Is Potassium Gluconate safe in cosmetics?
Potassium Gluconate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Potassium Gluconate
Also known as: Gluconic acid, monopotassium salt, D-, D-Gluconic acid, potassium salt (1:1), EINECS 206-074-2, Gluconic acid, monopotassium salt, Gluconic acid potassium salt (+10 more)
INCI: POTASSIUM GLUCONATE
Potassium Gluconate (CAS 299-27-4) is a cosmetic cosmetic ingredient functioning as Chelating agent, skin protecting. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 299-27-4 →
Auto-generated CPSR Part A draft with source citations
Function
Chelating agent, skin protecting
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
potassium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
InChIKey
HLCFGWHYROZGBI-JJKGCWMISA-M
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
GRAS food substance; no restrictions for cosmetic use; CIR reviewed related monosaccharide salts favorably
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Potassium Gluconate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Evaluation
D-GLUCONIC ACID POTASSIUM SALT | 1998 | NOT SPECIFIED | Group ADI for glucono delta-lactone, calcium gluconate, magnesium gluconate, potassium gluconate, and sodium gluconate | TRS 891-JECFA 51/46 | FAS 42-JECFA 51/203
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Flavouring and nutrient
Humectant
Softener and conditioner
Regulatory List Membership (2)
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Potassium Gluconate.
Regulatory Flags
epa_safer_alternative
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Potassium Gluconate by CAS number or substance name.
Studies
6
Lowest NOAEL
594 mg/kg bw/day
Highest NOAEL
695 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Gluconic acid, monopotassium salt, D-
D-Gluconic acid, potassium salt (1:1)
EINECS 206-074-2
Gluconic acid, monopotassium salt
Gluconic acid potassium salt
Gluconsan K
Kalium-beta
Kalium Gluconate
Kaon elixir
Katorin
Potalium
Potasoral
Potassuril
Sirokal
UNII-12H3K5QKN9
Chemical Function
Humectant
Chelating agent
Softener and conditioner
Flavouring and nutrient
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Europe; supplements
Europe; food_additive; supplements
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
POTASSIUM GLUCONATE
ChEMBL ID
CHEMBL2106978
Max Phase
1
Adverse Event Associations
301
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Potassium gluconate
E Number
E577
ADI
NOT SPECIFIED mg/kg bw
Food Category
preservative
Frequently Asked Questions
Is Potassium Gluconate allowed in the EU?
Potassium Gluconate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Potassium Gluconate do in cosmetics?
Potassium Gluconate functions as: Chelating agent, skin protecting. It is classified as a cosmetic ingredient in our database. CAS number: 299-27-4.
Is Potassium Gluconate used outside cosmetics?
Potassium Gluconate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Potassium Gluconate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Good
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