NOAEL Studies
Cosmetic Ingredient
NONANE NOAEL Studies
CAS: 111-84-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_inhalation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | 16.776 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=5112; Record_ID=acute_inhalation_1119; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9025796; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=16.776; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9025796; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9025796 |
| NTP_ICE_acute_inhalation | LC50 | 17 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=5113; Record_ID=acute_inhalation_1637; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9025796; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=17; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9025796; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9025796 |
NTP_ICE_adme_parameters 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_adme_parameters | Clint | 3.936 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=3663; Record_ID=adme_parameters_1135; Data_Type=Measured; DTXSID=DTXSID9025796; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=3.936; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9025796; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9025796 |
| NTP_ICE_adme_parameters | Clint | 3.936 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=3665; Record_ID=adme_parameters_1135; Data_Type=Measured; DTXSID=DTXSID9025796; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=3.936; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9025796; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9025796 |
| NTP_ICE_adme_parameters | Fu | 0.1523 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=3664; Record_ID=adme_parameters_1135; Data_Type=Measured; DTXSID=DTXSID9025796; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.1523; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9025796; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9025796 |
| NTP_ICE_adme_parameters | Fu | 0.08128 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=3666; Record_ID=adme_parameters_1135; Data_Type=Measured; DTXSID=DTXSID9025796; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.08128; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9025796; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9025796 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=12378; RecordID=ARPathway2016_580; DatasetName=ARPathway2016; DTXSID=DTXSID9025796; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9025796; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9025796 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =2035 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633819:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c4fcf37f77a4a8bbcbdeac50dac2324b |
ToxValDB_HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HESS | NOAEL | =100 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0de3e4b0a676289de2ac; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Absolute Organ Weight: Liver increase, Lung increase, Adrenal increase, Spleen decrease, Ovary decrease|Histopathology: Alimentary tract: Hyperplasia Alimentary tract: Hyperkeratosis Alimentary tract: Epidermal hyperplasia, perianal Alimentary tract: Epidermal hyperkeratosis, perianal Alimentary tract: Epidermal inflammation, perianal Alimentary tract: Epidermal necrosis, perianal Nose: Suppurative inflammation, nasal turbinate; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|organ weight; STUDY_GROUP=HESS:15638622:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_947c032134ee4ab52cc3b43980a31829 |
ToxValDB_PPRTV_(CPHEA) 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_PPRTV_(CPHEA) | NOAEL (HEC) | =66.4 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Carpenter et al. 1978; AUTHOR=Carpenter et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b85b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1834; TOXICOLOGICAL_EFFECT=salivation, lacrimation, and marginally reduced body weight; STUDY_GROUP=PPRTV (CPHEA):15653749:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a59c02b04f3153c8e52a1ed98671e21d |
| ToxValDB_PPRTV_(CPHEA) | RfC (provisional) | =0.02 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Carpenter et al. 1978; AUTHOR=Carpenter et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b85b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1834; TOXICOLOGICAL_EFFECT=Salivation, lacrimation, and marginally depressed body weight in male rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653747_15653748:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e190a4fbacba5003dfa9706ebfe0ddeb |
| ToxValDB_PPRTV_(CPHEA) | RfC (provisional) | =0.2 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Carpenter et al. 1978; AUTHOR=Carpenter et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b85b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1834; TOXICOLOGICAL_EFFECT=Salivation, lacrimation, and marginally depressed body weight in male rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653747_15653748:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fd8c1602764c572bede28f3e8dece622 |
| ToxValDB_PPRTV_(CPHEA) | RfD (provisional) | =0.003 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Dodd et al. 2003; AUTHOR=Dodd et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754d6e4b08a6b3934b85b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1834; TOXICOLOGICAL_EFFECT=proliferative forestomach lesions; STUDY_GROUP=PPRTV (CPHEA):15653357:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4bc4acf477bf49c87f9f19ff76fc3d89 |
ToxValDB_RSL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_RSL | RfD | =0.0003 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15657773:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8e9d09755a5bb849040982fc452f4c93 |
ToxValDB_TX_TCEQ 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_TX_TCEQ | NOAEL | =3095.02 | mg/m3 | Rat | inhalation | short-term; 4 days | short-term | LONG_REF=Carpenter CP, DL Geary, Jr., RC Myers et al. 1978. Petroleum Hydrocarbon Toxicity Studies XVII. Animal response to n-nonane vapor. Toxicol Appl Pharmacol 44: 53-61; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5adb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/nonane.pdf; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=central nervous system effects; STUDY_GROUP=TX TCEQ:15954601:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a08c2d8b9fd1dfbf0350fc976a282637 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | T9W3VH6G10 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H20","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"T9W3VH6G10"} |
| openFDA substances | FDA UNII substance identifier | T9W3VH6G10 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H20","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"T9W3VH6G10"} |
| openFDA substances | FDA UNII substance identifier | T9W3VH6G10 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H20","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"T9W3VH6G10"} |
| openFDA substances | FDA UNII substance identifier | T9W3VH6G10 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H20","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"T9W3VH6G10"} |