Is Lycopene Cosmetic safe in cosmetics?
Lycopene Cosmetic has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Lycopene Cosmetic
Also known as: EINECS 207-949-1, UNII-SB0N2N0WV6, Mexoryl SAQ, Tomat-O-Red, Redivivo (+3 more)
INCI: LYCOPENE
Lycopene Cosmetic (CAS 502-65-8) is a cosmetic antioxidant functioning as Inhibits reactions promoted by oxygen, preventing oxidation and deterioration. Reported NOAEL =100 mg/kg bw/day in Rat (INCHEM_WHO_jecfa_jecmono_v62je01); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 502-65-8 →
Auto-generated CPSR Part A draft with source citations
Function
Inhibits reactions promoted by oxygen, preventing oxidation and deterioration of both
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(6E,8E,10E,12E,14E,16E,18E,20E,22E,24E,26E)-2,6,10,14,19,23,27,31-octamethyldotriaconta-2,6,8,10,12,14,16,18,20,22,24,26,30-tridecaene
InChIKey
OAIJSZIZWZSQBC-GYZMGTAESA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR assessments of carotenoid-containing botanicals (Rosa canina-derived ingredients) concluded the ingredients are safe when formulated to be non-irritating and non-sensitizing.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Lycopene Cosmetic.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Lycopene Cosmetic. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =100 mg/kg bw/day | - | Rat | Toxicology study | INCHEM_WHO_jecfa_jecmono_v62je01 |
| NOAEL | =100 mg/kg bw/day | - | Rat | Toxicology study | INCHEM_WHO_jecfa_jecmono_v62je01 |
| NOAEL | =500 mg/kg bw/day | - | - | Developmental toxicity | INCHEM_WHO_jecfa_jecmono_v62je01 |
| NOAEL | =500 mg/kg bw/day | - | - | Developmental toxicity | INCHEM_WHO_jecfa_jecmono_v62je01 |
| NOAEL | =616 mg/kg bw/day | oral | - | Toxicology study | INCHEM_WHO_jecfa_jecmono_v62je01 |
| NOAEL | =616 mg/kg bw/day | oral | - | Toxicology study | INCHEM_WHO_jecfa_jecmono_v62je01 |
| NOAEL | =1000 mg/kg bw/day | - | - | Toxicology study | INCHEM_WHO_jecfa_jecmono_v62je01 |
| NOAEL | =1000 mg/kg bw/day | - | - | Toxicology study | INCHEM_WHO_jecfa_jecmono_v62je01 |
| NOAEL | =3290 mg/kg bw/day | oral | - | Toxicology study | INCHEM_WHO_jecfa_jecmono_v62je01 |
| NOAEL | =3290 mg/kg bw/day | oral | - | Toxicology study | INCHEM_WHO_jecfa_jecmono_v62je01 |
Dermal Penetration Profile
Skin absorption and penetration characteristics of Lycopene Cosmetic, relevant to systemic exposure and MoS calculations.
Absorption %
0.5-2%
Penetration Level
stratum-corneum
Penetration Depth
stratum corneum
Molecular Weight
536.9 Da
Log P
15.7
Systemic Absorption
minimal
Topical Bioavailability
0.2-1%
Safety Margin Factor
minimal
Vehicle Dependent
Yes — absorption varies by formulation
Source: Exp Dermatol 2001
EPA ToxValDB — Toxicity Values
4 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOEL | =1 mg/kg-day | Rat | oral | short-term | ECOTOX |
| NOAEL | =50 mg/kg-day | Rat | oral | chronic | EFSA |
| NOAEL | =50 mg/kg-day | Rat | oral | chronic | EFSA |
| NOAEL | =50 mg/kg-day | Rat | oral | chronic | EFSA |
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex IV — Permitted Colorants
Product type: Yellow
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (IV - Colorants)
BRIN Brazil/India Cosmetics
India: Permitted Colorant
Additional Ingredient Properties
10 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "antioxidant-protection, photoprotection", "mechanism_of_action": "Specialized bioactive mechanism", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "10-18", "clinical_study_duration_weeks": "12", "sample_size": "28", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "Specia…
anti_pollution
{"cas_number": "502-65-8", "ingredient_class": "blue_light_filter/antioxidant_pollution_shield", "primary_mechanism": "free_radical_scavenging", "pollution_types_targeted": "blue_light_HEV/UV_A/PM2_5/ozone", "blue_light_absorption_range_nm": "440-500", "blue_light_protection_factor": "High", "HEV_screening_efficacy_pct": "75-85", "IR_A_protection": "no", "visible_light_protection": "yes", "digital…
antioxidant
{"cas_number": "502-65-8", "antioxidant_class": "carotenoid", "chemical_subclass": "tetraterpene", "molecular_weight_daltons": "536.87", "orac_value_umol_te_per_g": "3150", "dpph_radical_scavenging_ic50_ug_per_ml": "8-16", "abts_trolox_equivalent": "1.2", "singlet_oxygen_quenching": "very high", "superoxide_dismutase_mimetic": "low", "hydroxyl_radical_scavenging": "high", "lipid_peroxidation_inhib…
depigmentation
{"cas_number": "502-65-8", "ingredient_class": "combined_mechanism", "primary_mechanism_of_action": "Synthetic or isolated bioactive with melanin reduction properties", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_clinical": "…
dermal_absorption
{"molecular_weight_da": "536.9", "log_p_value": "15.7", "skin_penetration_level": "stratum-corneum", "penetration_depth": "stratum corneum", "absorption_pct": "0.5-2", "systemic_absorption": "minimal", "penetration_enhancer": "no", "occlusion_effect": "yes", "vehicle_dependent": "yes", "skin_barrier_effect": "strengthens", "bioavailability_topical_pct": "0.2-1", "safety_margin_factor": "minimal", …
ph_stability
{"optimal_ph_min": "4.0", "optimal_ph_max": "8.0", "stable_ph_min": "3.5", "stable_ph_max": "9.0", "ph_dependent_function": "Carotenoid antioxidant", "formulation_note": "Lipophilic; oxidizes easily", "source": "Formulation literature"}
pregnancy_detail
{"pregnancy_safe": "yes", "breastfeeding_safe": "yes", "risk_category": "not-rated", "reason": "Safe; carotenoid antioxidant", "source": "dermatology literature"}
self_tanning
{"cas_number": "502-65-8", "ingredient_class": "instant_bronzer", "tanning_mechanism": "cosmetic_colorant", "color_development_onset_hours": "0.0", "full_color_development_hours": "0", "color_duration_days": "0", "color_depth": "light", "undertone": "warm_golden", "DHA_concentration_if_applicable_pct": "0", "erythrulose_concentration_pct": "0", "pH_dependent_color": "no", "formaldehyde_release_con…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Evaluation
LYCOPENE | 2009 | NOT SPECIFIED | Group ADI “not specified” for lycopene from all sources when used as food colour. Hence, the previous group ADI of 0–0.5 mg/kg for lycopene has been withdrawn. The group ADI “not specified” applies to synthetic lycopene, lycopene derived from the fungus Blakeslea trispora and lycopene extract from tomato that comply with the specifications, when used in accordance
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
LYCOPENE EXTRACT from TOMATO | 2009 | NOT SPECIFIED | Group ADI “not specified” for synthetic lycopene, lycopene derived from the fungus Blakeslea trispora and lycopene extract from tomato. | TRS 956-JECFA 71 | FAS 62-JECFA 71
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
LYCOPENE from BLAKESLEA TRISPORA | 2023 | 0-0.5 mg/kg bw | Group ADI for synthetic lycopene and lycopene from Blakeslea trispora. Considered for specification only. | TRS 1050-JECFA 96/37 | FAS 58-JECFA 67
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Dye
Flavouring and nutrient
Regulatory List Membership (3)
EU Regulated in Personal Care
FDA Substances Added to Food (EAFUS)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Lycopene Cosmetic.
Regulatory Flags
fda_food_additive
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Lycopene Cosmetic by CAS number or substance name.
Studies
12
Lowest NOAEL
100 mg/kg bw/day
Highest NOAEL
4500 mg/kg bw/day
INCHEM_WHO_jecfa_jecmono_v62je01
Known Synonyms
EINECS 207-949-1
UNII-SB0N2N0WV6
Mexoryl SAQ
Tomat-O-Red
Redivivo
(6E,8E,10E,12E,14E,16E,18E,20E,22E,24E,26E)-2,6,10,14,19,23,27,31-octamethyldotriaconta-2,6,8,10,12,14,16,18,20,22,24,26,30-tridecaene
Lycopene 7
all-trans-lycopene
Chemical Function
Dye
Antioxidant
Flavouring and nutrient
Regulatory Lists
Europe; Personal care
Canada; pharmaceutical
Canada; pharmaceutical
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe; Personal care
Canada; pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
LYCOPENE
ChEMBL ID
CHEMBL501174
Max Phase
3
Adverse Event Associations
154
Frequently Asked Questions
Is Lycopene Cosmetic allowed in the EU?
Lycopene Cosmetic EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Lycopene Cosmetic do in cosmetics?
Lycopene Cosmetic functions as: Inhibits reactions promoted by oxygen, preventing oxidation and deterioration of both. It is classified as a Antioxidant in our database. CAS number: 502-65-8.
What is the NOAEL for Lycopene Cosmetic?
The NOAEL (No Observed Adverse Effect Level) for Lycopene Cosmetic is =100 mg/kg bw/day based on a Toxicology study study via oral route in Rat. A total of 10 study endpoints are available. Source: INCHEM_WHO_jecfa_jecmono_v62je01.
Is Lycopene Cosmetic used outside cosmetics?
Lycopene Cosmetic also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Lycopene Cosmetic compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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