Is Menthanediol safe in cosmetics?
Menthanediol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Menthanediol
Also known as: Cyclohexanemethanol, 2-hydroxy-alpha,alpha,4-trimethyl-, 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexan-1-ol, 2-Hydroxy-α,α,4-trimethylcyclohexanemethano, 1-Hydroxy-2-(1-methyl-1-hydroxyethyl)-5-methylcyclohexane, 1-Hydroxy-5-methyl-2-(1-methyl-1-hydroxyethyl)cyclohexane (+14 more)
INCI: MENTHANEDIOL
Menthanediol (CAS 42822-86-6) is a cosmetic cosmetic ingredient functioning as Hair Conditioning, Oral Care, Skin Conditioning, Cooling Agent, Insect Repellent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 42822-86-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Menthanediol is classified GHS Danger (H319, H226, H318) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair Conditioning, Oral Care, Skin Conditioning, Cooling Agent, Insect Repellent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-(2-hydroxypropan-2-yl)-5-methylcyclohexan-1-ol
InChIKey
LMXFTMYMHGYJEI-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed in cosmetics - no specific prohibition or restriction. Also EPA-registered as an insect repellent active (PMD) outside cosmetic classification
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Menthanediol.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | - | 0 | 1000 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1416
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
p-MENTHANE-3,8-DIOL | 2023 | No safety concern at current levels of intake when used as a flavouring agent | Considered for specifications only | TRS 1050-JECFA 96/46 | ">FAS 60-JECFA 69/629
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Softener and conditioner
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Menthanediol.
Regulatory Flags
potential-allergen
ifra_fragrance
fda_food_additive
Known Synonyms
Cyclohexanemethanol, 2-hydroxy-alpha,alpha,4-trimethyl-
2-(2-Hydroxypropan-2-yl)-5-methylcyclohexan-1-ol
2-Hydroxy-α,α,4-trimethylcyclohexanemethano
1-Hydroxy-2-(1-methyl-1-hydroxyethyl)-5-methylcyclohexane
1-Hydroxy-5-methyl-2-(1-methyl-1-hydroxyethyl)cyclohexane
3,8-p-Menthanediol
Citrepel
Cooling agent 38D
2-hydroxy-α,α,4-trimethylcyclohexanemethanol
2-Hydroxy-α,α,4-trimethylcyclohexanmethanol
2-hidroxi-α,α,4-trimetilciclohexanometanol
O-menthane 3,8-diol
Para-menthane-3,8-diol
Ciclohexanometanol, 2-hidroxi-α,α,4-trimetil-
EINECS 255-953-7
Geranodyle
Geranium cyclohexane
Citriodiol
UNII-6T6Z1Z1NC4
Chemical Function
Softener and conditioner
Flavouring and nutrient
Fragrance
Regulatory Lists
IFRA Transparency
active_ingredient; Europe; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
P-MENTHANE-3,8-DIOL
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Menthanediol allowed in the EU?
Menthanediol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Menthanediol do in cosmetics?
Menthanediol functions as: Hair Conditioning, Oral Care, Skin Conditioning, Cooling Agent, Insect Repellent. It is classified as a cosmetic ingredient in our database. CAS number: 42822-86-6.
Is Menthanediol used outside cosmetics?
Menthanediol also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Menthanediol have different safety status in cosmetics vs industrial chemicals?
Menthanediol is classified GHS Danger (H319, H226, H318) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Menthanediol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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