Is OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE safe in cosmetics?
OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE has a safety rating of "GOOD" in our database. EU status: permitted. 1 toxicological study endpoint(s) are available in our database.
OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE
Also known as: Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, octadecyl ester, EINECS 218-216-0, Stearyl 3-(4-hydroxy-3,5-di-tert-butyl-4-hydroxyphenyl)propionate, Stearyl beta-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate, Octadecyl 3,5-bis(tert-butyl)-4-hydroxyhydrocinnamate (+1 more)
OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE (CAS 2082-79-3) is a cosmetic cosmetic ingredient functioning as Antioxidant. NOAEL 30 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 2082-79-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE is classified GHS CMR hazard (H317, H361, H411) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antioxidant
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
octadecyl 3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoate
InChIKey
SSDSCDGVMJFTEQ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
1 study endpoint found for OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =64 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100,000 - 1,000,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Fragrance
Heat stabilizer
Processing aids not otherwise specified
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE.
Regulatory Flags
cosing-sourced
eu-permitted
antioxidant
needs-enrichment
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE by CAS number or substance name.
Studies
1
Lowest NOAEL
64 mg/kg bw/day
Highest NOAEL
64 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, octadecyl ester
EINECS 218-216-0
Stearyl 3-(4-hydroxy-3,5-di-tert-butyl-4-hydroxyphenyl)propionate
Stearyl beta-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate
Octadecyl 3,5-bis(tert-butyl)-4-hydroxyhydrocinnamate
UNII-V88J661G2P
Chemical Function
Fragrance
Antioxidant
Processing aids not otherwise specified
Regulatory Lists
IFRA Transparency
drinking_water; Europe; manufacturing; plastic_additive
Europe
Indirect additives food contact (10/2018)
inert_ingredient; non_food_use; Pesticides
Europe; plastic_additive
Australian Status
AICIS status: listed
Frequently Asked Questions
Is OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE allowed in the EU?
OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE do in cosmetics?
OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 2082-79-3.
What is the NOAEL for OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE?
The NOAEL (No Observed Adverse Effect Level) for OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE is =64 mg/kg bw/day based on a chronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE used outside cosmetics?
OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE have different safety status in cosmetics vs industrial chemicals?
OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE is classified GHS CMR hazard (H317, H361, H411) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check OCTADECYL DI-T-BUTYL-4-HYDROXYHYDROCINNAMATE compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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