NOAEL Studies Emollient

Palmitoylethanolamide (PEA) NOAEL Studies

CAS: 544-31-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca78e4b0a7c65d2220bc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15928/7/6/2?documentUUID=316af4ce-fbb8-4f1a-b826-8916103a82a2; YEAR=1967; ORIGINAL_YEAR=1967; TOXICOLOGICAL_EFFECT=clinical biochemistry|clinical signs|food consumption and compound intake|gross pathology|histopathology: neoplastic|histopathology: non-neoplastic|mortality|neuropathology|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837301_15844410:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_138504bf5c8667b1845979eafe607bff
ToxValDB_ECHA_IUCLID NOEL =1000 mg/kg bw/day Rat oral short-term; 14 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb53e4b0a7c65d225acc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23420/7/6/2?documentUUID=19559223-831b-4ac4-ad28-7bc2127bd362; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=clinical signs|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|mortality/survival; STUDY_GROUP=ECHA IUCLID:15846106:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ef64b6980918df29084abc852ff20314
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =49.3 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633976:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_30460a6e684591f46fe6874c74d16c83
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 6R8T1UDM3V UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H37NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6R8T1UDM3V"}
openFDA substances FDA UNII substance identifier 6R8T1UDM3V UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H37NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6R8T1UDM3V"}
openFDA substances FDA UNII substance identifier 6R8T1UDM3V UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H37NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6R8T1UDM3V"}
openFDA substances FDA UNII substance identifier 6R8T1UDM3V UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H37NO2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"6R8T1UDM3V"}