NOAEL Studies
Emollient
Palmitic Acid NOAEL Studies
INCI: PALMITIC ACID
CAS: 57-10-3
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 7500 | mg/kg bw/day | mouse | oral | 10 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
NTP_ICE_acute_oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | >10000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_7807; row=3958; data_type=In Vivo; mixture=Chemical; chemical_name=Hexadecanoic acid; preferred_name=Hexadecanoic acid; dtxsid=DTXSID2021602; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021602; source_file=acute_oral.xlsx |
NTP_ICE_endocrine 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | AC50 | 37.6707981237727 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=10266; RecordID=ERPathway2016_458; DatasetName=ERPathway2016; DTXSID=DTXSID2021602; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=37.6707981237727; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021602 |
| NTP_ICE_endocrine | ACC | 49.5166866717265 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=10267; RecordID=ERPathway2016_458; DatasetName=ERPathway2016; DTXSID=DTXSID2021602; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=49.5166866717265; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021602 |
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=10262; RecordID=ARPathway2016_1338; DatasetName=ARPathway2016; DTXSID=DTXSID2021602; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021602 |
| NTP_ICE_endocrine | Model Score | 0.00386 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=10268; RecordID=ERPathway2016_458; DatasetName=ERPathway2016; DTXSID=DTXSID2021602; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.00386; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021602 |
NTP_ICE_skin_irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_irritation | Positive reaction | 0 | % | Human | Dermal | - | In Vivo; Four-hour Human Patch Test | sheet=Data_invivo; excel_row=534; Record_ID=skin_irritation_invivo_17; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID2021602; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=0; Response_Unit=%; Species=Human; Reference=Basketter et al. 2004; 15291823; 10.1111/j.0105-1873.2004.00385.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021602 |
ToxValDB_ECOTOX 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | NOEL | =0.09 | mM | European Rabbit | environmental | short-term; 5 days | developmental | LONG_REF=Biol. Reprod.20(2): 323-332 Kane,M.T. Fatty Acids as Energy Sources for Culture of One-Cell Rabbit Ova to Viable Morulae 1979; TITLE=Fatty Acids as Energy Sources for Culture of One-Cell Rabbit Ova to Viable Morulae; AUTHOR=Kane,M.T.; DOI=10.1095/biolreprod20.2.323; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=101665; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Development: Blastocyst stage; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598008_15605863:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5b5ba9b426181ea9647009668bb8a5b7 |
| ToxValDB_ECOTOX | NOEL | =0.9 | mM | European Rabbit | environmental | short-term; 5 days | developmental | LONG_REF=Biol. Reprod.20(2): 323-332 Kane,M.T. Fatty Acids as Energy Sources for Culture of One-Cell Rabbit Ova to Viable Morulae 1979; TITLE=Fatty Acids as Energy Sources for Culture of One-Cell Rabbit Ova to Viable Morulae; AUTHOR=Kane,M.T.; DOI=10.1095/biolreprod20.2.323; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=101665; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Development: Blastocyst stage; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598008_15605863:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=bc1ed74fa283039b98b80a8ab4a38001 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =17.632 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633977:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_71959c68f2b2b039eef20ac6181c7508 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 2V16EO95H1 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C16H32O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2V16EO95H1"} |
| openFDA substances | FDA UNII substance identifier | 2V16EO95H1 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C16H32O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2V16EO95H1"} |
| openFDA substances | FDA UNII substance identifier | 2V16EO95H1 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C16H32O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2V16EO95H1"} |
| openFDA substances | FDA UNII substance identifier | 2V16EO95H1 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C16H32O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2V16EO95H1"} |