Is Naringin safe in cosmetics?
Naringin has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Naringin
Also known as: 4H-1-Benzopyran-4-one, 7-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (2S)-, 4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (2S)-, EINECS 233-566-4, Naringenin-7-beta-neohesperidoside, 5-Hydroxy-2-(4-hydroxyphenyl)-7-(2-O-alpha-L-rhamnopyranosyl-beta-D-glucopyranosyloxy)-4-chromanon (+3 more)
INCI: NARINGIN
Naringin (CAS 10236-47-2) is a cosmetic cosmetic ingredient functioning as Skin protecting, Antioxidant, Skin brightening, UV absorbing. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 10236-47-2 →
Auto-generated CPSR Part A draft with source citations
Function
Skin protecting, Antioxidant, Skin brightening, UV absorbing
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
InChIKey
DFPMSGMNTNDNHN-ZPHOTFPESA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA cosmetic restrictions; grapefruit-derived flavanone glycoside; GRAS status for food use; no phototoxicity risk as it lacks furocoumarin structure
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Naringin.
Calculate MoS for your specific formulation with the MoS Calculator.
EPA ToxValDB — Toxicity Values
6 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOEL | =100 mg/kg-day | Rat | oral | short-term | ECOTOX |
| LD50 | >2000 mg/kg | Rat | dermal | acute | ECHA IUCLID |
| LD50 | >16000 mg/kg | Rat | oral | - | ECHA IUCLID |
| NOAEL | =1250 mg/kg-day | Rat | oral | chronic | EFSA |
| NOAEL | >1250 mg/kg-day | Rat | oral | chronic | ECHA IUCLID |
| NOAEL | >1250 mg/kg-day | Rat | oral | subchronic | ECHA IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Humectant
Expert Verdict
Expert safety assessment and concern-level summary for Naringin.
Regulatory Flags
flavonoid
antioxidant
brightening
tyrosinase-inhibitor
UV-absorbing
anti-glycation
grapefruit
non-phototoxic
botanical
Known Synonyms
4H-1-Benzopyran-4-one, 7-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (2S)-
4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (2S)-
EINECS 233-566-4
Naringenin-7-beta-neohesperidoside
5-Hydroxy-2-(4-hydroxyphenyl)-7-(2-O-alpha-L-rhamnopyranosyl-beta-D-glucopyranosyloxy)-4-chromanon
UNII-N7TD9J649B
Naringenin 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside]
Naringenin 7-O-alpha-L-rhamnosyl-(1->2)-beta-D-glucoside
Chemical Function
Humectant
Flavouring and nutrient
Regulatory Lists
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
NARINGIN
ChEMBL ID
CHEMBL451532
Frequently Asked Questions
Is Naringin allowed in the EU?
Naringin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Naringin do in cosmetics?
Naringin functions as: Skin protecting, Antioxidant, Skin brightening, UV absorbing. It is classified as a cosmetic ingredient in our database. CAS number: 10236-47-2.
Is Naringin used outside cosmetics?
Naringin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Naringin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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