NOAEL Studies Cosmetic Ingredient

Phenylacetic Acid NOAEL Studies

INCI: PHENYLACETIC ACID

CAS: 103-82-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB LOAEL 45 mg/kg bw/day rat oral 21 day Developmental PAFA; VOPR PITAN 3:64-68,Article in Russian
COSMOS_DB NOAEL 45 mg/kg bw/day rat oral NA Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 450 mg/kg bw/day rat oral 3 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =2250 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_331; row=3965; data_type=In Vivo; mixture=Chemical; chemical_name=Phenylacetic acid; preferred_name=Phenylacetic acid; dtxsid=DTXSID2021656; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021656; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2215; Record_ID=skin_sensitization_invivo_638; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2021656; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|RIFM 1972; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1975; Not available; 10.1016/0015-6264(75)90273-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021656
NTP_ICE_skin_sensitization Induction dose per skin area 1296 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2214; Record_ID=skin_sensitization_invivo_638; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2021656; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1296; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|RIFM 1972; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1975; Not available; 10.1016/0015-6264(75)90273-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021656
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=2219; Record_ID=skin_sensitization_invivo_638; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2021656; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|RIFM 1972; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1975; Not available; 10.1016/0015-6264(75)90273-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021656
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa4ae4b0a7c65d1b524d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24051/7/9/2?documentUUID=5e2df141-d3b0-42d5-866a-48abf8660177; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=P0: mortality|P0: body weight and weight gain|P0: food consumption and compound intake|P0: organ weights and organ / body weight ratios|P0: gross pathology|P0: histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|gross pathology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15857095:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a817f0d42010672030aa87b531dfbd79
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =16.4 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634076:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_96570eb313800a5dbbf0afd9a3377aff
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier ER5I1W795A UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"ER5I1W795A"}
openFDA substances FDA UNII substance identifier ER5I1W795A UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"ER5I1W795A"}
openFDA substances FDA UNII substance identifier ER5I1W795A UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"ER5I1W795A"}
openFDA substances FDA UNII substance identifier ER5I1W795A UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"ER5I1W795A"}