Is Mirodenafil safe in cosmetics?
Mirodenafil has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Mirodenafil
INCI: MIRODENAFIL
Mirodenafil (CAS 862189-95-5) is a cosmetic cosmetic ingredient functioning as Skin conditioning (as listed in CosIng/COSMILE). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 862189-95-5 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning (as listed in CosIng/COSMILE)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
5-ethyl-2-[5-[4-(2-hydroxyethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-7-propyl-3H-pyrrolo[3,2-d]pyrimidin-4-one
InChIKey
MIJFNYMSCFYZNY-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not approved as a cosmetic ingredient - As a PDE5 inhibitor, if a product containing mirodenafil makes drug claims or has pharmacological activity, the FDA would classify it as an unapproved drug. The FDA has issued warning letters to products containing undeclared PDE5 inhibitors
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Mirodenafil.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Mirodenafil.
Chemical Function
Softener and conditioner
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
MIRODENAFIL
ChEMBL ID
CHEMBL4297518
Max Phase
2
Frequently Asked Questions
Is Mirodenafil allowed in the EU?
Mirodenafil EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Mirodenafil do in cosmetics?
Mirodenafil functions as: Skin conditioning (as listed in CosIng/COSMILE). It is classified as a cosmetic ingredient in our database. CAS number: 862189-95-5.
Is Mirodenafil used outside cosmetics?
Mirodenafil also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Mirodenafil compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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