Is Poloxamer 181 safe in cosmetics?
Poloxamer 181 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Poloxamer 181
Also known as: 2-Methyl-oxirane polymer with oxirane, 1,2-Ethanediol, polymer with 1,2-propanediol, Ethylene glycol polyethylene-polypropylene glycol ether (1:2), Proxanol Tsl-3, Polyoxyethylene-oxy-propylene (+13 more)
INCI: POLOXAMER 181
Poloxamer 181 (CAS 9003-11-6) is a cosmetic cosmetic ingredient functioning as Surfactant, emulsifying agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 9003-11-6 →
Auto-generated CPSR Part A draft with source citations
Function
Surfactant, emulsifying agent
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR: safe as used (2008)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Poloxamer 181.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-streaking agent
Binder
Cleaning agent
Defoamer
Dispersing agent
Drier
Emulsifier
Filler
Humectant
Lubricating agent
Regulatory List Membership (2)
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Poloxamer 181.
Regulatory Flags
epa_safer_alternative
fda_food_additive
Known Synonyms
2-Methyl-oxirane polymer with oxirane
1,2-Ethanediol, polymer with 1,2-propanediol
Ethylene glycol polyethylene-polypropylene glycol ether (1:2)
Proxanol Tsl-3
Polyoxyethylene-oxy-propylene
Ethylene oxide, propylene oxide block polymer
UNII-52901V8XAR
UNII-P5QZM4T259
UNII-66UUC8WX0D
UNII-YWJ6837FL1
UNII-68T8I45V23
UNII-B9Y8J911BV
UNII-199SZS8E2Q
UNII-1AZW43116L
UNII-5Z46X21X7I
UNII-ETS9O8IMRZ
UNII-JP0CK963E0
Pluronic F-127
Chemical Function
Surfactant (surface active agent)
Solvent
Regulatory Lists
fracking; water
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
inert_ingredient; non_food_use; Pesticides
pharmaceutical
active_ingredient; animal_products; Europe; pharmaceutical; residue
SCIL (9/2019)
Canada; pharmaceutical
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
inert_ingredient; Pesticides
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Poloxamer 181 allowed in the EU?
Poloxamer 181 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Poloxamer 181 do in cosmetics?
Poloxamer 181 functions as: Surfactant, emulsifying agent. It is classified as a cosmetic ingredient in our database. CAS number: 9003-11-6.
Compliance Tools
Check Poloxamer 181 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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