NOAEL Studies Active Ingredient

Malic Acid NOAEL Studies

INCI: MALIC ACID

CAS: 617-48-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 40 mg/kg bw/day rat oral NA Multigeneration Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 200 mg/kg bw/day rat oral 728 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 266 mg/kg bw/day mouse oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 350 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1400 mg/kg bw/day dog oral 728 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 817L1N4CKP UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H6O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"817L1N4CKP"}
openFDA substances FDA UNII substance identifier 817L1N4CKP UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H6O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"817L1N4CKP"}
openFDA substances FDA UNII substance identifier 817L1N4CKP UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H6O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"817L1N4CKP"}
openFDA substances FDA UNII substance identifier 817L1N4CKP UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H6O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"817L1N4CKP"}