Is Pentapeptide-5 safe in cosmetics?
Pentapeptide-5 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Pentapeptide-5
INCI: PENTAPEPTIDE-5
Pentapeptide-5 (CAS SH-Pentapeptide-5 (Leu-enkephalin variant): 58822-25-6 ; base Pentapeptide-5 CAS not separately listed) is a cosmetic cosmetic ingredient functioning as Skin conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
Auto-generated CPSR Part A draft with source citations
CAS Number
SH-Pentapeptide-5 (Leu-enkephalin variant): 58822-25-6 ; base Pentapeptide-5 CAS not separately listed
View industrial chemical safety profile →
Function
Skin conditioning
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not listed as prohibited or restricted by FDA
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Pentapeptide-5.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Pentapeptide-5.
Frequently Asked Questions
Is Pentapeptide-5 allowed in the EU?
Pentapeptide-5 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Pentapeptide-5 do in cosmetics?
Pentapeptide-5 functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: SH-Pentapeptide-5 (Leu-enkephalin variant): 58822-25-6 ; base Pentapeptide-5 CAS not separately listed.
Compliance Tools
Check Pentapeptide-5 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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