Is Phytantriol safe in cosmetics?
Phytantriol has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Phytantriol
INCI: PHYTANTRIOL
Phytantriol (CAS 74563-64-7) is a cosmetic cosmetic ingredient functioning as Skin conditioning, hair conditioning, humectant, anticaking. NOAEL 150 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 74563-64-7 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning, hair conditioning, humectant, anticaking
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
3,7,11,15-tetramethylhexadecane-1,2,3-triol
InChIKey
CGIHFIDULQUVJG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Expert Panel concluded safe as cosmetic ingredient; not acute toxic in oral testing; no genotoxicity
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Phytantriol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Phytantriol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =150 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Phytantriol across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-caking agent
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Phytantriol.
Regulatory Flags
humectant
hair-conditioning
skin-conditioning
well-studied
cir-approved
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Phytantriol by CAS number or substance name.
Studies
1
Lowest NOAEL
150 mg/kg bw/day
Highest NOAEL
150 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Chemical Function
Humectant
Softener and conditioner
Anti-caking agent
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Phytantriol allowed in the EU?
Phytantriol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phytantriol do in cosmetics?
Phytantriol functions as: Skin conditioning, hair conditioning, humectant, anticaking. It is classified as a cosmetic ingredient in our database. CAS number: 74563-64-7.
What is the NOAEL for Phytantriol?
The NOAEL (No Observed Adverse Effect Level) for Phytantriol is =150 mg/kg bw/day based on a developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Phytantriol used outside cosmetics?
Phytantriol also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Phytantriol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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