NOAEL Studies Cosmetic Ingredient

Pigment Yellow 12 NOAEL Studies

INCI: PIGMENT YELLOW 12

CAS: 6358-85-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_inhalation 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 >0.23 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=841; Record_ID=acute_inhalation_855; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1021451; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.23; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15824/7/3/3/?documentUUID=14ea470e-4a1f-463f-8eb3-f5ff5e91a163; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021451; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021451
NTP_ICE_acute_inhalation LC50 >4.25 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=842; Record_ID=acute_inhalation_857; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID1021451; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=4.25; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15824/7/3/3/?documentUUID=8c6dbe41-d33a-4a56-8ece-3fab450d9223; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021451; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021451
NTP_ICE_acute_oral 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_8693; row=2216; data_type=In Vivo; mixture=Chemical; chemical_name=C.I. Pigment Yellow 12; preferred_name=C.I. Pigment Yellow 12; dtxsid=DTXSID1021451; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021451; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021451; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =2228 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_8694; row=2217; data_type=In Vivo; mixture=Chemical; chemical_name=C.I. Pigment Yellow 12; preferred_name=C.I. Pigment Yellow 12; dtxsid=DTXSID1021451; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021451; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021451; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >2350 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_8695; row=2218; data_type=In Vivo; mixture=Chemical; chemical_name=C.I. Pigment Yellow 12; preferred_name=C.I. Pigment Yellow 12; dtxsid=DTXSID1021451; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021451; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021451; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >15000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_8699; row=2219; data_type=In Vivo; mixture=Chemical; chemical_name=C.I. Pigment Yellow 12; preferred_name=C.I. Pigment Yellow 12; dtxsid=DTXSID1021451; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021451; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021451; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >10000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_8697; row=2220; data_type=In Vivo; mixture=Chemical; chemical_name=C.I. Pigment Yellow 12; preferred_name=C.I. Pigment Yellow 12; dtxsid=DTXSID1021451; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021451; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021451; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >2850 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_8696; row=2221; data_type=In Vivo; mixture=Chemical; chemical_name=C.I. Pigment Yellow 12; preferred_name=C.I. Pigment Yellow 12; dtxsid=DTXSID1021451; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021451; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021451; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >10800 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_8698; row=2222; data_type=In Vivo; mixture=Chemical; chemical_name=C.I. Pigment Yellow 12; preferred_name=C.I. Pigment Yellow 12; dtxsid=DTXSID1021451; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021451; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1021451; source_file=acute_oral.xlsx
NTP_ICE_cancer 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_cancer Top dose 5 % Rat - - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=1655; Record_ID=cancer_2973; Data_Type=In Vivo; Formulation_Name=Diarylanilide yellow; Mixture=Chemical; DTXSID=DTXSID1021451; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=5; Response_Unit=%; Species=Rat; Strain=F344/N; Sex=Male; Reference=TR-030; URL=https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr030/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021451; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1021451
ToxValDB_ECHA_IUCLID 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =9250 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa18e4b0a7c65d1b4431; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2229/7/8?documentUUID=9f75ab37-4312-49a9-972a-eecd37b11432; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820393_15820394_15820395_15820396:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6f02c8c74b54d4f86cb2e052bc415004
ToxValDB_ECHA_IUCLID NOAEL =1665 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216da4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11673/7/8?documentUUID=88b8eb08-e64e-4afd-872d-de733b239107; YEAR=1973; ORIGINAL_YEAR=1973; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820397_15820398_15820399_15820400:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6d8c327c6c42703dd889038d96b2acf7
ToxValDB_ECHA_IUCLID NOAEL =702 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3c49; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11673/7/8?documentUUID=88b8eb08-e64e-4afd-872d-de733b239107; YEAR=1973; ORIGINAL_YEAR=1973; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820411_15820412_15820413_15820414:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5fe532a1d47f589d3df226648a38c0ba
ToxValDB_ECHA_IUCLID NOAEL =3900 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9fee4b0a7c65d1b3bb2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2023/7/8?documentUUID=542e7187-04a0-4ac3-80fb-f10bdd3d414d; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820425_15820426_15820427_15820428_15820429:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_12f78152a673b96539f52d0269a336a2
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral short-term (developmental); 28 days reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaec9e4b0a7c65d1cae7e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2229/7/6/2?documentUUID=9f75ab37-4312-49a9-972a-eecd37b11432; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15848539_15848697_15848748_15849013_15849109:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7b53c39187687b63f3f97f31bd6a9cd8
ToxValDB_ECHA_IUCLID NOAEL =2500 mg/kg bw/day Rat oral - repeat dose other QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf22e4b0a7c65d1cc994; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22437/7/6/2?documentUUID=f797b7c7-899d-4e49-adb5-98ab6afcd218; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15849924:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0995f5ba8f86b62abb01819f2143c034
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier N52TUS5TRY UNII - - - chemical {"approval_status":null,"molecular_formula":"C32H26Cl2N6O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N52TUS5TRY"}
openFDA substances FDA UNII substance identifier N52TUS5TRY UNII - - - chemical {"approval_status":null,"molecular_formula":"C32H26Cl2N6O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N52TUS5TRY"}
openFDA substances FDA UNII substance identifier N52TUS5TRY UNII - - - chemical {"approval_status":null,"molecular_formula":"C32H26Cl2N6O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N52TUS5TRY"}
openFDA substances FDA UNII substance identifier N52TUS5TRY UNII - - - chemical {"approval_status":null,"molecular_formula":"C32H26Cl2N6O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"N52TUS5TRY"}