Is Methyl Diisopropyl Propionamide safe in cosmetics?
Methyl Diisopropyl Propionamide has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Methyl Diisopropyl Propionamide
Also known as: Butanamide, N,2,3-trimethyl-2-(1-methylethyl)-, EINECS 256-974-4, N,2,3-Trimethyl-2-isopropylbutanamide, N,2,3-Trimethyl-2-(1-methylethyl)butanamide, UNII-6QOP5A9489
INCI: METHYL DIISOPROPYL PROPIONAMIDE
Methyl Diisopropyl Propionamide (CAS 51115-67-4) is a cosmetic cosmetic ingredient functioning as Cooling agent / sensory modifier - provides long-lasting refreshing sensation. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 51115-67-4 →
Auto-generated CPSR Part A draft with source citations
Function
Cooling agent / sensory modifier - provides long-lasting refreshing sensation without menthol
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
N,2,3-trimethyl-2-propan-2-ylbutanamide
InChIKey
RWAXQWRDVUOOGG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific prohibition; allowed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Methyl Diisopropyl Propionamide.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1595
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-ISOPROPYL-N,2,3-TRIMETHYLBUTYRAMIDE | 2016 | ACCEPTABLE (CONDITIONAL) | Additional data required to complete evaluation. Concerns for in vivo genotoxicity and kidney effects at low doses. | ">TRS 1000-JECFA 82/99 | FAS 73 JECFA 82/343
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Methyl Diisopropyl Propionamide.
Regulatory Flags
potential-allergen
ifra_fragrance
fda_food_additive
Known Synonyms
Butanamide, N,2,3-trimethyl-2-(1-methylethyl)-
EINECS 256-974-4
N,2,3-Trimethyl-2-isopropylbutanamide
N,2,3-Trimethyl-2-(1-methylethyl)butanamide
UNII-6QOP5A9489
Chemical Function
Deodorizer
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. These obligations are: 1. A person introducing this chemical must tell us in writing within 28 calendar days if any of the following circumstances have occurred in relation to their introduction (importation or manufacture): a. the introduction volume of the chemical exceeds 1...
Frequently Asked Questions
Is Methyl Diisopropyl Propionamide allowed in the EU?
Methyl Diisopropyl Propionamide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Diisopropyl Propionamide do in cosmetics?
Methyl Diisopropyl Propionamide functions as: Cooling agent / sensory modifier - provides long-lasting refreshing sensation without menthol. It is classified as a cosmetic ingredient in our database. CAS number: 51115-67-4.
Is Methyl Diisopropyl Propionamide used outside cosmetics?
Methyl Diisopropyl Propionamide also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Methyl Diisopropyl Propionamide compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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