Is Liquiritin Apioside safe in cosmetics?
Liquiritin Apioside has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Liquiritin Apioside
INCI: LIQUIRITIN APIOSIDE
Liquiritin Apioside (CAS 74639-14-8) is a cosmetic cosmetic ingredient functioning as Skin conditioning, skin lightening/brightening (flavonoid active). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 74639-14-8 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning, skin lightening/brightening (flavonoid active)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(2S)-2-[4-[(2S,3R,4S,5S,6R)-3-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-7-hydroxy-2,3-dihydrochromen-4-one
InChIKey
FTVKHUHJWDMWIR-DWMQJYMWSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed as a cosmetic ingredient; no specific prohibitions. Not classified as an OTC drug active.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Liquiritin Apioside.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Liquiritin Apioside.
Regulatory Flags
potential-allergen
Chemical Function
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL4205314
Frequently Asked Questions
Is Liquiritin Apioside allowed in the EU?
Liquiritin Apioside EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Liquiritin Apioside do in cosmetics?
Liquiritin Apioside functions as: Skin conditioning, skin lightening/brightening (flavonoid active). It is classified as a cosmetic ingredient in our database. CAS number: 74639-14-8.
Is Liquiritin Apioside used outside cosmetics?
Liquiritin Apioside also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Liquiritin Apioside compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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