Is Manganese Gluconate safe in cosmetics?
Manganese Gluconate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Manganese Gluconate
INCI: MANGANESE GLUCONATE
Manganese Gluconate (CAS 6485-39-8) is a cosmetic cosmetic ingredient functioning as Skin conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 6485-39-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Manganese Gluconate is classified GHS Danger (H302, H318, H372, H319) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin conditioning
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
manganese(2+);bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate)
InChIKey
OXHQNTSSPHKCPB-IYEMJOQQSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed in cosmetics; also GRAS as a food-grade nutrient (USP/FCC standard)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Manganese Gluconate.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
2 property records from structured ingredient metadata.
acne
{"cas_number": "6485-39-8", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory/non_inflammatory", "sebum_reduction_pct_clinical": "5-15", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cos…
anti_aging
{"anti_aging_claim": "antioxidant-protection, collagen-boosting", "mechanism_of_action": "Cofactor for enzymatic reactions, antioxidant activity", "target_skin_layer": "epidermis", "collagen_stimulation": "Moderate", "elastin_protection": "Mild", "wrinkle_reduction_pct": "6-12", "clinical_study_duration_weeks": "12", "sample_size": "30", "double_blind": "No", "placebo_controlled": "Yes", "publishe…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Flavouring and nutrient
No specific technical function
Softener and conditioner
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Manganese Gluconate.
Regulatory Flags
potential-allergen
fda_food_additive
Chemical Function
Softener and conditioner
No specific technical function
Biocide
Flavouring and nutrient
Regulatory Lists
active_ingredient; animal_products; Europe; pharmaceutical; residue
Europe; supplements
Europe; food_additive; supplements
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Manganese Gluconate allowed in the EU?
Manganese Gluconate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Manganese Gluconate do in cosmetics?
Manganese Gluconate functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 6485-39-8.
Is Manganese Gluconate used outside cosmetics?
Manganese Gluconate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Manganese Gluconate have different safety status in cosmetics vs industrial chemicals?
Manganese Gluconate is classified GHS Danger (H302, H318, H372, H319) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Manganese Gluconate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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