NOAEL Studies Cosmetic Ingredient

NATAMYCIN NOAEL Studies

CAS: 7681-93-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
COSMOS_DB 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 15 mg/kg bw/day dog oral 730 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 50 mg/kg bw/day rat oral 730 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 100 mg/kg bw/day rat oral NA Multigeneration Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 40 mg/kg bw/day rat oral 49 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =6.25 mg/kg bw/day Dog oral: feed 730 days chronic/long term toxicity EFSA ANS - 2009 - OutputID 400 - body weight - systemic - Scientific Opinion on the use of natamycin (E 235) as a food additive - doi:10.2903/j.efsa.2009.1412
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =22.4 mg/kg bw/day Rat oral: feed 730 days chronic/long term toxicity EFSA ANS - 2009 - OutputID 400 - growth - systemic - Scientific Opinion on the use of natamycin (E 235) as a food additive - doi:10.2903/j.efsa.2009.1412
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =6.25 mg/kg bw/day Dog oral: feed 730 days chronic/long term toxicity EFSA ANS - 2009 - OutputID 400 - body weight - systemic - Scientific Opinion on the use of natamycin (E 235) as a food additive - doi:10.2903/j.efsa.2009.1412
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =22.4 mg/kg bw/day Rat oral: feed 730 days chronic/long term toxicity EFSA ANS - 2009 - OutputID 400 - growth - systemic - Scientific Opinion on the use of natamycin (E 235) as a food additive - doi:10.2903/j.efsa.2009.1412
INCHEM_WHO_jecfa_jeceval_jec_1687 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
INCHEM_WHO_jecfa_jeceval_jec_1687 ADI range:0-0.30.3 mg/kg bw/day - - - Health guidance value document_id=jecfa_jeceval_jec_1687; title=JECFA Evaluations-NATAMYCIN-; path=mirror/documents/jecfa/jeceval/jec_1687.htm; row_hash=5760923240396c94; raw_unit=mg/kg bw; context=The Committee confirmed the previously established ADI of 0-0.3 mg/kg bw Report:
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =2730 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_10149; row=10015; data_type=In Vivo; mixture=Chemical; chemical_name=Natamycin; preferred_name=Natamycin; dtxsid=DTXSID6021163; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021163; source_file=acute_oral.xlsx
ToxValDB_ECOTOX 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =200 mg/kg bw/day Rat oral short-term; 14 days developmental LONG_REF=Investig. Urol.9(1): 47-54 Robb,C.A., P.T. Carroll, J.B. Langston, and R.L. Zellers Evidence that Nutritional State and Well-Being are Involved in the Prostate Response to Certain Polyene Macrolides 1971; TITLE=Evidence that Nutritional State and Well-Being are Involved in the Prostate Response to Certain Polyene Macrolides; AUTHOR=Robb,C.A., P.T. Carroll, J.B. Langston, and R.L. Zellers; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=102834; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=Development: Weight|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=development|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601072_15601073:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ba583b00d02e5406192ad103cf20ce84
ToxValDB_ECOTOX LOEL =400 mg/kg bw/day Rat oral short-term; 14 days short-term LONG_REF=Investig. Urol.9(1): 47-54 Robb,C.A., P.T. Carroll, J.B. Langston, and R.L. Zellers Evidence that Nutritional State and Well-Being are Involved in the Prostate Response to Certain Polyene Macrolides 1971; TITLE=Evidence that Nutritional State and Well-Being are Involved in the Prostate Response to Certain Polyene Macrolides; AUTHOR=Robb,C.A., P.T. Carroll, J.B. Langston, and R.L. Zellers; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=102834; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601316_15601317_15608882_15609651_15609652_15610360:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2e8a2241c502549ac0401e1ffae82908
ToxValDB_ECOTOX LOEL =5 mg/kg bw/day Rat injection short-term; 14 days short-term LONG_REF=Investig. Urol.9(1): 47-54 Robb,C.A., P.T. Carroll, J.B. Langston, and R.L. Zellers Evidence that Nutritional State and Well-Being are Involved in the Prostate Response to Certain Polyene Macrolides 1971; TITLE=Evidence that Nutritional State and Well-Being are Involved in the Prostate Response to Certain Polyene Macrolides; AUTHOR=Robb,C.A., P.T. Carroll, J.B. Langston, and R.L. Zellers; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=102834; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=Growth: Weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601315_15607647_15607648:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ea6633f4e5f5b2f8c31115897ea00e46
ToxValDB_ECOTOX LOEL =7 mg/kg bw/day Dog oral short-term; 7 days short-term LONG_REF=Investig. Urol.9(1): 47-54 Robb,C.A., P.T. Carroll, J.B. Langston, and R.L. Zellers Evidence that Nutritional State and Well-Being are Involved in the Prostate Response to Certain Polyene Macrolides 1971; TITLE=Evidence that Nutritional State and Well-Being are Involved in the Prostate Response to Certain Polyene Macrolides; AUTHOR=Robb,C.A., P.T. Carroll, J.B. Langston, and R.L. Zellers; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=102834; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=Biochemistry: Cholesterol; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15611080:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=69718386431559a6773a737ded8d54b4
ToxValDB_ECOTOX NOEL =100 mg/kg bw/day Rat oral short-term; 14 days developmental LONG_REF=Investig. Urol.9(1): 47-54 Robb,C.A., P.T. Carroll, J.B. Langston, and R.L. Zellers Evidence that Nutritional State and Well-Being are Involved in the Prostate Response to Certain Polyene Macrolides 1971; TITLE=Evidence that Nutritional State and Well-Being are Involved in the Prostate Response to Certain Polyene Macrolides; AUTHOR=Robb,C.A., P.T. Carroll, J.B. Langston, and R.L. Zellers; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=102834; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=Development: Weight|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=development|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601072_15601073:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7d55e9d0283e83c02f52e8efaf7dc0c3
ToxValDB_ECOTOX NOEL =10 mg/kg bw/day Rat injection short-term; 14 days short-term LONG_REF=Investig. Urol.9(1): 47-54 Robb,C.A., P.T. Carroll, J.B. Langston, and R.L. Zellers Evidence that Nutritional State and Well-Being are Involved in the Prostate Response to Certain Polyene Macrolides 1971; TITLE=Evidence that Nutritional State and Well-Being are Involved in the Prostate Response to Certain Polyene Macrolides; AUTHOR=Robb,C.A., P.T. Carroll, J.B. Langston, and R.L. Zellers; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=102834; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=Biochemistry: Cholesterol; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601315_15607647_15607648:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b2b4c0027a130e450c552cc7972f9ef5
ToxValDB_ECOTOX NOEL =300 mg/kg bw/day Rat oral short-term; 14 days short-term LONG_REF=Investig. Urol.9(1): 47-54 Robb,C.A., P.T. Carroll, J.B. Langston, and R.L. Zellers Evidence that Nutritional State and Well-Being are Involved in the Prostate Response to Certain Polyene Macrolides 1971; TITLE=Evidence that Nutritional State and Well-Being are Involved in the Prostate Response to Certain Polyene Macrolides; AUTHOR=Robb,C.A., P.T. Carroll, J.B. Langston, and R.L. Zellers; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=102834; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601316_15601317_15608882_15609651_15609652_15610360:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d3d83f262776a76bfa948e8ec16ebfd3
ToxValDB_ECOTOX NOEL =1 mg/kg bw/day Rat injection short-term; 14 days short-term LONG_REF=Investig. Urol.9(1): 47-54 Robb,C.A., P.T. Carroll, J.B. Langston, and R.L. Zellers Evidence that Nutritional State and Well-Being are Involved in the Prostate Response to Certain Polyene Macrolides 1971; TITLE=Evidence that Nutritional State and Well-Being are Involved in the Prostate Response to Certain Polyene Macrolides; AUTHOR=Robb,C.A., P.T. Carroll, J.B. Langston, and R.L. Zellers; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=102834; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=Growth: Weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601315_15607647_15607648:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0ced53b29f316ea0b8506e29f61cd832
ToxValDB_ECOTOX NOEL =200 mg/kg bw/day Rat oral short-term; 14 days short-term LONG_REF=Investig. Urol.9(1): 47-54 Robb,C.A., P.T. Carroll, J.B. Langston, and R.L. Zellers Evidence that Nutritional State and Well-Being are Involved in the Prostate Response to Certain Polyene Macrolides 1971; TITLE=Evidence that Nutritional State and Well-Being are Involved in the Prostate Response to Certain Polyene Macrolides; AUTHOR=Robb,C.A., P.T. Carroll, J.B. Langston, and R.L. Zellers; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=102834; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=Biochemistry: Cholesterol; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601316_15601317_15608882_15609651_15609652_15610360:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1b8edbf2b84742adab4aaf47a1e65afd
ToxValDB_ECOTOX NOEL =170 mg/kg bw/day Rat oral short-term; 14 days short-term LONG_REF=Investig. Urol.9(1): 47-54 Robb,C.A., P.T. Carroll, J.B. Langston, and R.L. Zellers Evidence that Nutritional State and Well-Being are Involved in the Prostate Response to Certain Polyene Macrolides 1971; TITLE=Evidence that Nutritional State and Well-Being are Involved in the Prostate Response to Certain Polyene Macrolides; AUTHOR=Robb,C.A., P.T. Carroll, J.B. Langston, and R.L. Zellers; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=102834; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601316_15601317_15608882_15609651_15609652_15610360:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=661cf698fc0ac4aab95322552622f756
ToxValDB_EFSA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =22.4 mg/kg bw/day Rat oral chronic; 2 years chronic LONG_REF=EFSA ANS (2009). Scientific Opinion on the use of natamycin (E 235) as a food additive. doi:10.2903/j.efsa.2009.1412.; TITLE=Scientific Opinion on the use of natamycin (E 235) as a food additive; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2009.1412; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=growth; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15614318:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_37176326e3b244c64ecc50fe38cdf4a0
ToxValDB_EFSA NOAEL =6.25 mg/kg bw/day Dog oral chronic; 2 years chronic LONG_REF=EFSA ANS (2009). Scientific Opinion on the use of natamycin (E 235) as a food additive. doi:10.2903/j.efsa.2009.1412.; TITLE=Scientific Opinion on the use of natamycin (E 235) as a food additive; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2009.1412; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15614319:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3114457fd35bfe7eb7c5eb90a235587b
ToxValDB_WHO_JECFA_ADI 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_WHO_JECFA_ADI ADI <=0.3 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650b0266e4b0d99f5a885b2f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/3255; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=WHO JECFA ADI:15715660:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_232c60bdbbc0d2f5c097451a6502aae7
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 8O0C852CPO UNII - - - chemical {"approval_status":null,"molecular_formula":"C33H47NO13","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8O0C852CPO"}
openFDA substances FDA UNII substance identifier 8O0C852CPO UNII - - - chemical {"approval_status":null,"molecular_formula":"C33H47NO13","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8O0C852CPO"}
openFDA substances FDA UNII substance identifier 8O0C852CPO UNII - - - chemical {"approval_status":null,"molecular_formula":"C33H47NO13","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8O0C852CPO"}
openFDA substances FDA UNII substance identifier 8O0C852CPO UNII - - - chemical {"approval_status":null,"molecular_formula":"C33H47NO13","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8O0C852CPO"}