Is OCTOPAMINE safe in cosmetics?
OCTOPAMINE has a safety rating of "MODERATE" in our database. EU status: restricted. US status: prohibited.
Moderate
Cosmetic Ingredient
OCTOPAMINE
Also known as: 4-13-00-02656, BRN 1211019, EINECS 203-179-5, Octapamine, Paraoxyphenyl aminoethanol (+9 more)
OCTOPAMINE (CAS 104-14-3) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: restricted, max II/21. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 104-14-3 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
4-(2-amino-1-hydroxyethyl)phenol
InChIKey
QHGUCRYDKWKLMG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
II/21
US US Status
prohibited
US Notes
Allowed — not on the FDA prohibited/restricted list for cosmetics. Note: octopamine is banned as a dietary supplement ingredient by some sports authorities and has been flagged by FDA in supplement contexts, but this does not affect its cosmetic use.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Pharmaceutical
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for OCTOPAMINE.
Regulatory Flags
cosing-sourced
eu-restricted
skin-conditioning
needs-enrichment
Known Synonyms
4-13-00-02656
BRN 1211019
EINECS 203-179-5
Octapamine
Paraoxyphenyl aminoethanol
alpha-Aminoethyl-4-hydroxybenzylalkohol
alpha-(Aminoethyl)-p-hydroxybenzyl alcohol
p-Norsynephrin
UNII-14O50WS8JD
alpha-(Aminoethyl)-4-hydroxybenzenemethanol
alpha-(aminomethyl)-4-hydroxybenzenemethanol
alpha-(aminomethyl)-p-hydroxybenzyl alcohol
beta-hydroxytyramine
octopaminum
Chemical Function
Softener and conditioner
Pharmaceutical
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
pharmaceutical; prohibited
pharmaceutical; prohibited
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
OCTOPAMINE
ChEMBL ID
CHEMBL53929
Max Phase
2
Frequently Asked Questions
Is OCTOPAMINE allowed in the EU?
OCTOPAMINE EU regulatory status: restricted. Maximum allowed concentration: II/21. This is based on EU Regulation 1223/2009 and its amendments.
What does OCTOPAMINE do in cosmetics?
OCTOPAMINE functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 104-14-3.
Is OCTOPAMINE used outside cosmetics?
OCTOPAMINE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check OCTOPAMINE compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Fragrance ingredient
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