NOAEL Studies Cosmetic Ingredient

PEG-2 CAPRYLYLAMINE NOAEL Studies

CAS: 15520-05-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_ECHA_IUCLID 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL >=300 mg/kg bw/day Rat oral - developmental GUIDELINE=EPA OPP 83-3 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabe9e4b0a7c65d1bc6fa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18314/7/9/3?documentUUID=98212a4d-2220-47a8-b2e1-c53f85e9d5b0; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15824393:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9d1848bf5996b87f5ae5fddd30cb9c6b
ToxValDB_ECHA_IUCLID NOAEL >=150 mg/kg bw/day Rat oral - reproduction developmental GUIDELINE=EPA OPP 83-3 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabe9e4b0a7c65d1bc6fa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18314/7/9/3?documentUUID=98212a4d-2220-47a8-b2e1-c53f85e9d5b0; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: clinical signs|maternal: food consumption and compound intake|maternal: gross pathology|maternal: histopathology: non-neoplastic|maternal: mortality|maternal: necropsy findings; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15824394:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a005b8f1800069e23d9323c4e0f823e7
ToxValDB_ECHA_IUCLID NOAEL ~500 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead8ae4b0a7c65d1c4b68; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18314/7/6/2?documentUUID=98212a4d-2220-47a8-b2e1-c53f85e9d5b0; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838407_15850843:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_20ce0569f1cf205764e7c1edfc3affb8
ToxValDB_ECHA_IUCLID NOAEL =350 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead8ae4b0a7c65d1c4b72; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18314/7/6/2?documentUUID=98212a4d-2220-47a8-b2e1-c53f85e9d5b0; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15850844:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_38a1b2b220d8c9fa8de185791e662450
ToxValDB_ECHA_IUCLID NOAEL ~320 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaa7e4b0a7c65d1b6df4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18314/7/9/2?documentUUID=98212a4d-2220-47a8-b2e1-c53f85e9d5b0; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15862408:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_83b80cabdcaac951771b89d3e4e3af3b
ToxValDB_ECHA_IUCLID NOEL =20 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead8ae4b0a7c65d1c4b68; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18314/7/6/2?documentUUID=98212a4d-2220-47a8-b2e1-c53f85e9d5b0; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838407_15850843:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6abac80ed8cd5ef4afb0c417a901f8e3
ToxValDB_ECHA_IUCLID NOEL ~320 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaa7e4b0a7c65d1b6df4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18314/7/9/2?documentUUID=98212a4d-2220-47a8-b2e1-c53f85e9d5b0; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15861742:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0073699065b20d39640ca06d6f2eb1a7
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =61.7 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633905:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fe1a1f6a89836c3338205ea79b4d4f2c
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier HLR7HK4J1P UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H27NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"HLR7HK4J1P"}
openFDA substances FDA UNII substance identifier HLR7HK4J1P UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H27NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"HLR7HK4J1P"}
openFDA substances FDA UNII substance identifier HLR7HK4J1P UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H27NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"HLR7HK4J1P"}
openFDA substances FDA UNII substance identifier HLR7HK4J1P UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H27NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"HLR7HK4J1P"}