NOAEL Studies Active Ingredient

Pro-Retinol NOAEL Studies

INCI: RETINYL PALMITATE

CAS: 79-81-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 22 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 11 mg/kg bw/day primate oral 16-27 Gestation day Developmental PAFA;REACH
COSMOS DB NOAEL 1.2 mg/kg bw/day rat oral 240 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1.4 mg/kg bw/day rat oral 42 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 4.09999990463 mg/kg bw/day primate oral 16-27 Gestation day Developmental PAFA;REACH
COSMOS DB NOAEL 5.5 mg/kg bw/day rat oral 3 day Neurotoxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 14 mg/kg bw/day dog oral 300 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 24 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 28 mg/kg bw/day rat oral 300 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 30 mg/kg bw/day cat oral 287 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 33 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 44 mg/kg bw/day rat oral 3 day Neurotoxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 55 mg/kg bw/day hamster oral 1 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 60 mg/kg bw/day rat oral 26 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 69 mg/kg bw/day mouse oral 2 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 74 mg/kg bw/day mouse oral 4 day Immunotoxicology US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 83 mg/kg bw/day mouse oral 3 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 100 mg/kg bw/day rat oral 1 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 118 mg/kg bw/day rat oral 42 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 138 mg/kg bw/day rat oral 3 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 165 mg/kg bw/day rat oral 1 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 206 mg/kg bw/day mouse oral 1 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 220 mg/kg bw/day rat oral 12 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =7910 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_10652; row=2187; data_type=In Vivo; mixture=Chemical; chemical_name=Retinol palmitate; preferred_name=Retinol palmitate; dtxsid=DTXSID1021241; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021241; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021241; source_file=acute_oral.xlsx
ECHA 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL =10.368 mg/kg bw/day Rat oral subchronic; 3 months subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc3a3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13687/7/6/2?documentUUID=0e919042-2d24-4aed-b123-26d0020b4197; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834327_15834328_15839308_15839309:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_092c55e28752df37055a2c73a2200839
ECHA LOAEL =10.752 mg/kg bw/day Rat oral subchronic; 3 months subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbe6e4b0a7c65d228095; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13687/7/6/2?documentUUID=0e919042-2d24-4aed-b123-26d0020b4197; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834327_15834328_15839308_15839309:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_634593941b63404af532364fa1a3b824
ECHA NOAEL =2.688 mg/kg bw/day Rat oral subchronic; 3 months subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbe6e4b0a7c65d228095; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13687/7/6/2?documentUUID=0e919042-2d24-4aed-b123-26d0020b4197; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834327_15834328_15839308_15839309:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0dbecebd0269e2d540bd144fa91500ae
ECHA NOEL <2.592 mg/kg bw/day Rat oral subchronic; 3 months subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf08e4b0a7c65d1cc3a3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13687/7/6/2?documentUUID=0e919042-2d24-4aed-b123-26d0020b4197; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15834326:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_65bca897fd90c072e6b1782394771395
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 1D1K0N0VVC UNII - - - chemical {"approval_status":null,"molecular_formula":"C36H60O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1D1K0N0VVC"}
openFDA substances FDA UNII substance identifier 1D1K0N0VVC UNII - - - chemical {"approval_status":null,"molecular_formula":"C36H60O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1D1K0N0VVC"}
openFDA substances FDA UNII substance identifier 1D1K0N0VVC UNII - - - chemical {"approval_status":null,"molecular_formula":"C36H60O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1D1K0N0VVC"}
openFDA substances FDA UNII substance identifier 1D1K0N0VVC UNII - - - chemical {"approval_status":null,"molecular_formula":"C36H60O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1D1K0N0VVC"}