Is Magnesium Acetate safe in cosmetics?
Magnesium Acetate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Magnesium Acetate
Also known as: EINECS 205-554-9, NSC 75798, UNII-0E95JZY48K, Mg Acetate, Mg(II) acetate (+1 more)
INCI: MAGNESIUM ACETATE
Magnesium Acetate (CAS 142-72-3) is a cosmetic cosmetic ingredient functioning as Buffering (pH regulator). NOAEL 16.6667 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 142-72-3 →
Auto-generated CPSR Part A draft with source citations
Function
Buffering (pH regulator)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
magnesium diacetate
InChIKey
UEGPKNKPLBYCNK-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed - GRAS (Generally Recognized as Safe) for food use; permitted in cosmetics under general safety provisions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Magnesium Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Magnesium Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Magnesium Acetate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (1)
JECFA Evaluation
MAGNESIUM ACETATE | 1985 | NO ADI ALLOCATED | TRS 733-JECFA 29/25 | NOT PREPARED
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Catalyst
Processing aids not otherwise specified
pH regulating agent
Regulatory List Membership (1)
EPA Safer Chemical Ingredients List (SCIL)
Expert Verdict
Expert safety assessment and concern-level summary for Magnesium Acetate.
Regulatory Flags
potential-allergen
epa_safer_alternative
jecfa_concern
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Magnesium Acetate by CAS number or substance name.
Studies
1
Lowest NOAEL
50 mg/kg bw/day
Highest NOAEL
50 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
EINECS 205-554-9
NSC 75798
UNII-0E95JZY48K
Mg Acetate
Mg(II) acetate
acetic acid magnesium salt
Chemical Function
pH regulating agent
Processing aids not otherwise specified
Catalyst
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
active_ingredient; animal_products; Europe; pharmaceutical; residue
Europe; supplements
Europe; food_additive; supplements
SCIL (9/2019)
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
MAGNESIUM ACETATE
ChEMBL ID
CHEMBL1200691
Max Phase
4
Adverse Event Associations
4
Frequently Asked Questions
Is Magnesium Acetate allowed in the EU?
Magnesium Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Magnesium Acetate do in cosmetics?
Magnesium Acetate functions as: Buffering (pH regulator). It is classified as a cosmetic ingredient in our database. CAS number: 142-72-3.
What is the NOAEL for Magnesium Acetate?
The NOAEL (No Observed Adverse Effect Level) for Magnesium Acetate is =50 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Magnesium Acetate used outside cosmetics?
Magnesium Acetate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Magnesium Acetate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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