NOAEL Studies
Cosmetic Ingredient
Maleic Anhydride NOAEL Studies
INCI: MALEIC ANHYDRIDE
CAS: 108-31-6
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 60 | mg/kg bw/day | dog | oral | 90 day | Subchronic | REACH |
| COSMOS DB | LOAEL | 100 | mg/kg bw/day | rat | oral | 90 day | Subchronic | REACH |
| COSMOS DB | LOAEL | 250 | mg/kg bw/day | rat | oral | 183 day | Chronic | REACH |
| COSMOS DB | NOAEL | 40 | mg/kg bw/day | dog | oral | 90 day | Subchronic | REACH |
Regulatory source 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | NOAEL | =10 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=30a44e3721b42ecd; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL : 1.0e1 mg/kg-day; system=Urinary; basis=Renal lesions; point_of_departure=NOAEL : 1.0e1 mg/kg-day; composite_uf=100; confidence=Medium; dtxsid=DTXSID7024166; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=307; rfd_last_updated=08/22/1988; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0307_summary.pdf |
| Regulatory source | RfD | =0.1 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=671c2e28fa0f1868; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=1e-1; system=Urinary; basis=Renal lesions; point_of_departure=NOAEL : 1.0e1 mg/kg-day; composite_uf=100; confidence=Medium; dtxsid=DTXSID7024166; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=307; rfd_last_updated=08/22/1988; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0307_summary.pdf |
NTP ICE acute oral 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =235 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_720; row=11895; data_type=In Vivo; mixture=Chemical; chemical_name=2,5-Furandione; preferred_name=2,5-Furandione; dtxsid=DTXSID7024166; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7024166; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =400 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_721; row=11896; data_type=In Vivo; mixture=Chemical; chemical_name=2,5-Furandione; preferred_name=2,5-Furandione; dtxsid=DTXSID7024166; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7024166; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =900 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_722; row=11900; data_type=In Vivo; mixture=Chemical; chemical_name=2,5-Furandione; preferred_name=2,5-Furandione; dtxsid=DTXSID7024166; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7024166; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1030 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_723; row=11899; data_type=In Vivo; mixture=Chemical; chemical_name=2,5-Furandione; preferred_name=2,5-Furandione; dtxsid=DTXSID7024166; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7024166; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1050 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_724; row=11898; data_type=In Vivo; mixture=Chemical; chemical_name=2,5-Furandione; preferred_name=2,5-Furandione; dtxsid=DTXSID7024166; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7024166; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1090 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_725; row=11897; data_type=In Vivo; mixture=Chemical; chemical_name=2,5-Furandione; preferred_name=2,5-Furandione; dtxsid=DTXSID7024166; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7024166; source_file=acute_oral.xlsx |
NTP ICE skin irritation 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | Viability (240 minutes) | 2.7 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4830; Record_ID=skin_irritation_invitro_2096; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7024166; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=2.7; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024166 |
| NTP ICE skin irritation | Viability (240 minutes) | 4.3 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4819; Record_ID=skin_irritation_invitro_2098; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7024166; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=4.3; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024166 |
| NTP ICE skin irritation | Viability (240 minutes) | 5.5 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4824; Record_ID=skin_irritation_invitro_2100; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7024166; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=5.5; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024166 |
| NTP ICE skin irritation | Viability (3 minutes) | 72.5 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4826; Record_ID=skin_irritation_invitro_2098; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7024166; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=72.5; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024166 |
| NTP ICE skin irritation | Viability (3 minutes) | 78.8 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4829; Record_ID=skin_irritation_invitro_2096; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7024166; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=78.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024166 |
| NTP ICE skin irritation | Viability (3 minutes) | 80.2 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4820; Record_ID=skin_irritation_invitro_2100; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7024166; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=80.2; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024166 |
| NTP ICE skin irritation | Viability (60 minutes) | 6 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4822; Record_ID=skin_irritation_invitro_2100; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7024166; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=6; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024166 |
| NTP ICE skin irritation | Viability (60 minutes) | 10.1 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4827; Record_ID=skin_irritation_invitro_2098; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7024166; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=10.1; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024166 |
| NTP ICE skin irritation | Viability (60 minutes) | 13 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=4821; Record_ID=skin_irritation_invitro_2096; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7024166; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=13; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024166 |
NTP ICE skin sensitization 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD54, EC200 | 298.4 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=2967; Record_ID=skin_sensitization_invitro_697; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7024166; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=298.39999999999901; Reported_Response_Unit=ug/mL; Response=298.4; Response_Unit=ug/mL; Reference=Ashikaga et al. 2010; 20822320; 10.1177/026119291003800403|Nukada et al. 2011; 21767275; 10.1111/j.1600-0536.2011.01952.x|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada personal communication (undated)|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024166 |
| NTP ICE skin sensitization | CD86, EC150 | 156 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8336; Record_ID=skin_sensitization_invitro_2311; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7024166; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=1590.914654; Reported_Response_Unit=uM; Conversion_Factor_Value=98.057; Conversion_Factor_Source=EPA Dashboard; Converted_Response=156; Converted_Response_Unit=ug/mL; Response=156; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024166 |
| NTP ICE skin sensitization | CV75 | 658 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=2969; Record_ID=skin_sensitization_invitro_697; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7024166; Assay=h-CLAT; Endpoint=CV75; Reported_Response=658; Reported_Response_Unit=ug/mL; Response=658; Response_Unit=ug/mL; Reference=Ashikaga et al. 2010; 20822320; 10.1177/026119291003800403|Nukada et al. 2011; 21767275; 10.1111/j.1600-0536.2011.01952.x|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada personal communication (undated)|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024166 |
| NTP ICE skin sensitization | Depletion Cys | 100 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=786; Record_ID=skin_sensitization_invitro_220; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7024166; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=100; Reported_Response_Unit=%; Response=100; Response_Unit=%; Reference=Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024166 |
| NTP ICE skin sensitization | Depletion Lys | 41 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=789; Record_ID=skin_sensitization_invitro_221; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7024166; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=41; Reported_Response_Unit=%; Response=41; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024166 |
| NTP ICE skin sensitization | Depletion Lys | 45.9 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=785; Record_ID=skin_sensitization_invitro_220; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7024166; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=45.9; Reported_Response_Unit=%; Response=45.9; Response_Unit=%; Reference=Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024166 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 70.5 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=791; Record_ID=skin_sensitization_invitro_221; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7024166; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=70.5; Reported_Response_Unit=%; Response=70.5; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024166 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 73 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=787; Record_ID=skin_sensitization_invitro_220; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7024166; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=73; Reported_Response_Unit=%; Response=73; Response_Unit=%; Reference=Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024166 |
| NTP ICE skin sensitization | EC1.5 | 1475.9 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=4562; Record_ID=skin_sensitization_invitro_1052; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7024166; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=1475.9; Reported_Response_Unit=uM; Response=1475.9; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024166 |
| NTP ICE skin sensitization | EC3 | 0.16 | % | Mouse | Dermal | - | In Vivo; Urbisch_SkinSensitization2020; LLNA | sheet=Data_invivo; excel_row=12817; Record_ID=skin_sensitization_invivo_2814; Data_Type=In Vivo; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7024166; Assay=LLNA; Endpoint=EC3; Response=0.16; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024166 |
| NTP ICE skin sensitization | IC50 | >2000 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=4564; Record_ID=skin_sensitization_invitro_1052; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7024166; Assay=KeratinoSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024166 |
| NTP ICE skin sensitization | Imax | 2.5 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=4566; Record_ID=skin_sensitization_invitro_1052; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7024166; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=2.5; Reported_Response_Unit=Unitless; Response=2.5; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7024166; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7024166 |
ToxValDB Cal OEHHA REL derivations 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Cal OEHHA REL derivations | BMC (05) | =0.12 | mg/m3 | Rat | inhalation | chronic; 6 months | chronic | LONG_REF=Short RD, Johannsen FR, and Ulrich CE. 1988. A 6-month multispecies inhalation study with maleic anhydride. Fundam. Appl. Toxicol. 10:517-524.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Neutrophilic infiltration of the nasal epithelium; epithelial hyperplasia; respiratory irritation; STUDY_GROUP=Cal OEHHA REL derivations_dup_-_15952097_15952098:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a1a78ef96c6b3237ca5fdbf67bfb7bb6 |
| ToxValDB Cal OEHHA REL derivations | LOAEL | =1.1 | mg/m3 | Rat | inhalation | chronic; 6 months | chronic | LONG_REF=Short RD, Johannsen FR, and Ulrich CE. 1988. A 6-month multispecies inhalation study with maleic anhydride. Fundam. Appl. Toxicol. 10:517-524.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Neutrophilic infiltration of the nasal epithelium; epithelial hyperplasia; respiratory irritation; STUDY_GROUP=Cal OEHHA REL derivations_dup_-_15952097_15952098:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2fe9d7a0ff35805b5e3fff61ef590366 |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =56147.4 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=DOE Protective Action Criteria:15516789:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_77bce3495f10cfdac008702a5410de6b |
ECHA 16 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEC | =1.1 | mg/m3 | Hamster | inhalation | chronic; 6 months | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22679/7/6/3?documentUUID=0d1cfd58-dd6b-4f99-9f0b-f88594868ec4; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827802_15827803:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0f6dd3b4880207bf11a29307f9490877 |
| ECHA | LOAEC | =9.8 | mg/m3 | Rat | inhalation | chronic; 6 months | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22679/7/6/3?documentUUID=0d1cfd58-dd6b-4f99-9f0b-f88594868ec4; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829229_15829230_15829231:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3242d39048f3470943a8af748376cb34 |
| ECHA | LOAEC | =10 | mg/m3 | Rat | inhalation | subchronic; 1 months | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22679/7/6/3?documentUUID=0d1cfd58-dd6b-4f99-9f0b-f88594868ec4; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID:15827315:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7ab5512ba13cae6638ea94188347e36b |
| ECHA | LOAEL | =20 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b5605; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22679/7/9/2?documentUUID=0d1cfd58-dd6b-4f99-9f0b-f88594868ec4; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855151_15856026_15856669_15861964:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_32f4625f039af3a8bdc422604bcd89bc |
| ECHA | LOAEL | =600 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e43; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22679/7/6/2?documentUUID=0d1cfd58-dd6b-4f99-9f0b-f88594868ec4; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=gross pathology|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833810_15833811_15845179_15845181:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b95af0bcf8afc0c5e3f7fd91005ac914 |
| ECHA | LOEL | =32 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e3f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22679/7/6/2?documentUUID=0d1cfd58-dd6b-4f99-9f0b-f88594868ec4; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830665_15830666:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c6ea1c4eabb52a53c48b3874d9e5b480 |
| ECHA | LOEL | =100 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c1187; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1548/7/6/2?documentUUID=ac9eb4e4-e118-48fd-b1e3-a9d8c9a7d7b7; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833142_15835422_15837511:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_65b192d5cb02c11af107405c751e12f5 |
| ECHA | NOAEC | =3.3 | mg/m3 | Rat | inhalation | chronic; 6 months | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22679/7/6/3?documentUUID=0d1cfd58-dd6b-4f99-9f0b-f88594868ec4; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829229_15829230_15829231:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8e14c1d8e5954f05c52715a011b387d2 |
| ECHA | NOAEC | =9.8 | mg/m3 | Hamster | inhalation | chronic; 6 months | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22679/7/6/3?documentUUID=0d1cfd58-dd6b-4f99-9f0b-f88594868ec4; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15827802_15827803:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6017ceaa60fb133776756e20c79fbcd0 |
| ECHA | NOAEL | =55 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa57e4b0a7c65d1b5605; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22679/7/9/2?documentUUID=0d1cfd58-dd6b-4f99-9f0b-f88594868ec4; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855151_15856026_15856669_15861964:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_278b237ad526776d8a123b63dab4b79e |
| ECHA | NOAEL | =60 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e47; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22679/7/6/2?documentUUID=0d1cfd58-dd6b-4f99-9f0b-f88594868ec4; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834612_15846193:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2a268c1e2b2f1a865c53fdbed1d70ff7 |
| ECHA | NOAEL | >=100 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cee4b0a7c65d1b2ce6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22679/7/8?documentUUID=0d1cfd58-dd6b-4f99-9f0b-f88594868ec4; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=histopathology: neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818245_15819626_15819627:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5c3131aa5cdccf335236b3beaa0af66e |
| ECHA | NOAEL | >=140 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb769; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1548/7/9/3?documentUUID=198f9af6-680d-44de-a110-579a594a722d; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822234_15822441:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_292d5984325ed40d9dd108e8c866143c |
| ECHA | NOAEL | =250 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0e43; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22679/7/6/2?documentUUID=0d1cfd58-dd6b-4f99-9f0b-f88594868ec4; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=gross pathology|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833810_15833811_15845179_15845181:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3a71a5aa577ca02dd89b6a1901690211 |
| ECHA | NOEL | =10 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cee4b0a7c65d1b2d26; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1548/7/8?documentUUID=ac9eb4e4-e118-48fd-b1e3-a9d8c9a7d7b7; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818245_15819626_15819627:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_73051c57e4d5264813ba606fbf9eedbd |
| ECHA | NOEL | =40 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacd7e4b0a7c65d1c118b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/1548/7/6/2?documentUUID=ac9eb4e4-e118-48fd-b1e3-a9d8c9a7d7b7; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833142_15835422_15837511:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2aa7694e507cdaca8a754f830dfc7c11 |
ToxValDB GESTIS DNEL 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =0.081 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633147_15633148_15633149_15633150:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ce5209d7209cb947135ad91d05b4bafd |
| ToxValDB GESTIS DNEL | DNEL local | =0.32 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633147_15633148_15633149_15633150:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_788690c58a6eb6e1553329f2a3a5d8c6 |
| ToxValDB GESTIS DNEL | DNEL systemic | =0.19 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633147_15633148_15633149_15633150:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ccfc3794f2f3e530a81b75561c1077e2 |
ToxValDB IRIS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | RfD | =0.1 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=U.S. EPA, 1983; AUTHOR=U.S. EPA; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a571b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=307; TOXICOLOGICAL_EFFECT=Renal lesions in male/female rats; STUDY_GROUP=IRIS:15645021:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_188024ce36667478872c78bdc4eb7cb7 |
ToxValDB RSL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB RSL | RfC | =0.0007 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15657032:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_72e3ee2aaa9a86af1651cf86cc11d730 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | V5877ZJZ25 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H2O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V5877ZJZ25"} |
| openFDA substances | FDA UNII substance identifier | V5877ZJZ25 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H2O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V5877ZJZ25"} |
| openFDA substances | FDA UNII substance identifier | V5877ZJZ25 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H2O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V5877ZJZ25"} |
| openFDA substances | FDA UNII substance identifier | V5877ZJZ25 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C4H2O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V5877ZJZ25"} |