NOAEL Studies
Cosmetic Ingredient
PEG-3 Sorbitan Oleate NOAEL Studies
INCI: PEG-3 SORBITAN OLEATE
CAS: 9005-65-6
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 5000 | mg/kg bw/day | rat | oral | 720 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1000 | mg/kg bw/day | monkey | oral | 355 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 10000 | mg/kg bw/day | rat | oral | NA | Multigeneration Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 7500 | mg/kg bw/day | mouse | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 2500 | mg/kg bw/day | rat | oral | 90 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =2500 | mg/kg bw/day | Rat | oral: unspecified | 721 days | chronic/long term toxicity | EFSA ANS - 2015 - OutputID 2782 - mortality - systemic - Scientific Opinion on the re-evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene sorbitan tristearate (E 436) as food additives - doi:10.2903/j.efsa.2015.4152 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =2500 | mg/kg bw/day | Rat | oral: unspecified | 721 days | chronic/long term toxicity | EFSA ANS - 2015 - OutputID 2782 - mortality - systemic - Scientific Opinion on the re-evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene sorbitan tristearate (E 436) as food additives - doi:10.2903/j.efsa.2015.4152 |
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI (group) | =25 | mg/kg bw/day | Consumers | - | - | ADI (group) | EFSA ANS - 2015 - OutputID 2782 - Consumers - Scientific Opinion on the re-evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene sorbitan tristearate (E 436) as food additives - doi:10.2903/j.efsa.2015.4152 |
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI (group) | =25 | mg/kg bw/day | Consumers | - | - | ADI (group) | EFSA ANS - 2015 - OutputID 2782 - Consumers - Scientific Opinion on the re-evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene sorbitan tristearate (E 436) as food additives - doi:10.2903/j.efsa.2015.4152 |
NTP_ICE_cancer 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | POLY-3 lowest dose | 50000 | ppm | Rat | Dosed feed | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=415; Record_ID=cancer_4806; Data_Type=In Vivo; Formulation_Name=Polysorbate 80 (glycol); Mixture=Chemical; DTXSID=DTXSID0021175; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=50000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Male; Route=Dosed feed; Level_of_Evidence=Equivocal evidence; Tissue=Adrenal gland medulla; Lesion=Pheochromocytoma(Benign, complex, malignant); Reference=TR-415; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr415/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_cancer | Top dose | 5 | % | Rat | Dosed feed | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=408; Record_ID=cancer_4809; Data_Type=In Vivo; Formulation_Name=Polysorbate 80 (Glycol); Mixture=Chemical; DTXSID=DTXSID0021175; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=5; Response_Unit=%; Species=Rat; Strain=F344/N; Sex=Female; Route=Dosed feed; Reference=TR-415; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr415/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=13520; RecordID=ARPathway2016_1698; DatasetName=ARPathway2016; DTXSID=DTXSID0021175; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
NTP_ICE_eye_irritation 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_eye_irritation | Draize rabbit irritation score | 0 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=76; Record_ID=eye_irritation_178; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=0; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_eye_irritation | EPA Classification | 4 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=74; Record_ID=eye_irritation_178; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_eye_irritation | Intensity | 0.02 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=78; Record_ID=eye_irritation_1307; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=Vitrigel; Endpoint=Intensity; Response=0.02; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_eye_irritation | Lag time | >180 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=77; Record_ID=eye_irritation_1307; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=Vitrigel; Endpoint=Lag time; Response_Modifier=>; Response=180; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_eye_irritation | Plateau level | 0 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=79; Record_ID=eye_irritation_1307; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=Vitrigel; Endpoint=Plateau level; Response=0; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
NTP_ICE_skin_irritation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_irritation | Positive reaction | 3.5 | % | Human | Dermal | - | In Vivo; Four-hour Human Patch Test | sheet=Data_invivo; excel_row=79; Record_ID=skin_irritation_invivo_81; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=3.5; Response_Unit=%; Species=Human; Reference=Basketter et al. 2004; 15291823; 10.1111/j.0105-1873.2004.00385.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_skin_irritation | Positive reaction | 3.8 | % | Human | Dermal | - | In Vivo; Four-hour Human Patch Test | sheet=Data_invivo; excel_row=80; Record_ID=skin_irritation_invivo_82; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=3.8; Response_Unit=%; Species=Human; Reference=Robinson et al. 2001; 11422260; 10.1034/j.1600-0536.2001.045001001.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
NTP_ICE_skin_sensitization 18 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | CD86, EC150 | 8.73 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8636; Record_ID=skin_sensitization_invitro_2388; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=8.73; Reported_Response_Unit=ug/mL; Response=8.73; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_skin_sensitization | CV70 | >200 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8634; Record_ID=skin_sensitization_invitro_2388; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=U-SENS; Endpoint=CV70; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_skin_sensitization | CV75 | 5000 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; h-CLAT | sheet=Data_invitro; excel_row=1670; Record_ID=skin_sensitization_invitro_461; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=h-CLAT; Endpoint=CV75; Reported_Response=5000; Reported_Response_Unit=ug/mL; Response=5000; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_skin_sensitization | Depletion Cys | 10.2 | % | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; DPRA | sheet=Data_invitro; excel_row=246; Record_ID=skin_sensitization_invitro_67; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=10.2; Reported_Response_Unit=%; Response=10.2; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_skin_sensitization | Depletion Lys | 0 | % | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; DPRA | sheet=Data_invitro; excel_row=220; Record_ID=skin_sensitization_invitro_67; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_skin_sensitization | EC1.5 | 115.4742 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=6911; Record_ID=skin_sensitization_invitro_1636; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=115.4742; Reported_Response_Unit=uM; Response=115.4742; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_skin_sensitization | EC1.5 | 115.5 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6913; Record_ID=skin_sensitization_invitro_1637; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=115.5; Reported_Response_Unit=uM; Response=115.5; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_skin_sensitization | EC1.5 | <65.91 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=8015; Record_ID=skin_sensitization_invitro_1812; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=65.91; Reported_Response_Unit=uM; Response=65.91; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_skin_sensitization | EC3 | 677.4 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6915; Record_ID=skin_sensitization_invitro_1637; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=677.4; Reported_Response_Unit=uM; Response=677.4; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_skin_sensitization | IC50 | 4000 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=6917; Record_ID=skin_sensitization_invitro_1636; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=4000; Reported_Response_Unit=uM; Response=4000; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_skin_sensitization | IC50 | 813.1 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6919; Record_ID=skin_sensitization_invitro_1637; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=813.1; Reported_Response_Unit=uM; Response=813.1; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_skin_sensitization | IC50 | >164 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7644; Record_ID=skin_sensitization_invitro_1812; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=164; Reported_Response_Unit=uM; Response=164; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_skin_sensitization | Imax | 3.08 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6921; Record_ID=skin_sensitization_invitro_1637; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=3.08; Reported_Response_Unit=Unitless; Response=3.08; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_skin_sensitization | Imax | 3.085 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=6923; Record_ID=skin_sensitization_invitro_1636; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=3.08456; Reported_Response_Unit=Unitless; Response=3.085; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_skin_sensitization | Imax | 3.764 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7546; Record_ID=skin_sensitization_invitro_1812; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=LuSens; Endpoint=Imax; Reported_Response=3.764048241; Reported_Response_Unit=Unitless; Response=3.764; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10984; Record_ID=skin_sensitization_invivo_2401; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Magnusson and Kligman 1969; 5774356; 10.1038/jid.1969.42|Gad et al. 1986; 3715870; 10.1016/0041-008X(86)90419-9|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 15520 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10982; Record_ID=skin_sensitization_invivo_2401; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=15520; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Magnusson and Kligman 1969; 5774356; 10.1038/jid.1969.42|Gad et al. 1986; 3715870; 10.1016/0041-008X(86)90419-9|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP_ICE_skin_sensitization | Relative reliability score | 1 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10988; Record_ID=skin_sensitization_invivo_2401; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=1; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Magnusson and Kligman 1969; 5774356; 10.1038/jid.1969.42|Gad et al. 1986; 3715870; 10.1016/0041-008X(86)90419-9|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
ToxRefDB_ToxRefDB_v3_pod.csv 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =7500 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 2 year | CHR | study_id=7411; toxval_study_source_id=studyid7411_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-hyperplasia|pathology microscopic-stomach-ulcer|pathology microscopic-stomach-inflammation|in life observation-body weight-body weight; dose_level=2; study_year=1992; study_citation=NTP. (1992) Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP TR 415, NIH Publication No. 92-3146. (Chronic mouse); dsstox_substance_id=DTXSID0021175; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | >2500 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 2 year | CHR | study_id=7412; toxval_study_source_id=studyid7412_Adult_F0_F_NA; dose_level=2; study_year=1992; study_citation=NTP. (1992) Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP TR 415, NIH Publication No. 92-3146. (Chronic rat); dsstox_substance_id=DTXSID0021175; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =3750 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 2 year | CHR | study_id=7411; toxval_study_source_id=studyid7411_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology microscopic-stomach-hyperplasia|pathology microscopic-stomach-inflammation|pathology microscopic-stomach-ulcer; dose_level=1; study_year=1992; study_citation=NTP. (1992) Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP TR 415, NIH Publication No. 92-3146. (Chronic mouse); dsstox_substance_id=DTXSID0021175; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =1250 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 2 year | CHR | study_id=7412; toxval_study_source_id=studyid7412_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-spleen-hematopoietic cell proliferation erythrocytic|pathology microscopic-adrenal gland-pheochromocytoma benign; dose_level=1; study_year=1992; study_citation=NTP. (1992) Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP TR 415, NIH Publication No. 92-3146. (Chronic rat); dsstox_substance_id=DTXSID0021175; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | NOEL | =0.5 | % | Mouse | injection | acute; 0.6667 days | acute | LONG_REF=Teratog. Carcinog. Mutagen.19(5): 323-327 Przybojewska,B. Assessment of Aniline Derivatives-Induced DNA Damage in the Liver Cells of B6C3F1 Mice Using the Alkaline Single Cell Gel Electrophoresis (\"Comet\") Assay 1999; TITLE=Assessment of Aniline Derivatives-Induced DNA Damage in the Liver Cells of B6C3F1 Mice Using the Alkaline Single Cell Gel Electrophoresis ("Comet") Assay; AUTHOR=Przybojewska,B.; DOI=10.1002/(sici)1520-6866(1999)19:5<323::aid-tcm2>3.0.co;2-c; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=111819; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15602277:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b308da6db3651a466efc4b4396e06768 |
ToxValDB_EFSA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EFSA | NOAEL | =2500 | mg/kg bw/day | Rat | oral | chronic; 103 weeks | chronic | LONG_REF=EFSA ANS (2015). Scientific Opinion on the re-evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene sorbitan tristearate (E 436) as food additives. doi:10.2903/j.efsa.2015.4152.; TITLE=Scientific Opinion on the re-evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene sorbitan tristearate (E 436) as food additives; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2015.4152; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=EFSA:15624471:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8e00f56490122fb0c11cfcc86c2b71ca |
ToxValDB_HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HESS | NOEL | =4800 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0defe4b0a676289de90e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; STUDY_GROUP=HESS:15638662:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_43b1c007b42122c973f92dea1ff1415d |
ToxValDB_ToxRefDB 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ToxRefDB | LEL | =7500 | mg/kg bw/day | Mouse | oral | chronic; 2 years | chronic | LONG_REF=NTP. (1992) Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP TR 415, NIH Publication No. 92-3146. (Chronic mouse); TITLE=Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=7411; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-hyperplasia|systemic: pathology microscopic-stomach-inflammation|systemic: pathology microscopic-stomach-ulcer|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15712594_15712595_15712596_15712597:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7c4f8629f82108336e68a52f51d4f1d4 |
| ToxValDB_ToxRefDB | NEL | =3750 | mg/kg bw/day | Mouse | oral | chronic; 2 years | chronic | LONG_REF=NTP. (1992) Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP TR 415, NIH Publication No. 92-3146. (Chronic mouse); TITLE=Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=7411; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-inflammation|systemic: pathology microscopic-stomach-hyperplasia|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-stomach-ulcer; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15712594_15712595_15712596_15712597:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cc55bdc6a3568bca705b4d597168954b |
| ToxValDB_ToxRefDB | NEL | =1250 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=NTP. (1992) Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP TR 415, NIH Publication No. 92-3146. (Chronic rat); TITLE=Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=7412; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-spleen-hematopoietic cell proliferation erythrocytic|systemic: pathology microscopic-adrenal gland-pheochromocytoma benign; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15712606_15712607_15712608_15712609:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2b79cad9f9b28c28b23b3192bd8c4fc6 |
openFDA substances 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 2MSF640LWM | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"2MSF640LWM"} |
| openFDA substances | FDA UNII substance identifier | 58O7V09UCI | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"58O7V09UCI"} |
| openFDA substances | FDA UNII substance identifier | 6OZP39ZG8H | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"6OZP39ZG8H"} |
| openFDA substances | FDA UNII substance identifier | 2MSF640LWM | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"2MSF640LWM"} |
| openFDA substances | FDA UNII substance identifier | 2MSF640LWM | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"2MSF640LWM"} |
| openFDA substances | FDA UNII substance identifier | 58O7V09UCI | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"58O7V09UCI"} |
| openFDA substances | FDA UNII substance identifier | 58O7V09UCI | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"58O7V09UCI"} |
| openFDA substances | FDA UNII substance identifier | 6OZP39ZG8H | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"6OZP39ZG8H"} |
| openFDA substances | FDA UNII substance identifier | 6OZP39ZG8H | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"6OZP39ZG8H"} |
| openFDA substances | FDA UNII substance identifier | 2MSF640LWM | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"2MSF640LWM"} |
| openFDA substances | FDA UNII substance identifier | 58O7V09UCI | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"58O7V09UCI"} |
| openFDA substances | FDA UNII substance identifier | 6OZP39ZG8H | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"6OZP39ZG8H"} |