NOAEL Studies Cosmetic Ingredient

Phenethyl Phenylacetate NOAEL Studies

INCI: PHENETHYL PHENYLACETATE

CAS: 102-20-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 500 mg/kg bw/day rat oral 119 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =15000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_242; row=1419; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenylethyl phenylacetate; preferred_name=2-Phenylethyl phenylacetate; dtxsid=DTXSID0044494; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0044494; source_file=acute_oral.xlsx
NTP_ICE_adme_parameters 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 57.48 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=327; Record_ID=adme_parameters_1113; Data_Type=Measured; DTXSID=DTXSID0044494; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=57.48; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Paini 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0044494
NTP_ICE_skin_sensitization 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=1862; Record_ID=skin_sensitization_invivo_575; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0044494; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90276-X; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0044494
NTP_ICE_skin_sensitization Induction dose per skin area 1296 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=1861; Record_ID=skin_sensitization_invivo_575; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0044494; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1296; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90276-X; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0044494
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=1864; Record_ID=skin_sensitization_invivo_575; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0044494; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90276-X; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0044494
NTP_ICE_skin_sensitization Relative reliability score 4 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=1867; Record_ID=skin_sensitization_invivo_576; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0044494; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=4; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Majors 1971: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90276-X; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0044494
ToxValDB_GESTIS_DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =0.628 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15634049_15634050:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ee7e9a13ec0e05bb31db3aea53ddb9cc
ToxValDB_GESTIS_DNEL DNEL systemic =4.9 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15634049_15634050:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1a64b2a0f7acce70f01e8ae789e10231
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 5J5OJ7GH15 UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5J5OJ7GH15"}
openFDA substances FDA UNII substance identifier 5J5OJ7GH15 UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5J5OJ7GH15"}
openFDA substances FDA UNII substance identifier 5J5OJ7GH15 UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5J5OJ7GH15"}
openFDA substances FDA UNII substance identifier 5J5OJ7GH15 UNII - - - chemical {"approval_status":null,"molecular_formula":"C16H16O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5J5OJ7GH15"}