Is Piperazine Bisferulate safe in cosmetics?
Piperazine Bisferulate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Piperazine Bisferulate
Also known as: UNII-OU4LRY06IK, 2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, compd. with piperazine (2:1), Cinnamic acid, 4-hydroxy-3-methoxy-, compd. with piperazine (2:1), Oristar PRF, Piperazine ferulate (+1 more)
INCI: PIPERAZINE BISFERULATE
Piperazine Bisferulate (CAS 96585-18-1) is a cosmetic cosmetic ingredient functioning as Skin conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 96585-18-1 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
bis((E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid);piperazine
InChIKey
OEWLZTGXBCJPKL-MSEGBBJSSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically listed by FDA; general cosmetic ingredient status
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Piperazine Bisferulate.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Piperazine Bisferulate.
Regulatory Flags
potential-allergen
Known Synonyms
UNII-OU4LRY06IK
2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, compd. with piperazine (2:1)
Cinnamic acid, 4-hydroxy-3-methoxy-, compd. with piperazine (2:1)
Oristar PRF
Piperazine ferulate
Piperazine, bis(3-(4-hydroxy-3-methoxyphenyl)-2-propenoate)
Chemical Function
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA count match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Adverse Event Associations
9
Frequently Asked Questions
Is Piperazine Bisferulate allowed in the EU?
Piperazine Bisferulate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Piperazine Bisferulate do in cosmetics?
Piperazine Bisferulate functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 96585-18-1.
Is Piperazine Bisferulate used outside cosmetics?
Piperazine Bisferulate also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Piperazine Bisferulate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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