NOAEL Studies
Cosmetic Ingredient
NEROL NOAEL Studies
CAS: 106-25-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =345 | mg/kg bw/day | Rat | oral: feed | 98 days | subchronic | EFSA FEEDAP - 2016 - OutputID 2841 - histopathology non neoplastic - nephrotoxicity - Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4512 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =345 | mg/kg bw/day | Rat | oral: feed | 98 days | subchronic | EFSA FEEDAP - 2016 - OutputID 2841 - histopathology non neoplastic - nephrotoxicity - Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4512 |
NTP_ICE_acute_oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =4500 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_546; row=5877; data_type=In Vivo; mixture=Chemical; chemical_name=(2Z)-3,7-Dimethylocta-2,6-dien-1-ol; preferred_name=(Z)-Nerol; dtxsid=DTXSID3026728; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026728; source_file=acute_oral.xlsx |
NTP_ICE_adme_parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_adme_parameters | Clint | 1.57 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=1326; Record_ID=adme_parameters_1118; Data_Type=Measured; DTXSID=DTXSID3026728; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=1.57; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Paini 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026728 |
| NTP_ICE_adme_parameters | Fu | 0 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=1325; Record_ID=adme_parameters_1118; Data_Type=Measured; DTXSID=DTXSID3026728; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.0; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Paini 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026728 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=234; RecordID=ARPathway2016_468; DatasetName=ARPathway2016; DTXSID=DTXSID3026728; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026728 |
NTP_ICE_skin_sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=3013; Record_ID=skin_sensitization_invivo_792; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026728; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|RIFM 1972; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80026-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026728 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 2592 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=3011; Record_ID=skin_sensitization_invivo_792; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026728; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2592; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|RIFM 1972; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80026-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026728 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=3017; Record_ID=skin_sensitization_invivo_792; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID3026728; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|RIFM 1972; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80026-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3026728 |
ToxValDB_EFSA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EFSA | NOAEL | =345 | mg/kg bw/day | Rat | oral | chronic; 14 weeks | chronic | LONG_REF=EFSA FEEDAP (2016). Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species. doi:10.2903/j.efsa.2016.4512.; TITLE=Safety and efficacy of alpha,beta-unsaturated straight-chain and branched-chain aliphatic primary alcohols, aldehydes, acids and esters belonging to chemical group 3 when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2016.4512; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; STUDY_GROUP=EFSA:15621845:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3f79260dbb1f6dc7ad61c0fa52163caf |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =4.4 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633736:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f78f356c60358689a5fd873f55338790 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 38G5P53250 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"38G5P53250"} |
| openFDA substances | FDA UNII substance identifier | 38G5P53250 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"38G5P53250"} |
| openFDA substances | FDA UNII substance identifier | 38G5P53250 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"38G5P53250"} |
| openFDA substances | FDA UNII substance identifier | 38G5P53250 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"38G5P53250"} |