NOAEL Studies Cosmetic Ingredient

N,N'-METHYLENEBISACRYLAMIDE NOAEL Studies

CAS: 110-26-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =390 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_914; row=13825; data_type=In Vivo; mixture=Chemical; chemical_name=N,N'-Methylenebisacrylamide; preferred_name=N,N'-Methylenebisacrylamide; dtxsid=DTXSID8025595; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8025595; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID8025595; source_file=acute_oral.xlsx
NTP_ICE_adme_parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 2.954 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=3277; Record_ID=adme_parameters_257; Data_Type=Measured; DTXSID=DTXSID8025595; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=2.954; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8025595; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8025595
NTP_ICE_adme_parameters Fu 1 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=3276; Record_ID=adme_parameters_257; Data_Type=Measured; DTXSID=DTXSID8025595; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=1.0; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8025595; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8025595
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=12016; RecordID=ARPathway2016_541; DatasetName=ARPathway2016; DTXSID=DTXSID8025595; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8025595; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID8025595
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =2 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b566b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21036/7/9/2?documentUUID=3cc1f567-2b3a-4d72-914d-a6837b949381; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID:15857324:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a962f5607bf5760d66cf53f3f20bf4b9
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier EDK4RIE19C UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H10N2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EDK4RIE19C"}
openFDA substances FDA UNII substance identifier EDK4RIE19C UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H10N2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EDK4RIE19C"}
openFDA substances FDA UNII substance identifier EDK4RIE19C UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H10N2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EDK4RIE19C"}
openFDA substances FDA UNII substance identifier EDK4RIE19C UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H10N2O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"EDK4RIE19C"}