Is Methylrosanilinium Chloride safe in cosmetics?
Methylrosanilinium Chloride has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Methylrosanilinium Chloride
Also known as: Hexamethyl-p-rosaniline chloride, Methanaminium, N-[4-[bis[4-(dimethylamino)phenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-methyl-, chloride, Crystal violet, C.I. 42555, Methanaminium, N-[4-[bis[4-(dimethylamino)phenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-methyl-, chloride (1:1) (+15 more)
INCI: METHYLROSANILINIUM CHLORIDE
Methylrosanilinium Chloride (CAS 548-62-9) is a cosmetic cosmetic ingredient functioning as Hair dyeing - a triphenylmethane dye that adheres to the hair surface and lasts. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 548-62-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Methylrosanilinium Chloride is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H318, H350, H351, H400, H410).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair dyeing - a triphenylmethane dye that adheres to the hair surface and lasts 1-2 washes (temporary/semi-permanent coloring)
Safety Rating
MODERATE
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Crystal violet is not an FDA-approved color additive for cosmetics. In the US, it is primarily used as a topical antiseptic (OTC drug context), and its use as a cosmetic colorant would require color additive approval, which it does not have
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Methylrosanilinium Chloride.
Calculate MoS for your specific formulation with the MoS Calculator.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
2B
Volume
129
Evaluation Year
2021
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Health HazardHarmful / IrritantCorrosiveEnvironmental Hazard
Hazard Class and Category
Carc. 2; Acute Tox. 4 *; Eye Dam. 1; Aquatic Acute 1; Aquatic Chronic 1
Hazard Statements
- H351 Suspected of causing cancer
- H302 Harmful if swallowed
- H318 Causes serious eye damage
- H400 Very toxic to aquatic life
- H410 Very toxic to aquatic life with long lasting effects
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
Yes (since 18-Jun-2012)
Hazard classification: Restricted (Annex XVII)
SVHC reason: Carcinogenic (Article 57a)
Substance of Very High Concern (SVHC)
Included: 18-Jun-2012
Carcinogenic (Article 57a)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
ASEAN Cosmetic Directive (II)
Ref: 380
Additional Jurisdictional Restrictions (3)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| BR | banned | - | - |
| CA | banned | - | - |
| KR | prohibited | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (3)
California Proposition 65 (OEHHA)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Methylrosanilinium Chloride.
Regulatory Flags
prop65
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
Hexamethyl-p-rosaniline chloride
Methanaminium, N-[4-[bis[4-(dimethylamino)phenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-methyl-, chloride
Crystal violet
C.I. 42555
Methanaminium, N-[4-[bis[4-(dimethylamino)phenyl]methylene]-2,5-cyclohexadien-1-ylidene]-N-methyl-, chloride (1:1)
Aizen Crystal Violet Extra Pure
Caswell No. 264A
Crystal Violet chloride salt
Crystal Violet Extra Pure
Crystal Violet Extra Pure APN
Crystal Violet Extra Pure APNX
Crystal Violet HL2
EINECS 208-953-6
EPA Pesticide Chemical Code 039502
Hexamethyl p-rosaniline hydrochloride
Hidaco Crystal Violet
Methylrosanilini chloridum
Methylrosanilinum chloratum
NCI-C55969
NSC 3090
Chemical Function
Dye
Regulatory Lists
banned; Europe; Personal care
active_ingredient; Europe; Pesticides
OEHHA Proposition 65 (3/2019)
OEHHA Proposition 65 (1/2023)
pharmaceutical
active_ingredient; Europe; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
GENTIAN VIOLET
ChEMBL ID
CHEMBL64894
Max Phase
4
Adverse Event Associations
16
Frequently Asked Questions
Is Methylrosanilinium Chloride allowed in the EU?
Methylrosanilinium Chloride EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Methylrosanilinium Chloride do in cosmetics?
Methylrosanilinium Chloride functions as: Hair dyeing - a triphenylmethane dye that adheres to the hair surface and lasts 1-2 washes (temporary/semi-permanent coloring). It is classified as a cosmetic ingredient in our database. CAS number: 548-62-9.
Is Methylrosanilinium Chloride used outside cosmetics?
Methylrosanilinium Chloride also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Methylrosanilinium Chloride have different safety status in cosmetics vs industrial chemicals?
Methylrosanilinium Chloride is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H318, H350, H351, H400, H410).
Compliance Tools
Check Methylrosanilinium Chloride compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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