NOAEL Studies
Cosmetic Ingredient
OXALIC ACID NOAEL Studies
CAS: 144-62-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =7500 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_2734; row=816; data_type=In Vivo; mixture=Chemical; chemical_name=Oxalic acid; preferred_name=Oxalic acid; dtxsid=DTXSID0025816; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0025816; source_file=acute_oral.xlsx |
NTP_ICE_endocrine 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | AC50 | 25.7483810718647 | uM | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=12710; RecordID=ERPathway2016_27; DatasetName=ERPathway2016; DTXSID=DTXSID0025816; Assay=ER Pathway Model, Agonist; Endpoint=AC50; Response=25.7483810718647; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_endocrine | ACC | 18.5653394227728 | uM | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=12711; RecordID=ERPathway2016_27; DatasetName=ERPathway2016; DTXSID=DTXSID0025816; Assay=ER Pathway Model, Agonist; Endpoint=ACC; Response=18.5653394227728; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=12706; RecordID=ARPathway2016_860; DatasetName=ARPathway2016; DTXSID=DTXSID0025816; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_endocrine | Model Score | 0.00766 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=12712; RecordID=ERPathway2016_27; DatasetName=ERPathway2016; DTXSID=DTXSID0025816; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.00766; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_endocrine | Model Score | 0.0225 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=12713; RecordID=ERPathway2016_27; DatasetName=ERPathway2016; DTXSID=DTXSID0025816; Assay=ER Pathway Model, Antagonist; Endpoint=Model Score; Response=0.0225; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
NTP_ICE_skin_sensitization 22 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | CD86, EC150 | 310.33 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3006; Record_ID=skin_sensitization_invitro_705; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID0025816; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=310.33; Reported_Response_Unit=ug/mL; Response=310.33; Response_Unit=ug/mL; Reference=Ashikaga et al. 2010; 20822320; 10.1177/026119291003800403|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_skin_sensitization | CD86, EC150 | >630.238 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8224; Record_ID=skin_sensitization_invitro_2247; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0025816; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=7000; Reported_Response_Unit=uM; Conversion_Factor_Value=90.034; Conversion_Factor_Source=EPA Dashboard; Converted_Response_Modifier=>; Converted_Response=630.238; Converted_Response_Unit=ug/mL; Response=630.238; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_skin_sensitization | CV75 | 1000 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3028; Record_ID=skin_sensitization_invitro_705; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID0025816; Assay=h-CLAT; Endpoint=CV75; Reported_Response=1000; Reported_Response_Unit=ug/mL; Response=1000; Response_Unit=ug/mL; Reference=Ashikaga et al. 2010; 20822320; 10.1177/026119291003800403|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_skin_sensitization | Depletion Cys | 0.9 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=894; Record_ID=skin_sensitization_invitro_247; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID0025816; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=0.9; Reported_Response_Unit=%; Response=0.9; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_skin_sensitization | Depletion Lys | -0.9 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=893; Record_ID=skin_sensitization_invitro_247; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID0025816; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=-0.9; Reported_Response_Unit=%; Response=-0.9; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_skin_sensitization | Depletion Lys + Cys | 0.45 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=895; Record_ID=skin_sensitization_invitro_247; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID0025816; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.45; Reported_Response_Unit=%; Response=0.45; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_skin_sensitization | Depletion Lys + Cys | 0 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=899; Record_ID=skin_sensitization_invitro_248; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID0025816; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_skin_sensitization | EC1.5 | 717.2 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5133; Record_ID=skin_sensitization_invitro_1189; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID0025816; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=717.2; Reported_Response_Unit=uM; Response=717.2; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_skin_sensitization | EC3 | 6.3 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13506; Record_ID=skin_sensitization_invivo_3701; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID0025816; Assay=LLNA; Endpoint=EC3; Response=6.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Montelius et al. 1994; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_skin_sensitization | EC3 | 0.000011 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13507; Record_ID=skin_sensitization_invivo_3703; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID0025816; Assay=LLNA; Endpoint=EC3; Response=1.10E-05; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Montelius et al. 1994; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_skin_sensitization | EC3 | 15 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13508; Record_ID=skin_sensitization_invivo_3704; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID0025816; Assay=LLNA; Endpoint=EC3; Response=15; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_skin_sensitization | EC3 | 6.3 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13506; Record_ID=skin_sensitization_invivo_3701; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID0025816; Assay=LLNA; Endpoint=EC3; Response=6.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Montelius et al. 1994; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_skin_sensitization | EC3 | 0.000011 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13507; Record_ID=skin_sensitization_invivo_3703; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID0025816; Assay=LLNA; Endpoint=EC3; Response=1.10E-05; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Montelius et al. 1994; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_skin_sensitization | EC3 | 15 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13508; Record_ID=skin_sensitization_invivo_3704; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID0025816; Assay=LLNA; Endpoint=EC3; Response=15; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_skin_sensitization | EC3 | 6.3 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13506; Record_ID=skin_sensitization_invivo_3701; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID0025816; Assay=LLNA; Endpoint=EC3; Response=6.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Montelius et al. 1994; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_skin_sensitization | EC3 | 0.000011 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13507; Record_ID=skin_sensitization_invivo_3703; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID0025816; Assay=LLNA; Endpoint=EC3; Response=1.10E-05; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Montelius et al. 1994; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_skin_sensitization | EC3 | 15 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13508; Record_ID=skin_sensitization_invivo_3704; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID0025816; Assay=LLNA; Endpoint=EC3; Response=15; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_skin_sensitization | EC3 | 6.3 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13506; Record_ID=skin_sensitization_invivo_3701; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID0025816; Assay=LLNA; Endpoint=EC3; Response=6.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Montelius et al. 1994; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_skin_sensitization | EC3 | 0.000011 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13507; Record_ID=skin_sensitization_invivo_3703; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID0025816; Assay=LLNA; Endpoint=EC3; Response=1.10E-05; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Montelius et al. 1994; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_skin_sensitization | EC3 | 15 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13508; Record_ID=skin_sensitization_invivo_3704; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID0025816; Assay=LLNA; Endpoint=EC3; Response=15; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_skin_sensitization | IC50 | >2000 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5136; Record_ID=skin_sensitization_invitro_1189; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID0025816; Assay=KeratinoSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
| NTP_ICE_skin_sensitization | Imax | 2.7 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5138; Record_ID=skin_sensitization_invitro_1189; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID0025816; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=2.7; Reported_Response_Unit=Unitless; Response=2.7; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0025816; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0025816 |
ToxValDB_ECHA_IUCLID 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LOAEL | ~5000 | mg/kg bw/day | Rat | oral | subchronic; 70 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaebde4b0a7c65d1caaf5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/22283?documentUUID=338f1203-624a-49df-90d1-04dd897ae9b8; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=kidney: body weight and weight gain|clinical biochemistry|gross pathology|organ weights and organ / body weight ratios|urinalysis|water consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|gross pathology|organ weight|urinalysis; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835083_15840636_15847363_15849086:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_125935572959d65b3a044e07a73b22aa |
| ToxValDB_ECHA_IUCLID | LOAEL | =1900 | mg/kg bw/day | Rat | oral | - | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae73e4b0a7c65d1c95cd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22576/7/6/2?documentUUID=3778c08b-8bec-4d73-afbc-da0054a9e0e0; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=body weight and weight gain|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight; STUDY_GROUP=ECHA IUCLID:15847586:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f7ee5412ba897ede68c2589c6a39cdea |
| ToxValDB_ECHA_IUCLID | LOEL | =1980 | mg/kg bw/day | Rat | oral | subchronic; 70 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae73e4b0a7c65d1c95c6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22576/7/6/2?documentUUID=3778c08b-8bec-4d73-afbc-da0054a9e0e0; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=body weight and weight gain|mortality|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival|organ weight; STUDY_GROUP=ECHA IUCLID:15849598:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5966316478ea16014e6c534d33a1be7d |
| ToxValDB_ECHA_IUCLID | LOEL | =1780 | mg/kg bw/day | Rat | oral | subchronic; 70 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae73e4b0a7c65d1c95c6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22576/7/6/2?documentUUID=3778c08b-8bec-4d73-afbc-da0054a9e0e0; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=body weight and weight gain|mortality|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival|organ weight; STUDY_GROUP=ECHA IUCLID:15849599:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_03eae5ea4b1cea3fa2a2f98fa210ba04 |
| ToxValDB_ECHA_IUCLID | LOEL | =450 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb65e4b0a7c65d225e4c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22576/7/6/2?documentUUID=3778c08b-8bec-4d73-afbc-da0054a9e0e0; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECHA IUCLID:15849600:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8bb9b9081efd9f625c6f24f1887d8613 |
| ToxValDB_ECHA_IUCLID | LOEL | =340 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb65e4b0a7c65d225e4c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22576/7/6/2?documentUUID=3778c08b-8bec-4d73-afbc-da0054a9e0e0; YEAR=2016; ORIGINAL_YEAR=2016; STUDY_GROUP=ECHA IUCLID:15849601:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_70c7eb7fd0ab4d5787f2d7ad13544a00 |
| ToxValDB_ECHA_IUCLID | NOAEL | ~2000 | mg/kg bw/day | Rat | oral | subchronic; 70 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae13e4b0a7c65d1c7554; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/20906/7/6/2?documentUUID=433eac48-7cac-482d-b462-b1bbb33dfd4d; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835083_15840636_15847363_15849086:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ac94f139b5408a82446ebda48fa80c14 |
| ToxValDB_ECHA_IUCLID | NOAEL | =162 | mg/kg bw/day | Mouse | oral | chronic; 18 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae73e4b0a7c65d1c95c1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22576/7/6/2?documentUUID=3778c08b-8bec-4d73-afbc-da0054a9e0e0; YEAR=2016; ORIGINAL_YEAR=2016; STUDY_GROUP=ECHA IUCLID:15849597:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_408a54a2fd4d030f14257c22a3bc2fb6 |
| ToxValDB_ECHA_IUCLID | NOAEL | <=1000 | ppm | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8cbe4b0a7c65d21a236; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30874/7/9/2?documentUUID=8deeeee6-aebb-4d39-aed5-21c77c56310a; YEAR=1968; ORIGINAL_YEAR=1968; STUDY_GROUP=ECHA IUCLID:15859394:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ba208a1b260e389e5d11611d96f4c3e4 |
ToxValDB_ECOTOX 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =2.5 | % | Rat | oral | subchronic; 70 days | subchronic | LONG_REF=Toxicol. Appl. Pharmacol.48(3): 409-414 Goldman,M., and G.J. Doering The Effect of Dietary Ingestion of Oxalic Acid on Thyroid Function in Male and Female Long-Evans Rats 1979; TITLE=The Effect of Dietary Ingestion of Oxalic Acid on Thyroid Function in Male and Female Long-Evans Rats; AUTHOR=Goldman,M., and G.J. Doering; DOI=10.1016/0041-008x(79)90424-1; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151591; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Growth: Weight|Morphology: Organ weight in relationship to body weight|Physiology: Iodine uptake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597497_15599136_15599137_15607873:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c9bfe4e92c6bffc2e993d55b150b3b11 |
| ToxValDB_ECOTOX | LOEL | =5 | % | Rat | oral | subchronic; 70 days | subchronic | LONG_REF=Toxicol. Appl. Pharmacol.48(3): 409-414 Goldman,M., and G.J. Doering The Effect of Dietary Ingestion of Oxalic Acid on Thyroid Function in Male and Female Long-Evans Rats 1979; TITLE=The Effect of Dietary Ingestion of Oxalic Acid on Thyroid Function in Male and Female Long-Evans Rats; AUTHOR=Goldman,M., and G.J. Doering; DOI=10.1016/0041-008x(79)90424-1; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151591; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Hormone(s): Thyrotropin; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597497_15599136_15599137_15607873:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2a07ed8b3476a23c02d42f38a8d6cbe5 |
| ToxValDB_ECOTOX | LOEL | =80.6 | mg/L | Mouse | oral | short-term; 30.44 days | short-term | LONG_REF=Res. Commun. Chem. Pathol. Pharmacol.79(3): 377-380 Domingo,J.L., M. Gomez, D.J. Sanchez, J.M. Llobet, and J. Corbella Effect of Various Dietary Constituents on Gastrointestinal Absorption of Aluminum from Drinking Water and Diet 1993; TITLE=Effect of Various Dietary Constituents on Gastrointestinal Absorption of Aluminum from Drinking Water and Diet; AUTHOR=Domingo,J.L., M. Gomez, D.J. Sanchez, J.M. Llobet, and J. Corbella; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151648; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Biochemistry: Aluminum content; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599709_15601135:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=271d41b3afc5cf392448ccfc3d0173cb |
| ToxValDB_ECOTOX | LOEL | =8 | % | Rat | oral | subchronic; 70 days | subchronic | LONG_REF=Toxicol. Appl. Pharmacol.48(3): 409-414 Goldman,M., and G.J. Doering The Effect of Dietary Ingestion of Oxalic Acid on Thyroid Function in Male and Female Long-Evans Rats 1979; TITLE=The Effect of Dietary Ingestion of Oxalic Acid on Thyroid Function in Male and Female Long-Evans Rats; AUTHOR=Goldman,M., and G.J. Doering; DOI=10.1016/0041-008x(79)90424-1; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151591; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603267_15603268_15603737_15606457:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4aabc20df7afe6a3f2531ec3afa7f626 |
| ToxValDB_ECOTOX | LOEL | =1.88 | mg/mL | Mouse | oral | chronic; 231 days | chronic | LONG_REF=Final Rept. 8 May 84-15 Jan 85., Environmental Health Research and Testing, Inc., Lexington, KY:366 p. Gulati,D.K., L.H. Barnes, M. Welch, and W.S. Russell Oxalic Acid: Reproduction and Fertility Assessment in CD-1 Mice when Administered in Drinking Water (Revised September 1985) 1985; TITLE=Oxalic Acid: Reproduction and Fertility Assessment in CD-1 Mice when Administered in Drinking Water (Revised September 1985); AUTHOR=Gulati,D.K., L.H. Barnes, M. Welch, and W.S. Russell; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=152073; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610798_15611124:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e5fcc68e3e1b643b29628436ac547857 |
| ToxValDB_ECOTOX | NOEL | =0.2 | % | Mouse | oral | chronic; 361 days | chronic | LONG_REF=Fundam. Appl. Toxicol.39(1): 1-10 Bolon,B., T.J. Bucci, A.R. Warbritton, J.J. Chen, D.R. Mattison, and J.J. Heindel Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays 1997; TITLE=Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays; AUTHOR=Bolon,B., T.J. Bucci, A.R. Warbritton, J.J. Chen, D.R. Mattison, and J.J. Heindel; DOI=10.1006/faat.1997.2338; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=151647; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Reproduction: Number of ovarian follicles; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX:15598015:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2d794e03ba521b818efb599a780a2f55 |
| ToxValDB_ECOTOX | NOEL | =0.9 | mg/mL | Mouse | oral | chronic; 126 days | chronic | LONG_REF=Final Rept. 8 May 84-15 Jan 85., Environmental Health Research and Testing, Inc., Lexington, KY:366 p. Gulati,D.K., L.H. Barnes, M. Welch, and W.S. Russell Oxalic Acid: Reproduction and Fertility Assessment in CD-1 Mice when Administered in Drinking Water (Revised September 1985) 1985; TITLE=Oxalic Acid: Reproduction and Fertility Assessment in CD-1 Mice when Administered in Drinking Water (Revised September 1985); AUTHOR=Gulati,D.K., L.H. Barnes, M. Welch, and W.S. Russell; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=152073; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Growth: Weight|Reproduction: Progeny counts/numbers; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610821_15610822_15611093:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=56905ab76f62773afad7d7fb953f49ae |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =3.11 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633936:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2d25f9add64a6027302a2cba07d24e92 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 9E7R5L6H31 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C2H2O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9E7R5L6H31"} |
| openFDA substances | FDA UNII substance identifier | 9E7R5L6H31 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C2H2O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9E7R5L6H31"} |
| openFDA substances | FDA UNII substance identifier | 9E7R5L6H31 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C2H2O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9E7R5L6H31"} |
| openFDA substances | FDA UNII substance identifier | 9E7R5L6H31 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C2H2O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9E7R5L6H31"} |