Is OXYGEN safe in cosmetics?
OXYGEN has a safety rating of "GOOD" in our database. EU status: permitted. US status: allowed.
OXYGEN
Also known as: O2, EINECS 231-956-9, Hyperoxia, Liquid oxygen, Oxygen, liquified (+12 more)
OXYGEN (CAS 7782-44-7) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 7782-44-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
OXYGEN is classified GHS Danger (H335, H270, H280, H361, H281) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
molecular oxygen
InChIKey
MYMOFIZGZYHOMD-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
allowed
US Notes
Allowed for cosmetic use — also FDA-regulated as a drug substance in medical contexts (FDA 21 CFR 177.2800 referenced for food-contact)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance at very high concentrations is irritating to the respiratory tract. The substance may cause effects on the central nervous system, lungs and eyes.
Long-term Exposure Effects
Repeated or prolonged inhalation of high concentrations may cause effects on the lungs.
Routes of Exposure
The substance can be absorbed into the body by inhalation.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
OxidiserCompressed Gas
Hazard Class and Category
Ox. Gas 1; Press. Gas
Hazard Statements
- H270 May cause or intensify fire; oxidiser
Inserted via ATP: CLP00
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
ICSC Safety Card
0138
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
ICSC Safety Card
0880
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Liq: Irritant to skin & tissues. | The inhalation, at 1 atm, of 80% O2 for more than about 12 hr /causes/ ... Irritation of resp tract ... | Contact with liquid will cause frostbite. | ... Short-term /oxygen/ exposure ... at very high concentrations is irritating to the respiratory tract /and/ may cause effects on ... lungs and eyes.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Evaluation
OXYGEN
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Degradant/impurity
No specific technical function
Softener and conditioner
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for OXYGEN.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
needs-enrichment
Known Synonyms
O2
EINECS 231-956-9
Hyperoxia
Liquid oxygen
Oxygen, liquified
Pure oxygen
Oxygenium
Oxygenium medicinale
UNII-S88TT14065
Compressed oxygen
Disauerstoff
E 948
E-948
E948
[OO]
dioxygene
oxidanone
Chemical Function
Softener and conditioner
No specific technical function
Degradant/impurity
Regulatory Lists
drinking_water; Europe; manufacturing; plastic_additive
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
Indirect additives food contact (10/2018)
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
OXYGEN
ChEMBL ID
CHEMBL1234886
Max Phase
4
Adverse Event Associations
4526
Frequently Asked Questions
Is OXYGEN allowed in the EU?
OXYGEN EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does OXYGEN do in cosmetics?
OXYGEN functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 7782-44-7.
Is OXYGEN used outside cosmetics?
OXYGEN also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does OXYGEN have different safety status in cosmetics vs industrial chemicals?
OXYGEN is classified GHS Danger (H335, H270, H280, H361, H281) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check OXYGEN compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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