NOAEL Studies Cosmetic Ingredient

Potassium Nitrate NOAEL Studies

CAS: 7757-79-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 12 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 14 mg/kg bw/day rat oral 150 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 15 mg/kg bw/day rat oral 270 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 26 mg/kg bw/day rat oral NA Neurotoxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 29 mg/kg bw/day rat oral 180 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 50 mg/kg bw/day mouse oral 1 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 200 mg/kg bw/day rabbit oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 225 mg/kg bw/day mouse oral 35 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 250 mg/kg bw/day rat oral 7 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 737 mg/kg bw/day rabbit oral 1 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 2500 mg/kg bw/day rat oral 8 day Reproductive-developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 3000 mg/kg bw/day rat oral 42 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 8190 mg/kg bw/day guinea pig oral 143 day Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA ADI =3.7 mg/kg bw/day Consumers - - ADI EFSA ANS - 2017 - OutputID 2961 - Consumers - Re-evaluation of sodium nitrate (E 251) and potassium nitrate (E 252) as food additives - doi:10.2903/j.efsa.2017.4787
EFSA ADI =3.7 mg/kg bw/day Consumers - - ADI EFSA ANS - 2017 - OutputID 2961 - Consumers - Re-evaluation of sodium nitrate (E 251) and potassium nitrate (E 252) as food additives - doi:10.2903/j.efsa.2017.4787
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=13564; RecordID=ARPathway2016_1552; DatasetName=ARPathway2016; DTXSID=DTXSID4029692; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4029692
ToxValDB DOE Wildlife Benchmarks 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB DOE Wildlife Benchmarks LOAEL =1130 mg/kg bw/day Guinea Pig oral - repeat dose other STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511681_15511682:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e82fe90bacb64495e8dd19b7315e57b6
ToxValDB DOE Wildlife Benchmarks NOAEL =507 mg/kg bw/day Guinea Pig oral - repeat dose other STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511681_15511682:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_55f4a516d5ca76f94b5b9e87d6c6de68
ECHA 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =180 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1dce4b0a7c65d2308a7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16017/7/9/3?documentUUID=ecc33adf-7454-4096-9185-ca2f02fcd9c4; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15821552:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_312f6fa601e3ea3679f9a809cddda7bf
ECHA NOAEL =280 mg/kg bw/day Hamster oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1dce4b0a7c65d230863; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16017/7/9/3?documentUUID=ecc33adf-7454-4096-9185-ca2f02fcd9c4; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15821264:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4d312668bc28ec23599d87b845f9e2b7
ECHA NOAEL =400 mg/kg bw/day Mouse oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac32e4b0a7c65d1bdd6c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16017/7/9/3?documentUUID=ecc33adf-7454-4096-9185-ca2f02fcd9c4; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15821778:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f78c0fe6d3efb97b6423e3f56bd22de4
ECHA NOAEL >=1500 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac32e4b0a7c65d1bdd64; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16017/7/9/3?documentUUID=ecc33adf-7454-4096-9185-ca2f02fcd9c4; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ECHA IUCLID:15822506:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a9c683d39ccfb83b7df76c4e7afb181c
ToxValDB ECOTOX 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ECOTOX LOEL =120 mg/L Rat oral short-term (developmental); 5 days developmental LONG_REF=Acta Physiol. Hung.74(1): 69-75 Markel,E., C. Nyakas, and S. Ormai Nitrate Induced Changes in Sensoro-Motor Development and Learning Behaviour in Rats 1989; TITLE=Nitrate Induced Changes in Sensoro-Motor Development and Learning Behaviour in Rats; AUTHOR=Markel,E., C. Nyakas, and S. Ormai; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=95609; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Behavior: Movements, number of; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECOTOX:15603525:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=bdfa8f54020e002721b63e455a8de1b3
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier RU45X2JN0Z UNII - - - chemical {"approval_status":null,"molecular_formula":"K.NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RU45X2JN0Z"}
openFDA substances FDA UNII substance identifier RU45X2JN0Z UNII - - - chemical {"approval_status":null,"molecular_formula":"K.NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RU45X2JN0Z"}
openFDA substances FDA UNII substance identifier RU45X2JN0Z UNII - - - chemical {"approval_status":null,"molecular_formula":"K.NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RU45X2JN0Z"}
openFDA substances FDA UNII substance identifier RU45X2JN0Z UNII - - - chemical {"approval_status":null,"molecular_formula":"K.NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RU45X2JN0Z"}