Is Octyldodecanol safe in cosmetics?
Octyldodecanol has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Emollient
Octyldodecanol
INCI: OCTYLDODECANOL
Octyldodecanol (CAS 5333-42-6) is a cosmetic emollient functioning as emollient, solvent, skin-conditioning. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 5333-42-6 →
Auto-generated CPSR Part A draft with source citations
Function
emollient, solvent, skin-conditioning
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR: safe in cosmetics at present practices of use; branched fatty alcohol providing excellent spreading and co-solvent properties for pigment dispersion; reduces tackiness of polybutene-based gloss systems; no FDA restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Octyldodecanol.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Octyldodecanol across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
3 property records from structured ingredient metadata.
emulsion_hlb
{"hlb_required_as_emulsifier": "no", "hlb_required_of_oil_phase": "11-12", "co_emulsifier_pairs": "polysorbate_80,ceteth_20", "optimal_oil_phase_pct": "10-32", "optimal_water_phase_pct": "68-90", "droplet_size_range_um": "2-30", "creaming_resistance": "good", "coalescence_resistance": "good", "ostwald_ripening_resistance": "moderate", "freeze_thaw_stability": "moderate", "rheology_modifier_type": …
sensory
{"silky": "medium", "smooth, glides easily": "smooth, emollient", "dry-touch, non-greasy": "soft, smooth", "instant": "moderate", "low": "medium", "w/o": "o/w", "very-high": "high", "no": "no", "yes": "no", "light-diffusing": "luminous", "1.40": "1.45", "transparent": "transparent", "colorless": "colorless", "excellent": "good", "light": "medium", "synthetic": "synthetic"}
solubility_hlb
{"water_soluble": "no", "oil_soluble": "yes", "hlb_required": "11.0", "soluble_in": "oils, ethanol", "insoluble_in": "water, glycerin, propylene glycol", "log_p": "9.8", "melting_point_c": "-25", "appearance": "clear liquid", "source": "Evonik"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Fragrance
Softener and conditioner
Solvent
Regulatory List Membership (3)
EU Regulated in Personal Care
IFRA Fragrance Transparency List
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Octyldodecanol.
Regulatory Flags
cir-approved
lip-safe
fatty-alcohol
spreading-agent
pigment-dispersant
lip-gloss
tack-reducer
oral-safe
metabolizable
ifra_fragrance
Chemical Function
Softener and conditioner
Deodorizer
Fragrance
Solvent
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
IFRA Transparency
consumer_product
Europe; Personal care
Europe; Personal care
Canada; pharmaceutical
Europe; Personal care - make-up and related
Europe; Personal care - make-up and related
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
OCTYLDODECANOL
ChEMBL ID
CHEMBL1572050
Max Phase
-1
Frequently Asked Questions
Is Octyldodecanol allowed in the EU?
Octyldodecanol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Octyldodecanol do in cosmetics?
Octyldodecanol functions as: emollient, solvent, skin-conditioning. It is classified as a Emollient in our database. CAS number: 5333-42-6.
Is Octyldodecanol used outside cosmetics?
Octyldodecanol also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Octyldodecanol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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