Is OCTOXYNOL-1 safe in cosmetics?
OCTOXYNOL-1 has a safety rating of "GOOD" in our database. EU status: permitted. US status: allowed.
Good
Cosmetic Ingredient
OCTOXYNOL-1
Also known as: Ethanol, 2-[4-(1,1,3,3-tetramethylbutyl)phenoxy]-, Ethanol, 2-[p-(1,1,3,3-tetramethylbutyl)phenoxy]-, 2-[4-(1,1,3,3-Tetramethylbutyl)phenoxy]ethanol, 2-(4-tert-Octylphenoxy)ethanol, 2-[4-(2,4,4-Trimethylpentan-2-yl)phenoxy]ethanol (+6 more)
OCTOXYNOL-1 (CAS 2315-67-5) is a cosmetic cosmetic ingredient functioning as Surfactant - Cleansing, Surfactant - Emulsifying. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2315-67-5 →
Auto-generated CPSR Part A draft with source citations
Function
Surfactant - Cleansing, Surfactant - Emulsifying
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethanol
InChIKey
JYCQQPHGFMYQCF-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
allowed
US Notes
Allowed. CIR concluded octoxynol-1 (short-chain, ≤8 EO) is **safe as used in rinse-off products and safe at concentrations ≤5% in leave-on products**.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Confirmed
Evidence: High
(2012)
Health effects: No
Affected pathways: Estrogenic (ER agonist)
Regulatory framework: REACH
Source list: I
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Emulsifier
Surfactant (surface active agent)
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for OCTOXYNOL-1.
Regulatory Flags
cosing-sourced
eu-permitted
surfactant
needs-enrichment
fda_food_additive
Known Synonyms
Ethanol, 2-[4-(1,1,3,3-tetramethylbutyl)phenoxy]-
Ethanol, 2-[p-(1,1,3,3-tetramethylbutyl)phenoxy]-
2-[4-(1,1,3,3-Tetramethylbutyl)phenoxy]ethanol
2-(4-tert-Octylphenoxy)ethanol
2-[4-(2,4,4-Trimethylpentan-2-yl)phenoxy]ethanol
4-Octylphenol monoethoxylate
Ethylene glycol p-octylphenyl ether
NSC 5259
p-tert-Octylphenyl (2-hydroxyethyl) ether
2-(4-TERT-OCTYLPHENOXY)-AETHANOL
20CAX7IO75
Chemical Function
Surfactant (surface active agent)
Emulsifier
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
detected; drinking_water; MN Chemical Screening
detected; drinking_water; MN Chemical Screening
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
TRITON X
ChEMBL ID
CHEMBL39763
Frequently Asked Questions
Is OCTOXYNOL-1 allowed in the EU?
OCTOXYNOL-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does OCTOXYNOL-1 do in cosmetics?
OCTOXYNOL-1 functions as: Surfactant - Cleansing, Surfactant - Emulsifying. It is classified as a cosmetic ingredient in our database. CAS number: 2315-67-5.
Is OCTOXYNOL-1 used outside cosmetics?
OCTOXYNOL-1 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check OCTOXYNOL-1 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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