Is Matrine safe in cosmetics?
Matrine has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Matrine
Also known as: (+)-Matrine, Matridin-15-one, 1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, dodecahydro-, (7aS,13aR,13bR,13cS)-, (7aS,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, NSC 318810 (+6 more)
INCI: MATRINE
Matrine (CAS 519-02-8) is a cosmetic cosmetic ingredient functioning as Antioxidant, skin conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 519-02-8 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, skin conditioning
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(1R,2R,9S,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one
InChIKey
ZSBXGIUJOOQZMP-JLNYLFASSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed; not prohibited or restricted in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Matrine.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Matrine.
Known Synonyms
(+)-Matrine
Matridin-15-one
1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, dodecahydro-, (7aS,13aR,13bR,13cS)-
(7aS,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one
NSC 318810
Vegard
alpha-Matrine
5-24-02-00301
BRN 0085851
Matrene, (+)-
NSC 146051
Chemical Function
Antioxidant
Softener and conditioner
Frequently Asked Questions
Is Matrine allowed in the EU?
Matrine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Matrine do in cosmetics?
Matrine functions as: Antioxidant, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 519-02-8.
Is Matrine used outside cosmetics?
Matrine also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Matrine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2-O-Ethyl Ascorbic Acid
Excellent
Same category
Softener and conditioner
3-Glyceryl Ascorbate
Excellent
Same category
Antioxidant, Humectant, Skin Conditio...
Allantoin Ascorbate
Excellent
Same category
Antioxidant, Skin Conditioning, Skin ...
Aloe Vera Extract
Excellent
Same category
Skin Conditioning, Antioxidant
Althaea Officinalis Callus Culture Extract
Excellent
Same category
Antioxidant, skin protectant
Amaranthus Caudatus Seed Oil
Excellent
Same category
Emollient, skin conditioning, antioxi...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(SH-Pentapeptide-10 6-Aminocaprooyl SH-Pentapeptide-11) SP
Moderate
Similar safety
Skin/hair conditioning (peptide-based...
1,2,3,4,4a,5,6,7-Octahydro-2,5,5-Trimethyl-2-Naphthol
Moderate
Similar safety
Fragrance ingredient
MCE (S87)
Good
Browse nearby
Insufficient data
MDM Hydantoin
Moderate
Browse nearby
Antimicrobial - helps control the gro...
MEA PPG-6 Laureth-7 Carboxylate
Moderate
Browse nearby
Surfactant - cleansing agent
Is Matrine in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Matrine in your formulation.