NOAEL Studies
Cosmetic Ingredient
Methylene Chloride NOAEL Studies
INCI: DICHLOROMETHANE
CAS: 75-09-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
Regulatory source 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | LOAEL | =16 | mg/kg/day | Human (M/F) | oral | acute; 1 days | clinical | ATSDR MRLs; row_hash=eb3838d0e892de63; source_hash=ToxValhc_bf65408ed10284067b8f25bb5cbc261d; raw_endpoint_type=LOAEL; raw_endpoint_subtype=; raw_value=16; raw_unit=mg/kg/day; method=drinking water; effect=neurological; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Reitz RH, Hays SM, and Gargas ML. 1997. Assessing Priority Data Needs for Methylene Chloride with Physiologically-Based Pharmacokinetic Modeling. Halogenated Solvents Industry Alliance (HSIA), prepared for ATSDR, using human volunteer data from Winneke (1974).; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d5857b7 |
| Regulatory source | LOAEL | =86.8409 | mg/m3 | Rat (Not Specified; unknown) | inhalation | chronic; 14 weeks | chronic | ATSDR MRLs; row_hash=b1fbe4ba55d975dc; source_hash=ToxValhc_a85e2ee5ea3e91ed748707c88b6deae3; raw_endpoint_type=LOAEL (HEC); raw_endpoint_subtype=; raw_value=25; raw_unit=ppm; effect=hepatic; effect_category=other; file=toxval_ATSDR_MRLs.xlsx; long_ref=Haun CC, Vernot EH, Darmer KI, et al. 1972. Continuous animal exposure to low levels of dichloromethane. AMRL-TR-72-130, paper no. 12.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d5857b7 |
| Regulatory source | LOAEL | =1042.09 | mg/m3 | Human (M/F) | inhalation | acute; 1 days | clinical | ATSDR MRLs; row_hash=7183ba74d27e3088; source_hash=ToxValhc_e51cb202101d7d9444111066d689047b; raw_endpoint_type=LOAEL; raw_endpoint_subtype=; raw_value=300; raw_unit=ppm; method=chamber; effect=neurological; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Winneke G. 1974. Behavioral effects of methylene chloride and carbon monoxide as assessed by sensory and psychomotor performance. In: Behavioral Toxicology. Early Detection of Occupational Hazards, Eds. C Xintaras, B Johnson, I deGroot. U.S. Department of Health, Education, and Welfare. ; Reitz RH, Hays SM, Gargas ML. 1997. Assessing priority data needs for methylene chloride with physiologically-based pharmacokinetic modeling. Halogenated Solvents Industry Alliance (HSIA), prepared for ATSDR.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d5857b7 |
| Regulatory source | NOAEL | =6 | mg/kg/day | Rat (Fischer-344; M/F) | oral | chronic; 104 weeks | chronic | ATSDR MRLs; row_hash=82e270d6a3bef0a2; source_hash=ToxValhc_19ff313ac0592d3c5e86b2868a479fca; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=6; raw_unit=mg/kg/day; method=drinking water; effect=hepatic; effect_category=other; file=toxval_ATSDR_MRLs.xlsx; long_ref=Serota D, Thakur, AK, Ulland BM, et al. 1986a. A two year drinking water study of dichloromethane in rodents. I. Rats. Food Chem Toxicol 24:951-958.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d5857b7 |
| Regulatory source | NOAEL | =30.9848 | mg/m3 | Rat (Sprague Dawley; M/F) | inhalation | chronic; 2 years | chronic | ATSDR MRLs; row_hash=714476df8173b4cb; source_hash=ToxValhc_8dc5f8bb7d6d354fb0fb6e2d2108f51f; raw_endpoint_type=NOAEL (HEC); raw_endpoint_subtype=; raw_value=8.92; raw_unit=ppm; effect=hepatic; effect_category=other; file=toxval_ATSDR_MRLs.xlsx; long_ref=Nitschke KD, Burek JD, Bell TJ, et al. 1988a. Methylene Chloride: A 2-year inhalation toxicity and oncogenicity study in rats. Fundam Appl Toxicol 11:60-67.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d5857b7 |
| Regulatory source | NOAEL | =173.682 | mg/m3 | Rat (Sprague Dawley; M/F) | inhalation | chronic; 2 years | chronic | ATSDR MRLs; row_hash=e21e213c00e11a8c; source_hash=ToxValhc_60bebba44c7d6d0d865b15e5fc27e427; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=50; raw_unit=ppm; effect=hepatic; effect_category=other; file=toxval_ATSDR_MRLs.xlsx; long_ref=Nitschke KD, Burek JD, Bell TJ, et al. 1988a. Methylene Chloride: A 2-year inhalation toxicity and oncogenicity study in rats. Fundam Appl Toxicol 11:60-67.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d5857b7 |
| Regulatory source | BMDL 10 (HEC) | =17.2 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system PoD | row_hash=c5289a076de7cd7f; file=iris_rfc_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=BMDL 10 (HEC): 17.2 mg/m^3; system=Hepatic; basis=Hepatic effects (hepatic vacuolation); point_of_departure=BMDL 10 (HEC): 17.2 mg/m^3; composite_uf=30; confidence=Medium/High; dtxsid=DTXSID0020868; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=70; rfc_last_updated=11/18/2011; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0070_summary.pdf |
| Regulatory source | RfC | =0.6 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system | row_hash=9be6361f7ed04ee6; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=6e-1; system=Hepatic; basis=Hepatic effects (hepatic vacuolation); point_of_departure=BMDL 10 (HEC): 17.2 mg/m^3; composite_uf=30; confidence=Medium/High; dtxsid=DTXSID0020868; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=70; rfc_last_updated=11/18/2011; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0070_summary.pdf |
| Regulatory source | BMDL 10 (HED) | =0.19 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=52e8c4bb0b51965e; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=BMDL 10 (HED): 0.19 mg/kg-day; system=Hepatic; basis=Hepatic effects (hepatic vacuolation, liver foci); point_of_departure=BMDL 10 (HED): 0.19 mg/kg-day; composite_uf=30; confidence=High; dtxsid=DTXSID0020868; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=70; rfd_last_updated=11/18/2011; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0070_summary.pdf |
| Regulatory source | RfD | =0.006 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=a491784808a2a3fe; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=6e-3; system=Hepatic; basis=Hepatic effects (hepatic vacuolation, liver foci); point_of_departure=BMDL 10 (HED): 0.19 mg/kg-day; composite_uf=30; confidence=High; dtxsid=DTXSID0020868; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=70; rfd_last_updated=11/18/2011; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0070_summary.pdf |
CIR Safety Assessment 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR Safety Assessment | NOAEL | =5 | mg/kg/day | rat | oral (drinking water) | 24 months | carcinogenicity / chronic toxicity (no-effect for toxicologic and nonneoplastic histopathologic effects) | {"citation":"273","page":798,"pdf":"pr151.pdf","row_type":"noael_study","study_id":"2"} |
| CIR Safety Assessment | NOAEL | =185 | mg/kg/day | mouse | oral (drinking water) | 24 months | carcinogenicity / chronic toxicity (no-effect for toxicologic and nonneoplastic histopathologic effects) | {"citation":"274","page":799,"pdf":"pr151.pdf","row_type":"noael_study","study_id":"3"} |
| CIR Safety Assessment | NOAEL | =50 | ppm | rat | inhalation | 20 months (males) / 24 months (females) | chronic toxicity / oncogenicity (hepatic changes, benign mammary tumors) | {"citation":"279","page":808,"pdf":"pr151.pdf","row_type":"noael_study","study_id":"4"} |
| CIR Safety Assessment | NOAEL | =5 | mg/kg/day | rat | oral (drinking water) | 24 months | carcinogenicity / chronic toxicity (no-effect for toxicologic and nonneoplastic histopathologic effects) | {"citation":"273","page":798,"pdf":"pr151.pdf","row_type":"noael_study","study_id":"2"} |
| CIR Safety Assessment | NOAEL | =185 | mg/kg/day | mouse | oral (drinking water) | 24 months | carcinogenicity / chronic toxicity (no-effect for toxicologic and nonneoplastic histopathologic effects) | {"citation":"274","page":799,"pdf":"pr151.pdf","row_type":"noael_study","study_id":"3"} |
| CIR Safety Assessment | NOAEL | =50 | ppm | rat | inhalation | 20 months (males) / 24 months (females) | chronic toxicity / oncogenicity (hepatic changes, benign mammary tumors) | {"citation":"279","page":808,"pdf":"pr151.pdf","row_type":"noael_study","study_id":"4"} |
| CIR Safety Assessment | NOAEL | =5 | mg/kg/day | rat | oral (drinking water) | 24 months | carcinogenicity / chronic toxicity (no-effect for toxicologic and nonneoplastic histopathologic effects) | {"citation":"273","page":798,"pdf":"pr151.pdf","row_type":"noael_study","study_id":"2"} |
| CIR Safety Assessment | NOAEL | =185 | mg/kg/day | mouse | oral (drinking water) | 24 months | carcinogenicity / chronic toxicity (no-effect for toxicologic and nonneoplastic histopathologic effects) | {"citation":"274","page":799,"pdf":"pr151.pdf","row_type":"noael_study","study_id":"3"} |
| CIR Safety Assessment | NOAEL | =50 | ppm | rat | inhalation | 20 months (males) / 24 months (females) | chronic toxicity / oncogenicity (hepatic changes, benign mammary tumors) | {"citation":"279","page":808,"pdf":"pr151.pdf","row_type":"noael_study","study_id":"4"} |
COSMOS DB 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 50 | mg/kg bw/day | rat | oral | 2 year | Chronic | PAFA; FOOD CHEM TOXICOL 24:951-958 |
| COSMOS DB | LOAEL | 55 | mg/kg bw/day | rat | oral | 104 week | Chronic | PAFA;IRIS |
| COSMOS DB | LOAEL | 250 | mg/kg bw/day | mouse | oral | 2 year | Chronic | PAFA; FOOD CHEM TOXICOL 24:959-963 |
| COSMOS DB | NOAEL | 5 | mg/kg bw/day | rat | oral | 2 year | Chronic | PAFA; FOOD CHEM TOXICOL 24:951-958 |
| COSMOS DB | NOAEL | 6 | mg/kg bw/day | rat | oral | 104 week | Chronic | PAFA;IRIS |
| COSMOS DB | NOAEL | 55 | mg/kg bw/day | rat | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 100 | mg/kg bw/day | mouse | oral | 448 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 166 | mg/kg bw/day | rat | oral | 90 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 185 | mg/kg bw/day | mouse | oral | 2 year | Chronic | PAFA; FOOD CHEM TOXICOL 24:959-963 |
| COSMOS DB | NOAEL | 236 | mg/kg bw/day | mouse | oral | 728 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 238 | mg/kg bw/day | mouse | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 500 | mg/kg bw/day | rat | oral | 448 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
California Proposition 65 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 NSRL | SQEinhalation=200 | ug/day | - | - | 1988-04-01 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"1988-04-01","listing_mechanism":"SQE","madl":null,"nsrl":"inhalation=200","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 NSRL | SQEinhalation=200 | ug/day | - | - | 1988-04-01 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"1988-04-01","listing_mechanism":"SQE","madl":null,"nsrl":"inhalation=200","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 NSRL | SQEinhalation=200 | ug/day | - | - | 1988-04-01 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"1988-04-01","listing_mechanism":"SQE","madl":null,"nsrl":"inhalation=200","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEcancer | listing type | - | - | 1988-04-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"1988-04-01","listing_mechanism":"SQE","madl":null,"nsrl":"inhalation=200","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEcancer | listing type | - | - | 1988-04-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"1988-04-01","listing_mechanism":"SQE","madl":null,"nsrl":"inhalation=200","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | SQEcancer | listing type | - | - | 1988-04-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"1988-04-01","listing_mechanism":"SQE","madl":null,"nsrl":"inhalation=200","source_table":"prop65_listings"} |
EFSA 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | LOAEL | =0.3 | mg/kg bw/day | Common quail | oral: unspecified | 120 days | chronic/long term toxicity | EFSA CONTAM - 2005 - OutputID 64 - organ weights - endocrine - Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to Camphechlor as undesirable substance in animal feed - doi:10.2903/j.efsa.2005.179 |
| EFSA | LOAEL | =0.3 | mg/kg bw/day | Common quail | oral: unspecified | 120 days | chronic/long term toxicity | EFSA CONTAM - 2005 - OutputID 64 - organ weights - endocrine - Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to Camphechlor as undesirable substance in animal feed - doi:10.2903/j.efsa.2005.179 |
| EFSA | LOAEL | =0.6 | mg/kg bw/day | Black duck | oral: feed | 90 days | reproduction toxicity | EFSA CONTAM - 2005 - OutputID 64 - development - developmental - Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to Camphechlor as undesirable substance in animal feed - doi:10.2903/j.efsa.2005.179 |
| EFSA | LOAEL | =0.6 | mg/kg bw/day | Black duck | oral: feed | 90 days | reproduction toxicity | EFSA CONTAM - 2005 - OutputID 64 - development - developmental - Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to Camphechlor as undesirable substance in animal feed - doi:10.2903/j.efsa.2005.179 |
| EFSA | LOEL | =0.05 | mg/kg bw/day | Chicken | oral: feed | 210 days | reproduction toxicity | EFSA CONTAM - 2005 - OutputID 64 - morphology - musclo-skeletal - Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to Camphechlor as undesirable substance in animal feed - doi:10.2903/j.efsa.2005.179 |
| EFSA | LOEL | =0.05 | mg/kg bw/day | Chicken | oral: feed | 210 days | reproduction toxicity | EFSA CONTAM - 2005 - OutputID 64 - morphology - musclo-skeletal - Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to Camphechlor as undesirable substance in animal feed - doi:10.2903/j.efsa.2005.179 |
| EFSA | NOAEL | =0.2 | mg/kg bw/day | Dog | oral: capsule | 91 days | subchronic | EFSA CONTAM - 2005 - OutputID 64 - histopathology non neoplastic - hepatotoxicity - Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to Camphechlor as undesirable substance in animal feed - doi:10.2903/j.efsa.2005.179 |
| EFSA | NOAEL | =0.2 | mg/kg bw/day | Dog | oral: capsule | 91 days | subchronic | EFSA CONTAM - 2005 - OutputID 64 - histopathology non neoplastic - hepatotoxicity - Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to Camphechlor as undesirable substance in animal feed - doi:10.2903/j.efsa.2005.179 |
| EFSA | NOAEL | =12 | mg/kg bw/day | Common pheasant | oral: feed | 90 days | reproduction toxicity | EFSA CONTAM - 2005 - OutputID 64 - mortality - developmental - Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to Camphechlor as undesirable substance in animal feed - doi:10.2903/j.efsa.2005.179 |
| EFSA | NOAEL | =12 | mg/kg bw/day | Common pheasant | oral: feed | 90 days | reproduction toxicity | EFSA CONTAM - 2005 - OutputID 64 - mortality - developmental - Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to Camphechlor as undesirable substance in animal feed - doi:10.2903/j.efsa.2005.179 |
| EFSA | NOAEL | =100 | µg/kg bw/day | Cynomolgus monkey | - | 231 days | chronic/long term toxicity | EFSA CONTAM - 2005 - OutputID 64 - immunology - immunotoxicity - Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to Camphechlor as undesirable substance in animal feed - doi:10.2903/j.efsa.2005.179 |
| EFSA | NOAEL | =100 | µg/kg bw/day | Cynomolgus monkey | - | 231 days | chronic/long term toxicity | EFSA CONTAM - 2005 - OutputID 64 - immunology - immunotoxicity - Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission related to Camphechlor as undesirable substance in animal feed - doi:10.2903/j.efsa.2005.179 |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 2A | IARC group | - | - | 2014 | IARC Monographs | {"additional_info":"volume_publication_year=2017","evaluation_year":2014,"source_table":"iarc_classifications","volume":"Sup 7, 71, 110"} |
WHO/JECFA 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | LOEL | =7100 | mg/m3 | - | inhalation | - | Inhalation toxicity | document_id=ehc_ehc_ehc164; title=Methylene chloride (EHC 164, 1996, 2nd edition); path=mirror/documents/ehc/ehc/ehc164.htm; row_hash=ad5b2e309618bfc1; raw_unit=mg/m 3; context=The lowest-observed-effect level (LOEL) for this effect in all animal species is 7100 mg/m 3 by inhalation. |
| WHO/JECFA | LOEL | =7100 | mg/m3 | - | inhalation | - | Inhalation toxicity | document_id=ehc_ehc_ehc164; title=Methylene chloride (EHC 164, 1996, 2nd edition); path=mirror/documents/ehc/ehc/ehc164.htm; row_hash=ad5b2e309618bfc1; raw_unit=mg/m 3; context=The lowest-observed-effect level (LOEL) for this effect in all animal species is 7100 mg/m 3 by inhalation. |
| WHO/JECFA | NOAEL | =710 | mg/m3 | Rat | inhalation | - | Carcinogenicity | document_id=ehc_ehc_ehc164; title=Methylene chloride (EHC 164, 1996, 2nd edition); path=mirror/documents/ehc/ehc/ehc164.htm; row_hash=fff25c1012a174aa; raw_unit=mg/m 3; context=NOAEL 710 mg/m 3 Rat Fischer-344/N, Inhalation, 6 h/day, 5 O, 3500, Dose-dependent increase in benign NTP (1986) male and female days/week for 102 7100, mammary tumours; male: |
| WHO/JECFA | NOAEL | =710 | mg/m3 | Rat | inhalation | - | Carcinogenicity | document_id=ehc_ehc_ehc164; title=Methylene chloride (EHC 164, 1996, 2nd edition); path=mirror/documents/ehc/ehc/ehc164.htm; row_hash=fff25c1012a174aa; raw_unit=mg/m 3; context=NOAEL 710 mg/m 3 Rat Fischer-344/N, Inhalation, 6 h/day, 5 O, 3500, Dose-dependent increase in benign NTP (1986) male and female days/week for 102 7100, mammary tumours; male: |
| WHO/JECFA | NOEL | =125 | mg/m3 | Rat | oral | - | Toxicology study | document_id=ehc_ehc_ehc164; title=Methylene chloride (EHC 164, 1996, 2nd edition); path=mirror/documents/ehc/ehc/ehc164.htm; row_hash=3c9f8f7329a56ac4; raw_unit=mg/m 3; context=Oral administration of methylene chloride to rats caused effects on the liver with a no-observed-effect level of 125 mg/m 3 . |
| WHO/JECFA | NOEL | =125 | mg/m3 | Rat | oral | - | Toxicology study | document_id=ehc_ehc_ehc164; title=Methylene chloride (EHC 164, 1996, 2nd edition); path=mirror/documents/ehc/ehc/ehc164.htm; row_hash=3c9f8f7329a56ac4; raw_unit=mg/m 3; context=Oral administration of methylene chloride to rats caused effects on the liver with a no-observed-effect level of 125 mg/m 3 . |
| WHO/JECFA | NOAEL | range:260-350350 | mg/m3 | - | inhalation | long-term | Inhalation toxicity | document_id=ehc_ehc_ehc32; title=Methylene chloride (EHC 32, 1984, 1st edition); path=mirror/documents/ehc/ehc/ehc32.htm; row_hash=04d3594bc1e5bbbf; raw_unit=mg/m 3; context=A no-observed-adverse-effect level for long-term inhalation exposure was of the order of 260 - 350 mg/m 3 (Cherry et al., 1981). |
NTP ICE acute inhalation 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 52 | mg/L | - | Inhalation | Duration=6 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=117; Record_ID=acute_inhalation_2793; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0020868; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=52; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020868; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020868 |
| NTP ICE acute inhalation | LC50 | 52.0441 | mg/L | - | Inhalation | Duration=6 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=120; Record_ID=acute_inhalation_2335; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0020868; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=52.0441; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020868; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020868 |
| NTP ICE acute inhalation | LC50 | 74.744 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=121; Record_ID=acute_inhalation_2337; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0020868; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=74.744; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020868; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020868 |
| NTP ICE acute inhalation | LC50 | 76 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=118; Record_ID=acute_inhalation_1704; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0020868; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=76; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020868; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020868 |
| NTP ICE acute inhalation | LC50 | 197.8731 | mg/L | - | Inhalation | Duration=0.25 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=119; Record_ID=acute_inhalation_2333; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0020868; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=197.8731; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020868; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020868 |
NTP ICE adme parameters 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 13.72 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=85; Record_ID=adme_parameters_1194; Data_Type=Measured; DTXSID=DTXSID0020868; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=13.72; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020868; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020868 |
| NTP ICE adme parameters | Clint | 74.39 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=83; Record_ID=adme_parameters_1194; Data_Type=Measured; DTXSID=DTXSID0020868; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=74.39; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020868; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020868 |
| NTP ICE adme parameters | Fu | 0.3875 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=84; Record_ID=adme_parameters_1194; Data_Type=Measured; DTXSID=DTXSID0020868; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.3875; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020868; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020868 |
| NTP ICE adme parameters | Fu | 0.7057 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=86; Record_ID=adme_parameters_1194; Data_Type=Measured; DTXSID=DTXSID0020868; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.7057; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020868; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020868 |
NTP ICE cancer 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 2 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=292; Record_ID=cancer_3680; Data_Type=WOE; Formulation_Name=Dichloromethane; Mixture=Chemical; DTXSID=DTXSID0020868; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=2A; Response_Unit=Unitless; URL=http://publications.iarc.fr/139; http://publications.iarc.fr/89; http://publications.iarc.fr/547; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020868; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020868 |
| NTP ICE cancer | Inhalation risk unit | 1e-8 | ug/m3 | - | Inhalation | - | WOE; IRIS Carcinogenicity | sheet=Data; excel_row=289; Record_ID=cancer_3682; Data_Type=WOE; Formulation_Name=Dichloromethane; Mixture=Chemical; DTXSID=DTXSID0020868; Assay=IRIS Carcinogenicity; Endpoint=Inhalation risk unit; Response=1E-8; Response_Unit=ug/m3; Route=Inhalation; URL=https://cfpub.epa.gov/ncea/iris/iris_documents/documents/subst/0070_summary.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020868; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020868 |
| NTP ICE cancer | Oral slope factor | 0.002 | mg/kg bw/day | - | Oral | - | WOE; IRIS Carcinogenicity | sheet=Data; excel_row=287; Record_ID=cancer_3683; Data_Type=WOE; Formulation_Name=Dichloromethane; Mixture=Chemical; DTXSID=DTXSID0020868; Assay=IRIS Carcinogenicity; Endpoint=Oral slope factor; Response=2E-3; Response_Unit=mg/kg/day; Route=Oral; URL=https://cfpub.epa.gov/ncea/iris/iris_documents/documents/subst/0070_summary.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020868; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020868 |
| NTP ICE cancer | Top dose | 4000 | ppm | Mouse | Inhalation | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=277; Record_ID=cancer_3679; Data_Type=In Vivo; Formulation_Name=Methylene Chloride; Mixture=Chemical; DTXSID=DTXSID0020868; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=4000; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Inhalation; Reference=TR-306; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr306/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020868; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020868 |
ToxValDB ATSDR MRLs 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ATSDR MRLs | LOAEL | =16 | mg/kg bw/day | Human | oral | acute; 1 days | clinical | LONG_REF=Reitz RH, Hays SM, and Gargas ML. 1997. Assessing Priority Data Needs for Methylene Chloride with Physiologically-Based Pharmacokinetic Modeling. Halogenated Solvents Industry Alliance (HSIA), prepared for ATSDR, using human volunteer data from Winneke (1974).; TITLE=Assessing Priority Data Needs for Methylene Chloride with Physiologically-Based Pharmacokinetic Modeling; AUTHOR=Reitz RH; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d5857b7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp14.pdf; TOXICOLOGICAL_EFFECT=neurological; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447704:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bf65408ed10284067b8f25bb5cbc261d |
| ToxValDB ATSDR MRLs | LOAEL | =1042.09 | mg/m3 | Human | inhalation | acute; 1 days | clinical | LONG_REF=Winneke G. 1974. Behavioral effects of methylene chloride and carbon monoxide as assessed by sensory and psychomotor performance. In: Behavioral Toxicology. Early Detection of Occupational Hazards, Eds. C Xintaras, B Johnson, I deGroot. U.S. Department of Health, Education, and Welfare. ; Reitz RH, Hays SM, Gargas ML. 1997. Assessing priority data needs for methylene chloride with physiologically-based pharmacokinetic modeling. Halogenated Solvents Industry Alliance (HSIA), prepared for ATSDR.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d5857b7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp14.pdf; TOXICOLOGICAL_EFFECT=neurological; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447699:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e51cb202101d7d9444111066d689047b |
| ToxValDB ATSDR MRLs | LOAEL (HEC) | =86.8409 | mg/m3 | Rat | inhalation | chronic; 14 weeks | chronic | LONG_REF=Haun CC, Vernot EH, Darmer KI, et al. 1972. Continuous animal exposure to low levels of dichloromethane. AMRL-TR-72-130, paper no. 12.; TITLE=Continuous animal exposure to low levels of dichloromethane; AUTHOR=Haun CC; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d5857b7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp14.pdf; TOXICOLOGICAL_EFFECT=hepatic; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs:15447700:unknown:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a85e2ee5ea3e91ed748707c88b6deae3 |
| ToxValDB ATSDR MRLs | MRL | =0.2 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=neurological; STUDY_GROUP=ATSDR MRLs_dup_-_15447155_15447156:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c69006a6b1f53326544cc277309c01ef |
| ToxValDB ATSDR MRLs | MRL | =1.04209 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=hepatic in sex not reported rats; STUDY_GROUP=ATSDR MRLs_dup_-_15447152_15447153_15447154:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2d593ffb358aa05d12877a41eefedfa2 |
| ToxValDB ATSDR MRLs | MRL | =2.08418 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=neurological; STUDY_GROUP=ATSDR MRLs_dup_-_15447152_15447153_15447154:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b2723ab14b4acfcc824d25af423b658d |
| ToxValDB ATSDR MRLs | NOAEL | =6 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | LONG_REF=Serota D, Thakur, AK, Ulland BM, et al. 1986a. A two year drinking water study of dichloromethane in rodents. I. Rats. Food Chem Toxicol 24:951-958.; TITLE=A two year drinking water study of dichloromethane in rodents. I. Rats; AUTHOR=Serota D; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d5857b7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp14.pdf; TOXICOLOGICAL_EFFECT=hepatic; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs:15447705:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_19ff313ac0592d3c5e86b2868a479fca |
| ToxValDB ATSDR MRLs | NOAEL | =173.682 | mg/m3 | Rat | inhalation | chronic; 2 years | chronic | LONG_REF=Nitschke KD, Burek JD, Bell TJ, et al. 1988a. Methylene Chloride: A 2-year inhalation toxicity and oncogenicity study in rats. Fundam Appl Toxicol 11:60-67.; TITLE=Methylene Chloride: A 2-year inhalation toxicity and oncogenicity study in rats; AUTHOR=Nitschke KD; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d5857b7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp14.pdf; TOXICOLOGICAL_EFFECT=hepatic; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs_dup_-_15447702_15447703:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_60bebba44c7d6d0d865b15e5fc27e427 |
| ToxValDB ATSDR MRLs | NOAEL (HEC) | =30.9848 | mg/m3 | Rat | inhalation | chronic; 2 years | chronic | LONG_REF=Nitschke KD, Burek JD, Bell TJ, et al. 1988a. Methylene Chloride: A 2-year inhalation toxicity and oncogenicity study in rats. Fundam Appl Toxicol 11:60-67.; TITLE=Methylene Chloride: A 2-year inhalation toxicity and oncogenicity study in rats; AUTHOR=Nitschke KD; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d5857b7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp14.pdf; TOXICOLOGICAL_EFFECT=hepatic; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs_dup_-_15447702_15447703:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8dc5f8bb7d6d354fb0fb6e2d2108f51f |
ToxValDB Alaska DEC 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Alaska DEC | RfC | =3 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445690:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ab900bb429b3d6b11b33e8b3b5deb9b6 |
| ToxValDB Alaska DEC | RfC | =3 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445690:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ab900bb429b3d6b11b33e8b3b5deb9b6 |
| ToxValDB Alaska DEC | RfD | =0.057 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445685:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=afe5e00fa4060858d6362a70501e99cd |
| ToxValDB Alaska DEC | RfD | =0.057 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445685:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=afe5e00fa4060858d6362a70501e99cd |
| ToxValDB Alaska DEC | RfD | =0.06 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445686:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=9df73a72788a85efef6aef2e991e861d |
| ToxValDB Alaska DEC | RfD | =0.06 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445686:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=9df73a72788a85efef6aef2e991e861d |
| ToxValDB Alaska DEC | RfD | =0.857 | mg/kg bw/day | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445688:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=a1d9e9f0a41ec3528a70cfd8161bc044 |
| ToxValDB Alaska DEC | RfD | =0.857 | mg/kg bw/day | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445688:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=a1d9e9f0a41ec3528a70cfd8161bc044 |
ToxValDB Cal OEHHA REL derivations 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Cal OEHHA REL derivations | LOAEL | =138.945 | mg/m3 | Human | inhalation | occupational | occupational | LONG_REF=DiVincenzo GD, and Kaplan CJ. 1981a. Uptake, metabolism, and elimination of methylene chloride vapor by humans. Toxicol. Appl. Pharmacol. 59:130-140; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Significantly elevated carboxyhemoglobin levels (> 2%); STUDY_GROUP=Cal OEHHA REL derivations:15952110:-:-workers; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_989f9f757459a9e1e2cca700eab10ea6 |
| ToxValDB Cal OEHHA REL derivations | LOAEL | =677.359 | mg/m3 | Human | inhalation | acute; 90 minutes | clinical | LONG_REF=Putz VR, Johnson BL, Setzer JV. A comparative study of the effects of carbon monoxide and methylene chloride on human performance. J Environ Path Toxicol 1976;2:97-112; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd2final.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=impaired performance on dual-task and auditory vigilance tests; STUDY_GROUP=Cal OEHHA REL derivations:15951955:-:-healthy adult volunteers; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_509d0ec8908cb183c168e2f01f81fa38 |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =451573 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=DOE Protective Action Criteria:15517299:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d57502ef7c0749ec6d34acf76d551584 |
ToxValDB DOE Wildlife Benchmarks 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Wildlife Benchmarks | LOAEL | =50 | mg/kg bw/day | Rat | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511666_15511667:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c3e645e83bbc68750f04da4580571181 |
| ToxValDB DOE Wildlife Benchmarks | NOAEL | =5.85 | mg/kg bw/day | Rat | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511666_15511667:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a5064e6e9b3493970619de0dfddfc0bc |
ECHA 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEC | =3473.64 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c836e4b0a7c65d217597; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1615/7/8?documentUUID=60bc278e-428b-4392-85fb-bb56f5d14a1b; YEAR=1947; ORIGINAL_YEAR=1947; STUDY_GROUP=ECHA IUCLID:15816074:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9ed75f0ee676d3757daec4f379ba9e24 |
| ECHA | LOAEC | =17700 | mg/m3 | Rat | inhalation | - | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c851e4b0a7c65d217ea8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1615/7/10/2?documentUUID=60bc278e-428b-4392-85fb-bb56f5d14a1b; YEAR=1947; ORIGINAL_YEAR=1947; STUDY_GROUP=ECHA IUCLID:15825462:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2c56d8c80df7627b4786f27d9f211294 |
| ECHA | LOAEL | =64 | mg/kg bw/day | Mouse | oral | chronic; 36 weeks | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaee3e4b0a7c65d1cb809; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1615/7/6/2?documentUUID=60bc278e-428b-4392-85fb-bb56f5d14a1b; YEAR=1947; ORIGINAL_YEAR=1947; STUDY_GROUP=ECHA IUCLID:15839025:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a682b71931731f4b8e9d415829997636 |
| ECHA | LOAEL | =320 | mg/kg bw/day | Rat | oral | chronic; 36 weeks | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaee2e4b0a7c65d1cb7f6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1615/7/6/2?documentUUID=60bc278e-428b-4392-85fb-bb56f5d14a1b; YEAR=1947; ORIGINAL_YEAR=1947; STUDY_GROUP=ECHA IUCLID:15831145:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_04d0358b6b42d151f20a028d14001bd0 |
| ECHA | LOEL | =333 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbc8e4b0a7c65d2278a2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1615/7/6/2?documentUUID=60bc278e-428b-4392-85fb-bb56f5d14a1b; YEAR=1947; ORIGINAL_YEAR=1947; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832857_15832858:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0b701197fc193b6637de96262da5f240 |
| ECHA | NOAEC | <3473.64 | mg/m3 | Mouse | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c836e4b0a7c65d217599; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1615/7/8?documentUUID=60bc278e-428b-4392-85fb-bb56f5d14a1b; YEAR=1947; ORIGINAL_YEAR=1947; STUDY_GROUP=ECHA IUCLID:15816360:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8c95868d00d57286710acaad23e007d7 |
| ECHA | NOAEC | =6947.27 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c836e4b0a7c65d217597; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1615/7/8?documentUUID=60bc278e-428b-4392-85fb-bb56f5d14a1b; YEAR=1947; ORIGINAL_YEAR=1947; STUDY_GROUP=ECHA IUCLID:15816075:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d181ee49bf0d9ae18ca61a476d16363d |
| ECHA | NOAEC | >=15631.4 | mg/m3 | Rat | inhalation | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d216e4b0a7c65d23177c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1615/7/9/3?documentUUID=60bc278e-428b-4392-85fb-bb56f5d14a1b; YEAR=1947; ORIGINAL_YEAR=1947; STUDY_GROUP=ECHA IUCLID:15821651:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f9ef004ff1b141bd13a710f32cd2ec01 |
| ECHA | NOAEC | >=18017.8 | mg/m3 | Rat | inhalation | - | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c851e4b0a7c65d217eac; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1615/7/10/2?documentUUID=60bc278e-428b-4392-85fb-bb56f5d14a1b; YEAR=1947; ORIGINAL_YEAR=1947; STUDY_GROUP=ECHA IUCLID:15825510:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6ecacfcb9f0c500af45d26e453a5635f |
| ECHA | NOAEL | =125 | mg/L | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbc9e4b0a7c65d2278a7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1615/7/6/2?documentUUID=60bc278e-428b-4392-85fb-bb56f5d14a1b; YEAR=1947; ORIGINAL_YEAR=1947; STUDY_GROUP=ECHA IUCLID:15836626:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_77001696d7bd18d2eb12ccfd20ca242c |
| ECHA | NOAEL | =166 | mg/kg bw/day | Rat | oral | subchronic; 3 months | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaee2e4b0a7c65d1cb7fd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1615/7/6/2?documentUUID=60bc278e-428b-4392-85fb-bb56f5d14a1b; YEAR=1947; ORIGINAL_YEAR=1947; STUDY_GROUP=ECHA IUCLID:15831798:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3946b6e646704b53d55f818137489443 |
| ECHA | NOAEL | =185 | mg/kg bw/day | Mouse | oral | chronic; 104 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaee2e4b0a7c65d1cb805; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1615/7/6/2?documentUUID=60bc278e-428b-4392-85fb-bb56f5d14a1b; YEAR=1947; ORIGINAL_YEAR=1947; STUDY_GROUP=ECHA IUCLID:15838897:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5e28f20f0db4825461a5c8eae683945c |
| ECHA | NOAEL | =209 | mg/kg bw/day | Rat | oral | subchronic; 3 months | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaee2e4b0a7c65d1cb7fd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1615/7/6/2?documentUUID=60bc278e-428b-4392-85fb-bb56f5d14a1b; YEAR=1947; ORIGINAL_YEAR=1947; STUDY_GROUP=ECHA IUCLID:15831797:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f7350f71ec62caaa9372e93fe60f64ec |
| ECHA | NOAEL | =226 | mg/kg bw/day | Mouse | oral | subchronic; 3 months | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaee3e4b0a7c65d1cb818; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1615/7/6/2?documentUUID=60bc278e-428b-4392-85fb-bb56f5d14a1b; YEAR=1947; ORIGINAL_YEAR=1947; STUDY_GROUP=ECHA IUCLID:15839711:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8bc39a55439be10d8b6043ea79e81758 |
| ECHA | NOAEL | >=665 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbc8e4b0a7c65d2278a2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1615/7/6/2?documentUUID=60bc278e-428b-4392-85fb-bb56f5d14a1b; YEAR=1947; ORIGINAL_YEAR=1947; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832857_15832858:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7a67fd308776957a139fd4e7c7ec4858 |
ToxValDB ECOTOX 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =115 | mg/kg bw/day | Rat | injection | acute; 1 days | acute | LONG_REF=Fundam. Appl. Toxicol.35(1): 31-48 Herr,D.W., and W.K. Boyes A Comparison of the Acute Neuroactive Effects of Dichloromethane, 1,3-Dichloropropane, and 1,2-Dichlorobenzene on Rat Flash Evoked Potentials (FEPs) 1997; TITLE=A Comparison of the Acute Neuroactive Effects of Dichloromethane, 1,3-Dichloropropane, and 1,2-Dichlorobenzene on Rat Flash Evoked Potentials (FEPs); AUTHOR=Herr,D.W., and W.K. Boyes; DOI=10.1006/faat.1996.2255; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=77998; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Physiology: P amplitude; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603421_15603422:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=de1a2f74264808f956502f1f7a83ac17 |
| ToxValDB ECOTOX | LOEL | =1720 | mg/kg bw/day | Mouse | oral | acute; 1 days | acute | LONG_REF=Mutat. Res.419(1-3): 13-20 Sasaki,Y.F., A. Saga, M. Akasaka, S. Ishibashi, K. Yoshida, Y.Q. Su, N. Matsusaka, and S. Tsuda Detection of In Vivo Genotoxicity of Haloalkanes and Haloalkenes Carcinogenic to Rodents by the Alkaline Single Cell Gel Electrophoresis (Comet) Assay in Multiple Mouse Organs 1998; TITLE=Detection of In Vivo Genotoxicity of Haloalkanes and Haloalkenes Carcinogenic to Rodents by the Alkaline Single Cell Gel Electrophoresis (Comet) Assay in Multiple Mouse Organs; AUTHOR=Sasaki,Y.F., A. Saga, M. Akasaka, S. Ishibashi, K. Yoshida, Y.Q. Su, N. Matsusaka, and S. Tsuda; DOI=10.1016/s1383-5718(98)00114-4; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=89044; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Genetics: DNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15595890:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=77150b515916552f03382f9c7435a655 |
| ToxValDB ECOTOX | NOEL | =25 | mg/kg bw/day | Rat | oral | chronic; 217 days | reproduction developmental | LONG_REF=EPA/OTS Doc.#878210707:109 p. General Electric Corp. Dichloromethane Fourteen Day Range Finding Study in Rats 1982; TITLE=Dichloromethane Fourteen Day Range Finding Study in Rats; AUTHOR=General Electric Corp.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=96702; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15612673:M/F:F1-; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=b09097b8b8f6e66c364c584d4eb3479c |
| ToxValDB ECOTOX | NOEL | =57.5 | mg/kg bw/day | Rat | injection | acute; 1 days | acute | LONG_REF=Fundam. Appl. Toxicol.35(1): 31-48 Herr,D.W., and W.K. Boyes A Comparison of the Acute Neuroactive Effects of Dichloromethane, 1,3-Dichloropropane, and 1,2-Dichlorobenzene on Rat Flash Evoked Potentials (FEPs) 1997; TITLE=A Comparison of the Acute Neuroactive Effects of Dichloromethane, 1,3-Dichloropropane, and 1,2-Dichlorobenzene on Rat Flash Evoked Potentials (FEPs); AUTHOR=Herr,D.W., and W.K. Boyes; DOI=10.1006/faat.1996.2255; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=77998; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Physiology: P amplitude; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603421_15603422:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=85ce8dff950cc6243f2f0078fbad347d |
ToxValDB EPA TSCA 8e 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EPA TSCA 8e | LEL | =500 | mg/kg bw/day | Mouse | oral | chronic; 103 weeks | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88920010318_75092_1BF92DF7084B94FA85256930004F1B3E.pdf; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=decreased body weight gain, epithelial hyperplasia of the urinary bladder; STUDY_GROUP=EPA TSCA 8e:15957233:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_12d5c5d9166f60533ffcd4ccda768e98 |
| ToxValDB EPA TSCA 8e | LEL | =1000 | mg/kg bw/day | Mouse | oral | short-term | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88920010318_75092_1BF92DF7084B94FA85256930004F1B3E.pdf; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=mortality incidence following intermediate exposure; STUDY_GROUP=EPA TSCA 8e_dup_-_15957240_15957241_15957242:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bd4a98b4e75126b058e1b2b89b6f0515 |
| ToxValDB EPA TSCA 8e | LEL | =1500 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88920010318_75092_1BF92DF7084B94FA85256930004F1B3E.pdf; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=EPA TSCA 8e:15957239:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6284d3d786a1a04dab655b843cb9d8fa |
| ToxValDB EPA TSCA 8e | LEL | =2000 | mg/kg bw/day | Mouse | oral | short-term | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88920010318_75092_1BF92DF7084B94FA85256930004F1B3E.pdf; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=mortality following continuous exposure; STUDY_GROUP=EPA TSCA 8e_dup_-_15957240_15957241_15957242:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1b38a825beb76a1be1d0154fe1fce42c |
| ToxValDB EPA TSCA 8e | LEL | =8684.09 | mg/m3 | Dog | inhalation | subchronic; 12 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88920010379_75092_F328A6A7147FDB3A85256930004CD8B4.pdf; YEAR=1949; ORIGINAL_YEAR=1949; TOXICOLOGICAL_EFFECT=drowsiness, stupor, incoordination and loss of bowel and bladder control, drop in diastolic blood pressure; STUDY_GROUP=EPA TSCA 8e:15957238:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cb7f81d270a81f4bb8a56a41f60567a0 |
| ToxValDB EPA TSCA 8e | NEL | =1000 | mg/kg bw/day | Mouse | oral | acute | acute | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=tscats/88920010318_75092_1BF92DF7084B94FA85256930004F1B3E.pdf; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=no clinical signs of toxicity; STUDY_GROUP=EPA TSCA 8e:15957231:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_372c60e990dc5987353f466734deba06 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =176 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633377:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0f34e4bb4787fbceef6ecfeeb85bc39c |
ToxValDB Health Canada 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Health Canada | NOAEL | =5 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=PSL1: HC, 1996a; EC/HC, 1993e (based on Serota et al., 1986); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/61003a57e4b01a90a3f9c305; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://publications.gc.ca/site/eng/9.694269/publication.html; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=increased incidence of foci/areas of cellular alterations and fatty change in liver; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=Health Canada:15637539:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_24952caff6e301f4cf655cb3ddbb4d71 |
| ToxValDB Health Canada | TDI | =0.05 | mg/kg bw/day | Human | oral | chronic; 2 years | Toxicity Value | LONG_REF=PSL1: HC, 1996a; EC/HC, 1993e (based on Serota et al., 1986); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/61003a57e4b01a90a3f9c305; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://publications.gc.ca/site/eng/9.694269/publication.html; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=increased incidence of foci/areas of cellular alterations and fatty change in liver; STUDY_GROUP=Health Canada:15637417:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0de95c598d9e9f9b9857d3109c09d63f |
ToxValDB IRIS 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | BMDL (HEC) | =17.2 | mg/m3 | Rat | inhalation | chronic; 2 years | chronic | LONG_REF=Nitschke, KD; Burek, JD; Bell, TJ; et al. (1988a) Methylene chloride: a 2-year inhalation toxicity and oncogenicity study in rats. Fundam Appl Toxicol 11:48-59.; TITLE=Methylene chloride: a 2-year inhalation toxicity and oncogenicity study in rats; AUTHOR=Nitschke, KD; Burek, JD; Bell, TJ; et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4d36; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=70; TOXICOLOGICAL_EFFECT=hepatic effects (hepatic vacuolation); STUDY_GROUP=IRIS:15644701:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_eb166bb02ee743354b63c2df845eb494 |
| ToxValDB IRIS | BMDL (HED) | =0.19 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=Serota, DG; Thakur, AK; Ulland, BM; et al. (1986a) A two-year drinking water study of dichloromethane in rodents. I. Rats. Food Chem Toxicol 24(9):951-958.; TITLE=A two-year drinking water study of dichloromethane in rodents. I. Rats; AUTHOR=Serota, DG; Thakur, AK; Ulland, BM; et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4d36; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=70; TOXICOLOGICAL_EFFECT=hepatic effects (hepatic vacuolation, liver foci); TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=IRIS:15644449:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_436bb58c71e4b6d4e392085dad57b73e |
| ToxValDB IRIS | RfC | =0.6 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Nitschke, KD; Burek, JD; Bell, TJ; et al. (1988a) Methylene chloride: a 2-year inhalation toxicity and oncogenicity study in rats. Fundam Appl Toxicol 11:48-59.; TITLE=Methylene chloride: a 2-year inhalation toxicity and oncogenicity study in rats; AUTHOR=Nitschke, KD; Burek, JD; Bell, TJ; et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4d36; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=70; TOXICOLOGICAL_EFFECT=Hepatic effects (hepatic vacuolation) in male/female rats; STUDY_GROUP=IRIS:15644702:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e39ee93734777c70240d39850ac0cc50 |
| ToxValDB IRIS | RfD | =0.006 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Serota, DG; Thakur, AK; Ulland, BM; et al. (1986a) A two-year drinking water study of dichloromethane in rodents. I. Rats. Food Chem Toxicol 24(9):951-958.; TITLE=A two-year drinking water study of dichloromethane in rodents. I. Rats; AUTHOR=Serota, DG; Thakur, AK; Ulland, BM; et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4d36; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=70; TOXICOLOGICAL_EFFECT=Hepatic effects (hepatic vacuolation, liver foci) in male/female rats; STUDY_GROUP=IRIS:15644700:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f75925e0bdac693ee58d420c1ee43c85 |
ToxValDB TX TCEQ 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB TX TCEQ | NOAEL | =691.254 | mg/m3 | Rat | inhalation | chronic; 2 years | chronic | LONG_REF=Nitschke KD, Burek JD, Bell TJ, et al. 1988b. Methylene chloride: A 2-year inhalation toxicity and oncogenicity study in rats. Fundam Appl Toxicol 11:48-59.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5ae3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/methylene_chloride.pdf; YEAR=2011 Accessible 2013; ORIGINAL_YEAR=2011 Accessible 2013; TOXICOLOGICAL_EFFECT=Significant increases in the incidence of hepatocellular cytoplasmic vacuolization and multi-nucleated hepatocytes (i.e., liver histopathology) in female rats; STUDY_GROUP=TX TCEQ:15954544:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ab6b44606be3e7a9fbd04e63a530f2ba |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 588X2YUY0A | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"CH2Cl2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"588X2YUY0A"} |
| openFDA substances | FDA UNII substance identifier | 588X2YUY0A | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"CH2Cl2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"588X2YUY0A"} |
| openFDA substances | FDA UNII substance identifier | 588X2YUY0A | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"CH2Cl2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"588X2YUY0A"} |
| openFDA substances | FDA UNII substance identifier | 588X2YUY0A | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"CH2Cl2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"588X2YUY0A"} |