NOAEL Studies Cosmetic Ingredient

OCTYL ACETATE NOAEL Studies

CAS: 112-14-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 500 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1000 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =3000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_1166; row=14437; data_type=In Vivo; mixture=Chemical; chemical_name=Octyl acetate; preferred_name=Octyl acetate; dtxsid=DTXSID8044202; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044202; source_file=acute_oral.xlsx
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=12594; RecordID=ARPathway2016_597; DatasetName=ARPathway2016; DTXSID=DTXSID8044202; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044202
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3769; Record_ID=skin_sensitization_invivo_935; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8044202; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90132-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044202
NTP_ICE_skin_sensitization Induction dose per skin area 5184 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3767; Record_ID=skin_sensitization_invivo_935; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8044202; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=5184; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90132-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044202
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3773; Record_ID=skin_sensitization_invivo_935; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8044202; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1974: report to RIFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90132-1; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044202
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =500 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eace1e4b0a7c65d1c15b0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18731/7/6/2?documentUUID=026ac15b-75af-4dfe-8051-73c49f5e9eb0; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15842105:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_853469a6ed87e7267d6991d9db14e1cf
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa64e4b0a7c65d1b59f5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18731/7/9/2?documentUUID=026ac15b-75af-4dfe-8051-73c49f5e9eb0; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15857760:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f73cdf364ca912e1cfce547ede46e4e8
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier X0FN2J413S UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X0FN2J413S"}
openFDA substances FDA UNII substance identifier X0FN2J413S UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X0FN2J413S"}
openFDA substances FDA UNII substance identifier X0FN2J413S UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X0FN2J413S"}
openFDA substances FDA UNII substance identifier X0FN2J413S UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X0FN2J413S"}