition of Na+,K+-ATPase from Rat Brain Cortex by Propionic Acid 1998; TITLE=Inhibition of Na+,K+-ATPase from Rat Brain Cortex by Propionic Acid; AUTHOR=Wyse,A.T.S., A.M. Brusque, C.G. Silva, E.L. Streck, M. Wajner, and C.M.D. Wannmacher; DOI=10.1097/00001756-199806010-00009; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101599; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Growth: Weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596210_15605690:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=18db5db5b92dd987e4c64becff32d876
ToxValDB_ECOTOX NOEL <=1.92 umol/g org Rat injection short-term; 23 days short-term LONG_REF=Pharmacol. Biochem. Behav.73(3): 623-629 Pettenuzzo,L.F., P.F. Schuck, F. Fontella, C.M.D. Wannmacher, A.T. Wyse, C.S. Dutra-Filho, C.A. Netto, and M. Wajner Ascorbic Acid Prevents Cognitive Deficits Caused by Chronic Administration of Propionic Acid to Rats in the Water Maze 2002; TITLE=Ascorbic Acid Prevents Cognitive Deficits Caused by Chronic Administration of Propionic Acid to Rats in the Water Maze; AUTHOR=Pettenuzzo,L.F., P.F. Schuck, F. Fontella, C.M.D. Wannmacher, A.T. Wyse, C.S. Dutra-Filho, C.A. Netto, and M. Wajner; DOI=10.1016/s0091-3057(02)00856-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101663; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15610717:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=dcd2c00ee9f47306ab093e1a13a82b82
ToxValDB_ECOTOX NOEL =4 % Rat oral short-term; 7 days short-term LONG_REF=Toxicology38(1): 103-117 Rodrigues,C., E. Lok, E. Nera, F. Iverson, D. Page, K. Karpinski, and D.B. Clayson Short-Term Effects of Various Phenols and Acids on the Fischer 344 Male Rat Forestomach Epithelium 1986; TITLE=Short-Term Effects of Various Phenols and Acids on the Fischer 344 Male Rat Forestomach Epithelium; AUTHOR=Rodrigues,C., E. Lok, E. Nera, F. Iverson, D. Page, K. Karpinski, and D.B. Clayson; DOI=10.1016/0300-483x(86)90176-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=101597; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX:15594685:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b0eaf64b5c744dfd4001ca26b356999d
ToxValDB_ECOTOX NOEL <=8 ul/g Rat injection subchronic; 55 days subchronic LONG_REF=J. Neurol. Sci.158(2): 121-124 Brusque,A.M., S.T. Terracciano, F.U. Fontella, C. Vargas, C.G. Da Silva, A.T. Wyse, V.M.T. Trindade, C.M.D. Wannmacher, Chronic Administration of Propionic Acid Reduces Ganglioside N-Acetylneuraminic Acid Concentration in Cerebellum of Young Rats 1998; TITLE=Chronic Administration of Propionic Acid Reduces Ganglioside N-Acetylneuraminic Acid Concentration in Cerebellum of Young Rats; AUTHOR=Brusque,A.M., S.T. Terracciano, F.U. Fontella, C. Vargas, C.G. Da Silva, A.T. Wyse, V.M.T. Trindade, C.M.D. Wannmacher,; DOI=10.1016/s0022-510x(98)00109-9; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101586; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Growth: Weight|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight; STUDY_GROUP=ECOTOX:15610714:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9876e69b92c9651ccaa4be8b6d624296
ToxValDB_ECOTOX NOEL =100 mM Rat injection subchronic; 35 days subchronic LONG_REF=Nutr. Res.13(2): 209-217 Ebihara,K., T. Miyada, and A. Nakajima Hypocholesterolemic Effect of Cecally Infused Propionic Acid in Rats Fed a Cholesterol-Free, Casein Diet 1993; TITLE=Hypocholesterolemic Effect of Cecally Infused Propionic Acid in Rats Fed a Cholesterol-Free, Casein Diet; AUTHOR=Ebihara,K., T. Miyada, and A. Nakajima; DOI=10.1016/S0271-5317(05)80442-7; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=101589; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECOTOX:15606848:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=002d103c8711bbd9a626108efee27e86
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier JHU490RVYR UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"JHU490RVYR"}
openFDA substances FDA UNII substance identifier JHU490RVYR UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"JHU490RVYR"}
openFDA substances FDA UNII substance identifier JHU490RVYR UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"JHU490RVYR"}
openFDA substances FDA UNII substance identifier JHU490RVYR UNII - - - chemical {"approval_status":null,"molecular_formula":"C3H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"JHU490RVYR"}