| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
ADI |
range:0-0.00070.0007 |
mg/kg bw/day |
Rat |
- |
- |
Health guidance value |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=35b5fcb1870a39b6; raw_unit=mg/kg bw; context=The Meeting established a group ADI of 0-0.0007 mg/kg bw for racemic haloxyfop, haloxyfop-R and their methyl esters based on a NOAEL of 0.065 mg/kg bw per day for low pup body weight in multigeneration studies in rats, and applying a safety factor of 100. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
ADI |
range:0-0.0050.005 |
mg/kg bw/day |
Rat |
- |
92-day |
Health guidance value |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=ce832259fbd1ee5f; raw_unit=mg/kg bw; context=After considering all previously evaluated data and the new studies, the Meeting established an ADI of 0-0.005 mg/kg bw based on the highest NOAEL of 0.5 mg/kg bw per day for inhibition of erythrocyte cholinesterase activity in a 92-day repeat-dose study in rats, and with a safety factor of 100. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
ADI |
range:0-0.010.01 |
mg/kg bw/day |
Dog |
- |
one-year |
Health guidance value |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=3c8465549b6a3c16; raw_unit=mg/kg bw; context=linical signs observed in available toxicological studies 43 BIFENAZATE X-X JMPR 2006 Medical data No signifi cant adverse health effects reported Summary Value Study Safety factor ADI 0-0.01 mg/kg bw Dog, one-year study of toxicity 100 ARfD Unnecessary - - References Andre, J.C. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
ADI |
range:0-0.020.02 |
mg/kg bw/day |
- |
oral |
- |
Health guidance value |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=dfce0b1b2433add9; raw_unit=mg/kg bw.; context=In 1997, the Joint FAO/WHO Expert Committee on Food Additives (JECFA) also established an ADI of 0-0.02 mg/kg bw. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
ADI |
range:0-0.040.04 |
mg/kg bw/day |
Rat |
oral |
24-month |
Health guidance value |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=c45e19b5bf74c790; raw_unit=mg/kg bw; context=Toxicological evaluation An ADI of 0-0.04 mg/kg bw was established for boscalid based on the NOAEL of 4.4 mg/kg bw per day, identifi ed on the basis of increased gamma-glutamyltransferase activity and increased incidences of hepatic eosinophilic foci in male rats in a 24-month long-term dietary study of toxici |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
ADI |
range:0-0.050.05 |
mg/kg bw/day |
- |
- |
- |
Health guidance value |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=dc19c64503d40d78; raw_unit=mg/kg bw per day; context=New t oxicological data were e valuated by the 1981 JMPR and an ADI of 0-0.05 mg/kg bw per day was established. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
ADI |
range:0-0.060.06 |
mg/kg bw/day |
Rat |
oral |
2-year |
Health guidance value |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=45fc97ab3bbbf9e5; raw_unit=mg/kg bw; context=Toxicological evaluation The Meeting considered establishing a group ADI of 0-0.06 mg/kg bw on the basis of an overall NOAEL of 6.2 mg/kg bw per day for reductions in body-weight gain observed in a 2-year dietary study with cyfl uthrin in rats, and using an safety factor of 100. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
ADI |
range:0-0.10.1 |
mg/kg bw/day |
- |
- |
- |
Health guidance value |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=f38c6f87f6950800; raw_unit=mg/ kg bw.; context=In 1997, the Committee established an ADI of 0-0.1 mg/ kg bw. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
ADI |
range:0-0.20.2 |
mg/kg bw/day |
Rat; Dog |
oral |
24-month |
Health guidance value |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=e76ba76a79b814ad; raw_unit=mg/kg bw; context=Toxicological evaluation The Meeting established an ADI for quinoxyfen of 0-0.2 mg/kg bw on the basis of NOAELs of 20 mg/kg bw per day identifi ed in three studies: the 24-month study in rats, on the basis of reduced body-weight gain, liver and kidney effects at 80 mg/kg bw per day; the 1-year study in dogs, on the basis of reduced food consumptio |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=0.2 |
mg/kg bw/day |
Rat; Mouse |
- |
six-week |
Carcinogenicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=93573e6ac271abdb; raw_unit=mg/kg bw per day; context=Levels relevant to risk assessment Species Study Effect NOAEL LOAEL Mouse Thirty-six-week study of toxicitya,e Toxicity 0.2 mg/kg bw per day 2 mg/kg bw per day Two-year study of carcinogenicitya,fe Toxicity 0.6 mg/kg bw per dayd - Carcinogenicity 0.065 mg/kg bw per dayd 0.6 mg/kg bw per day Rat Sixteen-week study of toxicitya,b Toxicity 0.2 mg/kg bw per day 2 mg/kg bw per day Two-year study of tox |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=0.6 |
mg/kg bw/day |
Mouse |
- |
- |
Carcinogenicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=6a5491c7be788e68; raw_unit=mg/kg bw per day; context=The LOAEL for production of liver tumours in mice was 0.6 mg/kg bw per day and the NOAEL was 0.065 mg/kg bw per day. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=1 |
mg/kg bw/day |
Rat |
- |
4-week |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=c7ef25aa0916d38c; raw_unit=mg/kg bw per day; context=(b) Beta-cyfl uthrin Species Study Effect NOAEL LOAEL Rat 4-week study of toxicityb Toxicity 1 mg/kg bw per day 4 mg/kg bw per day Developmental toxicityb Maternal toxicity Fetotoxicity 9.4 mg/kg bw per day 9.4 mg/kg bw per day 42 mg/kg bw per day 42 mg/kg bw per day Acute neurotoxicityb Neurotoxicity 0.5 mg/kg bw 2 mg/kg bw 13-week study of neurotoxicitya Neurotoxicit |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=1.5 |
mg/kg bw/day |
Rat; Mouse |
- |
79-week |
Carcinogenicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=d41340aef6bf5626; raw_unit=mg/kg bw per day; context=Levels relevant to risk assessment Species Study Effect NOAEL LOAEL Mouse 79-week study of toxicity and carcinogenicitya Toxicity 10 ppm, equal to 1.5 mg/kg bw per day 100 ppm, equal to 15.4 mg/kg bw per day Carcinogenicity 175 ppm, equal to 35.7 mg/kg bw per dayc Rat Two-year study of toxicity and carcinogenicitya Toxicity 80 ppm, equal to 3.9 mg/kg bw per day 160 ppm, equal to 9.7 mg/kg bw per day 41 BIFENAZATE X-X JMPR 2 |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=2.5 |
mg/kg bw |
Human; Rat |
- |
3-month |
Subchronic toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=2856b18b1dd19562; raw_unit=mg/kg bw; context=Levels relevant to risk assessment Species Study Effect NOAEL LOAEL Rat Acute neurotoxicityb Behavioural changes and cholinesterase inhibition in erythrocytes 2.5 mg/kg bw 150 mg/kg bw Time course of cholinesterase inhibition after a single doseb Cholinesterase inhibition in erythrocytes and brain 2.5 mg/kg bw 25 mg/kg bw Human Acute toxicityc No inhibition of cholinesterase activity 0.21 mg/kg bw - Rat 3-month studies of toxic |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=2.5 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=ecee7d46b8e8155c; raw_unit=mg/kg bw per day; context=Effects at the lowest- observed-adverse-effect level (LOAEL) of 2.5 mg/kg bw per day included liver toxicity and thyroid changes (follicular epithelial hypertrophy) secondary to liver enzyme induction. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=6.2 |
mg/kg bw/day |
Rat |
- |
Two-year |
Reproductive toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=35080af4d82fcd53; raw_unit=mg/kg bw per day; context=Levels relevant for risk assessment (a) Cyfl uthrin Species Study Effect NOAEL LOAEL Rat Two-year study of toxicity and carcinogenicitya Toxicity Carcinogenicity 150 ppm, equal to 6.2 mg/kg bw per day 450 ppm, equal to 19.2 mg/kg bw per dayc 450 ppm, equal to 19.2 mg/kg bw per day-c Two-generation study of reproductive toxicitya Parental 50 ppm, equal to 3.8 mg/kg bw per day 150 ppm, equal to 11.4 mg/kg bw per dayd 144 CYFLUTHRIN AND BETA-CYFLUTHRIN X-X JM |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=6.3 |
mg/kg bw/day |
Rat; Mouse |
- |
Three-month |
Carcinogenicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=25728113e8f8201a; raw_unit=mg/kg bw per day; context=215 CYPERMETHRINS X-X JMPR 2006 (b) Alpha-Cypermethrin Species Study Effect NOAEL LOAEL Mouse Three-month study of toxicitya Toxicity 50 ppm, equal to 6.3 mg/kg bw per day 250 ppm, equal to 33 mg/kg bw per day Eighteen-month study of toxicity and c arcinogenicitya Toxicity 30 ppm, equal to 3 mg/kg bw per day 100 ppm, equal to 10.6 mg/kg bw per day Carcinogenicity 300 ppm, equal to 35 mg/kg bw per dayd - Rat Three-month study of |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=6.9 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=83beeec11cf69666; raw_unit=mg/kg bw per day; context=The LOAEL for parental toxicity was 80 ppm, equal to 6.1 and 6.9 mg/kg bw per day in males and females, respectively, on the basis of decreased body weights and body-weight gains. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=6.9 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=83beeec11cf69666; raw_unit=mg/kg bw per day; context=The LOAEL for parental toxicity was 80 ppm, equal to 6.1 and 6.9 mg/kg bw per day in males and females, respectively, on the basis of decreased body weights and body-weight gains. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=8.9 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=e31e00121eb127d1; raw_unit=mg/kg bw per day; context=The LOAEL was 400 ppm, equal to 8.9 mg/kg bw per day in males and 10.4 mg/kg bw per day in females for changes in haematology (decreases in erythrocyte counts, haemoglobin and erythrocyte volume fraction values; increases in reticulocyte counts and MCV), clinical chemistry and urine analysis parameters (increas |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=8.9 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=e31e00121eb127d1; raw_unit=mg/kg bw per day; context=The LOAEL was 400 ppm, equal to 8.9 mg/kg bw per day in males and 10.4 mg/kg bw per day in females for changes in haematology (decreases in erythrocyte counts, haemoglobin and erythrocyte volume fraction values; increases in reticulocyte counts and MCV), clinical chemistry and urine analysis parameters (increas |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=9.4 |
mg/kg bw/day |
Rat |
oral |
13-week |
Subchronic toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=29163b9901fc37f4; raw_unit=mg/kg bw per day; context=The overall LOAEL for this effect was 9.4 mg/kg bw per day, observed in a 13-week dietary study with beta-cyfl uthrin in rats. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=9.7 |
mg/kg bw/day |
- |
oral |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=f140748862b490ce; raw_unit=mg/kg bw per day; context=The LOAEL was 200 ppm for males and 160 ppm for females (equal to 9.7 mg/kg bw per day in males and females) for decreases in body weight, body-weight gain, food consumption and haematological parameters. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=9.7 |
mg/kg bw/day |
- |
oral |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=f140748862b490ce; raw_unit=mg/kg bw per day; context=The LOAEL was 200 ppm for males and 160 ppm for females (equal to 9.7 mg/kg bw per day in males and females) for decreases in body weight, body-weight gain, food consumption and haematological parameters. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=10 |
mg/kg bw/day |
Rat |
- |
28-day |
Carcinogenicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=f5a8abdd4e401389; raw_unit=mg/kg bw per day; context=Levels relevant to risk assessment Species Study Effect NOAEL LOAEL Rat 28-day and 44-day study of toxicityb Clinical signs 10 mg/kg bw per day 100 mg/kg bw per day 90-day study in ratsa Inhibition of acetylcholinesterase in brain 2.3 mg/kg bw per dayd - 2-year study of toxicity and carcinogenicitya Carcinogenicity (cholinesterase activity not measured) 300 ppm (15 mg/kg bw per day)d - Three-generati |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=10.4 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=fac1cdb34c016798; raw_unit=mg/kg bw per day; context=The LOAEL was 400 ppm, equal to 10.4 mg/kg bw per day in males and 10.7 mg/kg bw per day in females, for alterations in haematological parameters (decreases in erythrocytes, haemoglobin, and erythrocyte volume fraction, increases in reticulocytes, MCV, MCH, anisocytosis and platelets), a decrease in protein peak |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=10.4 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=fac1cdb34c016798; raw_unit=mg/kg bw per day; context=The LOAEL was 400 ppm, equal to 10.4 mg/kg bw per day in males and 10.7 mg/kg bw per day in females, for alterations in haematological parameters (decreases in erythrocytes, haemoglobin, and erythrocyte volume fraction, increases in reticulocytes, MCV, MCH, anisocytosis and platelets), a decrease in protein peak |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=13 |
mg/kg bw/day |
Rat; Mouse |
- |
18-month |
Carcinogenicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=445740022bccb124; raw_unit=mg/kg bw per day; context=Levels relevant to risk assessment Species Study Effect NOAEL LOAEL Mouse 18-month study of toxicity and carcinogenicity Toxicity 80 ppm, equal to 13 mg/kg bw per day 400 ppm, equal to 65 mg/kg bw per day Carcinogenicity 8000 ppma, equal to 1345 mg/kg bw per day - 97 BOSCALID X-X JMPR 2006 Rat 24-month studies of toxicity and carcinogenicity Toxicity 100 ppm, equal to 4.4 mg/kg bw per day 500ppm, equal to 23 mg/kg bw per d |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=15 |
mg/kg bw |
Human; Rat |
oral |
28-day |
Acute toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=7e9575c4d3adf515; raw_unit=mg/kg bw; context=The recovery of brain cholinesterase activity is slow. • Levels relevant for risk assessment Species Study Effect NOAEL LOAEL Rat Acute neurotoxicitya Neurotoxicity 15 mg/kg bw 150 mg/kg bw Human 28-day, 56-day toxicity (Neuro-)toxicity 0.25 mg/kg bw -b a Gavage administration b Highest dose tested Estimate of acute reference dose 0.2 mg/kg bw Information that would be useful for the continued evaluation of the compound Results from |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=15.4 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=dc4e40f219ceda00; raw_unit=mg/kg bw per day; context=The LOAEL was 100 ppm (equal to 15.4 mg/kg bw per day) in the males (for changes in haematology parameters and possibly kidney weights) and 175 ppm (equivalent to 35.7 mg/kg bw per day) in the females (for decreased body weights and body-weight gains) (Ivett, 1999a). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=15.4 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=dc4e40f219ceda00; raw_unit=mg/kg bw per day; context=The LOAEL was 100 ppm (equal to 15.4 mg/kg bw per day) in the males (for changes in haematology parameters and possibly kidney weights) and 175 ppm (equivalent to 35.7 mg/kg bw per day) in the females (for decreased body weights and body-weight gains) (Ivett, 1999a). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=16.3 |
mg/kg bw/day |
- |
oral |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=fc519b597d7d5f48; raw_unit=mg/kg bw per day; context=The LOAEL was 200 ppm, equal to 13.8 and 16.3 mg/kg bw per day in males and females, respectively, for increased centrilobullar hypertrophy, liver cell necrosis, vacuolation of the zona fasciculate of the adrenal cortex and extramedullary haematopoiesis in males and decreases in body-weight gains, decreases in food consu |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=16.3 |
mg/kg bw/day |
- |
oral |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=fc519b597d7d5f48; raw_unit=mg/kg bw per day; context=The LOAEL was 200 ppm, equal to 13.8 and 16.3 mg/kg bw per day in males and females, respectively, for increased centrilobullar hypertrophy, liver cell necrosis, vacuolation of the zona fasciculate of the adrenal cortex and extramedullary haematopoiesis in males and decreases in body-weight gains, decreases in food consu |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=17 |
mg/kg bw/day |
Rat |
- |
Three-month |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=c28f84be08deb156; raw_unit=mg/kg bw per day; context=(c) Zeta-Cypermethrin Species Study Effect NOAEL LOAEL Rat Three-month study of toxicitya Toxicity 250 ppm, equal to 17 mg/kg bw per day 500 ppm, equal to 34 mg/kg bw per day Multigeneration r eproductive toxicitya Parental and offspring toxicity 100 ppm, equal to 6 mg/kg bw per day 375 ppm, equal to 22 mg/kg bw per day Developmental t oxicityc Maternal toxicity 12.5 mg/kg bw per day 25 mg/kg |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=19.9 |
mg/kg bw/day |
Mouse |
- |
14-week |
Carcinogenicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=e7ed25769c6531db; raw_unit=mg/kg bw per day; context=Levels relevant to risk assessment Species Study Effect NOAEL LOAEL Mouse 14-week study of toxicitya Toxicity 50 ppm, equal to 19.9 mg/kg bw per day 250 ppm, equal to 102.6 mg/kg bw per day 2-year study of carcinogenicitya Toxicity 30 ppm, equal to 5.7 mg/kg bw per day 1250 ppm, equal to 234.1 mg/kg bw per day Carcinogenicity Females: |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=25 |
mg/kg bw/day |
Rat; Mouse; Rabbit |
oral |
- |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=3db110b364e10e6f; raw_unit=mg/kg bw per day; context=Levels relevant to acute dietary risk assessment Species Study Effect NOAEL LOAEL Mouse Developmental t oxicityb Maternal toxicity 25 mg/kg bw per day 100 mg/kg bw per day Developmental toxicity 25 mg/kg bw per day 100 mg/kg bw per day Rat Single-dose toxicity study Toxicity 100 mg/kg bwb 200 mg/kg bw 600 ppm, equal to 46 mg/kg bwa,c __ Rabbit Developmental t oxicityb Maternal toxicity 24 mg/kg bw per day 1 |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=37 |
mg/kg bw/day |
- |
- |
3-week |
Chronic toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=db62d31f15a10f54; raw_unit=mg/kg bw per day; context=NOAELs and LOAELs for key effects in the mode of action of thiacloprid in the thyroid Effect NOAEL/LOAEL Liver Induction of UDP-GT 9/37 mg/kg bw per day (3-week mechanistic study) 2.5/25 mg/kg bw per day (2-year study) Increase in liver weight 37/145 mg/kg bw per day (3-week mechanistic study) 25/52 mg/kg bw per day (2-year study) Hepatocellular hypertrophy 1.2/2.5 mg/kg bw per day (2-year study) Hormones Dec |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=60 |
mg/kg bw/day |
Rat; Mouse |
- |
Two-year |
Carcinogenicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=e185b7dc37e8dead; raw_unit=mg/kg bw per day; context=Levels relevant to risk assessment (a) Cypermethrin Species Study Effect NOAEL LOAEL Mouse Two-year study of toxicity and carcinogenicitya Toxicity 400 ppm, equivalent to 60 mg/kg bw per day 1600 ppm, equivalent to 240 mg/kg bw per day Carcinogenicity 1600 ppm, equivalent to 240 mg/kg bw per dayd - Rat Three-month studies of toxicitya,b Toxicity 400 ppm, equivalent to 40 mg/kg bw per day 1500 ppm, equal to 116 mg/kg bw per day Two-year studies of |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=80 |
mg/kg bw/day |
Rat; Mouse |
- |
18-month |
Reproductive toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=331e802ae98cf9c8; raw_unit=mg/kg bw per day; context=397 QUINOXYFEN X-X JMPR 2006 Levels relevant to risk assessment Species Study Effect NOAEL LOAEL Mouse 18-month studyc Toxicity 80 mg/kg bw per day 250 mg/kg bw per day Carcinogenicity 250 mg/kg bw per daya - Rat Acute neurotoxicityb Toxicity 2000 mg/kg bw per daya - Two-generation study of reproductive toxicityc Reproduction 110 mg/kg bw per daya - Offspring 20 mg/kg bw per day 110 mg/kg bw per day Pare |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=100 |
mg/kg bw/day |
- |
oral |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=c0d8e7a49c31d9fb; raw_unit=mg/kg bw per day; context=The LOAEL for maternal toxicity was 100 mg/kg bw per day on the basis of abnormal clinical signs, reduced body weights and body- weight gains and reduced food consumption. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=100 |
mg/kg bw/day |
- |
oral |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=c0d8e7a49c31d9fb; raw_unit=mg/kg bw per day; context=The LOAEL for maternal toxicity was 100 mg/kg bw per day on the basis of abnormal clinical signs, reduced body weights and body- weight gains and reduced food consumption. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=113 |
mg/kg bw/day |
- |
- |
7-day |
Reproductive toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=03066d0dcfe8f45a; raw_unit=mg/kg bw per day; context=NOAELs and LOAELs for key effects in the mode of action of thiacloprid in the thyroid Effect NOAEL/LOAEL Liver Induction of hepatic aromatase -/113 mg/kg bw per day (7-day mechanistic study) -/60.4 mg/kg bw per day (one-generation study) 6.6/20.4 mg/kg bw per day (4-week mechanistic study) Increase in liver weight 20.4/47.5 mg/kg bw per day (4-week mechanistic study) 34/69 mg/kg bw per day (2-year study) Hepatocellular h |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=126 |
mg/kg bw/day |
Rat; Mouse |
- |
Two-year |
Carcinogenicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=9b98355679b98047; raw_unit=mg/kg bw per day; context=Levels relevant to risk assessment Species Study Effect NOAEL LOAEL Mouse Two-year studies of toxicity and carcinogenicitya Toxicity 1000 ppm, equal to 126 mg/kg bw per day 3000 ppm, equal to 384 mg/kg bw per day Carcinogenicity 1000 ppm, equal to 164 mg/kg bw per day 3000 ppm, equal to 476 mg/kg bw per day Rat Two-year studies of toxicity and carcinogenicitya Toxicity 300 ppm, equal to 15 mg/kg bw per day 3000 ppm, equal to 156 |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=139 |
mg/kg bw/day |
- |
- |
13-week |
Chronic toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=c560c48a77b5d73a; raw_unit=mg/kg bw per day; context=NOAELs and LOAELs for key effects in the mode of action of thiacloprid in the thyroid Effect NOAEL/LOAEL Liver Induction of hepatic aromatase 18/139 mg/kg bw per day (13-week mechanistic study) Increase in liver weight 139/704 mg/kg bw per day (14-week study) 11/475 mg/kg bw per day (2-year study) Hepatocellular hypertrophy 139/704 mg/kg bw per day (14-week study) 11/475 mg/kg bw perday (2-year study) Hormones Decrease in |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
~150 |
mg/kg bw/day |
Rat; Mouse |
oral |
90 days |
Subchronic toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=0d826146f8739456; raw_unit=mg/kg bw per day; context=3161 mg/kg bw (males) Main toxic effects of dietary administration to rats and mice: calculi formation, infl ammatory reactions and hyperplasia in the urinary bladder LOAEL calculus formation: about 150 mg/kg bw per day in rats (90 days) NOAEL hyperplasia: |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
LOAEL |
=500 |
ppm |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=8c8c83c690202e9a; raw_unit=ppm; context=amyltransferase activity and hepatic centrilobular hypertrophy and eosinophilic foci in males and increased concentration of cholesterol and reduced prothrombin times in females at 500 ppm, which may be considered as an LOAEL. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=0.019 |
mg/kg bw/day |
- |
- |
- |
Neurotoxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=53d4fa518729ee8c; raw_unit=mg/kg bw per day; context=The NOAEL was 0.3 ppm (equal to 0.019 mg/kg bw per day but rounded up to 0.02 mg/kg bw per day) on the basis of signifi cant inhibition of erythrocyte acetylcholinesterase activity at 30 ppm in males and females (Pettersen & Morrissey, 1994). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
range:0-0.020.02 |
mg/kg bw/day |
Rat |
oral |
2-year |
Reproductive toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=4fff9dc6d5311509; raw_unit=mg/kg bw; context=228 CYROMAZINE X-X JMPR 2006 Cyromazine was fi rst evaluated by the 1990 JMPR, when an acceptable daily intake (ADI) of 0-0.02 mg/kg bw was established on the basis of a no-observed-adverse-effect level (NOAEL of 1.8 mg/kg bw per day for body-weight changes in a 2-year dietary study in rats and a NOAEL of 2 mg/kg bw per day in a two-generation study of reproductive toxicity in rats, with a safety factor of 100. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=0.025 |
mg/kg bw/day |
- |
- |
- |
Neurotoxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=c55fd8642e10224a; raw_unit=mg/kg bw per day; context=The NOAEL was 0.025 mg/kg bw per day on the basis of depression of plasma cholinesterase activity, the only effect observed at this dose (Lazanas et al., 1966, referenced in Annex 5, reference 7 as Ind. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=0.03 |
mg/kg bw |
Human; Rat |
- |
- |
Acute toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=ed07c96a465b420f; raw_unit=mg/kg bw; context=Although a new study of acute toxicity in humans was submitted, the ARfD of 0.03 mg/kg bw was based on a no-observed-adverse-effect level (NOAEL) of 2.5 mg/kg bw observed in a study of acute neurotoxicity in rats. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=0.03 |
mg/kg bw/day |
- |
- |
- |
Neurotoxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=a86eb3fde0609e2f; raw_unit=mg/kg bw per day; context=The NOAEL was 0.03 mg/kg bw per day on the basis of transitory depression of plasma cholinesterase activity, the only effect observed at this dose (Payot, 1966; |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=0.05 |
mg/L |
Rat; Dog; Rabbit |
inhalation |
90-day |
Carcinogenicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=0955f39c7200a861; raw_unit=mg/l; context=xicity Lowest relevant oral NOAEL 2.2 mg/kg bw per day (90-day study in dogs) Lowest relevant dermal NOAEL 20 mg/kg bw per day (21-day study in rabbits) Lowest relevant inhalation NOAEL 0.050 mg/l (21-day study in rats) Genotoxicity No genotoxic potential Long-term studies of toxicity and carcinogenicity Target/critical effect Reduced body-weight gain and food consumption Lowest relevant NOAEL 7.5 mg/kg bw per day (2-year dietary study in rats) Carcino |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=0.05 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=c008e2ca14f4420c; raw_unit=mg/kg bw per day; context=The NOAEL was 0.05 mg/kg bw per day on the basis of hepatocellular hypertrophy at 1.0 mg/kg bw per day. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=0.065 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=caea637e638fa8ac; raw_unit=mg/kg bw per day; context=The NOAEL was 0.065 mg/kg bw per day on the basis of an increase in liver weight in males at 0.2 mg/kg bw per day. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=0.07 |
mg/kg bw/day |
- |
oral |
- |
Neurotoxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=24de71defd527166; raw_unit=mg/kg bw per day; context=The NOAEL was 1.5 ppm (equal to 0.07 mg/kg bw per day) on the basis of inhibition of erythrocyte and brain cholinesterase activity at dietary concentrations of 125 ppm and above (Kirchner et al., 1991; |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
range:0-0.080.08 |
mg/kg bw/day |
Rat; Dog |
- |
1-year |
Reproductive toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=3b6158bbc3abefb8; raw_unit=mg/kg bw; context=In 1998, an acceptable daily intake (ADI) of 0-0.08 mg/kg bw was established based on the no-observed-adverse-effect level (NOAEL) of 8 mg/kg bw per day in a three-generation study of reproductive toxicity in rats and in a 1-year study in dogs (both of these studies having been evaluated at earlier meetings) and a safety factor of 100. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=0.1 |
mg/kg bw/day |
Human |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=491f786e99e9fee2; raw_unit=mg/kg bw per day; context=The NOAEL was 0.1 mg/kg bw per day on the basis of hepatic changes in males that were of no signifi cance to humans. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=0.2 |
mg/kg bw/day |
- |
- |
- |
Neurotoxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=5700934c967728a5; raw_unit=mg/kg bw per day; context=The NOAEL for this study was 2 ppm (equivalent to 0.2 mg/kg bw per day) based on a statistically signifi cant (> 20%) inhibition of erythrocyte acetylcholinesterase activity at the next highest dose of 25 ppm (equivalent to 2.5 mg/kg bw per day) (Davies & Holub, 1980a). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=0.21 |
mg/kg bw |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=d289a5ceba854081; raw_unit=mg/kg bw; context=The NOAEL was 0.21 mg/kg bw (the highest dose was ignored, as only one man received it) (Meyer, 1999; |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=0.25 |
mg/kg bw/day |
Human |
- |
28-day |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=da503589e0287cb4; raw_unit=mg/kg bw per day; context=In 1992, an acceptable daily intake (ADI) of 0-0.03 mg/kg bw was established based on a NOAEL of 0.25 mg/kg bw per day in a 28-day and a 58-day study in human volunteers, and a safety factor of 10. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=0.4 |
mg/kg bw/day |
- |
- |
35 days |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=c568355af3791748; raw_unit=mg/kg bw per day; context=The NOAEL for females in the second and third studies can be established at the highest tested doses of 4 ppm (equivalent to 0.4 mg/kg bw per day) and 2 ppm (equivalent to 0.2 mg/kg bw per day) after dosing for 42 and 35 days respectively (Davies & Holub 1980b). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=0.5 |
mg/kg bw |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=0c184eb51dd7573f; raw_unit=mg/kg bw; context=On the basis of the perianal staining and the effects in the FOB and motor activity tests, the NOAEL for beta-cyfl uthrin was 0.5 mg/kg bw (Sheets et al., 1997). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=0.5 |
mg/kg bw/day |
- |
oral |
- |
Acute toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=f9a7a0f96e7f96d5; raw_unit=mg/kg bw per day; context=In a study in which single doses were administered by gavage, the NOAEL was 0.5 mg/kg bw per day on the basis of perianal staining, effects in the functional observational battery (decreased approach response in both sexes, oral staining in males and a decreased activity in females) and decreased motor and locomotor activities in females. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=0.6 |
mg/kg bw/day |
Human |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=56eedf659ef5a63c; raw_unit=mg/kg bw per day; context=The NOAEL for effects of relevance to humans was the highest dose tested, 0.6 mg/kg bw per day (Tollett et al., 1985). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
range:0.6-0.80.8 |
mg/kg bw/day |
Rabbit |
dermal |
21-day |
Neurotoxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=37d149daf471994d; raw_unit=mg/kg bw per day; context=The NOAEL was 10 ppm, equal to 0.6-0.8 mg/kg bw per day, on the basis of inhibition of erythrocyte cholinesterase activity at 50 ppm, equal to 3-4 mg/kg bw per day (Gaines et al., 1967). (b) Dermal toxicity Rabbits In a 21-day study that complied with GLP, undiluted temephos (purity, 93.1%) was administered to the |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=0.9 |
mg/kg bw |
- |
- |
- |
Acute toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=e3c8ea4c7d349fe7; raw_unit=mg/kg bw; context=Furthermore, this overall NOAEL is in line with the threshold dose of 0.9 mg/kg bw for acute effects of beta-cyfl uthrin on motor activity (Wolansky et al., 2006). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=0.9 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=5281020f8303cc36; raw_unit=mg/kg bw per day; context=The NOAEL was 40 ppm, equal to 0.9 mg/kg bw per day in males and 1.3 mg/kg bw per day in females. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=0.9 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=5281020f8303cc36; raw_unit=mg/kg bw per day; context=The NOAEL was 40 ppm, equal to 0.9 mg/kg bw per day in males and 1.3 mg/kg bw per day in females. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=1 |
mg/kg bw/day |
Dog |
- |
52-week |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=2b284e5ca28f30c5; raw_unit=mg/kg bw per day; context=Toxicological evaluation The Meeting established an acceptable daily intake (ADI) of 0-0.01 mg/kg bw based on a NOAEL of 40 ppm (equal to 1.0 mg/kg bw per day) for compensatory haematopoiesis, alteration in urine analysis parameters and liver toxicity seen at 400 ppm (equal to 9.0 mg/kg bw per day) and above in a 52-week study in dogs fed bifenazate, and using a 100-fold safety factor. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=1 |
mg/kg bw |
- |
oral |
4-week |
Acute toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=ed3a3326cc09bead; raw_unit=mg/kg bw; context=The Meeting established a group ARfD for cyfl uthrin and beta-cyfl uthrin of 0.04 mg/kg bw based on a NOAEL of 1 mg/kg bw for fi ndings of acute neurotoxicity observed in a 4-week study with beta-cyfl uthrin administered by gavage, and using a safety factor of 25. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=1.01 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=bb6a4c6ebbb79cdb; raw_unit=mg/kg bw per day; context=The NOAEL was 40 ppm, equal to 1.01 mg/kg bw per day in males and 1.05 mg/kg bw per day in females. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=1.01 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=bb6a4c6ebbb79cdb; raw_unit=mg/kg bw per day; context=The NOAEL was 40 ppm, equal to 1.01 mg/kg bw per day in males and 1.05 mg/kg bw per day in females. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=1.2 |
mg/kg bw/day |
Rat |
- |
long-term |
Carcinogenicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=0cee3ef4a157e0b7; raw_unit=mg/kg bw per day; context=In the long-term study of toxicity and carcinogenicity in rats, the NOAEL for systemic toxicity was 25 ppm, equal to 1.2 mg/kg bw per day, on the basis of liver toxicity (increased mixed eosinophilic-clear cell foci) and thyroid effects (follicular epithelial hypertrophy) in males at 50 ppm and greater. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=1.3 |
mg/kg bw/day |
Rat |
inhalation |
- |
Inhalation toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=8ffa7cc641825203; raw_unit=mg/kg bw per day; context=On the basis of clinical signs in both sexes, the NOAEL was 60 ppm, equivalent to 1.3 mg/kg bw per day (Von Keutz, 1987). (b) Exposure by inhalation Rats In a dose range-fi nding study, groups of 10 male and 10 female Wistar rats were exposed to aerosols containing beta-cyfl uthrin (purity, 98%) at actual concentrations of 0, 0.3, 3.8 or 28.0 ug/l air by nose-on |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=1.5 |
ppm |
- |
oral |
13-week |
Subchronic toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=1185d91ac9b3b713; raw_unit=ppm; context=ce probably relates to the 13-week feeding study by Singh et al., 1988) so that for long-term dosing the NOEL was anticipated to be 0.1 ppm while the second lowest concentration of 1.5 ppm was anticipated to be the NOAEL with only serum cholinesterase activity being affected. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=1.5 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=059dab7a03eb4285; raw_unit=mg/kg bw per day; context=The NOAEL was 10 ppm (equal to 1.5 mg/kg bw per day) in males and 100 ppm (equal to 19.7 mg/kg bw per day) in females. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=1.5 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=059dab7a03eb4285; raw_unit=mg/kg bw per day; context=The NOAEL was 10 ppm (equal to 1.5 mg/kg bw per day) in males and 100 ppm (equal to 19.7 mg/kg bw per day) in females. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=1.6 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=20845f2aeab93720; raw_unit=mg/kg bw per day; context=The NOAEL for systemic toxicity was 25 ppm, equal to 1.2 and 1.6 mg/kg bw per day in males and females, respectively, on the basis of liver toxicity (increased mixed eosinophilic- clear cell foci) and thyroid effects (follicular epithelial hypertrophy) at 50 ppm and greater. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=1.7 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=ed3caf316f698a42; raw_unit=mg/kg bw per day; context=The NOAEL for parental toxicity was 20 ppm, equal to 1.5 and 1.7 mg/kg bw per day in males and females, respectively. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=1.7 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=ed3caf316f698a42; raw_unit=mg/kg bw per day; context=The NOAEL for parental toxicity was 20 ppm, equal to 1.5 and 1.7 mg/kg bw per day in males and females, respectively. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=1.8 |
mg/kg bw/day |
- |
- |
- |
Neurotoxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=e068145a747ac198; raw_unit=mg/kg bw per day; context=The NOAEL was 20 ppm (equivalent to an average dose of 1.8 mg/kg bw per day or a range of doses of 1.2 to 2.4 mg/kg bw per day), with inhibition of erythrocyte cholinesterase activity at 200 ppm (equal to 11-24 mg/kg bw per day) or more. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=1.9 |
mg/kg bw/day |
Rat |
oral |
- |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=4affdc5d1fc511fc; raw_unit=mg/kg bw per day; context=The NOAEL for reproductive effects, parental and offspring toxicity was 50 ppm, equal to 1.9 mg/kg bw per day, i.e. the highest dose tested (Eigenberg, 1997). (b) Developmental toxicity (i) Oral administration Rats Groups of 25 inseminated FB30 rats were treated with cyfl uthrin (purity, about 85%) as daily oral doses at 0, 3, 10, and 30 mg/kg bw by gavage from day 6 |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=2 |
mg/kg bw/day |
Rat |
- |
2-year |
Chronic toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=78a7740c5b41b472; raw_unit=mg/kg bw per day; context=It was evaluated by the JMPR in 1987, when an acceptable daily intake (ADI) of 0-0.02 mg/kg bw was established based on a no- observed-adverse-effect level (NOAEL) of 50 ppm, equal to 2 mg/kg bw per day, which was identifi ed on the basis of reduced body-weight gains in a 2-year study in rats and using a safety factor of 100. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=2.2 |
mg/kg bw/day |
- |
- |
3-month |
Subchronic toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=ce5babb403a15f25; raw_unit=mg/kg bw per day; context=The NOAEL for clinical signs in the 3-month study was 90 ppm, equivalent to 2.2 mg/kg bw per day. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=2.25 |
mg/kg bw/day |
- |
oral |
- |
Neurotoxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=5ff3b4dd2e487337; raw_unit=mg/kg bw per day; context=The NOAEL was 90 mg/kg feed, equivalent to 2.25 mg/kg bw per day, on the basis of clinical signs of neurotoxicity at 270 mg/kg feed, equivalent to 6.75 mg/kg bw per day (JECFA, 1996; modifi ed with reference to the original report of Greenough et al., 1984). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=2.3 |
mg/kg bw/day |
- |
oral |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=e745636b1da0955c; raw_unit=mg/kg bw per day; context=On the basis of the decreased body-weight gain and food consumption in females of the group at 125 ppm, the NOAEL was 30 ppm, equal to 2.3 mg/kg bw per day (Sheets & Hamilton, 1997). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=2.4 |
mg/kg bw/day |
Rat |
dermal |
7-day |
Neurotoxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=b7bba2cfd847a5ba; raw_unit=mg/kg bw per day; context=On the basis of the neurological effects, the NOAEL was 100 ppm, equal to 2.4 mg/kg bw per day (Jones & Hastings, 1997). (b) Dermal administration Rats In a 7-day study from published literature, groups of fi ve male albino rats received daily dermal applications of a 40% formulation of cyfl uthrin at a dose (active ingredient) of 0, 80, 160, 240 or 320 |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=2.5 |
mg/kg bw |
- |
- |
- |
Neurotoxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=4afb8f09afa12059; raw_unit=mg/kg bw; context=The NOAEL was 2.5 mg/kg bw on the basis of depressed erythrocyte cholinesterase and behavioural changes at 150 mg/kg bw (Chow & Richter, 1994; |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=2.5 |
mg/kg bw/day |
- |
- |
- |
Carcinogenicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=f40368b1e5ca935c; raw_unit=mg/kg bw per day; context=The NOAEL for oncogenicity was 50 ppm, equal to 2.5 mg/kg bw per day, on the basis of the increased incidences of thyroid follicular cell adenoma in males and uterine adenocarcinoma in females at 500 ppm and greater. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=3 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=76c63ac4850b2e63; raw_unit=mg/kg bw per day; context=On the basis of the clinical signs, the NOAEL for maternal toxicity was 3 mg/kg bw per day. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=3.1 |
mg/kg bw |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=1e734df748798a62; raw_unit=mg/kg bw; context=The NOAEL was 3.1 mg/kg bw for females on the basis of decreases in motor and locomotor activity at 11 mg/kg bw (Sheets, 1997). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=3.2 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=8f8fe670bd3a6e0d; raw_unit=mg/kg bw per day; context=The NOAEL was 40 ppm, equal to 2.7 and 3.2 mg/kg bw per day in males and females, respectively. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=3.2 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=8f8fe670bd3a6e0d; raw_unit=mg/kg bw per day; context=The NOAEL was 40 ppm, equal to 2.7 and 3.2 mg/kg bw per day in males and females, respectively. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=3.3 |
mg/kg bw/day |
- |
- |
- |
Carcinogenicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=54230195d8308e89; raw_unit=mg/kg bw per day; context=The NOAEL for oncogenicity was 50 ppm, equal to 2.5 and 3.3 mg/kg bw per day in males and females, respectively, on the basis of increased incidences of thyroid follicular cell adenoma in males and uterine adenocarcinoma in females at 500 ppm and greater (Bomhard et al., 1998). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=3.4 |
mg/kg bw/day |
- |
oral |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=3cfa4cfa22451ba8; raw_unit=mg/kg bw per day; context=The NOAEL for systemic toxicity was 50 ppm, equal to 2.9 and 3.4 mg/kg bw per day in males and females, respectively, on the basis of reduced feed intake at 400 ppm and greater. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=3.41 |
mg/kg bw/day |
- |
oral |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=ac7f977ec63ee045; raw_unit=mg/kg bw per day; context=The NOAEL for systemic toxicity was 50 ppm, equal to 2.94 and 3.41 mg/kg bw per day in males and females, respectively, on the basis of reduced feed intake at 400 ppm and greater. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=3.5 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=4744105c51290247; raw_unit=mg/kg bw per day; context=The NOAEL was 30 ppm, equal to 3.5 mg/kg bw per day for males and 3.0 mg/kg bw per day for females, on the basis of decreased body-weight gain at the higher doses (Green, 1996a, 1996b; |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=3.8 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=e92af70c26e2d708; raw_unit=mg/kg bw per day; context=On the basis of the borderline reductions in body-weight gain at 150 ppm, the NOAEL for parental toxicity was 50 ppm, equal to 3.8 mg/kg bw per day. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=3.9 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=61dd5512763ae0b1; raw_unit=mg/kg bw per day; context=The NOAEL was 80 ppm, equal to 3.9 mg/kg bw per day in males and 4.8 mg/kg bw per day in females. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=3.9 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=61dd5512763ae0b1; raw_unit=mg/kg bw per day; context=The NOAEL was 80 ppm, equal to 3.9 mg/kg bw per day in males and 4.8 mg/kg bw per day in females. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=4 |
mg/kg bw |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=ade499b3b2c1ff91; raw_unit=mg/kg bw; context=The NOAEL was 4 mg/kg bw on the basis of death, clinical signs, fi ndings in the FOB and degenerative changes to the sciatic nerve at doses of 20 mg/kg bw and higher (JECFA, 1996; |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=4 |
mg/kg bw/day |
Rat; Bird |
dermal |
- |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=9ac10d16538e830e; raw_unit=mg/kg bw per day; context=vant developmental NOAEL 9 mg/kg bw per day Neurotoxicity Target/critical effect Clinical signs, changes in FOB tests and degenerative changes to the sciatic nerve Lowest relevant NOAEL 4 mg/kg bw per day (single-dose study in rats) Delayed neurotoxicity Target/critical effect No delayed effect Lowest relevant NOAEL > 1000 mg/kg bw per day (hens) Medical data Paraesthesia after dermal exposure 217 CYPERMETHRINS X-X JMPR 2006 Summary for cypermethrins, includin |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=4.4 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=0067d6000bd3fa5e; raw_unit=mg/kg bw per day; context=oup 20 20 20 20 20 20 20 20 81 BOSCALID X-X JMPR 2006 Diffuse hypertrophy 3 1 3 6 0 1 0 4 Focal hyperplasia 1 1 2 4 0 0 0 2 Adenoma 0 0 2 1 0 0 1 0 From Mellert et al. (2001b) The NOAEL was 100 ppm, equal to 4.4 mg/kg bw per day in males and 5.9 mg/kg bw in females, on the basis of increased serum gamma-glutamyltransferase activity in males at 500 ppm, equal to 21.9 mg/kg bw per day in males and 30.0 mg/kg bw per day in females (Mellert et al., 2001b). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=5 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=55c26e7b18548b81; raw_unit=mg/kg bw per day; context=The NOAEL for toxicity was 100 ppm, equivalent to 5 mg/kg bw per day, on the basis of reduced body weights in both sexes at 1000 ppm, equivalent to 50 mg/kg bw per day. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=5.1 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=75faf10fb802ffc5; raw_unit=mg/kg per day; context=On the basis of decreased body weight, soft faeces and disturbances in the gait in males and the increased spleen weight in females at the highest dose, the NOAEL was 160 ppm, equal to 5.1 mg/kg per day (Hoffmann & Schilde, 1983). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=5.4 |
mg/kg bw/day |
Rabbit |
- |
- |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=bde57b9ba46d1245; raw_unit=mg/kg bw per day; context=The NOAEL for reproductive effects was the highest dose used, 125 ppm, equivalent to 5.4 mg/kg bw per day (McNerney et al., 1968). (b) Developmental toxicity Rabbits In a study of developmental toxicity, which did not comply with GLP, groups of 15-16 pregnant New Zealand White rabbits were given technical-grade temephos (purity, 90.4%) at a dose of 3, 10, or 30 m |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=5.7 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=85cf40f675487bc4; raw_unit=mg/kg bw per day; context=The NOAEL was 200 ppm, equal to 5.7 mg/kg bw per day, in males on the basis of haematological effects observed at the next higher dose and 800 ppm, equal to 25 mg/kg bw per day, in females on the basis of haematological effects and histopathological changes in heart and kidney observed at 3500 ppm. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=6 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=911e5535e86d1a12; raw_unit=mg/kg bw per day; context=The NOAEL was 200 ppm, equal to 6.0 mg/kg bw per day in males and 5.7 mg/kg bw per day in females, on the basis of mortality, clinical signs (particularly irregular gait and whole-body tremors), and decreased body weight at 600 ppm and greater (Daly, 1995). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=6.2 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=d15d45541e775e18; raw_unit=mg/kg bw per day; context=On the basis of the reductions in blood glucose in males at the intermediate dose, the NOAEL was 100 ppm, equal to 6.2 mg/kg bw per day (Oikawa & Iyatomi, 1983). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=6.3 |
mg/kg bw/day |
- |
oral |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=59dc1922e0244857; raw_unit=mg/kg bw per day; context=The NOAEL was 50 mg/kg feed, equal to 6.3 mg/kg bw per day, on the basis of one death, clinical signs, reduced body-weight gain and decreased food conversion effi ciency, and increased AST activity in males at 250 mg/kg feed, equal to 33 mg/kg bw per day (JECFA, 1996; modifi ed with reference to the original report of |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=6.5 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=981c7b9b868806a1; raw_unit=mg/kg bw per day; context=On the basis of the clinical signs in both sexes and reduced body-weight gain in females at the highest dose, the NOAEL was 200 ppm, equal to 6.5 mg/kg bw per day (Hoffmann & Kaliner, 1981). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=6.6 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=24a83b5510b2d560; raw_unit=mg/kg bw per day; context=The NOAEL for aromatase induction in the liver was 100 ppm, equal to 6.6 mg/kg bw per day. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=7 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=1a2a447f0b9139e1; raw_unit=mg/kg bw per day; context=On the basis of coarse tremors in the pups during lactation, the NOAEL for offspring toxicity was 50 ppm, equal to 7 mg/kg bw per day (based on the cyfl uthrin intake of the dams during lactation). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=7.5 |
mg/kg bw |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=6d9cc0c496994bac; raw_unit=mg/kg bw; context=The NOAEL with regard to changes in slip angle was 7.5 mg/kg bw (Andrews, 1999). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=7.5 |
mg/kg bw/day |
- |
oral |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=afea901f94262c5d; raw_unit=mg/kg bw per day; context=The NOAEL for parental toxicity was 100 ppm, equivalent to 7.5 mg/kg bw per day, on the basis of reduced body-weight gain and food consumption at 500 ppm, equivalent to 38 mg/kg bw per day. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=7.6 |
mg/kg bw/day |
Dog |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=c5b23deecf1d5594; raw_unit=mg/kg bw per day; context=The NOAEL for beagle dogs was 250 ppm, equal to 7.6 mg/kg bw per day in males and 8.1 mg/kg bw per day in females, on the basis of increased serum triglyceride concentrations and effects on organ weight of liver in males and females at 2500 ppm, equal to78.1 mg/kg bw per day in males and 81.7 mg/kg bw per day in females (Schil |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=8 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=fbe1973b5da3d756; raw_unit=mg/kg bw per day; context=The NOAEL was 50 ppm (equal to 8.0 mg/kg bw per day). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=8 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=fbe1973b5da3d756; raw_unit=mg/kg bw per day; context=The NOAEL was 50 ppm (equal to 8.0 mg/kg bw per day). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=8.3 |
mg/kg bw/day |
Rat |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=26fbd318659c0a83; raw_unit=mg/kg bw per day; context=On the basis of the reduced blood glucose concentrations in male rats at 300 ppm, the NOAEL was 100 ppm, equal to 8.3 mg/kg bw per day (Watanabe et al., 1982a). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=8.5 |
mg/kg bw/day |
Dog |
oral |
15-week |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=61fb67016de90007; raw_unit=mg/kg bw per day; context=In a 15-week feeding study in dogs, the NOAEL was 250 ppm, equal to 8.5 mg/kg bw per day, on the basis of reduced T4 levels, liver effects (increased weight, enzyme induction) and prostate effects (increased weight, hypertrophy of the glandular epithelium) at 1000 ppm and higher. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=9 |
mg/kg bw/day |
- |
oral |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=ae37190f473f02b2; raw_unit=mg/kg bw per day; context=On the basis of effects on body weight and food consumption the NOAEL for parental toxicity was 125 ppm, equal to 9 mg/kg bw per day. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=9.4 |
mg/kg bw/day |
- |
oral |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=159c1157f125500d; raw_unit=mg/kg bw per day; context=On the basis of increased mortality, clinical signs, decreased body-weight gain and food consumption, the NOAEL for maternal toxicity was 9.4 mg/kg bw per day. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=9.5 |
mg/kg bw/day |
Rat |
oral |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=a54028b100d385e2; raw_unit=mg/kg bw per day; context=On the basis of the clinical signs and reductions in food and water consumption and body- weight gain of rats during the fi rst week of treatment, the NOAEL was 125 ppm, equal to 9.5 mg/kg bw per day (Suberg & Wood, 1988). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=9.8 |
mg/kg bw/day |
Rat |
oral |
2-week |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=ec78dad4755eff84; raw_unit=mg/kg bw per day; context=In a 2-week feeding study in rats, the NOAEL was 100 ppm, equal to 9.8 mg/kg bw per day, on the basis of decreased body weights in females and thyroid effects (increased mitosis) in males at 500 ppm and higher. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=10 |
mg/kg bw |
- |
- |
- |
Acute toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=24624a57074fb0dc; raw_unit=mg/kg bw; context=The NOAEL for acute neurotoxicity was 10 mg/kg bw on the basis of clinical signs and FOB fi ndings at 50 mg/kg bw (Watt, 1998). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=10 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=8226870bd5234145; raw_unit=mg/kg bw per day; context=The NOAEL for maternal toxicity was 10 mg/kg bw per day. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=10 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=8226870bd5234145; raw_unit=mg/kg bw per day; context=The NOAEL for maternal toxicity was 10 mg/kg bw per day. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=10.1 |
mg/kg bw/day |
Rat |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=441e2cb15e1e486b; raw_unit=mg/kg bw per day; context=The NOAEL for toxicity in adult rats was 100 ppm, equal to 10.1 mg/kg bw per day in males and 10.7 mg/kg bw per day in females, on the basis of reduced body-weight gain during lactation, liver-and spleen-weight changes and hepatic histopathology at 1000 ppm, equal to 101.2 mg boscalid/ kg bw per day in males and 106.8 mg boscalid/kg bw pe |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=10.9 |
mg/kg bw/day |
- |
- |
- |
Reproductive toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=0ffe89e132495506; raw_unit=mg/kg bw per day; context=The NOAEL for systemic toxicity was 30 ppm, equal to 5.7 and 10.9 mg/kg bw per day in males and females, respectively, on the basis of effects in liver (increased weight, hepatocellular hypertrophy, fatty change, degeneration) and lymph nodes (vacuolization) in both sexes and in the adrenal cortex (vacuolization in the X-zone) in females at |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=11 |
mg/kg bw/day |
- |
oral |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=1c6f1bb1411b9ae8; raw_unit=mg/kg bw per day; context=On the basis of the reduced body-weight gain and food consumption in the dams, the NOAEL for maternal toxicity was 133 ppm, equal to 11.0 mg/kg bw per day. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=11 |
mg/kg bw |
- |
- |
- |
Neurotoxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=f605540b1200bb85; raw_unit=mg/kg bw; context=The NOAEL for neurotoxicity was 11 mg/kg bw in males on the basis of FOB observations (slight tremors, ptosis) at 22 mg/kg bw and greater, and 3.1 mg/kg bw in females on the basis of decreased motor and locomotor activity at 11 mg/kg bw and greater. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=11.6 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=6860f75f2b469cac; raw_unit=mg/kg bw per day; context=On the basis of the reduced body weight and alopecia, the NOAEL was 225 ppm, equal to 11.6 mg/kg bw per day (Wahle & Christenson, 1997). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=12 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=a53f93e2cbae741f; raw_unit=mg/kg bw per day; context=In females, the NOAEL was 300 ppm, equal to 12 mg/kg bw per day, on the basis of a decrease in body-weight gain at 1000 ppm (Jessup, 1979). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=12.3 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=7910753e726ade88; raw_unit=mg/kg bw per day; context=UDP-GT, uridine diphosphate glucuronosyl t ransferase * p < 0.05, ** p < 0.01 519 THIACLOPRID X-X JMPR 2006 The NOAEL was 100 ppm, equal to 9.0 and 12.3 mg/kg bw per day in males and females, respectively, on the basis of thyroid effects and induction of UDP-GT at 400 ppm and higher (Andrews, 2000). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=12.5 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=da3fa92ec11224da; raw_unit=mg/kg bw per day; context=The NOAEL was 500 ppm, equivalent to 12.5 mg/kg bw per day, on the basis of clinical signs at 1500 ppm (equivalent to 37.5 mg/kg bw per day) (JECFA, 1996; |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=13 |
mg/kg bw/day |
Mouse |
- |
18-month |
Carcinogenicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=a4521e7e81bd6ace; raw_unit=mg/kg bw per day; context=The NOAEL in this 18-month study of toxicity and carcinogenicity in mice was 80 ppm, equal to 13 mg/kg bw per day in males, on the basis of reduced body-weight gain in male mice at 400 ppm, equal to 65 mg/kg bw per day. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=14 |
mg/kg bw/day |
- |
- |
- |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=07a2a4025e3fa3da; raw_unit=mg/kg bw per day; context=The NOAEL for developmental toxicity was 100 ppm, equal to 14 mg/kg bw per day, on the basis of reduced body weights of pups during lactation at 1000 ppm, equal to 147 mg/kg bw per day. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
range:13.6-14.514.5 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=e69cc4f70499a22d; raw_unit=mg/kg bw per day; context=563 THIOPHANATE-METHYL X-X JMPR 2006 The NOAEL for parental toxicity was 200 ppm (equal to 13.6-14.5 mg/kg bw per day in males and 16.4-17.5 mg/kg bw per day in females, respectively), on the basis of reduced body- weight gain in males, increased thyroid weights in males and females and increased liver weights in females at 1200 ppm and above. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=15 |
mg/kg bw/day |
- |
- |
- |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=b9fb57ac658fb318; raw_unit=mg/kg bw per day; context=On the basis of the two abortions and a single case of complete resorption, the NOAEL for maternal and embryo/fetotoxicity was 15 mg/kg bw per day (Roetz, 1983). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=15 |
mg/kg bw |
- |
- |
- |
Neurotoxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=e6c882c53b1cae45; raw_unit=mg/kg bw; context=On the basis of inhibition of brain cholinesterase activity in some brain regions at 150 mg/kg bw, the NOAEL was 15 mg/kg bw (Nemec, 1995). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=17 |
mg/kg bw/day |
- |
dermal |
21-day |
Dermal toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=2d1d8538b20a5b75; raw_unit=mg/kg bw per day; context=The NOAEL was 250 ppm, equal to 17 mg/kg bw per day for males and 20 mg/kg bw per day for females, on the basis of decreased body-weight gain at 500 ppm (34/38 mg/kg bw per day for males/females) (McCarty, 1990). (a) Dermal In a 21-day repeat-dose dermal study, zeta-cypermethrin (purity, 86%; total cypermethri |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=17.2 |
mg/kg bw/day |
Rat |
- |
- |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=6e2d2c52f7699ae1; raw_unit=mg/kg bw per day; context=The NOAEL for reproductive and neonatal toxicity was 200 ppm, equal to 15.3 and 17.2 mg/kg bw per day in males and females, respectively, the highest dose tested (Schardein, 1996). (b) Developmental toxicity Rats In a study of developmental toxicity, groups of 25 pregnant Sprague-Dawley (Crl:CD BR) rats were given bifenazate (lot No. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=17.2 |
mg/kg bw/day |
Rat |
- |
- |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=6e2d2c52f7699ae1; raw_unit=mg/kg bw per day; context=The NOAEL for reproductive and neonatal toxicity was 200 ppm, equal to 15.3 and 17.2 mg/kg bw per day in males and females, respectively, the highest dose tested (Schardein, 1996). (b) Developmental toxicity Rats In a study of developmental toxicity, groups of 25 pregnant Sprague-Dawley (Crl:CD BR) rats were given bifenazate (lot No. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=17.5 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=ba4da3f2f0316197; raw_unit=mg/kg bw per day; context=The NOAEL for maternal toxicity was 17.5 mg/kg bw per day on the basis of reduced body- weight gain at 35 mg/kg bw per day and higher. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=18 |
mg/kg bw/day |
- |
oral |
- |
Reproductive toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=cbe6e309d321f19f; raw_unit=mg/kg bw per day; context=The NOAEL was 180 mg/kg feed, equivalent to 18 mg/kg bw per day, on the basis of abnormal gait in males, decreased body-weight gain and food consumption, haematological changes, and axonal degeneration of the sciatic nerve at 540 mg/kg feed, equivalent to 54 mg/kg bw per day (JECFA, 1996; |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=18 |
ppm |
- |
- |
- |
Neurotoxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=db6d0de32406f9e9; raw_unit=ppm; context=The NOAEL for consistent adverse effects on erythrocyte acetylcholinesterase activity was 18 ppm (0.78 mg/kg bw per day), while for brain acetylcholinesterase activity it was the highest dose tested, 54 ppm (2.35 mg/kg bw per day) (Hutchinson, et al., 1966). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=19.7 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=c756120c56eaed5f; raw_unit=mg/kg bw per day; context=The NOAEL was 10 ppm (1.5 mg/kg bw per day) in males and 100 ppm (equal to 19.7 mg/kg bw per day) in females. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=19.7 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=c756120c56eaed5f; raw_unit=mg/kg bw per day; context=The NOAEL was 10 ppm (1.5 mg/kg bw per day) in males and 100 ppm (equal to 19.7 mg/kg bw per day) in females. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=20 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=7131082270832326; raw_unit=mg/kg bw per day; context=On the basis of effects on mortality, clinical signs, body weight (males only) and effects on absolute and relative adrenal and liver weights, the NOAEL was 20 mg/kg bw per day (Flucke & Schilde, 1980). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=20.7 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=68d21f4caf015f7c; raw_unit=mg/kg bw per day; context=The NOAEL was 600 ppm, equal to 20.7 mg/kg bw per day in males and 25.4 mg/kg bw per day in females, on the basis of tremors in one male at 24.6 mg/kg bw per day and body-weight loss in females at 34.3 mg/kg bw per day (Daly, 1994). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=21.8 |
mg/kg bw/day |
Dog |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=b0bd7817fcbeb58b; raw_unit=mg/kg bw per day; context=The NOAEL was 800 ppm, equal to 21.8 mg/kg bw per day in males and 22.1 mg/kg bw per day in females, on the basis of body-weight reductions in females and thyroid-weight increases in male and female dogs at 2000 ppm, equal to 57.4 mg/kg bw per day in males and 58.3 mg/kg bw per day in females (Wiemann et al., 20 |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
<22 |
mg/kg bw |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=3b37f04887bf9680; raw_unit=mg/kg bw; context=The NOAEL was < 22 mg/kg bw for males and females on the basis of neurobehavioural effects at all doses. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=22.5 |
mg/kg bw/day |
- |
- |
3 months |
Subchronic toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=82bba26d4686560f; raw_unit=mg/kg bw per day; context=On the basis of the absence of toxicologically relevant effects at 3 months, the NOAEL was 300 ppm, equal to 22.5 mg/kg bw per day (Loser & Schilde, 1980). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=24 |
mg/kg bw/day |
- |
- |
- |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=02558132d1b7d9f2; raw_unit=mg/kg bw per day; context=The NOAEL for maternal and developmental toxicity was 24 mg/kg bw per day (Hoberman, 1989; |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
<=25 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=900424f2f0e3b111; raw_unit=mg/kg bw per day; context=272 CYROMAZINE X-X JMPR 2006 The NOAEL for maternal toxicity was less than 25 mg/kg bw per day in the fi rst experiment (the lowest dose tested) and 10 mg/kg bw per day in the second experiment. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
~27 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=fc5f2564c6a53b05; raw_unit=mg/kg bw per day; context=The NOAEL for parental toxicity was 400 ppm, equivalent to about 27 mg/kg bw per day, on the basis of microscopic hepatic and thyroid changes in F0 and F1 animals at 1600 ppm. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=28.6 |
mg/kg bw/day |
Rat |
oral |
13-week |
Subchronic toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=6597aa3d451fe864; raw_unit=mg/kg bw per day; context=In a 13-week feeding study with a 5-week recovery period in rats, the NOAEL was 400 ppm, equal to 28.6 mg/kg bw per day, on the basis of reduced body weight, clinical chemistry changes (increased cholesterol and protein concentration in plasma) and thyroid effects (increased weight) at 1600 ppm. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=29 |
mg/kg bw/day |
- |
- |
- |
Reproductive toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=80a9e6d3d13497fb; raw_unit=mg/kg bw per day; context=The NOAEL for reproductive effects was 400 ppm, equal to 29 mg/kg bw per day, i.e. the highest dose tested (Eigenberg & Elcock, 1996). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=30 |
mg/kg bw/day |
- |
- |
- |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=729a826f23635f02; raw_unit=mg/kg bw per day; context=The NOAEL for embryo/fetotoxicity was 30 mg/kg bw per day, i.e. the highest dose tested (Schlüter, 1982). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=34 |
mg/kg bw/day |
Rat |
oral |
3 months |
Subchronic toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=4a79ef96caeeed31; raw_unit=mg/kg bw per day; context=Taking these factors into consideration, the Meeting concluded that the NOAEL in male rats given diets containing boscalid for 3 months was 500 ppm, equal to 34 mg/kg bw per day, on the basis of altered clinical-chemical changes (increases in gamma-glutamyltransferase activity) and increased incidences of thyroid hypertrophy and hyperplasia in male rats at 2000 ppm, equal to 137 mg/kg bw in male rats and this dose, equal to 159 mg/kg |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=34.7 |
mg/kg bw/day |
- |
- |
- |
Reproductive toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=5d7bd7f05d1cce84; raw_unit=mg/kg bw per day; context=The NOAEL for reproductive toxicity was 450 ppm, equal to 34.7 mg/kg bw per day, i.e. the highest dose tested (Loser & Eiben, 1983). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=34.9 |
mg/kg bw/day |
- |
oral |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=c4f50fd6f73b8934; raw_unit=mg/kg bw per day; context=The NOAEL for general toxicity was 500 ppm (equal to 30.3 and 34.9 mg/kg bw per day in males and females, respectively) on the basis of decreased body weights and feed consumption in females and increased liver and thyroid weights in both sexes at 2500 ppm. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=35 |
mg/kg bw/day |
- |
- |
- |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=c3f48886c9c1220d; raw_unit=mg/kg bw per day; context=As there was no evidence of treatment-related effects on fetal developmental or survival in this study, the NOAEL for developmental toxicity was 35 mg/kg bw per day, the highest dose tested (Hoberman, 1990). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=36 |
mg/kg bw/day |
Dog |
oral |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=783492eaff0db0cc; raw_unit=mg/kg bw per day; context=The NOAEL was 1000 ppm, equal to 36 mg/kg bw per day, for males on the basis of decreases in body-weight gains, food consumption and some haematological parameters in dogs fed 3000 ppm. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=37 |
mg/kg bw/day |
Rat |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=d3e45fa9c213618d; raw_unit=mg/kg bw per day; context=173 CYPERMETHRINS X-X JMPR 2006 The NOAEL in rats was 1500 ppm, equal to 37 mg/kg bw per day in males and 45 mg/kg bw per day in females, on the basis of deaths, clinical signs, decreased body-weight gain and effects on haematological and clinical chemistry parameters at 1500 ppm (Norvell, 1983). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=38.4 |
mg/kg bw/day |
Mouse |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=74585703e17f78dd; raw_unit=mg/kg bw per day; context=On the basis of the reductions in body weight in the female mice and the macroscopic and histological effects in males, the NOAEL was 200 ppm, equal to 38.4 mg/kg bw per day (Wahle & Christenson, 1998). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=40 |
mg/kg bw/day |
- |
oral |
- |
Neurotoxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=21f0d25b5167f8bf; raw_unit=mg/kg bw per day; context=The no- observed-adverse-effect level (NOAEL) was 400 ppm, equal to 40 mg/kg bw per day, on the basis of deaths, clinical signs of neurotoxicity, reduced body-weight gain and food consumption, microscopic abnormalities of the sciatic nerve, and changes in a number of haematological and clinical chemistry parameters at 1600 ppm, equivalent to 160 |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=40 |
ppm |
- |
- |
1-year |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=22d849e58ed7a26b; raw_unit=ppm; context=This defi ciency was not insignifi cant, but it is noted that a NOAEL of 40 ppm was found in a 1-year study of toxicity (Goldenthal, 1997). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=40 |
ppm |
- |
- |
1-year |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=22d849e58ed7a26b; raw_unit=ppm; context=This defi ciency was not insignifi cant, but it is noted that a NOAEL of 40 ppm was found in a 1-year study of toxicity (Goldenthal, 1997). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=43.1 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=fb75bf6f003908a0; raw_unit=mg/kg bw per day; context=On the basis of the histological changes in the liver (males only) and the submaxillary glands, the NOAEL was 300 ppm, equal to 43.1 mg/kg bw per day (Watanabe et al., 1982b). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=43.9 |
mg/kg bw/day |
Rat |
- |
- |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=4181e5a755e751a4; raw_unit=mg/kg bw per day; context=increased incidence of stillbirths, decreased live birth index, decreased pup viability and pup weights at maternally toxic doses Lowest relevant reproductive NOAEL 43.9 mg/kg bw per day (effects on fertility at highest dose tested in a two- generation study in rats)3.5 mg/kg bw per day (systemic toxicity in offspring and parents) Developmental target/critical effect Increased resorptions, increased skeletal retardations and variations, decre |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=45 |
mg/kg bw/day |
Rat |
- |
2 weeks |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=a7535aed07ff0fe1; raw_unit=mg/kg bw per day; context=The NOAEL for xenobiotic enzyme induction in rats exposed to quinoxyfen for 2 weeks was 500 ppm, equal to 45 mg/kg bw per day (Weaver, 1988). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=45.8 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=0dc634ae3810d048; raw_unit=mg/kg bw per day; context=On the basis of the effects on body weight, the NOAEL was 200 ppm, equal to 45.8 mg/kg bw per day (Suberg & Loser, 1983a). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=48 |
mg/kg bw/day |
- |
- |
- |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=dd9112c2fdb15192; raw_unit=mg/kg bw per day; context=Therefore the NOAEL for embryo/fetotoxicity was 48 mg/kg bw per day, i.e. the highest dose tested (Barton & Hastings, 1994). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=50 |
mg/kg bw/day |
- |
- |
- |
Carcinogenicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=c7e9500b1fe1b223; raw_unit=mg/kg bw per day; context=The NOAEL for carcinogenicity was 1000 ppm, equivalent to 50 mg/kg bw per day, the highest concentration tested (Annex 1, reference 33; |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=50 |
mg/kg bw |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=23268791de841698; raw_unit=mg/kg bw; context=Subsequently, in order to identify an NOAEL, groups of fi ve females receiving diazinon at 25 or 50 mg/kg bw were added. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=50 |
ppm |
Rat |
- |
- |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=dd8d6451a172a404; raw_unit=ppm; context=The NOAEL for reproductive toxicity was 50 ppm on the basis of dystocia and decreased pup weights at 300 ppm and greater and decreased live birth index at 600 ppm (Eigenberg & Hamilton, 1997). (b) Developmental toxicity Rats In a study of prenatal developmental toxicity, groups of 35 (initially 28) insemi |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=51 |
mg/kg bw/day |
- |
- |
- |
Reproductive toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=b696bd83609bf73b; raw_unit=mg/kg bw per day; context=The NOAEL for parental toxicity, reproductive and offspring toxicity was 1000 ppm (equal to 51 mg/kg bw per day). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=55 |
mg/kg bw/day |
Mouse |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=6975fd4ba2fbbdaf; raw_unit=mg/kg bw per day; context=The NOAEL for liver enzyme induction in the mouse was 400 ppm, equivalent to 55 mg/kg bw per day (Weaver, 1989). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=60 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=88cf7d34c8c57179; raw_unit=mg/kg bw per day; context=177 CYPERMETHRINS X-X JMPR 2006 The NOAEL was 400 ppm, equivalent to 60 mg/kg bw per day, on the basis of reduced body-weight gain at 1600 ppm, equivalent to 240 mg/kg bw per day. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=64 |
mg/kg bw/day |
Rat |
- |
- |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=ab9ca927df8faac8; raw_unit=mg/kg bw per day; context=The NOAEL for parental toxicity, reproduction and offspring toxicity was 1000 ppm, equal to 64 mg/kg bw per day in males and 51 mg/kg bw per day in females (Blair, 1981a). (b) Developmental toxicity Rats In a study that complied with the principles of GLP (with QA certifi cate provided), groups of 20 pregnant Charles River COBS®CD® rats were given cyromazine (purity, 96 |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=70 |
mg/kg bw/day |
- |
- |
- |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=cadaf1f49e1481c1; raw_unit=mg/ kg bw per day; context=The NOAEL for developmental toxicity was 70 mg/ kg bw per day on the basis of the absence of fetal effects at the highest dose tested (Annex 1, reference 33; |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=80 |
mg/kg bw/day |
- |
oral |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=d64eb1e27909c85f; raw_unit=mg/kg bw per day; context=The NOAEL was 80 mg/kg bw per day on the basis of decrease in body-weight gains, decrease in food consumption, clinical haematology (decreased haemoglobin, erythrocyte volume fraction and erythrocyte counts), urine analysis (increase in ketones, protein and specifi c gravity and decrease in ur |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=80 |
mg/kg bw/day |
- |
oral |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=d64eb1e27909c85f; raw_unit=mg/kg bw per day; context=The NOAEL was 80 mg/kg bw per day on the basis of decrease in body-weight gains, decrease in food consumption, clinical haematology (decreased haemoglobin, erythrocyte volume fraction and erythrocyte counts), urine analysis (increase in ketones, protein and specifi c gravity and decrease in ur |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=90 |
mg/kg bw/day |
Mouse |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=52b2ddffefcb4d55; raw_unit=mg/kg bw per day; context=The NOAEL in female mice was 400 ppm, equal to 90 mg/kg bw per day, on the basis of liver-weight increases and hepatic peripheral hypertrophy at 2000 ppm, equal to 443 mg/kg bw per day (Mellert et al., 2001d). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=100 |
mg/kg bw/day |
- |
- |
- |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=646854ae64cc2798; raw_unit=mg/kg bw per day; context=The NOAEL for maternal toxicity was 100 mg/kg bw per day and the NOAEL for developmental toxicity was 300 mg/kg bw per day (Rodwell, 1979). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=100 |
mg/kg bw |
Rat |
oral |
- |
Acute toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=cdb4f6a4b439c3f9; raw_unit=mg/kg bw; context=The Meeting established an ARfD of 1 mg/kg bw for the general population on the basis of a NOAEL of 100 mg/kg bw identifi ed on the basis of some slight neuroactive effects at doses of 200 mg/ kg bw and greater in a study of acute toxicity in rats treated by gavage, and a safety factor of 100. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=109 |
mg/kg bw |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=ac58d2fb6c845696; raw_unit=mg/kg bw; context=The NOAEL for microscopic lesions was 109 mg/kg bw for males and females, the highest dose tested (Sheets et al., 1997). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=113.2 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=abea1fd653f5f5ca; raw_unit=mg/kg bw per day; context=467 THIACLOPRID X-X JMPR 2006 The NOAEL was 200 ppm, equal to 84.3 and 113.2 mg/kg bw per day in males and females, respectively, on the basis of reduced water intake in males and liver effects (increased weight, increased lipid content of hepatocytes) at 2000 ppm and greater (Kroetlinger, 1997a). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=115 |
mg/kg bw/day |
- |
- |
- |
Neurotoxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=744e0e47fa99ee4d; raw_unit=mg/kg bw per day; context=The NOAEL for neurotoxicity was 1600 ppm, equal to 101 and 115 mg/kg bw per day in males and females, respectively, the highest dose tested (Sheets & Hamilton, 1997). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=125 |
mg/kg bw |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=03bbe6c59783626a; raw_unit=mg/kg bw.; context=The NOAEL was 125 mg/kg bw. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=126 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=81a2172fe657d4cc; raw_unit=mg/kg bw per day; context=The NOAEL was 1000 ppm in males, equal to 126 mg/kg bw per day, on the basis of changes in body weight (Blair, 1982a). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
range:86-130130 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=4815581282aed5da; raw_unit=mg/kg bw per day; context=The NOAEL was 86-130 mg/kg bw per day (100 mg/kg bw per day nominal dose) on the basis of body-weight loss and histopathological changes in the liver [including slight multifocal hepatocellular necrosis] at 305-340 mg/kg bw per day (nominal dose, 500 mg/kg bw per day). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=133 |
ppm |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=847e07d6d8d30aad; raw_unit=ppm; context=On the basis of the reduced body weight during lactation and the reduced startle habituation at postnatal day 22, observed in the pups at the highest dose, the NOAEL for offspring toxicity was 133 ppm. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=150 |
mg/kg bw/day |
- |
oral |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=3851c4a4f534986e; raw_unit=mg/kg bw per day; context=The NOAEL was 150 ppm, equivalent to 150 mg/kg bw per day, on the basis of clinical signs and reduced body-weight gain and food consumption at 1500 ppm, equivalent to 150 mg/kg bw per day (Annex 1, reference 33; |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=159 |
mg/kg bw |
Rat |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=c76e93398871cb4f; raw_unit=mg/kg bw; context=a-glutamyltransferase activity) and increased incidences of thyroid hypertrophy and hyperplasia in male rats at 2000 ppm, equal to 137 mg/kg bw in male rats and this dose, equal to 159 mg/kg bw could be considered as a NOAEL in female rats (Mellert et al., 2000b). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=166.3 |
mg/kg bw/day |
- |
- |
- |
Neurotoxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=579f1d797f343a7a; raw_unit=mg/kg bw per day; context=The NOAEL for neurotoxicity was 2500 ppm (equal to 149.6 and 166.3 mg/kg bw per day in males and females, respectively), the highest dose tested (Foss, 2005b). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=200 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=31e7d4b87db12fba; raw_unit=mg/kg bw per day; context=The NOAEL was 200 mg/kg bw per day, the highest dose tested (Schardein, 1997a). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=200 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=31e7d4b87db12fba; raw_unit=mg/kg bw per day; context=The NOAEL was 200 mg/kg bw per day, the highest dose tested (Schardein, 1997a). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=232 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=1ac5ceee30c354e9; raw_unit=mg/kg bw per day; context=The NOAEL was 3000 ppm, equal to 232 mg/kg bw per day in males and 264 mg/kg bw per day in females, the highest dose tested considering that the slight reductions of body-weight gain observed at 1000 and 3000 ppm were not toxicologically relevant (Goldenthal, 1979). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=240 |
mg/kg bw/day |
- |
- |
- |
Carcinogenicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=2d24551fe90ae2c6; raw_unit=mg/kg bw per day; context=The NOAEL for carcinogenicity was 1600 ppm, equivalent to 240 mg/kg bw per day, the highest dose tested (JECFA, 1996; |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=250 |
mg/kg bw/day |
- |
inhalation |
short-term |
Inhalation toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=e4a51e7c3837b212; raw_unit=mg/kg bw per day; context=The NOAEL was 250 mg/kg bw per day (Flucke & Vogel, 1980). (c) Inhalation In a short-term study of exposure by inhalation, two experiments were performed. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=250 |
mg/kg bw |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=ce2b56758ba28e4f; raw_unit=mg/kg bw.; context=The NOAEL was 250 mg/kg bw. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=270 |
mg/kg bw |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=76b7ace4a3d61e9d; raw_unit=mg/kg bw; context=These effects consisted of deformed limbs at doses of 480 mg/kg bw and higher (NOAEL, 270 mg/kg bw) and fusion of vertebrae and ribs at 240 mg/kg bw and higher (NOAEL, 130 mg/kg bw). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=300 |
mg/kg bw/day |
- |
- |
- |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=414b3e6fbd25c5d5; raw_unit=mg/kg bw per day; context=The NOAEL for developmental toxicity was 300 mg/kg bw per day on the basis of reduced ossifi cation of thoracic centra at 1000 mg/kg bw per day (Schilling & Hellwig, 2000b). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=300 |
ppm |
- |
- |
- |
Reproductive toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=c7cff4d1483b1707; raw_unit=ppm; context=The NOAEL for reproductive toxicity was 300 ppm on the basis of dystocia and decreased pup viability at 1000 ppm (Eigenberg, 1998a). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=340 |
mg/kg bw/day |
- |
oral |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=e299cd8cb27867f7; raw_unit=mg/kg bw per day; context=On the basis of the effects on food consumption during the fi rst week and clinical signs, the NOAEL for systemic effects was 340 mg/kg bw per day (Warren et al., 1996). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
range:361.3-375.3375.3 |
mg/kg bw/day |
- |
- |
- |
Reproductive toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=2cc1fd692e7df6e2; raw_unit=mg/ kg bw per day; context=The NOAEL for reproductive toxicity was 6000 ppm (equal to 361.3-375.3 mg/ kg bw per day in males and 474.2-480.8 mg/kg bw per day in females, respectively), the highest dose tested (Müller, 1992). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=400 |
ppm |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=a63898e5bfbee4a7; raw_unit=ppm; context=The NOAEL was established at 400 ppm (equal to 28.6 and 35.6 mg/kg bw in males and females, respectively) on the basis of reduced body weight, clinical chemistry changes (increased cholesterol and protein concentrations in plasma) and thyroid effects (increased weight) at 1600 ppm, the highest d |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=450 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=f9ce2d09dfcf4b73; raw_unit=mg/kg bw per day; context=The NOAEL for maternal toxicity was 450 mg/kg bw per day on the basis of decreased body-weight gain and clinical signs at 700 mg/kg bw per day. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=500 |
mg/kg bw/day |
- |
- |
- |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=be6671b4d4033e29; raw_unit=mg/kg bw per day; context=The NOAEL for developmental toxicity was 500 mg/kg bw per day, the highest dose tested (Schardein, 1997b). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=500 |
mg/kg bw/day |
- |
- |
- |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=be6671b4d4033e29; raw_unit=mg/kg bw per day; context=The NOAEL for developmental toxicity was 500 mg/kg bw per day, the highest dose tested (Schardein, 1997b). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
>=600 |
ppm |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=d433dba04ad0f89e; raw_unit=ppm; context=In view of the absence of treatment-related effects or clinical signs under this experimental scenario, the NOAEL for thiabendazole was at least 600 ppm (equal to 48 mg/kg bw for males and 46 mg/kg bw for females), the highest dose tested (Noakes, 2005b). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=700 |
mg/kg bw/day |
- |
- |
- |
Developmental toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=1b07632a7c23aeeb; raw_unit=mg/ kg bw per day; context=The NOAEL for fetal toxicity was 700 mg/ kg bw per day, the highest dose tested (Freeman, 1994). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=714 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=09e10708e163c451; raw_unit=mg/kg bw per day; context=The NOAEL was 714 mg/kg bw per day. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=1000 |
mg/kg bw/day |
Rat |
- |
4 weeks |
Dermal toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=d5655fcdf750660e; raw_unit=mg/kg bw per day; context=The NOAEL in rats exposed dermally for 4 weeks was 1000 mg/kg bw per day, the highest dose tested (Mellert et al., 2000c). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=1034 |
mg/kg bw/day |
Rat |
- |
two-generation |
Reproductive toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=8278e5de12fef675; raw_unit=mg/kg bw per day; context=Reproductive function was not affected in rats in the two-generation study with boscalid and the NOAEL for reproductive function was 10 000 ppm, equal to 1034 mg/kg bw per day, the highest dose tested. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=1442 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=c4ebfbd549391352; raw_unit=mg/kg bw per day; context=The NOAEL for maternal toxicity was 10 000 ppm, equal to 1442 mg/kg bw per day, the highest dose tested. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=2000 |
mg/kg bw |
Rat |
oral |
- |
Neurotoxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=1eed3563c680afc5; raw_unit=mg/kg bw; context=The NOAEL for neurotoxicity after a single oral dose of boscalid was 2000 mg/kg bw in male and female rats (Mellert et al., 2000d). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=2000 |
mg/kg bw/day |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=b40f9b342536babf; raw_unit=mg/kg bw per day; context=In the absence of any treatment-related effect, the NOAEL was 2000 mg/kg bw per day, the highest dose tested (Kuhn, 1992). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOAEL |
=5000 |
ppm |
- |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=c54ba63176f0ef9e; raw_unit=ppm; context=The details given of the study were limited, but the highest NOAEL appeared to be 5000 ppm (National Toxicology Program, 1983). |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOEL |
range:0-0.0020.002 |
mg/kg bw/day |
Human |
- |
43-day |
Neurotoxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=53f7e1ba74c6e635; raw_unit=mg/kg bw per day; context=In 1966, an acceptable daily intake (ADI) of 0-0.002 mg/kg bw per day was established based on a no-observed-effect level (NOEL) of 0.02 mg/kg bw per day for inhibition of plasma cholinesterase activity in a 37-43-day study in humans. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOEL |
=0.02 |
mg/kg bw/day |
Rat; Mouse |
- |
- |
Toxicology study |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=d694d994449c259a; raw_unit=mg/kg bw per day; context=The lowest NOEL for this effect was 0.02 mg/kg bw per day in short- term studies of toxicity in mice and rats. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOEL |
=0.1 |
ppm |
- |
oral |
13-week |
Subchronic toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=a0b7e9bbd8490d46; raw_unit=ppm; context=sults of short-term study/ies (although not explicitly stated, this reference probably relates to the 13-week feeding study by Singh et al., 1988) so that for long-term dosing the NOEL was anticipated to be 0.1 ppm while the second lowest concentration of 1.5 ppm was anticipated to be the NOAEL with only serum cholinesterase activity being affected. |
| INCHEM_WHO_jmpr_jmpmono_v2006pr01 |
NOEL |
=20 |
mg/kg bw/day |
Rat; Mouse |
- |
2-year |
Reproductive toxicity |
document_id=jmpr_jmpmono_v2006pr01; title=Pesticide residues in food - 2006: Toxicological evaluations; path=mirror/documents/jmpr/jmpmono/v2006pr01.pdf; row_hash=a21c850a9b082822; raw_unit=mg/kg bw per day; context=Lowest relevant NOAEL/NOEL 20 mg/kg bw per day (2-year study in rats) Carcinogenicity No evidence of treatment related tumorigenicity in rats or mice Reproductive toxicity Reproduction target/critical effect No effects on reproductive indices Reduction in body-weight gain in offspring during lactation Low |