Is Proline safe in cosmetics?
Proline has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Proline
INCI: PROLINE
Proline (CAS 147-85-3 (L-Proline); 609-36-9 (DL-Proline)) is a cosmetic cosmetic ingredient functioning as Skin conditioning, hair conditioning, buffering/pH stabilizer, moisturizing. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 147-85-3 (L-Proline); 609-36-9 (DL-Proline) →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning, hair conditioning, buffering/pH stabilizer, moisturizing (NMF component)
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; GRAS amino acid
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Proline.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Proline, relevant to systemic exposure and MoS calculations.
Absorption %
3-6%
Penetration Level
surface
Penetration Depth
stratum corneum
Molecular Weight
115.1 Da
Log P
-2.5
Systemic Absorption
minimal
Topical Bioavailability
2-4%
Safety Margin Factor
low
Vehicle Dependent
Yes — absorption varies by formulation
Source: Cosmetic Science
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "147-85-3", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_a…
anti_aging
{"anti_aging_claim": "collagen-boosting", "mechanism_of_action": "Building block for proteins, NMF component", "target_skin_layer": "epidermis", "collagen_stimulation": "Yes", "elastin_protection": "Mild", "wrinkle_reduction_pct": "8-15", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "Int J Cosmet Sci", "improvem…
anti_pollution
{"cas_number": "147-85-3", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibitio…
concentration
{"min_concentration_pct": "0.1", "max_concentration_pct": "2.0", "typical_concentration_pct": "1.0", "product_type": "Serum", "function_at_concentration": "Collagen synthesis", "source": "Clinical literature; Supplier TDS"}
dermal_absorption
{"molecular_weight_da": "115.1", "log_p_value": "-2.5", "skin_penetration_level": "surface", "penetration_depth": "stratum corneum", "absorption_pct": "3-6", "systemic_absorption": "minimal", "penetration_enhancer": "no", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "neutral", "bioavailability_topical_pct": "2-4", "safety_margin_factor": "low", "source": "Cosmetic S…
hair_care
{"hair_function": "protein-treatment", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "all", "protein_sensitivity": "protein", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "strengthen…
humectant
{"cas_number": "147-85-3", "ingredient_class": "humectant/NMF_component/amino_acid", "molecular_weight_Da": "115.13", "chemical_type": "amino_acid", "water_binding_mechanism": "hydrogen_bonding/hygroscopic/osmotic", "water_holding_capacity_g_per_g": "0.4-0.7", "hygroscopicity_at_50_RH": "good", "hygroscopicity_at_80_RH": "excellent", "NMF_component": "yes", "NMF_percentage_natural": "2-4", "TEWL_r…
pediatric_safety
{"safe_for_newborn_0_6m": "yes", "safe_for_infant_6_12m": "yes", "safe_for_toddler_1_3y": "yes", "safe_for_child_3_12y": "yes", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "5.0", "adult_max_concentration_pct": "5.0", "pediatric_dermal_absorption_factor": "normal", "diaper_area_safe": "yes", "pediatric_allergy_prevalence": "low", "banned_in_children_products_eu": "no", "banned…
Expert Verdict
Expert safety assessment and concern-level summary for Proline.
Regulatory Flags
natural-origin
Frequently Asked Questions
Is Proline allowed in the EU?
Proline EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Proline do in cosmetics?
Proline functions as: Skin conditioning, hair conditioning, buffering/pH stabilizer, moisturizing (NMF component). It is classified as a cosmetic ingredient in our database. CAS number: 147-85-3 (L-Proline); 609-36-9 (DL-Proline).
Compliance Tools
Check Proline compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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