Is Phloretin safe in cosmetics?
Phloretin has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Phloretin
INCI: PHLORETIN
Phloretin (CAS 60-82-2 [^1_9]) is a cosmetic cosmetic ingredient functioning as Antioxidant, anti-sebum; enhances skin penetration of other actives. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 60-82-2 [^1_9] →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, anti-sebum; enhances skin penetration of other actives
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA permitted; CIR has not published a dedicated review; widely used in commercial products (e.g., SkinCeuticals)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Phloretin.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
2 property records from structured ingredient metadata.
acne
{"cas_number": "60-82-2", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "10-15", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_…
antioxidant
{"cas_number": "60-82-2", "antioxidant_class": "polyphenol", "chemical_subclass": "dihydrochalcone", "molecular_weight_daltons": "274.27", "orac_value_umol_te_per_g": "13800", "dpph_radical_scavenging_ic50_ug_per_ml": "12-22", "abts_trolox_equivalent": "1.1", "singlet_oxygen_quenching": "high", "superoxide_dismutase_mimetic": "moderate", "hydroxyl_radical_scavenging": "high", "lipid_peroxidation_i…
Expert Verdict
Expert safety assessment and concern-level summary for Phloretin.
Regulatory Flags
endocrine_disruptor
Frequently Asked Questions
Is Phloretin allowed in the EU?
Phloretin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phloretin do in cosmetics?
Phloretin functions as: Antioxidant, anti-sebum; enhances skin penetration of other actives. It is classified as a cosmetic ingredient in our database. CAS number: 60-82-2 [^1_9].
Compliance Tools
Check Phloretin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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