NOAEL Studies
Fragrance
Linalool NOAEL Studies
INCI: LINALOOL
CAS: 78-70-6
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | NOAEL | 1000 | mg/kg bw/day | rat | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1500 | mg/kg bw/day | rat | oral | 5 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
ECHA 33 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | 500 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=cdfe25b5-4568-4d85-b549-300eaf48dc8f_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=cdfe25b5-4568-4d85-b549-300eaf48dc8f/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2006; ReportDate=2006-07-07; basis=other:; key_result=true; entry_uuid=f91bb3e5-6199-4a52-917e-3e24d15d741f |
| ECHA | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=cdfe25b5-4568-4d85-b549-300eaf48dc8f_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=cdfe25b5-4568-4d85-b549-300eaf48dc8f/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2006; ReportDate=2006-07-07; basis=other:; key_result=true; entry_uuid=2db1c69d-d080-42f0-a0e2-ea638d2e9e26 |
| ECHA | NOAEL | 375 | mg/kg bw/day | mouse | other: | - | immunotoxicity | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=b83ba716-6c6f-43e9-a054-4e87d0b2940f_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=b83ba716-6c6f-43e9-a054-4e87d0b2940f/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=Immunotoxicity; literature=Name=Unnamed; ReferenceYear=1994; basis=other:; key_result=true; entry_uuid=a8f18d9e-7f77-41dd-8864-e05f966c66ec |
| ECHA | NOAEL | 250 | mg/kg bw/day | rat | - | - | sub-chronic toxicity: dermal | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=b03ad03a-4a87-4359-804c-43d1a6dad0e2_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=b03ad03a-4a87-4359-804c-43d1a6dad0e2/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1980; ReportDate=1980-04-04; basis=other:; key_result=true; entry_uuid=081cae69-8dd3-4286-852c-b7e338769d9a |
| ECHA | NOAEL | >=532.1 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=ecefd8ac-c437-49f2-baf7-fbb745650fb4_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=ecefd8ac-c437-49f2-baf7-fbb745650fb4/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2020; ReportDate=2020-12-16; key_result=true; entry_uuid=65535616-9963-4940-b523-f89e52e4917b |
| ECHA | NOAEL | >=497.9 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=ecefd8ac-c437-49f2-baf7-fbb745650fb4_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=ecefd8ac-c437-49f2-baf7-fbb745650fb4/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2020; ReportDate=2020-12-16; key_result=true; entry_uuid=8e1d9766-ae4d-448c-a28e-808ae62ca3ee |
| ECHA | NOAEL | 200 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=1cd87b18-e405-4750-8108-80e90dc5d438_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=1cd87b18-e405-4750-8108-80e90dc5d438/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-09-15; basis=clinical signs; key_result=true; entry_uuid=e4b989ba-a437-4bc0-adff-6b3c9990cc20 |
| ECHA | NOAEL | 750 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=1cd87b18-e405-4750-8108-80e90dc5d438_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=1cd87b18-e405-4750-8108-80e90dc5d438/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-09-15; basis=other:; key_result=true; entry_uuid=a7fc54e1-7b88-4382-b68b-881350c27cfc |
| ECHA | NOAEL | 365 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=f51f4c4d-2d44-4339-bdb7-b5da5184cc1e_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=f51f4c4d-2d44-4339-bdb7-b5da5184cc1e/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1989; ReportDate=1989-04-12; basis=other:; key_result=true; entry_uuid=8cf1ff74-36e1-4c08-92a4-6452e8c6402d |
| ECHA | NOAEL | 160 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=ff4a2d4b-0f36-4987-bf75-8022fa1f61a8_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=ff4a2d4b-0f36-4987-bf75-8022fa1f61a8/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; ReportDate=1990-01-26; basis=other:; key_result=true; entry_uuid=42a5f834-0357-4927-8bfb-c1c68e94097d |
| ECHA | NOAEL | 117 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=ff4a2d4b-0f36-4987-bf75-8022fa1f61a8_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=ff4a2d4b-0f36-4987-bf75-8022fa1f61a8/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; ReportDate=1990-01-26; basis=other:; key_result=true; entry_uuid=bd442242-15a3-43a4-a9c2-ef554790d2a5 |
| ECHA | NOAEL | 500 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=cdfe25b5-4568-4d85-b549-300eaf48dc8f_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=cdfe25b5-4568-4d85-b549-300eaf48dc8f/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2006; ReportDate=2006-07-07; basis=other:; key_result=true; entry_uuid=f91bb3e5-6199-4a52-917e-3e24d15d741f |
| ECHA | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=cdfe25b5-4568-4d85-b549-300eaf48dc8f_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=cdfe25b5-4568-4d85-b549-300eaf48dc8f/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2006; ReportDate=2006-07-07; basis=other:; key_result=true; entry_uuid=2db1c69d-d080-42f0-a0e2-ea638d2e9e26 |
| ECHA | NOAEL | 375 | mg/kg bw/day | mouse | other: | - | immunotoxicity | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=b83ba716-6c6f-43e9-a054-4e87d0b2940f_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=b83ba716-6c6f-43e9-a054-4e87d0b2940f/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=Immunotoxicity; literature=Name=Unnamed; ReferenceYear=1994; basis=other:; key_result=true; entry_uuid=a8f18d9e-7f77-41dd-8864-e05f966c66ec |
| ECHA | NOAEL | 250 | mg/kg bw/day | rat | - | - | sub-chronic toxicity: dermal | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=b03ad03a-4a87-4359-804c-43d1a6dad0e2_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=b03ad03a-4a87-4359-804c-43d1a6dad0e2/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1980; ReportDate=1980-04-04; basis=other:; key_result=true; entry_uuid=081cae69-8dd3-4286-852c-b7e338769d9a |
| ECHA | NOAEL | >=532.1 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=ecefd8ac-c437-49f2-baf7-fbb745650fb4_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=ecefd8ac-c437-49f2-baf7-fbb745650fb4/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2020; ReportDate=2020-12-16; key_result=true; entry_uuid=65535616-9963-4940-b523-f89e52e4917b |
| ECHA | NOAEL | >=497.9 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=ecefd8ac-c437-49f2-baf7-fbb745650fb4_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=ecefd8ac-c437-49f2-baf7-fbb745650fb4/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2020; ReportDate=2020-12-16; key_result=true; entry_uuid=8e1d9766-ae4d-448c-a28e-808ae62ca3ee |
| ECHA | NOAEL | 200 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=1cd87b18-e405-4750-8108-80e90dc5d438_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=1cd87b18-e405-4750-8108-80e90dc5d438/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-09-15; basis=clinical signs; key_result=true; entry_uuid=e4b989ba-a437-4bc0-adff-6b3c9990cc20 |
| ECHA | NOAEL | 750 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=1cd87b18-e405-4750-8108-80e90dc5d438_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=1cd87b18-e405-4750-8108-80e90dc5d438/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-09-15; basis=other:; key_result=true; entry_uuid=a7fc54e1-7b88-4382-b68b-881350c27cfc |
| ECHA | NOAEL | 365 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=f51f4c4d-2d44-4339-bdb7-b5da5184cc1e_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=f51f4c4d-2d44-4339-bdb7-b5da5184cc1e/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1989; ReportDate=1989-04-12; basis=other:; key_result=true; entry_uuid=8cf1ff74-36e1-4c08-92a4-6452e8c6402d |
| ECHA | NOAEL | 160 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=ff4a2d4b-0f36-4987-bf75-8022fa1f61a8_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=ff4a2d4b-0f36-4987-bf75-8022fa1f61a8/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; ReportDate=1990-01-26; basis=other:; key_result=true; entry_uuid=42a5f834-0357-4927-8bfb-c1c68e94097d |
| ECHA | NOAEL | 117 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=ff4a2d4b-0f36-4987-bf75-8022fa1f61a8_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=ff4a2d4b-0f36-4987-bf75-8022fa1f61a8/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; ReportDate=1990-01-26; basis=other:; key_result=true; entry_uuid=bd442242-15a3-43a4-a9c2-ef554790d2a5 |
| ECHA | NOAEL | 500 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=cdfe25b5-4568-4d85-b549-300eaf48dc8f_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=cdfe25b5-4568-4d85-b549-300eaf48dc8f/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2006; ReportDate=2006-07-07; basis=other:; key_result=true; entry_uuid=f91bb3e5-6199-4a52-917e-3e24d15d741f |
| ECHA | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=cdfe25b5-4568-4d85-b549-300eaf48dc8f_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=cdfe25b5-4568-4d85-b549-300eaf48dc8f/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2006; ReportDate=2006-07-07; basis=other:; key_result=true; entry_uuid=2db1c69d-d080-42f0-a0e2-ea638d2e9e26 |
| ECHA | NOAEL | 375 | mg/kg bw/day | mouse | other: | - | immunotoxicity | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=b83ba716-6c6f-43e9-a054-4e87d0b2940f_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=b83ba716-6c6f-43e9-a054-4e87d0b2940f/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=Immunotoxicity; literature=Name=Unnamed; ReferenceYear=1994; basis=other:; key_result=true; entry_uuid=a8f18d9e-7f77-41dd-8864-e05f966c66ec |
| ECHA | NOAEL | 250 | mg/kg bw/day | rat | - | - | sub-chronic toxicity: dermal | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=b03ad03a-4a87-4359-804c-43d1a6dad0e2_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=b03ad03a-4a87-4359-804c-43d1a6dad0e2/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1980; ReportDate=1980-04-04; basis=other:; key_result=true; entry_uuid=081cae69-8dd3-4286-852c-b7e338769d9a |
| ECHA | NOAEL | >=532.1 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=ecefd8ac-c437-49f2-baf7-fbb745650fb4_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=ecefd8ac-c437-49f2-baf7-fbb745650fb4/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2020; ReportDate=2020-12-16; key_result=true; entry_uuid=65535616-9963-4940-b523-f89e52e4917b |
| ECHA | NOAEL | >=497.9 | mg/kg bw/day | rat | oral: feed | - | sub-chronic toxicity: oral | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=ecefd8ac-c437-49f2-baf7-fbb745650fb4_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=ecefd8ac-c437-49f2-baf7-fbb745650fb4/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2020; ReportDate=2020-12-16; key_result=true; entry_uuid=8e1d9766-ae4d-448c-a28e-808ae62ca3ee |
| ECHA | NOAEL | 200 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=1cd87b18-e405-4750-8108-80e90dc5d438_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=1cd87b18-e405-4750-8108-80e90dc5d438/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-09-15; basis=clinical signs; key_result=true; entry_uuid=e4b989ba-a437-4bc0-adff-6b3c9990cc20 |
| ECHA | NOAEL | 750 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=1cd87b18-e405-4750-8108-80e90dc5d438_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=1cd87b18-e405-4750-8108-80e90dc5d438/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-09-15; basis=other:; key_result=true; entry_uuid=a7fc54e1-7b88-4382-b68b-881350c27cfc |
| ECHA | NOAEL | 365 | mg/kg bw/day | rat | oral: gavage | - | screening for reproductive / developmental toxicity | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=f51f4c4d-2d44-4339-bdb7-b5da5184cc1e_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=f51f4c4d-2d44-4339-bdb7-b5da5184cc1e/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1989; ReportDate=1989-04-12; basis=other:; key_result=true; entry_uuid=8cf1ff74-36e1-4c08-92a4-6452e8c6402d |
| ECHA | NOAEL | 160 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=ff4a2d4b-0f36-4987-bf75-8022fa1f61a8_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=ff4a2d4b-0f36-4987-bf75-8022fa1f61a8/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; ReportDate=1990-01-26; basis=other:; key_result=true; entry_uuid=42a5f834-0357-4927-8bfb-c1c68e94097d |
| ECHA | NOAEL | 117 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6z; document=ff4a2d4b-0f36-4987-bf75-8022fa1f61a8_b6d3b55d-6689-44f8-b201-5cb4ee6bdb05.i6d; document_key=ff4a2d4b-0f36-4987-bf75-8022fa1f61a8/b6d3b55d-6689-44f8-b201-5cb4ee6bdb05; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1990; ReportDate=1990-01-26; basis=other:; key_result=true; entry_uuid=bd442242-15a3-43a4-a9c2-ef554790d2a5 |
EFSA 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =117 | mg/kg bw/day | Rat | oral: unspecified | 28 days | short-term toxicity | EFSA FEEDAP - 2012 - OutputID 2155 - histopathology non neoplastic - hepatotoxicity - Scientific Opinion on the safety and efficacy of aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols and esters with esters containing tertiary alcohols ethers (chemical group 6) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2966 |
| EFSA | NOAEL | =117 | mg/kg bw/day | Rat | oral: unspecified | 28 days | short-term toxicity | EFSA FEEDAP - 2012 - OutputID 2155 - histopathology non neoplastic - hepatotoxicity - Scientific Opinion on the safety and efficacy of aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols and esters with esters containing tertiary alcohols ethers (chemical group 6) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2966 |
| EFSA | NOAEL | =117 | mg/kg bw/day | Rat | oral: unspecified | 28 days | short-term toxicity | EFSA FEEDAP - 2012 - OutputID 2155 - histopathology non neoplastic - hepatotoxicity - Scientific Opinion on the safety and efficacy of aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols and esters with esters containing tertiary alcohols ethers (chemical group 6) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2966 |
| EFSA | NOAEL | =117 | mg/kg bw/day | Rat | oral: unspecified | 28 days | short-term toxicity | EFSA FEEDAP - 2012 - OutputID 2155 - histopathology non neoplastic - hepatotoxicity - Scientific Opinion on the safety and efficacy of aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols and esters with esters containing tertiary alcohols ethers (chemical group 6) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2966 |
| EFSA | LEL | =300 | mg/kg bw/day | Chicken | oral | subchronic; 36 days | subchronic | LONG_REF=EFSA FEEDAP (2020). Safety of 31 flavouring compounds belonging to different chemical groups when used as feed additives for all animal species. doi:10.2903/j.efsa.2020.6338.; TITLE=Safety of 31 flavouring compounds belonging to different chemical groups when used as feed additives for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2020.6338; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2020; ORIGINAL_YEAR=2020; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15622185:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_837ab675c2c541367a747989f4c027e4 |
| EFSA | NOAEL | =117 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols and esters with esters containing tertiary alcohols ethers (chemical group 6) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2966.; TITLE=Scientific Opinion on the safety and efficacy of aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols and esters with esters containing tertiary alcohols ethers (chemical group 6) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2966; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; STUDY_GROUP=EFSA:15622184:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7a8a89fe5879564573db46d2d5906546 |
WHO/JECFA 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | ADI | range:0-0.050.05 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v042je17; title=943. Aliphatic acyclic/alicyclic terpenoid tertiary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je17.htm; row_hash=79c3ee2e1096e89b; raw_unit=mg/kg bw; context=N/D, no intake data reported a The group ADI of 0-0.05 mg/kg bw established at the twenty-third meeting for citral, citronellol, linalool, and linalyl acetate as citral was maintained. |
| WHO/JECFA | ADI | range:0-0.050.05 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v042je17; title=943. Aliphatic acyclic/alicyclic terpenoid tertiary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je17.htm; row_hash=79c3ee2e1096e89b; raw_unit=mg/kg bw; context=N/D, no intake data reported a The group ADI of 0-0.05 mg/kg bw established at the twenty-third meeting for citral, citronellol, linalool, and linalyl acetate as citral was maintained. |
| WHO/JECFA | ADI | range:0-0.50.5 | mg/kg bw/day | - | - | short-term | Health guidance value | document_id=jecfa_jecmono_v042je17; title=943. Aliphatic acyclic/alicyclic terpenoid tertiary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je17.htm; row_hash=766e89148cc6c34d; raw_unit=mg/kg bw; context=A group ADI of 0-0.5 mg/kg bw was established on the basis of the clearly defined metabolism of these substances, their rapid excretion, and their low toxicity in short-term studies. |
| WHO/JECFA | ADI | range:0-0.50.5 | mg/kg bw/day | - | - | short-term | Health guidance value | document_id=jecfa_jecmono_v042je17; title=943. Aliphatic acyclic/alicyclic terpenoid tertiary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je17.htm; row_hash=766e89148cc6c34d; raw_unit=mg/kg bw; context=A group ADI of 0-0.5 mg/kg bw was established on the basis of the clearly defined metabolism of these substances, their rapid excretion, and their low toxicity in short-term studies. |
| WHO/JECFA | NOEL | =0.019 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v042je17; title=943. Aliphatic acyclic/alicyclic terpenoid tertiary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je17.htm; row_hash=7d337cf5e3c8c992; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=This NOEL is > 10 000 times the estimated daily per capita intakes of 44 and 19 ug/kg bw per day from use of the structurally related substance linalool as a flavouring substance in Europe and the United States, respectively. |
| WHO/JECFA | NOEL | =0.019 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v042je17; title=943. Aliphatic acyclic/alicyclic terpenoid tertiary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je17.htm; row_hash=7d337cf5e3c8c992; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=This NOEL is > 10 000 times the estimated daily per capita intakes of 44 and 19 ug/kg bw per day from use of the structurally related substance linalool as a flavouring substance in Europe and the United States, respectively. |
| WHO/JECFA | NOEL | =0.05 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v042je17; title=943. Aliphatic acyclic/alicyclic terpenoid tertiary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je17.htm; row_hash=4971ec4431710250; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=This NOEL provides safety margins of > 10 000 and > 500 for intake of alpha-terpineol (18 or 50 ug/kg bw per day) and total alpha-terpineol (23 or 53 ug/kg bw per day), respectively, in both Europe and the United States. |
| WHO/JECFA | NOEL | =0.05 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v042je17; title=943. Aliphatic acyclic/alicyclic terpenoid tertiary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je17.htm; row_hash=4971ec4431710250; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=This NOEL provides safety margins of > 10 000 and > 500 for intake of alpha-terpineol (18 or 50 ug/kg bw per day) and total alpha-terpineol (23 or 53 ug/kg bw per day), respectively, in both Europe and the United States. |
| WHO/JECFA | NOEL | >50 | mg/kg bw/day | Rat | - | 90-day | Subchronic toxicity | document_id=jecfa_jecmono_v042je17; title=943. Aliphatic acyclic/alicyclic terpenoid tertiary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je17.htm; row_hash=fb365ad0e5361b52; raw_unit=mg/kg bw per day; context=NOEL values of > 50 mg/kg bw per day for linalool and > 24 mg/kg bw per day for linalyl acetate have been found in 90-day studies in rats. |
| WHO/JECFA | NOEL | >50 | mg/kg bw/day | Rat | - | 90-day | Subchronic toxicity | document_id=jecfa_jecmono_v042je17; title=943. Aliphatic acyclic/alicyclic terpenoid tertiary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je17.htm; row_hash=fb365ad0e5361b52; raw_unit=mg/kg bw per day; context=NOEL values of > 50 mg/kg bw per day for linalool and > 24 mg/kg bw per day for linalyl acetate have been found in 90-day studies in rats. |
| WHO/JECFA | NOEL | >500 | mg/kg bw/day | Rat | - | 20-week | Toxicology study | document_id=jecfa_jecmono_v042je17; title=943. Aliphatic acyclic/alicyclic terpenoid tertiary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je17.htm; row_hash=b540263e41d9284e; raw_unit=mg/kg bw per day; context=A NOEL of > 500 mg/kg bw per day terpinyl acetate was found in a 20-week study in rats. |
| WHO/JECFA | NOEL | >500 | mg/kg bw/day | Rat | - | 20-week | Toxicology study | document_id=jecfa_jecmono_v042je17; title=943. Aliphatic acyclic/alicyclic terpenoid tertiary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je17.htm; row_hash=b540263e41d9284e; raw_unit=mg/kg bw per day; context=A NOEL of > 500 mg/kg bw per day terpinyl acetate was found in a 20-week study in rats. |
| WHO/JECFA | NOEL | =1000 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v042je17; title=943. Aliphatic acyclic/alicyclic terpenoid tertiary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je17.htm; row_hash=4d937ed166a9b04e; raw_unit=mg/kg bw per day; context=The NOEL of 1000 mg/kg bw per day (710 mg/kg bw per day geranyl acetate and 290 mg/kg bw per day citronellyl acetate) for the mixture provides a safety margin of > 10 000 for total intake of linalool and of alpha-terpineol. |
| WHO/JECFA | NOEL | =1000 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v042je17; title=943. Aliphatic acyclic/alicyclic terpenoid tertiary alcohols... (WHO Food Additives Series 42); path=mirror/documents/jecfa/jecmono/v042je17.htm; row_hash=4d937ed166a9b04e; raw_unit=mg/kg bw per day; context=The NOEL of 1000 mg/kg bw per day (710 mg/kg bw per day geranyl acetate and 290 mg/kg bw per day citronellyl acetate) for the mixture provides a safety margin of > 10 000 for total intake of linalool and of alpha-terpineol. |
NTP ICE acute oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =2790 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10360; row=11968; data_type=In Vivo; mixture=Chemical; chemical_name=Linalool; preferred_name=Linalool; dtxsid=DTXSID7025502; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7025502; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >2440 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_10358; row=11969; data_type=In Vivo; mixture=Chemical; chemical_name=Linalool; preferred_name=Linalool; dtxsid=DTXSID7025502; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7025502; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | <3180 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_10362; row=11970; data_type=In Vivo; mixture=Chemical; chemical_name=Linalool; preferred_name=Linalool; dtxsid=DTXSID7025502; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7025502; source_file=acute_oral.xlsx |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=11022; RecordID=ARPathway2016_1577; DatasetName=ARPathway2016; DTXSID=DTXSID7025502; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
NTP ICE skin irritation 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | Viability | 14.67 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=4832; Record_ID=skin_irritation_invitro_1212; Data_Type=In Vitro; Formulation_Name=Linalol; Concentration=97; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=EpiSkin Irritation; Endpoint=Viability; Response=14.67; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin irritation | Viability | 5.31 | % | - | Dermal | - | In Vitro; EpiSkin Irritation | sheet=Data_invitro; excel_row=4836; Record_ID=skin_irritation_invitro_1210; Data_Type=In Vitro; Formulation_Name=Linalol; Concentration=97; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=EpiSkin Irritation; Endpoint=Viability; Response=5.31; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin irritation | Viability | 79.3 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=4840; Record_ID=skin_irritation_invitro_1218; Data_Type=In Vitro; Formulation_Name=Linalol; Concentration=97; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=EpiDerm Irritation; Endpoint=Viability; Response=79.3; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin irritation | Viability | 71.5 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=4841; Record_ID=skin_irritation_invitro_1216; Data_Type=In Vitro; Formulation_Name=Linalol; Concentration=97; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=EpiDerm Irritation; Endpoint=Viability; Response=71.5; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin irritation | Viability | 68.5 | % | - | Dermal | - | In Vitro; EpiDerm Irritation | sheet=Data_invitro; excel_row=4842; Record_ID=skin_irritation_invitro_1214; Data_Type=In Vitro; Formulation_Name=Linalol; Concentration=97; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=EpiDerm Irritation; Endpoint=Viability; Response=68.5; Response_Unit=%; Reference=Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin irritation | Viability (18 hours) | 5.1 | % | - | Dermal | - | In Vitro; Vitrolife-Skin Irritation | sheet=Data_invitro; excel_row=4831; Record_ID=skin_irritation_invitro_221; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (18 hours); Response=5.1; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin irritation | Viability (42 hours) | 2.7 | % | - | Dermal | - | In Vitro; Vitrolife-Skin Irritation | sheet=Data_invitro; excel_row=4834; Record_ID=skin_irritation_invitro_221; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (42 hours); Response=2.7; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
NTP ICE skin sensitization 25 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD54, EC200 | 68.3 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2141; Record_ID=skin_sensitization_invitro_530; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=68.3; Reported_Response_Unit=ug/mL; Response=68.3; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | CD86, EC150 | 94.804 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8204; Record_ID=skin_sensitization_invitro_2227; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=614.6; Reported_Response_Unit=uM; Conversion_Factor_Value=154.253; Conversion_Factor_Source=EPA Dashboard; Converted_Response=94.804; Converted_Response_Unit=ug/mL; Response=94.804; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | CD86, EC150 | 41.39 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8623; Record_ID=skin_sensitization_invitro_2384; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=41.39; Reported_Response_Unit=ug/mL; Response=41.39; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | CV70 | >200 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8622; Record_ID=skin_sensitization_invitro_2384; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=U-SENS; Endpoint=CV70; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | CV75 | 290 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2142; Record_ID=skin_sensitization_invitro_530; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=h-CLAT; Endpoint=CV75; Reported_Response=290; Reported_Response_Unit=ug/mL; Response=290; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | Depletion Cys | 1.3 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=766; Record_ID=skin_sensitization_invitro_215; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=1.3; Reported_Response_Unit=%; Response=1.3; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | Depletion Cys | 0 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=770; Record_ID=skin_sensitization_invitro_216; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | Depletion Lys | 1.4 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=765; Record_ID=skin_sensitization_invitro_215; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=1.4; Reported_Response_Unit=%; Response=1.4; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | Depletion Lys | 7.9 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=769; Record_ID=skin_sensitization_invitro_216; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=7.9; Reported_Response_Unit=%; Response=7.9; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 1.35 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=767; Record_ID=skin_sensitization_invitro_215; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=1.35; Reported_Response_Unit=%; Response=1.35; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 3.95 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=771; Record_ID=skin_sensitization_invitro_216; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=3.95; Reported_Response_Unit=%; Response=3.95; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | EC1.5 | >2000 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6753; Record_ID=skin_sensitization_invitro_1610; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | EC3 | 55 | % | Mouse | Dermal | - | In Vivo; Urbisch_SkinSensitization2020; LLNA | sheet=Data_invivo; excel_row=12899; Record_ID=skin_sensitization_invivo_2835; Data_Type=In Vivo; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=LLNA; Endpoint=EC3; Response=55; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | EC3 | 30 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13421; Record_ID=skin_sensitization_invivo_3564; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=LLNA; Endpoint=EC3; Response=30; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | EC3 | 30 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13421; Record_ID=skin_sensitization_invivo_3564; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=LLNA; Endpoint=EC3; Response=30; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | EC3 | 30 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13421; Record_ID=skin_sensitization_invivo_3564; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=LLNA; Endpoint=EC3; Response=30; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | EC3 | 30 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13421; Record_ID=skin_sensitization_invivo_3564; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=LLNA; Endpoint=EC3; Response=30; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | Imax | 1.22 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6759; Record_ID=skin_sensitization_invitro_1610; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.22; Reported_Response_Unit=Unitless; Response=1.22; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10317; Record_ID=skin_sensitization_invivo_2270; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1975; Not available; 10.1016/0015-6264(75)90239-4|Bickers et al. 2003; 12804649; 10.1016/S0278-6915(03)00016-4|Hostynek and Maibach 2003; Not available; 10.1159/000078688|Letizia et al. 2003; 12804650; 10.1016/S0278-6915(03)00015-2|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Api et al. 2015; 25637759; 10.1016/j.fct.2015.01.005|Api et al. 2016; 27663839; 10.1016/j.fct.2016.09.024; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | Induction dose per skin area | 4966 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10315; Record_ID=skin_sensitization_invivo_2270; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=4966; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1975; Not available; 10.1016/0015-6264(75)90239-4|Bickers et al. 2003; 12804649; 10.1016/S0278-6915(03)00016-4|Hostynek and Maibach 2003; Not available; 10.1159/000078688|Letizia et al. 2003; 12804650; 10.1016/S0278-6915(03)00015-2|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Api et al. 2015; 25637759; 10.1016/j.fct.2015.01.005|Api et al. 2016; 27663839; 10.1016/j.fct.2016.09.024; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | Induction dose per skin area | 5184 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10322; Record_ID=skin_sensitization_invivo_2271; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=5184; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80069-7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | Induction dose per skin area | 12960 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10328; Record_ID=skin_sensitization_invivo_2272; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=12960; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1970: report to RIFM|RIFM 1970; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1975; Not available; 10.1016/0015-6264(75)90239-4|Bickers et al. 2003; 12804649; 10.1016/S0278-6915(03)00016-4|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | Induction dose per skin area | 15000 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=10334; Record_ID=skin_sensitization_invivo_2273; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.7; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=15000; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 2005; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Lapczynski et al. 2008; 19097259; 10.1016/j.fct.2008.06.087|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Api et al. 2015; 25637759; 10.1016/j.fct.2015.01.005|Api et al. 2016; 27663839; 10.1016/j.fct.2016.09.024; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | Relative reliability score | 2 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10321; Record_ID=skin_sensitization_invivo_2270; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1975; Not available; 10.1016/0015-6264(75)90239-4|Bickers et al. 2003; 12804649; 10.1016/S0278-6915(03)00016-4|Hostynek and Maibach 2003; Not available; 10.1159/000078688|Letizia et al. 2003; 12804650; 10.1016/S0278-6915(03)00015-2|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Belsito et al. 2008; 18655821; 10.1016/j.fct.2008.06.085|Api et al. 2015; 25637759; 10.1016/j.fct.2015.01.005|Api et al. 2016; 27663839; 10.1016/j.fct.2016.09.024; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10326; Record_ID=skin_sensitization_invivo_2271; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7025502; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1976; Not available; 10.1016/S0015-6264(76)80069-7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025502; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7025502 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =24.58 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633060:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c31fa5f49abf4a86b6c0fe83f20e334a |
ToxValDB HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HESS | NOAEL | =160 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0de5e4b0a676289de443; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Deaths|Blood Chemistry: TP increase, Alb increase, Ca increase, Glu decrease|Absolute Organ Weight: Liver increase, Kidney increase|Necropsy: Liver: Thickened lobes Kidney: Pale area Stomach: thickened mucosa|Histopathology: Liver: Hepatocellular cytoplasmic vacuolation Kidney: Degeneration, cortex Stomach: Erosion Stomach: Subacute inflammation Stomach: Acanthosis; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|gross pathology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=HESS:15638570:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8d69cdbb05443b9a111c395f3be98bf3 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | D81QY6I88E | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"D81QY6I88E"} |
| openFDA substances | FDA UNII substance identifier | D81QY6I88E | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"D81QY6I88E"} |
| openFDA substances | FDA UNII substance identifier | D81QY6I88E | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"D81QY6I88E"} |
| openFDA substances | FDA UNII substance identifier | D81QY6I88E | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"D81QY6I88E"} |