NOAEL Studies Cosmetic Ingredient

MORPHOLINE NOAEL Studies

CAS: 110-91-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 6316 mg/kg bw/day mouse oral 200 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 50 mg/kg bw/day rat oral 875 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 120 mg/kg bw/day hamster oral 770 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 160 mg/kg bw/day rat oral 30 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 90 mg/kg bw/day guinea pig oral 30 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
IARC Monographs 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1998 IARC Monographs {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"47, 71"}
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1998 IARC Monographs {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"47, 71"}
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1998 IARC Monographs {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"47, 71"}
INCHEM_WHO_ehc_ehc_ehc179 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
INCHEM_WHO_ehc_ehc_ehc179 NOAEL =90 mg/m3 Rat - 5 days Subchronic toxicity document_id=ehc_ehc_ehc179; title=Morpholine (EHC 179, 1996); path=mirror/documents/ehc/ehc/ehc179.htm; row_hash=4751ac01e73a8553; raw_unit=mg/m 3; context=A concentration of 90 mg/m 3 may be considered the NOAEL in the conditions of the 13-week experiment in rats (6 h/day, 5 days/week).
INCHEM_WHO_ehc_ehc_ehc179 NOAEL =90 mg/m3 Rat - 5 days Subchronic toxicity document_id=ehc_ehc_ehc179; title=Morpholine (EHC 179, 1996); path=mirror/documents/ehc/ehc/ehc179.htm; row_hash=4751ac01e73a8553; raw_unit=mg/m 3; context=A concentration of 90 mg/m 3 may be considered the NOAEL in the conditions of the 13-week experiment in rats (6 h/day, 5 days/week).
NTP_ICE_acute_inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 28.4884 mg/L - Inhalation Duration=8 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=1483; Record_ID=acute_inhalation_1102; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2025688; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=28.4884; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025688; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2025688
NTP_ICE_acute_oral 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =1050 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_973; row=4169; data_type=In Vivo; mixture=Chemical; chemical_name=Morpholine; preferred_name=Morpholine; dtxsid=DTXSID2025688; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025688; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2025688; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >1420 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_974; row=4168; data_type=In Vivo; mixture=Chemical; chemical_name=Morpholine; preferred_name=Morpholine; dtxsid=DTXSID2025688; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025688; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2025688; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 <1440 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_975; row=4164; data_type=In Vivo; mixture=Chemical; chemical_name=Morpholine; preferred_name=Morpholine; dtxsid=DTXSID2025688; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025688; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2025688; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =1450 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_976; row=4165; data_type=In Vivo; mixture=Chemical; chemical_name=Morpholine; preferred_name=Morpholine; dtxsid=DTXSID2025688; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025688; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2025688; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =1600 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_977; row=4167; data_type=In Vivo; mixture=Chemical; chemical_name=Morpholine; preferred_name=Morpholine; dtxsid=DTXSID2025688; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025688; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2025688; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >1610 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_978; row=4171; data_type=In Vivo; mixture=Chemical; chemical_name=Morpholine; preferred_name=Morpholine; dtxsid=DTXSID2025688; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025688; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2025688; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 <1630 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_979; row=4166; data_type=In Vivo; mixture=Chemical; chemical_name=Morpholine; preferred_name=Morpholine; dtxsid=DTXSID2025688; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025688; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2025688; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =1913 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1445; row=4170; data_type=In Vivo; mixture=Chemical; chemical_name=Morpholine; preferred_name=Morpholine; dtxsid=DTXSID2025688; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025688; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2025688; source_file=acute_oral.xlsx
NTP_ICE_cancer 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=2976; Record_ID=cancer_5667; Data_Type=WOE; Formulation_Name=Morpholine; Mixture=Chemical; DTXSID=DTXSID2025688; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/65; http://publications.iarc.fr/89; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025688; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2025688
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=11798; RecordID=ARPathway2016_555; DatasetName=ARPathway2016; DTXSID=DTXSID2025688; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025688; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2025688
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_DOE_Protective_Action_Criteria LEL =49886.1 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=DOE Protective Action Criteria:15517547:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3fa162ac55b139df2aee7121f5b750fa
ToxValDB_EU_SCOEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EU_SCOEL NOAEL =36 mg/m3 Rat inhalation chronic; 2 years chronic LONG_REF=Harbison, R. D., Marino, D. J., Conaway, C. C., Rubin, L. F. and Gandy, J. (1989). Chronic morpholine exposure of rats. Fundam. Appl. Toxicol. 12, 491-507.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985c4e4b02565fc7d38f9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/071_morpholine_oel_en.pdf; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=no inflammatory signs; STUDY_GROUP=EU SCOEL:15952468:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a5f30780d6e20c78cc30d1f7c613b683
ToxValDB_EU_SCOEL NOAEL =90 mg/m3 Rat inhalation subchronic; 13 weeks subchronic LONG_REF=Conaway, C. C., Coate, W. B., Voelker, R. W. (1984b). Subchronic inhalation toxicity of morpholine in rats. Fundam. Appl. Toxicol., 4, 465-472. Conaway, C. C., Tong, C., Williams, G. M. (1984a). Evaluation of morpholine, 3-morpholine and N-substituted morpholines in the rat primary culture/DNA repair test. Mutat. Res. 136, 153-157. et al., 1984; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985c4e4b02565fc7d38f9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/071_morpholine_oel_en.pdf; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=Lesions of the nasal septum, anterior cavities, nasoturbinates and maxilloturbinates; STUDY_GROUP=EU SCOEL:15952469:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a582f92d8589296435c52d3c7ced77e6
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL local =36 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633579:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3ce2511f1f6e487ff66e57e2a4bf5d7a
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 8B2ZCK305O UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H9NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8B2ZCK305O"}
openFDA substances FDA UNII substance identifier 8B2ZCK305O UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H9NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8B2ZCK305O"}
openFDA substances FDA UNII substance identifier 8B2ZCK305O UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H9NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8B2ZCK305O"}
openFDA substances FDA UNII substance identifier 8B2ZCK305O UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H9NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8B2ZCK305O"}