NOAEL Studies Fragrance

Limonene NOAEL Studies

INCI: LIMONENE

CAS: 5989-27-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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EFSA 14 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =215 mg/kg bw/day Rat oral: gavage 721 days chronic/long term toxicity EFSA CEF - 2011 - OutputID 2102 - mortality - systemic - Scientific Opinion on Flavouring Group Evaluation 25, Revision 2 (FGE.25Rev2): Aliphatic and aromatic hydrocarbons from chemical group 31 - doi:10.2903/j.efsa.2011.2177
EFSA NOAEL =215 mg/kg bw/day Rat oral: gavage 721 days chronic/long term toxicity EFSA CEF - 2011 - OutputID 2102 - mortality - systemic - Scientific Opinion on Flavouring Group Evaluation 25, Revision 2 (FGE.25Rev2): Aliphatic and aromatic hydrocarbons from chemical group 31 - doi:10.2903/j.efsa.2011.2177
EFSA NOAEL =215 mg/kg bw/day Rat oral: gavage 721 days chronic/long term toxicity EFSA CEF - 2011 - OutputID 2102 - mortality - systemic - Scientific Opinion on Flavouring Group Evaluation 25, Revision 2 (FGE.25Rev2): Aliphatic and aromatic hydrocarbons from chemical group 31 - doi:10.2903/j.efsa.2011.2177
EFSA NOAEL =215 mg/kg bw/day Rat oral: gavage 721 days chronic/long term toxicity EFSA CEF - 2011 - OutputID 2102 - mortality - systemic - Scientific Opinion on Flavouring Group Evaluation 25, Revision 2 (FGE.25Rev2): Aliphatic and aromatic hydrocarbons from chemical group 31 - doi:10.2903/j.efsa.2011.2177
EFSA NOAEL =250 mg/kg bw/day Mouse - - - EFSA FEEDAP - 2015 - OutputID 2784 - gross pathology - hepatotoxicity - Scientific Opinion on the safety and efficacy of aliphatic and aromatic hydrocarbons (chemical group 31) when used as flavourings for all animal species - doi:10.2903/j.efsa.2015.4053
EFSA NOAEL =250 mg/kg bw/day Mouse - - - EFSA FEEDAP - 2015 - OutputID 2784 - gross pathology - hepatotoxicity - Scientific Opinion on the safety and efficacy of aliphatic and aromatic hydrocarbons (chemical group 31) when used as flavourings for all animal species - doi:10.2903/j.efsa.2015.4053
EFSA NOEL =10 mg/kg bw/day Rat - 91 days subchronic EFSA CONTAM - 2012 - OutputID 602 - histopathology non neoplastic - hepatotoxicity - Scientific Opinion on the evaluation of the substances currently on the list in the annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part II of III - doi:10.2903/j.efsa.2012.2703
EFSA NOEL =10 mg/kg bw/day Rat - 91 days subchronic EFSA CONTAM - 2012 - OutputID 602 - histopathology non neoplastic - hepatotoxicity - Scientific Opinion on the evaluation of the substances currently on the list in the annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part II of III - doi:10.2903/j.efsa.2012.2703
EFSA NOAEL =60 mg/kg bw/day Rat - - reproduction toxicity ENDPOINTSTUDY_ID 697582; TOX_ID 8346 - OP_ID 2558 - EFSA - 2014 - Conclusion on the peer review of the pesticide risk assessment of the active substance terpenoid blend QRD-460 - doi:10.2903/j.efsa.2014.3816
EFSA NOAEL =60 mg/kg bw/day Rat - - reproduction toxicity ENDPOINTSTUDY_ID 697582; TOX_ID 8346 - OP_ID 2558 - EFSA - 2014 - Conclusion on the peer review of the pesticide risk assessment of the active substance terpenoid blend QRD-460 - doi:10.2903/j.efsa.2014.3816
EFSA NOAEL =215 mg/kg bw/day Rat oral chronic; 103 weeks chronic LONG_REF=EFSA CEF (2011). Scientific Opinion on Flavouring Group Evaluation 25, Revision 2 (FGE.25Rev2): Aliphatic and aromatic hydrocarbons from chemical group 31. doi:10.2903/j.efsa.2011.2177.; TITLE=Scientific Opinion on Flavouring Group Evaluation 25, Revision 2 (FGE.25Rev2): Aliphatic and aromatic hydrocarbons from chemical group 31; AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2011.2177; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=EFSA_dup_-_15622267_15622268:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_31ff217fa3af8035d9b7fa58a91c84ae
EFSA NOAEL =215 mg/kg bw/day Mouse injection - repeat dose other LONG_REF=EFSA CEF (2011). Scientific Opinion on Flavouring Group Evaluation 78, Revision 1 (FGE.78Rev1): Consideration of aliphatic and alicyclic and aromatic hydrocarbons evaluated by JECFA (63rd meeting) structurally related to aliphatic and aromatic hydrocarbons evaluated by EFSA in FGE.25Rev2. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF). doi:10.2903/j.efsa.2011.2178.; TITLE=Scientific Opinion on Flavouring Group Evaluation 78, Revision 1 (FGE.78Rev1): Consideration of aliphatic and alicyclic and aromatic hydrocarbons evaluated by JECFA (63rd meeting) structurally related to aliphatic and aromatic hydrocarbons evaluated by EFSA in FGE.25Rev2. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2011.2178; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2011; ORIGINAL_YEAR=2011; STUDY_GROUP=EFSA:15621552:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a7144e8e11664154e3b5332c69f575dd
EFSA NOAEL =250 mg/kg bw/day Mouse oral - repeat dose other LONG_REF=EFSA FEEDAP (2015). Scientific Opinion on the safety and efficacy of aliphatic and aromatic hydrocarbons (chemical group 31) when used as flavourings for all animal species. doi:10.2903/j.efsa.2015.4053.; TITLE=Scientific Opinion on the safety and efficacy of aliphatic and aromatic hydrocarbons (chemical group 31) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2015.4053; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=gross pathology; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=EFSA:15621554:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6b299f067e7c30bd370b179e38a66a6f
EFSA NOEL =10 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=EFSA CONTAM (2012). Scientific Opinion on the evaluation of the substances currently on the list in the annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part II of III. doi:10.2903/j.efsa.2012.2703.; TITLE=Scientific Opinion on the evaluation of the substances currently on the list in the annex to Commission Directive 96/3/EC as acceptable previous cargoes for edible fats and oils - Part II of III; AUTHOR=EFSA CONTAM; DOI=doi:10.2903/j.efsa.2012.2703; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; STUDY_GROUP=EFSA:15622269:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_73a0f1c3c2f98e8d80af1c73cd77148c
IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1998 IARC Monographs {"additional_info":"NB Overall evaluation downgraded to Group 3 with supporting evidence from other relevant data; volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"56, 73"}
WHO/JECFA 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
WHO/JECFA NOEL =10 mg/kg bw/day - - - Toxicology study document_id=cicads_cicads_cicad05; title=Limonene (CICADS); path=mirror/documents/cicads/cicads/cicad05.htm; row_hash=62e144bd6af9eed5; raw_unit=mg/kg body weight; context=The NOEL for effects in the liver was 10 mg/kg body weight; the no-observed-adverse-effect level (NOAEL) for effects in the liver was 30 mg/kg body weight per day.
WHO/JECFA NOEL =0.1 mg/kg bw/day Human oral - Toxicology study document_id=cicads_cicads_cicad05; title=Limonene (CICADS); path=mirror/documents/cicads/cicads/cicad05.htm; row_hash=bb804d8d0d12ba5c; raw_unit=mg/kg body weight per day; context=Using uncertainty factors of 10 for intraspecies differences and 10 for interspecies differences, a tolerable intake for ingestion of d- limonene by humans of 0.1 mg/kg body weight per day may be calculated from the NOEL.
WHO/JECFA ADI range:0-1.51.5 mg/kg bw/day Rat; Mouse; Rabbit - - Health guidance value document_id=jecfa_jecmono_v30je05; title=750. Limonene (WHO Food Additives Series 30); path=mirror/documents/jecfa/jecmono/v30je05.htm; row_hash=51cac6dfc1865336; raw_unit=mg/kg bw; context=EVALUATION Based on the significant decreases in body weight gain associated with administration of d- limonene to male and female mice and rats and female rabbits, an ADI of 0-1.5 mg/kg bw was established for this substance.
WHO/JECFA ADI range:0-1.51.5 mg/kg bw/day Rat; Mouse; Rabbit - - Health guidance value document_id=jecfa_jecmono_v30je05; title=750. Limonene (WHO Food Additives Series 30); path=mirror/documents/jecfa/jecmono/v30je05.htm; row_hash=51cac6dfc1865336; raw_unit=mg/kg bw; context=EVALUATION Based on the significant decreases in body weight gain associated with administration of d- limonene to male and female mice and rats and female rabbits, an ADI of 0-1.5 mg/kg bw was established for this substance.
WHO/JECFA LOEL =75 mg/kg bw/day Rat oral 21-day Toxicology study document_id=jecfa_jecmono_v30je05; title=750. Limonene (WHO Food Additives Series 30); path=mirror/documents/jecfa/jecmono/v30je05.htm; row_hash=dbcd4b592496e779; raw_unit=mg/kg bw/day; context=A NOEL for the d- limonene-associated increase in alpha 2u -globulin levels in male rat kidney has not been identified, but the lowest-observed-effect level from a 21-day gavage study of d- limonene in male rats was 75 mg/kg bw/day.
WHO/JECFA LOEL =75 mg/kg bw/day Rat oral 21-day Toxicology study document_id=jecfa_jecmono_v30je05; title=750. Limonene (WHO Food Additives Series 30); path=mirror/documents/jecfa/jecmono/v30je05.htm; row_hash=dbcd4b592496e779; raw_unit=mg/kg bw/day; context=A NOEL for the d- limonene-associated increase in alpha 2u -globulin levels in male rat kidney has not been identified, but the lowest-observed-effect level from a 21-day gavage study of d- limonene in male rats was 75 mg/kg bw/day.
WHO/JECFA NOEL =250 mg/kg bw/day Mouse oral 2 years Chronic toxicity document_id=jecfa_jecmono_v30je05; title=750. Limonene (WHO Food Additives Series 30); path=mirror/documents/jecfa/jecmono/v30je05.htm; row_hash=99bfc6a60c9ca48a; raw_unit=mg/kg bw/day; context=The NOEL for these effects was 250 mg/kg bw/day administered by gavage to male mice for 2 years.
WHO/JECFA NOEL =250 mg/kg bw/day Mouse oral 2 years Chronic toxicity document_id=jecfa_jecmono_v30je05; title=750. Limonene (WHO Food Additives Series 30); path=mirror/documents/jecfa/jecmono/v30je05.htm; row_hash=99bfc6a60c9ca48a; raw_unit=mg/kg bw/day; context=The NOEL for these effects was 250 mg/kg bw/day administered by gavage to male mice for 2 years.
NTP ICE acute oral 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =5300 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_2482; row=4294; data_type=In Vivo; mixture=Chemical; chemical_name=Limonene; preferred_name=Limonene; dtxsid=DTXSID2029612; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029612; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =5000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_2480; row=4295; data_type=In Vivo; mixture=Chemical; chemical_name=Limonene; preferred_name=Limonene; dtxsid=DTXSID2029612; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029612; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =4400 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_8184; row=2081; data_type=In Vivo; mixture=Chemical; chemical_name=D-Limonene; preferred_name=D-Limonene; dtxsid=DTXSID1020778; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020778; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =5000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_8186; row=2080; data_type=In Vivo; mixture=Chemical; chemical_name=D-Limonene; preferred_name=D-Limonene; dtxsid=DTXSID1020778; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID1020778; source_file=acute_oral.xlsx
NTP ICE cancer 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=1370; Record_ID=cancer_2568; Data_Type=WOE; Formulation_Name=D-Limonene; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/74; http://publications.iarc.fr/91; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE cancer Top dose 150 mg/kg bw/day Rat Gavage - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=1371; Record_ID=cancer_2567; Data_Type=In Vivo; Formulation_Name=d-Limonene; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=150; Response_Unit=mg/kg/day; Species=Rat; Strain=F344/N; Sex=Male; Route=Gavage; Reference=TR-347; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr347/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE cancer Top dose 500 mg/kg bw/day Mouse Gavage - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=1375; Record_ID=cancer_2565; Data_Type=In Vivo; Formulation_Name=d-Limonene; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=500; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Gavage; Reference=TR-347; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr347/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE cancer Top dose 600 mg/kg bw/day Rat Gavage - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=1367; Record_ID=cancer_2570; Data_Type=In Vivo; Formulation_Name=d-Limonene; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=600; Response_Unit=mg/kg/day; Species=Rat; Strain=F344/N; Sex=Female; Route=Gavage; Reference=TR-347; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr347/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE cancer Top dose 1000 mg/kg bw/day Mouse Gavage - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=1373; Record_ID=cancer_2566; Data_Type=In Vivo; Formulation_Name=d-Limonene; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=1000; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Gavage; Reference=TR-347; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr347/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE dart 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE dart LOEL 500 mg/kg bw/day Rat Oral - In Vivo; DART, Developmental malformation sheet=Data; excel_row=42036; Record_ID=dart_11659; Data_Type=In Vivo; DTXSID=DTXSID2029612; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=500; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C1883702;CUI;Supernumerary; Reference=ToxRefDB v2 , ID = 465; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029612
NTP ICE dart LOEL 500 mg/kg bw/day Rat Oral - In Vivo; DART, In life observation sheet=Data; excel_row=42037; Record_ID=dart_11654; Data_Type=In Vivo; DTXSID=DTXSID2029612; Assay=DART, In life observation; Endpoint=LOEL; Response=500; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0043094;CUI;Weight Gain; Reference=ToxRefDB v2 , ID = 465; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029612
NTP ICE dart LOEL 500 mg/kg bw/day Rat Oral - In Vivo; DART, Developmental malformation sheet=Data; excel_row=42038; Record_ID=dart_11657; Data_Type=In Vivo; DTXSID=DTXSID2029612; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=500; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C0000846;CUI;Agenesis; Reference=ToxRefDB v2 , ID = 465; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029612
NTP ICE dart LOEL 500 mg/kg bw/day Rat Oral - In Vivo; DART, Developmental malformation sheet=Data; excel_row=42039; Record_ID=dart_11658; Data_Type=In Vivo; DTXSID=DTXSID2029612; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=500; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C1883702;CUI;Supernumerary; Reference=ToxRefDB v2 , ID = 465; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029612
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=11014; RecordID=ARPathway2016_816; DatasetName=ARPathway2016; DTXSID=DTXSID2029612; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029612
NTP ICE skin irritation 28 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin irritation ET50 39.8 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=867; Record_ID=skin_irritation_invitro_1562; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=ET50; Response=39.8; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation ET50 47.6 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=868; Record_ID=skin_irritation_invitro_1564; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=ET50; Response=47.6; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation ET50 52.5 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=869; Record_ID=skin_irritation_invitro_1566; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=ET50; Response=52.5; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation ET50 74.8 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=861; Record_ID=skin_irritation_invitro_1522; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=ET50; Response=74.8; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation ET50 76.2 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=862; Record_ID=skin_irritation_invitro_1525; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=ET50; Response=76.2; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation ET50 95.8 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=863; Record_ID=skin_irritation_invitro_1527; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=ET50; Response=95.8; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation ET50 142 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=864; Record_ID=skin_irritation_invitro_1529; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=ET50; Response=142; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation ET50 224 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=865; Record_ID=skin_irritation_invitro_1531; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=ET50; Response=224; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation ET50 258 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=866; Record_ID=skin_irritation_invitro_1533; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=ET50; Response=258; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation Viability 5.9 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=870; Record_ID=skin_irritation_invitro_1036; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiSkin Irritation; Endpoint=Viability; Response=5.9; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation Viability 7.3 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=871; Record_ID=skin_irritation_invitro_1038; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiSkin Irritation; Endpoint=Viability; Response=7.3; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation Viability 8.1 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=898; Record_ID=skin_irritation_invitro_1047; Data_Type=In Vitro; Formulation_Name=d-Limonene; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=Viability; Response=8.1; Response_Unit=%; Reference=Zuang et al. 2002; 11827575; 10.1177/026119290203000110; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation Viability 8.2 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=899; Record_ID=skin_irritation_invitro_1049; Data_Type=In Vitro; Formulation_Name=d-Limonene; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=Viability; Response=8.20; Response_Unit=%; Reference=Zuang et al. 2002; 11827575; 10.1177/026119290203000110; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation Viability 8.4 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=900; Record_ID=skin_irritation_invitro_1052; Data_Type=In Vitro; Formulation_Name=d-Limonene; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=Viability; Response=8.4; Response_Unit=%; Reference=Zuang et al. 2002; 11827575; 10.1177/026119290203000110; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation Viability 10.4 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=910; Record_ID=skin_irritation_invitro_1024; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=Viability; Response=10.4; Response_Unit=%; Reference=Kandarova et al. 2004; 15329774; Not available|Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation Viability 12.8 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=894; Record_ID=skin_irritation_invitro_1039; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiSkin Irritation; Endpoint=Viability; Response=12.8; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation Viability 13.3 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=895; Record_ID=skin_irritation_invitro_1041; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiSkin Irritation; Endpoint=Viability; Response=13.3; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation Viability 13.8 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=896; Record_ID=skin_irritation_invitro_1043; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiSkin Irritation; Endpoint=Viability; Response=13.8; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation Viability 14 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=897; Record_ID=skin_irritation_invitro_1045; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiSkin Irritation; Endpoint=Viability; Response=14; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation Viability 15 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=911; Record_ID=skin_irritation_invitro_1026; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=Viability; Response=15; Response_Unit=%; Reference=Kandarova et al. 2004; 15329774; Not available|Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation Viability 18.63 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=908; Record_ID=skin_irritation_invitro_1020; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiSkin Irritation; Endpoint=Viability; Response=18.63; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation Viability 23.6 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=912; Record_ID=skin_irritation_invitro_1028; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiDerm Irritation; Endpoint=Viability; Response=23.6; Response_Unit=%; Reference=Kandarova et al. 2004; 15329774; Not available|Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation Viability 33.14 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=857; Record_ID=skin_irritation_invitro_1022; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiSkin Irritation; Endpoint=Viability; Response=33.14; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation Viability 35 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=858; Record_ID=skin_irritation_invitro_1030; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiSkin Irritation; Endpoint=Viability; Response=35; Response_Unit=%; Reference=Portes et al. 2002; 12423661; 10.1016/s0887-2333(02)00090-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation Viability 68.7 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=859; Record_ID=skin_irritation_invitro_1032; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiSkin Irritation; Endpoint=Viability; Response=68.7; Response_Unit=%; Reference=Portes et al. 2002; 12423661; 10.1016/s0887-2333(02)00090-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation Viability 92.3 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=860; Record_ID=skin_irritation_invitro_1034; Data_Type=In Vitro; Formulation_Name=d-Limonene; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=EpiSkin Irritation; Endpoint=Viability; Response=92.3; Response_Unit=%; Reference=Portes et al. 2002; 12423661; 10.1016/s0887-2333(02)00090-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation Viability (18 hours) 51 % - Dermal - In Vitro; Vitrolife-Skin Irritation sheet=Data_invitro; excel_row=901; Record_ID=skin_irritation_invitro_211; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (18 hours); Response=51; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin irritation Viability (42 hours) 25.5 % - Dermal - In Vitro; Vitrolife-Skin Irritation sheet=Data_invitro; excel_row=906; Record_ID=skin_irritation_invitro_211; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (42 hours); Response=25.5; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin sensitization 20 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization CD54, EC200 216.7 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; h-CLAT sheet=Data_invitro; excel_row=1731; Record_ID=skin_sensitization_invitro_443; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=216.7; Reported_Response_Unit=ug/mL; Response=216.7; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin sensitization CD86, EC150 30.03 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8676; Record_ID=skin_sensitization_invitro_2401; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=30.03; Reported_Response_Unit=ug/mL; Response=30.03; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin sensitization CD86, EC150 278 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; h-CLAT sheet=Data_invitro; excel_row=1698; Record_ID=skin_sensitization_invitro_443; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=278; Reported_Response_Unit=ug/mL; Response=278; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin sensitization CV70 >200 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8675; Record_ID=skin_sensitization_invitro_2401; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=U-SENS; Endpoint=CV70; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin sensitization CV75 736.6 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; h-CLAT sheet=Data_invitro; excel_row=1712; Record_ID=skin_sensitization_invitro_443; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=h-CLAT; Endpoint=CV75; Reported_Response=736.6; Reported_Response_Unit=ug/mL; Response=736.6; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin sensitization Depletion Cys 18.6 % - Dermal - In Vitro; Urbisch_SkinSensitization2020; DPRA sheet=Data_invitro; excel_row=264; Record_ID=skin_sensitization_invitro_76; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=18.6; Reported_Response_Unit=%; Response=18.6; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin sensitization Depletion Lys 0 % - Dermal - In Vitro; Urbisch_SkinSensitization2020; DPRA sheet=Data_invitro; excel_row=235; Record_ID=skin_sensitization_invitro_76; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin sensitization EC1.5 >2000 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=6264; Record_ID=skin_sensitization_invitro_1479; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin sensitization EC1.5 4000 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; KeratinoSens sheet=Data_invitro; excel_row=6266; Record_ID=skin_sensitization_invitro_1480; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=4000; Reported_Response_Unit=uM; Response=4000; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin sensitization EC3 69 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13420; Record_ID=skin_sensitization_invivo_3563; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=LLNA; Endpoint=EC3; Response=69; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin sensitization EC3 69 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13420; Record_ID=skin_sensitization_invivo_3563; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=LLNA; Endpoint=EC3; Response=69; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin sensitization EC3 69 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13420; Record_ID=skin_sensitization_invivo_3563; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=LLNA; Endpoint=EC3; Response=69; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin sensitization EC3 69 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13420; Record_ID=skin_sensitization_invivo_3563; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=LLNA; Endpoint=EC3; Response=69; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin sensitization IC50 82.27 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; KeratinoSens sheet=Data_invitro; excel_row=6272; Record_ID=skin_sensitization_invitro_1480; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=82.26686357; Reported_Response_Unit=uM; Response=82.27; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin sensitization IC50 118.1 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=6270; Record_ID=skin_sensitization_invitro_1479; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=118.1; Reported_Response_Unit=uM; Response=118.1; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin sensitization Imax 1.14 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=6274; Record_ID=skin_sensitization_invitro_1479; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1399999999999999; Reported_Response_Unit=Unitless; Response=1.14; Response_Unit=Ratio; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin sensitization Imax 1.205 ratio - Dermal - In Vitro; Urbisch_SkinSensitization2020; KeratinoSens sheet=Data_invitro; excel_row=6276; Record_ID=skin_sensitization_invitro_1480; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.205020865; Reported_Response_Unit=Unitless; Response=1.205; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=8713; Record_ID=skin_sensitization_invivo_1950; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1975; Not available; 10.1016/0015-6264(75)90238-2|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin sensitization Induction dose per skin area 4966 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=8711; Record_ID=skin_sensitization_invivo_1950; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=4966; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1975; Not available; 10.1016/0015-6264(75)90238-2|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
NTP ICE skin sensitization Relative reliability score 2 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=8718; Record_ID=skin_sensitization_invivo_1950; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1020778; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Greif 1967; Not available; Not available|Opdyke 1975; Not available; 10.1016/0015-6264(75)90238-2|Api et al. 2008; 18406028; 10.1016/j.yrtph.2007.10.008|Api et al. 2015; 25430073; 10.3109/15569527.2014.979425; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1020778; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID1020778
EPA ToxRefDB v3 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EPA ToxRefDB v3 LEL =500 mg/kg bw/day rat (sprague dawley; Sprague Dawley (CD)) oral 6 GD to 15 GD DEV study_id=465; toxval_study_source_id=studyid465_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-clinical signs-salivation|in life observation-food consumption-food consumption; dose_level=2; study_year=1992; study_citation=Hoberman, A. (1992) Developmental Toxicity (Embryo-Fetal Toxicity and Teratogenic Potential) Study of D-Limonene Technical Administered Orally Via Gavage to Crl:CD BR VAF/Plus Presumed Pregnant Rats. Final Report. Lab Project Number: 2119-001. Unpublished; dsstox_substance_id=DTXSID2029612; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =75 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 103 week CHR study_id=7416; toxval_study_source_id=studyid7416_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-kidney-hyperplasia|pathology microscopic-kidney-mineralization|pathology microscopic-kidney-nephropathy|pathology microscopic-kidney-adenoma/carcinoma combined|pathology microscopic-kidney-adenoma|in life observation-body weight-body weight; dose_level=1; study_year=1990; study_citation=Jameson CW (1990) TOXICOLOGY AND CARCINOGENESIS STUDIES OF d-LIMONENE (CAS NO. 5989-27-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 347, NIH Publication No. 90-2802. (Chronic rat); dsstox_substance_id=DTXSID1020778; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =600 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 103 week CHR study_id=7416; toxval_study_source_id=studyid7416_Adult_F0_F_systemic; toxval_effect_list=in life observation-mortality-mortality|in life observation-body weight-body weight; dose_level=4; study_year=1990; study_citation=Jameson CW (1990) TOXICOLOGY AND CARCINOGENESIS STUDIES OF d-LIMONENE (CAS NO. 5989-27-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 347, NIH Publication No. 90-2802. (Chronic rat); dsstox_substance_id=DTXSID1020778; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 LEL =1000 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 103 week CHR study_id=7415; toxval_study_source_id=studyid7415_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=3; study_year=1990; study_citation=Jameson CW (1990) TOXICOLOGY AND CARCINOGENESIS STUDIES OF d-LIMONENE (CAS NO. 5989-27-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 347, NIH Publication No. 90-2802. (Chronic mouse); dsstox_substance_id=DTXSID1020778; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NEL =250 mg/kg bw/day rat (sprague dawley; Sprague Dawley (CD)) oral 6 GD to 15 GD DEV study_id=465; toxval_study_source_id=studyid465_Adult_F0_F_systemic; toxval_effect_list=in life observation-food consumption-food consumption|in life observation-clinical signs-salivation|in life observation-body weight-body weight gain; dose_level=1; study_year=1992; study_citation=Hoberman, A. (1992) Developmental Toxicity (Embryo-Fetal Toxicity and Teratogenic Potential) Study of D-Limonene Technical Administered Orally Via Gavage to Crl:CD BR VAF/Plus Presumed Pregnant Rats. Final Report. Lab Project Number: 2119-001. Unpublished; dsstox_substance_id=DTXSID2029612; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NEL >0 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 103 week CHR study_id=7416; toxval_study_source_id=studyid7416_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-kidney-adenoma/carcinoma combined|pathology microscopic-kidney-nephropathy|pathology microscopic-kidney-adenoma|in life observation-body weight-body weight|pathology microscopic-kidney-mineralization|pathology microscopic-kidney-hyperplasia; dose_level=0; study_year=1990; study_citation=Jameson CW (1990) TOXICOLOGY AND CARCINOGENESIS STUDIES OF d-LIMONENE (CAS NO. 5989-27-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 347, NIH Publication No. 90-2802. (Chronic rat); dsstox_substance_id=DTXSID1020778; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NEL =250 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 103 week CHR study_id=7415; toxval_study_source_id=studyid7415_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-liver-multinucleated|pathology microscopic-liver-cytomegaly; dose_level=1; study_year=1990; study_citation=Jameson CW (1990) TOXICOLOGY AND CARCINOGENESIS STUDIES OF d-LIMONENE (CAS NO. 5989-27-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 347, NIH Publication No. 90-2802. (Chronic mouse); dsstox_substance_id=DTXSID1020778; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NEL =300 mg/kg bw/day rat (fischer; Fischer 344) oral 0 day to 103 week CHR study_id=7416; toxval_study_source_id=studyid7416_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-mortality-mortality; dose_level=3; study_year=1990; study_citation=Jameson CW (1990) TOXICOLOGY AND CARCINOGENESIS STUDIES OF d-LIMONENE (CAS NO. 5989-27-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 347, NIH Publication No. 90-2802. (Chronic rat); dsstox_substance_id=DTXSID1020778; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
EPA ToxRefDB v3 NEL =500 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 day to 103 week CHR study_id=7415; toxval_study_source_id=studyid7415_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=2; study_year=1990; study_citation=Jameson CW (1990) TOXICOLOGY AND CARCINOGENESIS STUDIES OF d-LIMONENE (CAS NO. 5989-27-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP TR 347, NIH Publication No. 90-2802. (Chronic mouse); dsstox_substance_id=DTXSID1020778; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ECHA 19 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL =30 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cab7e4b0a7c65d223234; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27274/7/6/2?documentUUID=05d136e2-1dab-4289-a837-60a2b39bed0b; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15836951_15842423_15847868_15848253:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_06b45b4b58ea3f52e125323888949b0c
ECHA LOAEL =1000 mg/kg bw/day Mouse oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc35e4b0a7c65d229728; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27274/7/6/2?documentUUID=05d136e2-1dab-4289-a837-60a2b39bed0b; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831207_15848173_15848768:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b4c4bab7085331ca95c1abccf04e168d
ECHA LOAEL =1200 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb02e4b0a7c65d224734; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27274/7/6/2?documentUUID=05d136e2-1dab-4289-a837-60a2b39bed0b; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832463_15847290_15848298:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1ac2b71139fe73e88f17f4c608d28f23
ECHA LOAEL =1650 mg/kg bw/day Rat oral short-term; 12 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca27e4b0a7c65d220922; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27274/7/6/2?documentUUID=05d136e2-1dab-4289-a837-60a2b39bed0b; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=body weight and weight gain|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832709_15832710_15839816:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_716eb6214608ca1b81e54a0568ef47ff
ECHA LOAEL =3000 mg/kg bw/day Dog oral chronic; 6 months chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca4fe4b0a7c65d2214f4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27274/7/6/2?documentUUID=05d136e2-1dab-4289-a837-60a2b39bed0b; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838793_15842492_15850617_15850618:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_52b3d27b32b9cef3b32ff578a90f937e
ECHA LOAEL =3300 mg/kg bw/day Mouse oral short-term; 12 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7caf2e4b0a7c65d2241b7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27274/7/6/2?documentUUID=05d136e2-1dab-4289-a837-60a2b39bed0b; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830046_15830047_15844787:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_35f091971bf938f0507c65d48a2e4a49
ECHA NOAEL =5 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb68e4b0a7c65d2260ca; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15256/7/6/2?documentUUID=95eae7f7-d100-400d-9f43-779d4b4ba3c2; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15836951_15842423_15847868_15848253:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2ed6d473e8e14ff9f366789c755ad717
ECHA NOAEL >=75 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216ec2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15256/7/8?documentUUID=95eae7f7-d100-400d-9f43-779d4b4ba3c2; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819966_15820520:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_53b685a173f5146dbcbd541a3b00df8b
ECHA NOAEL =100 mg/kg bw/day Dog oral chronic; 180 days chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb68e4b0a7c65d2260ee; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15256/7/6/2?documentUUID=95eae7f7-d100-400d-9f43-779d4b4ba3c2; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=- |organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=-|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15843767_15847179_15847651:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ee63a31be6ee2ed9aeb6be3cc8a88c52
ECHA NOAEL <=150 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216ec2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15256/7/8?documentUUID=95eae7f7-d100-400d-9f43-779d4b4ba3c2; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819966_15820520:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_70d22329dc7ae943ef4c385a0b6d78cd
ECHA NOAEL >=250 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216ec6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15256/7/8?documentUUID=95eae7f7-d100-400d-9f43-779d4b4ba3c2; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820033_15820521:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_35ad2ddd6042b4d8ab7a5d53f414292e
ECHA NOAEL >=300 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216ec2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15256/7/8?documentUUID=95eae7f7-d100-400d-9f43-779d4b4ba3c2; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819967_15820519:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3610f8e68601008613f514d1f74fae85
ECHA NOAEL =340 mg/kg bw/day Dog oral chronic; 6 months chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca4fe4b0a7c65d2214f4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27274/7/6/2?documentUUID=05d136e2-1dab-4289-a837-60a2b39bed0b; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838794_15842493_15850616:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6f54a5ca660d1e37861d95886e4d8dd8
ECHA NOAEL >=500 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216ec6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15256/7/8?documentUUID=95eae7f7-d100-400d-9f43-779d4b4ba3c2; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820034_15820522:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5054a9d415b305a868b31c411d3d9fe6
ECHA NOAEL =591 mg/kg bw/day Rat oral - reproduction developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1ece4b0a7c65d230ba5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15256/7/9/3?documentUUID=95eae7f7-d100-400d-9f43-779d4b4ba3c2; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15824983_15824984:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2b3654cac178fae3bae916ad14b4f92d
ECHA NOAEL <=600 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216ec2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15256/7/8?documentUUID=95eae7f7-d100-400d-9f43-779d4b4ba3c2; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819967_15820519:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_93eb2f3fa1de3279d79101f542a80169
ECHA NOAEL =825 mg/kg bw/day Rat oral short-term; 12 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca27e4b0a7c65d220922; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27274/7/6/2?documentUUID=05d136e2-1dab-4289-a837-60a2b39bed0b; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15832709_15832710_15839816:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_70db390c0937fdcdb8ea5e48166ff471
ECHA NOAEL <=1000 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216ec6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15256/7/8?documentUUID=95eae7f7-d100-400d-9f43-779d4b4ba3c2; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820034_15820522:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_449fecd245494677f64e4d85b83a45d4
ECHA NOAEL =1650 mg/kg bw/day Mouse oral short-term; 12 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7caf2e4b0a7c65d2241b7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27274/7/6/2?documentUUID=05d136e2-1dab-4289-a837-60a2b39bed0b; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830046_15830047_15844787:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5ccf0bb3cafaed73c29c6de6b68cf297
ToxValDB ECOTOX 29 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ECOTOX LOEL =25 mg/kg bw/day Rat injection acute; 0.0208 days acute LONG_REF=PTR. Phytother.Res.8(5): 305-307 Trabace,L., P. Avato, M. Mazzoccoli, and G. Siro-Brigiani Choleretic Activity of Thapsia Chem I, II, and III in Rats: Comparison with Terpenoid Constituents and Peppermint Oil 1994; TITLE=Choleretic Activity of Thapsia Chem I, II, and III in Rats: Comparison with Terpenoid Constituents and Peppermint Oil; AUTHOR=Trabace,L., P. Avato, M. Mazzoccoli, and G. Siro-Brigiani; DOI=10.1002/ptr.2650080511; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=105648; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Physiology: Secretion; STUDY_GROUP=ECOTOX:15595421:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1bd2fa404fea64808ab6a6807253d9bd
ToxValDB ECOTOX LOEL =3 mmol/kg Rat oral acute; 0.7083 days acute LONG_REF=Biochem. Pharmacol.29(15): 2125-2127 Clegg,R.J., B. Middleton, G.D. Bell, and D.A. White Inhibition of Hepatic Cholesterol Synthesis and S-3-Hydroxy-3-Methylglutaryl-CoA Reductase by Mono and Bicyclic Monoterpenes Administered In Vivo 1980; TITLE=Inhibition of Hepatic Cholesterol Synthesis and S-3-Hydroxy-3-Methylglutaryl-CoA Reductase by Mono and Bicyclic Monoterpenes Administered In Vivo; AUTHOR=Clegg,R.J., B. Middleton, G.D. Bell, and D.A. White; DOI=10.1016/0006-2952(80)90183-5; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=117777; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=Enzyme(s): beta-Hydroxy-beta-methylglutaryl-CoA reductase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15598230:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=39cdd1274220fec2035d596b4fd9ca8e
ToxValDB ECOTOX LOEL =0.0001193 mM Mouse oral short-term; 28 days short-term LONG_REF=J. Toxicol. Environ. Health20:51-66 Evans,D.L., D.M. Miller, K.L. Jacobsen, and P.B. Bush Modulation of Immune Responses in Mice by d-Limonene 1987; TITLE=Modulation of Immune Responses in Mice by d-Limonene; AUTHOR=Evans,D.L., D.M. Miller, K.L. Jacobsen, and P.B. Bush; DOI=10.1080/15287398709530961; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=86540; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Cell(s): T-cell; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600224_15605073:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=dd65a57272af37013504e43e6791df76
ToxValDB ECOTOX LOEL =0.2 mL Mouse dermal chronic; 224 days chronic LONG_REF=Carcinogenesis7(12): 2047-2049 Elegbede,J.A., T.H. Maltzman, A.K. Verma, M.A. Tanner, C.E. Elson, and M.N. Gould Mouse Skin Tumor Promoting Activity of Orange Peel Oil and d-Limonene: A Re-Evaluation 1986; TITLE=Mouse Skin Tumor Promoting Activity of Orange Peel Oil and d-Limonene: A Re-Evaluation; AUTHOR=Elegbede,J.A., T.H. Maltzman, A.K. Verma, M.A. Tanner, C.E. Elson, and M.N. Gould; DOI=10.1093/carcin/7.12.2047; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=117947; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Injury: Tumor induction; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECOTOX:15609501:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1791324fae290614bf6ccdc32f61be9c
ToxValDB ECOTOX LOEL =1 % Rat oral chronic; 168 days chronic LONG_REF=Jpn. J. Cancer Res.87(6): 589-594 Kimura,J., S. Takahashi, T. Ogiso, Y. Yoshida, K. Akagi, R. Hasegawa, M. Kurata, M. Hirose, and T. Shirai Lack of Chemoprevention Effects of the Monoterpene d-Limonene in a Rat Multi-Organ Carcinogenesis Model 1996; TITLE=Lack of Chemoprevention Effects of the Monoterpene d-Limonene in a Rat Multi-Organ Carcinogenesis Model; AUTHOR=Kimura,J., S. Takahashi, T. Ogiso, Y. Yoshida, K. Akagi, R. Hasegawa, M. Kurata, M. Hirose, and T. Shirai; DOI=10.1111/j.1349-7006.1996.tb00264.x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117948; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596647_15596648_15598118_15598119:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4e417694e1f94f35c0f652275bcabd68
ToxValDB ECOTOX LOEL =2 % Rat oral chronic; 168 days chronic LONG_REF=Jpn. J. Cancer Res.87(6): 589-594 Kimura,J., S. Takahashi, T. Ogiso, Y. Yoshida, K. Akagi, R. Hasegawa, M. Kurata, M. Hirose, and T. Shirai Lack of Chemoprevention Effects of the Monoterpene d-Limonene in a Rat Multi-Organ Carcinogenesis Model 1996; TITLE=Lack of Chemoprevention Effects of the Monoterpene d-Limonene in a Rat Multi-Organ Carcinogenesis Model; AUTHOR=Kimura,J., S. Takahashi, T. Ogiso, Y. Yoshida, K. Akagi, R. Hasegawa, M. Kurata, M. Hirose, and T. Shirai; DOI=10.1111/j.1349-7006.1996.tb00264.x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117948; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Growth: Weight|Histology: Lesions|Injury: Adenoma; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596647_15596648_15598118_15598119:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1abd477c21eb94bd1015b4502b34a6c4
ToxValDB ECOTOX LOEL =7.813 mM Mouse oral short-term; 24 days short-term LONG_REF=J. Toxicol. Environ. Health20:51-66 Evans,D.L., D.M. Miller, K.L. Jacobsen, and P.B. Bush Modulation of Immune Responses in Mice by d-Limonene 1987; TITLE=Modulation of Immune Responses in Mice by d-Limonene; AUTHOR=Evans,D.L., D.M. Miller, K.L. Jacobsen, and P.B. Bush; DOI=10.1080/15287398709530961; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=86540; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Immunological: Antibody titres; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596645_15596646_15599949:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1053df40e7df97a38bd0596be9e5682f
ToxValDB ECOTOX LOEL =28.8 mg/kg bw/day Rat oral short-term; 7 days subchronic LONG_REF=- | Toxicology303:133-138 Brott,D.A., P. Bentley, M.V.P. Nadella, D. Thurman, J. Fikes, L. Cheatham, F. McGrath, W. Luo, and L.B. Kinter Renal Biomarker Changes Associated with Hyaline Droplet Nephropathy in Rats are Time and Potentially Compound Dependent 2013; TITLE=Renal Biomarker Changes Associated with Hyaline Droplet Nephropathy in Rats are Time and Potentially Compound Dependent; AUTHOR=Brott,D.A., P. Bentley, M.V.P. Nadella, D. Thurman, J. Fikes, L. Cheatham, F. McGrath, W. Luo, and L.B. Kinter; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=160109; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=Abnormal kidney histopathology: hyalin droplet formation| mRNA expression of renal biomarkers; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX:15612935:M:-adult; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=7f0a031776c6b5fc4a6cef9cadae6407
ToxValDB ECOTOX LOEL =41 mg/kg bw/day Rat oral acute; 1 days acute LONG_REF=Toxicol. Appl. Pharmacol.99(2): 250-259 Lehman-McKeeman,L.D., P.A. Rodriguez, R. Takigiku, D. Caudill, and M.L. Fey d-Limonene-Induced Male Rat-Specific Nephrotoxicity: Evaluation of the Association Between d-Limonene and alpha 2u-Globulin 1989; TITLE=d-Limonene-Induced Male Rat-Specific Nephrotoxicity: Evaluation of the Association Between d-Limonene and alpha 2u-Globulin; AUTHOR=Lehman-McKeeman,L.D., P.A. Rodriguez, R. Takigiku, D. Caudill, and M.L. Fey; DOI=10.1016/0041-008x(89)90007-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=159983; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Histology: Cytoplasmic inclusions; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598377_15598378:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d889da77c870b084bae332258496f9a3
ToxValDB ECOTOX LOEL =50 mg/kg bw/day Rat oral acute; 1 days acute LONG_REF=Food Chem. Toxicol.31(1): 45-52 Jonker,D., M.A. Jones, P.J. Van Bladeren, R.A. Woutersen, H.P. Til, and V.J. Feron Acute (24 HR) Toxicity of a Combination of Four Nephrotoxicants in Rats Compared with the Toxicity of the Individual Compounds 1993; TITLE=Acute (24 HR) Toxicity of a Combination of Four Nephrotoxicants in Rats Compared with the Toxicity of the Individual Compounds; AUTHOR=Jonker,D., M.A. Jones, P.J. Van Bladeren, R.A. Woutersen, H.P. Til, and V.J. Feron; DOI=10.1016/0278-6915(93)90178-2; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=156124; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Histology: Proliferation; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604741_15604742_15604743_15608336:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=de75f0ec05f9b0f254669ee2e6c49649
ToxValDB ECOTOX LOEL =75 mg/kg bw/day Rat oral short-term; 21 days short-term LONG_REF=- | Natl. Toxicol. Program Tech. Rep. Ser.347:167 p. Jameson,C.W. Toxicology and Carcinogenesis Studies of d-Limonene in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1990; TITLE=Toxicology and Carcinogenesis Studies of d-Limonene in F344/N Rats and B6C3F1 Mice (Gavage Studies); AUTHOR=Jameson,C.W.; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=160004; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Biochemistry: Alpha 2u-globulin; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15613515:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=956ba73cc270bc802f6687e5c928a429
ToxValDB ECOTOX LOEL =85 mg/kg bw/day Rat oral acute; 0.125 days acute LONG_REF=Life Sci.19(10): 1559-1567 Kodama,R., H. Inoue, K. Noda, H. Ide, H. Yamamoto, S. Yoshihara, and H. Yoshimura Effect of d-Limonene and Related Compounds on Bile Flow and Biliary Lipid Composition in Rats and Dogs 1976; TITLE=Effect of d-Limonene and Related Compounds on Bile Flow and Biliary Lipid Composition in Rats and Dogs; AUTHOR=Kodama,R., H. Inoue, K. Noda, H. Ide, H. Yamamoto, S. Yoshihara, and H. Yoshimura; DOI=10.1016/0024-3205(76)90102-8; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=119044; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=Physiology: Fluid volume; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603191_15603192:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6cc5ed50175ca313ca4571b59b1544af
ToxValDB ECOTOX LOEL =100 mg/kg bw/day Rat oral subchronic; 45 days subchronic LONG_REF=- | Basic Clin. Pharmacol. Toxicol.112(3): 175-181 Murali,R., A. Karthikeyan, and R. Saravanan Protective Effects of d-Limonene on Lipid Peroxidation and Antioxidant Enzymes in Streptozotocin-Induced Diabetic Rats 2013; TITLE=Protective Effects of d-Limonene on Lipid Peroxidation and Antioxidant Enzymes in Streptozotocin-Induced Diabetic Rats; AUTHOR=Murali,R., A. Karthikeyan, and R. Saravanan; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=160154; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=ROS: Decreased plasma thiobarbituric acid reactive substances (TBARS)|ROS: Decreased plasma lipid hydroperoxides (LOOH)| ROS: Decreased kidney conjugated dienes (CD) | Enzyme(s): Increased erythrocyte Glutathione peroxidase | Antioxidants: Increased plasma vitamin C | Antiodidants: Increased Liver Vitamin C | Antioxidants: Increased kidney Vitamin E | Antioxidants: Increased plasma GSH | Antioxidants: Increased Liver GSH | Antioxidants: Increased Kidney GSH; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|other; STUDY_GROUP=ECOTOX:15613453:M:-adult; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=0e2f4fba893022d9035f9a9c2b550d88
ToxValDB ECOTOX LOEL =250 mg/kg bw/day Rat oral acute; 0.0417 days acute LONG_REF=Life Sci.19(10): 1559-1567 Kodama,R., H. Inoue, K. Noda, H. Ide, H. Yamamoto, S. Yoshihara, and H. Yoshimura Effect of d-Limonene and Related Compounds on Bile Flow and Biliary Lipid Composition in Rats and Dogs 1976; TITLE=Effect of d-Limonene and Related Compounds on Bile Flow and Biliary Lipid Composition in Rats and Dogs; AUTHOR=Kodama,R., H. Inoue, K. Noda, H. Ide, H. Yamamoto, S. Yoshihara, and H. Yoshimura; DOI=10.1016/0024-3205(76)90102-8; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=119044; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=Biochemistry: Phosphatidyl choline (phospholipid) content; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15600802:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=aa0f15da09fa114e136ecb0eab084c5e
ToxValDB ECOTOX LOEL =500 ppm Rat oral short-term; 28 days short-term LONG_REF=Food Chem. Toxicol.31(2): 125-136 Jonker,D., R.A. Woutersen, P.J. Van Bladeren, H.P. Til, and V.J. Feron Subacute (4-wk) Oral Toxicity of a Combination of Four Nephrotoxins in Rats: Comparison with the Toxicity of the Individual Compounds 1993; TITLE=Subacute (4-wk) Oral Toxicity of a Combination of Four Nephrotoxins in Rats: Comparison with the Toxicity of the Individual Compounds; AUTHOR=Jonker,D., R.A. Woutersen, P.J. Van Bladeren, H.P. Til, and V.J. Feron; DOI=10.1016/0278-6915(93)90126-j; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=118781; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells|Histology: Proliferation; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601227_15601228:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7ae60b777b57ca26ce096b257360d7b2
ToxValDB ECOTOX LOEL =20000 ppm Rat oral short-term; 28 days short-term LONG_REF=Eur. J. Nutr.51:57-68 Santiago,J.V.A., J. Jayachitra, M. Shenbagam, and N. Nalini Dietary d-Limonene Alleviates Insulin Resistance and Oxidative Stress-Induced Liver Injury in High-Fat Diet and L-NAME-Treated Rats 2012; TITLE=Dietary d-Limonene Alleviates Insulin Resistance and Oxidative Stress-Induced Liver Injury in High-Fat Diet and L-NAME-Treated Rats; AUTHOR=Santiago,J.V.A., J. Jayachitra, M. Shenbagam, and N. Nalini; DOI=10.1007/s00394-011-0182-7; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=160159; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=Biochemistry: Glucose|Enzyme(s): Aspartate aminotransferase|Hormone(s): Insulin|Morphology: Weight|Physiology: Systolic pressure; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|clinical signs|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601297_15609066:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4e2de0dce9e1d13a27ab9ddac245d1d9
ToxValDB ECOTOX LOEL =100000 ppm Mouse dermal chronic; 133 days chronic LONG_REF=Biomed. Pharmacother.63(9): 643-649 Arruda,D.C., D.C. Miguel, J.K.U. Yokoyama-Yasunaka, A.M. Katzin, and S.R.B. Uliana Inhibitory Activity of Limonene Against Leishmania Parasites In Vitro and In Vivo 2009; TITLE=Inhibitory Activity of Limonene Against Leishmania Parasites In Vitro and In Vivo; AUTHOR=Arruda,D.C., D.C. Miguel, J.K.U. Yokoyama-Yasunaka, A.M. Katzin, and S.R.B. Uliana; DOI=10.1016/j.biopha.2009.02.004; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=160278; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=Immunological: Amount or percent animals infested with parasites; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15598492:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=bfcf7c153c88944f324cae4ea94610d5
ToxValDB ECOTOX NOEL =5201 ppm Rat oral short-term; 24 days short-term LONG_REF=Mutagenesis16(4): 329-332 Turner,S.D., H. Tinwell, W. Piegorsch, P. Schmezer, and J. Ashby The Male Rat Carcinogens Limonene and Sodium Saccharin are not Mutagenic to Male Big Blue Rats 2001; TITLE=The Male Rat Carcinogens Limonene and Sodium Saccharin are not Mutagenic to Male Big Blue Rats; AUTHOR=Turner,S.D., H. Tinwell, W. Piegorsch, P. Schmezer, and J. Ashby; DOI=10.1093/mutage/16.4.329; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117963; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Genetics: Mutation; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15610975:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2d8d8d884e3c3193508e78f5cf78ffe3
ToxValDB ECOTOX NOEL =0.4883 mM Mouse oral short-term; 24 days short-term LONG_REF=J. Toxicol. Environ. Health20:51-66 Evans,D.L., D.M. Miller, K.L. Jacobsen, and P.B. Bush Modulation of Immune Responses in Mice by d-Limonene 1987; TITLE=Modulation of Immune Responses in Mice by d-Limonene; AUTHOR=Evans,D.L., D.M. Miller, K.L. Jacobsen, and P.B. Bush; DOI=10.1080/15287398709530961; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=86540; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Immunological: Antibody titres; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596645_15596646_15599949:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c52605b1d3cdc0096791ca45c73a770b
ToxValDB ECOTOX NOEL =0.5 % Rat oral chronic; 168 days chronic LONG_REF=Jpn. J. Cancer Res.87(6): 589-594 Kimura,J., S. Takahashi, T. Ogiso, Y. Yoshida, K. Akagi, R. Hasegawa, M. Kurata, M. Hirose, and T. Shirai Lack of Chemoprevention Effects of the Monoterpene d-Limonene in a Rat Multi-Organ Carcinogenesis Model 1996; TITLE=Lack of Chemoprevention Effects of the Monoterpene d-Limonene in a Rat Multi-Organ Carcinogenesis Model; AUTHOR=Kimura,J., S. Takahashi, T. Ogiso, Y. Yoshida, K. Akagi, R. Hasegawa, M. Kurata, M. Hirose, and T. Shirai; DOI=10.1111/j.1349-7006.1996.tb00264.x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=117948; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596647_15596648_15598118_15598119:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b94bc95afb9796624d9fa59614be46fc
ToxValDB ECOTOX NOEL =10 mg/kg bw/day Rat oral acute; 1 days acute LONG_REF=Food Chem. Toxicol.31(1): 45-52 Jonker,D., M.A. Jones, P.J. Van Bladeren, R.A. Woutersen, H.P. Til, and V.J. Feron Acute (24 HR) Toxicity of a Combination of Four Nephrotoxicants in Rats Compared with the Toxicity of the Individual Compounds 1993; TITLE=Acute (24 HR) Toxicity of a Combination of Four Nephrotoxicants in Rats Compared with the Toxicity of the Individual Compounds; AUTHOR=Jonker,D., M.A. Jones, P.J. Van Bladeren, R.A. Woutersen, H.P. Til, and V.J. Feron; DOI=10.1016/0278-6915(93)90178-2; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=156124; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Histology: Proliferation; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604741_15604742_15604743_15608336:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=88fd8e4fa2cd7e4a1c7d2b0dc331d884
ToxValDB ECOTOX NOEL =14 mg/kg bw/day Rat oral acute; 1 days acute LONG_REF=Toxicol. Appl. Pharmacol.99(2): 250-259 Lehman-McKeeman,L.D., P.A. Rodriguez, R. Takigiku, D. Caudill, and M.L. Fey d-Limonene-Induced Male Rat-Specific Nephrotoxicity: Evaluation of the Association Between d-Limonene and alpha 2u-Globulin 1989; TITLE=d-Limonene-Induced Male Rat-Specific Nephrotoxicity: Evaluation of the Association Between d-Limonene and alpha 2u-Globulin; AUTHOR=Lehman-McKeeman,L.D., P.A. Rodriguez, R. Takigiku, D. Caudill, and M.L. Fey; DOI=10.1016/0041-008x(89)90007-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=159983; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Histology: Cytoplasmic inclusions; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598377_15598378:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=902f2772067c5de78d2b848db248b389
ToxValDB ECOTOX NOEL =25 mg/kg bw/day Rat oral acute; 0.125 days acute LONG_REF=Life Sci.19(10): 1559-1567 Kodama,R., H. Inoue, K. Noda, H. Ide, H. Yamamoto, S. Yoshihara, and H. Yoshimura Effect of d-Limonene and Related Compounds on Bile Flow and Biliary Lipid Composition in Rats and Dogs 1976; TITLE=Effect of d-Limonene and Related Compounds on Bile Flow and Biliary Lipid Composition in Rats and Dogs; AUTHOR=Kodama,R., H. Inoue, K. Noda, H. Ide, H. Yamamoto, S. Yoshihara, and H. Yoshimura; DOI=10.1016/0024-3205(76)90102-8; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=119044; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=Physiology: Fluid volume; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603191_15603192:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=20515b43e708f92123d19da9f8f67dc5
ToxValDB ECOTOX NOEL =50 % Mouse dermal short-term; 17 days short-term LONG_REF=Contact Dermatitis15(1): 17-23 Maisey,J., and K. Miller Assessment of the Ability of Mice Fed on Vitamin A Supplemented Diet to Respond to a Variety of Potential Contact Sensitizers 1986; TITLE=Assessment of the Ability of Mice Fed on Vitamin A Supplemented Diet to Respond to a Variety of Potential Contact Sensitizers; AUTHOR=Maisey,J., and K. Miller; DOI=10.1111/j.1600-0536.1986.tb01255.x; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=81179; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Immunological: Thickness; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15610628:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b12828f8a09c346c9b8316f126b459d6
ToxValDB ECOTOX NOEL =125 mM Mouse oral subchronic; 56 days subchronic LONG_REF=J. Toxicol. Environ. Health20:51-66 Evans,D.L., D.M. Miller, K.L. Jacobsen, and P.B. Bush Modulation of Immune Responses in Mice by d-Limonene 1987; TITLE=Modulation of Immune Responses in Mice by d-Limonene; AUTHOR=Evans,D.L., D.M. Miller, K.L. Jacobsen, and P.B. Bush; DOI=10.1080/15287398709530961; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=86540; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Cell(s): B-cell|Cell(s): T-cell; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15595033:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fff7635b3a5bff0a7cd64ba234c5c52d
ToxValDB ECOTOX NOEL =150 mg/kg bw/day Rat oral short-term; 5 days short-term LONG_REF=Food Chem. Toxicol.25(5): 345-353 Kanerva,R.L., G.M. Ridder, F.R. Lefever, and C.L. Alden Comparison of Short-Term Renal Effects Due to Oral Administration of Decalin or d-Limonene in Young Adult Male Fischer-344 Rats 1987; TITLE=Comparison of Short-Term Renal Effects Due to Oral Administration of Decalin or d-Limonene in Young Adult Male Fischer-344 Rats; AUTHOR=Kanerva,R.L., G.M. Ridder, F.R. Lefever, and C.L. Alden; DOI=10.1016/0278-6915(87)90167-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=117976; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15608757_15608758:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=156d4f8a450e1b1ea9eccc1e28b770d8
ToxValDB ECOTOX NOEL =200 mg/kg bw/day Rat oral acute; 1 days acute LONG_REF=Food Chem. Toxicol.31(1): 45-52 Jonker,D., M.A. Jones, P.J. Van Bladeren, R.A. Woutersen, H.P. Til, and V.J. Feron Acute (24 HR) Toxicity of a Combination of Four Nephrotoxicants in Rats Compared with the Toxicity of the Individual Compounds 1993; TITLE=Acute (24 HR) Toxicity of a Combination of Four Nephrotoxicants in Rats Compared with the Toxicity of the Individual Compounds; AUTHOR=Jonker,D., M.A. Jones, P.J. Van Bladeren, R.A. Woutersen, H.P. Til, and V.J. Feron; DOI=10.1016/0278-6915(93)90178-2; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=156124; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Biochemistry: Glucose|Biochemistry: Urea|Cell(s): Number of cells|Enzyme(s): (gamma) -glutamyl transferase|Feeding behavior: Food consumption|Growth: Weight|Injury: Occult blood|Morphology: Organ weight in relationship to body weight|Morphology: Weight|Physiology: Fluid volume; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|enzyme activity|food and/or water consumption|gross pathology|nonneoplastic histopathology|organ weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604741_15604742_15604743_15608336:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3df831ebdc1b0a30a1cbda1e1debfedc
ToxValDB ECOTOX NOEL =300 mg/kg bw/day Rat oral short-term; 10 days short-term LONG_REF=Toxicology258(2-3): 131-138 Borghoff,S.J., G.C. Hard, N.M. Berdasco, R. Gingell, S.M. Green, and W. Gulledge Methyl Isobutyl Ketone (MIBK) Induction of alpha2u-Globulin Nephropathy in Male, but Not Female Rats 2009; TITLE=Methyl Isobutyl Ketone (MIBK) Induction of alpha2u-Globulin Nephropathy in Male, but Not Female Rats; AUTHOR=Borghoff,S.J., G.C. Hard, N.M. Berdasco, R. Gingell, S.M. Green, and W. Gulledge; DOI=10.1016/j.tox.2009.01.018; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=118305; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total|Cell(s): Number of cells|Growth: Weight|Morphology: Organ weight in relationship to body weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology|organ weight|other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596950_15597267:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fe6855309643a23141a44da9bf6d2461
ToxValDB ECOTOX NOEL =4000 ppm Rat oral short-term; 28 days short-term LONG_REF=Food Chem. Toxicol.31(2): 125-136 Jonker,D., R.A. Woutersen, P.J. Van Bladeren, H.P. Til, and V.J. Feron Subacute (4-wk) Oral Toxicity of a Combination of Four Nephrotoxins in Rats: Comparison with the Toxicity of the Individual Compounds 1993; TITLE=Subacute (4-wk) Oral Toxicity of a Combination of Four Nephrotoxins in Rats: Comparison with the Toxicity of the Individual Compounds; AUTHOR=Jonker,D., R.A. Woutersen, P.J. Van Bladeren, H.P. Til, and V.J. Feron; DOI=10.1016/0278-6915(93)90126-j; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=118781; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content|Cell(s): Number of cells|Enzyme(s): Aspartate aminotransferase|Feeding behavior: Food consumption|Growth: Weight|Histology: Proliferation|Morphology: Organ weight in relationship to body weight|Physiology: Fluid volume; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|gross pathology|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ECOTOX:15600131:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5177cf8e1274e7fbc82aa1046040f360
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =66.7 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633057:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_85f897c68361b2c9ecebb3b19d3d0efa
ToxValDB HESS 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB HESS NOEL <150 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0e0ae4b0a676289df28a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Histopathology: Kidney-Nephropathy; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=HESS:15638510:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_962afedee6eefa56e3a24e0e5f0f2657
ToxValDB HPVIS 12 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB HPVIS LOAEL =30 mg/kg bw/day Rat oral short-term; 13 days short-term LONG_REF=Webb D.R., Ridder M., and Alden C.L. (1989) Acute and subchronic nephrotoxicity of d-limonene in Fischer 344 rats.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: November 13, 2006.; QUALITY=2; EXTERNAL_SOURCE_ID=62971; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639961_15640037:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5ccc92deaefa55a6ea4bec14c6d5c821
ToxValDB HPVIS LOAEL =500 mg/kg bw/day Rabbit oral short-term; 13 days reproduction developmental LONG_REF=Kodama R., Okubo A., Sato K., Araki E., Noda K., Ide H., and Ikeda T. (1977a) Studies on d-limonene as a gallstone solubilizer: Effect on development of rabbit fetuses and offsprings.Journal Oyo Yakuri, 13(6), 885-898.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: November 13, 2006.; QUALITY=2; EXTERNAL_SOURCE_ID=58047; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642328_15642808_15642817:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3e5edd41fe69bb94bbf4e230cccb25f0
ToxValDB HPVIS LOAEL =600 mg/kg bw/day Rat oral short-term; 13 days short-term LONG_REF=National Toxicology Program (NTP) (1990) Carcinogenicity and toxicology studies of d-limonene in F344/N Rats and B6C3F1 mice. NTP-TR-347. U.S. Dept of Health and Human Services. NIH Publication No. 90-2802. Tarone R.E. (1975) Tests for trend in life table analysis. Biometrika 62; 679-682. Cox D.R. (1972) Regression models and life tables. J.R. Stat. Soc. B34: 187-220.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: November 13, 2006.; QUALITY=1; EXTERNAL_SOURCE_ID=62175; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639861_15640113:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e12bfaef6a2a116dd500a623a5f87c13
ToxValDB HPVIS LOAEL =1000 mg/kg bw/day Mouse oral short-term; 13 days short-term LONG_REF=National Toxicology Program (NTP) (1990) Carcinogenicity and toxicology studies of d-limonene in F344/N Rats and B6C3F1 mice. NTP-TR-347. U.S. Dept of Health and Human Services. NIH Publication No. 90-2802.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: November 13, 2006.; QUALITY=1; EXTERNAL_SOURCE_ID=61676; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639779_15639994:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_280878b544ebcf941e271c11be8b34fb
ToxValDB HPVIS LOAEL =2363 mg/kg bw/day Mouse oral short-term; 6 days reproduction developmental LONG_REF=Kodama R., Okubo A., Sato K., Araki E., Noda K., Ide H., and Ikeda T. (1977a) Studies on d-limonene as a gallstone solubilizer: Effect on development of mouse fetuses and offsprings. Journal Oyo Yakuri, 13(6), 885-898.; TITLE=Studies on d-limonene as a gallstone solubilizer: Effect on development of mouse fetuses and offsprings; AUTHOR=Kodama R., Okubo A., Sato K., Araki E., Noda K., Ide H., and Ikeda T; QUALITY=2; EXTERNAL_SOURCE_ID=59613; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642579_15642696_15642810_15642945:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_169344cf8374573ef537aae5869b751e
ToxValDB HPVIS LOAEL =2770 mg/kg bw/day Rat oral short-term; 30 days short-term LONG_REF=Kodama R., Tahara S., Sato K., Noda K., Ide H., Nishihara H. (1977b) Studies on d-limonene as a Gallstone Solubilizer Fine Structure of Liver, Kidneys and Blood Cells from Rats given d- limonene. Oyo Yakuri 13(6), 875.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: November 13, 2006.; QUALITY=2; EXTERNAL_SOURCE_ID=62715; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639862_15639930:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ed3213b33ad16540fda25f5643f94283
ToxValDB HPVIS LOAEL =2869 mg/kg bw/day Rat oral short-term; 7 days developmental LONG_REF=Tsuji M., Y.Fujisaki, Y.Arikawa, S.Masuda, S.Kinoshita, A.Okubo, K.Noda, H.Ide and Y.Iwanaga (1975b) Studies on d-limonene as a gallstone solubilizer: Effects on Development of Rat Fetuses and Offsprings. Journal Oyo Yakuri, 10(2), 179.; TITLE=Studies on d- limonene as a gallstone solubilizer: Effects on Development of Rat Fetuses and Offsprings; AUTHOR=Tsuji M., Y.Fujisaki, Y.Arikawa, S.Masuda, S.Kinoshita, A.Okubo, K.Noda, H.Ide and Y.Iwanaga; QUALITY=2; EXTERNAL_SOURCE_ID=59979; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1975; ORIGINAL_YEAR=1975; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Devtox_15642695_15642934:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e00ca0d28d867347da04cdcbd464ad1c
ToxValDB HPVIS NOAEL =5 mg/kg bw/day Rat oral short-term; 13 days short-term LONG_REF=Webb D.R., Ridder M., and Alden C.L. (1989) Acute and subchronic nephrotoxicity of d-limonene in Fischer 344 rats.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: November 13, 2006.; QUALITY=2; EXTERNAL_SOURCE_ID=63489; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639961_15640037:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3a532ef4aa0a923b548a1bffb6cf3eb2
ToxValDB HPVIS NOAEL =300 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=National Toxicology Program (NTP) (1990) Carcinogenicity and toxicology studies of d-limonene in F344/N Rats and B6C3F1 mice. NTP-TR-347. U.S. Dept of Health and Human Services. NIH Publication No. 90-2802.; TITLE=Carcinogenicity and toxicology studies of d-limonene in F344/N Rats and B6C3F1 mice; AUTHOR=National Toxicology Program; QUALITY=1; EXTERNAL_SOURCE_ID=62419; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639046_15639146_15639297:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b5276d26f0e89fde26000ac5ce2ef966
ToxValDB HPVIS NOAEL =500 mg/kg bw/day Mouse oral short-term; 13 days short-term LONG_REF=National Toxicology Program (NTP) (1990) Carcinogenicity and toxicology studies of d-limonene in F344/N Rats and B6C3F1 mice. NTP-TR-347. U.S. Dept of Health and Human Services. NIH Publication No. 90-2802.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: November 13, 2006.; QUALITY=1; EXTERNAL_SOURCE_ID=63230; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639779_15639994:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_90c65ce7a407e64dd74b4df0de142861
ToxValDB HPVIS NOAEL >1000 mg/kg bw/day Rabbit oral short-term; 13 days reproduction developmental LONG_REF=Kodama R., Okubo A., Sato K., Araki E., Noda K., Ide H., and Ikeda T. (1977a) Studies on d-limonene as a gallstone solubilizer: Effect on development of rabbit fetuses and offsprings. Journal Oyo Yakuri, 13(6), 885-898.; TITLE=Studies on d-limonene as a gallstone solubilizer: Effect on development of rabbit fetuses and offsprings; AUTHOR=Kodama R., Okubo A., Sato K., Araki E., Noda K., Ide H., and Ikeda T; QUALITY=2; EXTERNAL_SOURCE_ID=59612; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=HPVIS:15642809:-:F1offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_711a21f69026dc7cdad25ba24aa6b0e7
ToxValDB HPVIS NOAEL =1385 mg/kg bw/day Rat oral short-term; 30 days short-term LONG_REF=Kodama R., Tahara S., Sato K., Noda K., Ide H., Nishihara H. (1977b) Studies on d-limonene as a Gallstone Solubilizer Fine Structure of Liver, Kidneys and Blood Cells from Rats given d- limonene. Oyo Yakuri 13(6), 875.Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: November 13, 2006.; QUALITY=2; EXTERNAL_SOURCE_ID=62176; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639862_15639930:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3bf56b62ca08414c0f79f2b78f4696ef
ToxValDB ToxRefDB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ToxRefDB LEL =500 mg/kg bw/day Rat oral short-term (developmental); 10 days reproduction developmental LONG_REF=Hoberman, A. (1992) Developmental Toxicity (Embryo-Fetal Toxicity and Teratogenic Potential) Study of D-Limonene Technical Administered Orally Via Gavage to Crl:CD BR VAF/Plus Presumed Pregnant Rats. Final Report. Lab Project Number: 2119-001. Unpublished; TITLE=Developmental Toxicity (Embryo-Fetal Toxicity and Teratogenic Potential) Study of D-Limonene Technical Administered Orally Via Gavage to Crl:CD BR VAF/Plus Presumed Pregnant Rats; AUTHOR=Hoberman, A; EXTERNAL_SOURCE_ID=465; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-clinical signs-salivation|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15680610_15680611_15680612_15680613:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_00b3a383235de152448f1464e688bb47
ToxValDB ToxRefDB NEL =250 mg/kg bw/day Rat oral short-term (developmental); 10 days reproduction developmental LONG_REF=Hoberman, A. (1992) Developmental Toxicity (Embryo-Fetal Toxicity and Teratogenic Potential) Study of D-Limonene Technical Administered Orally Via Gavage to Crl:CD BR VAF/Plus Presumed Pregnant Rats. Final Report. Lab Project Number: 2119-001. Unpublished; TITLE=Developmental Toxicity (Embryo-Fetal Toxicity and Teratogenic Potential) Study of D-Limonene Technical Administered Orally Via Gavage to Crl:CD BR VAF/Plus Presumed Pregnant Rats; AUTHOR=Hoberman, A; EXTERNAL_SOURCE_ID=465; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption|systemic: in life observation-clinical signs-salivation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15680610_15680611_15680612_15680613:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5895b62e876f606778399dc910305947
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier GFD7C86Q1W UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H16","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"GFD7C86Q1W"}
openFDA substances FDA UNII substance identifier GFD7C86Q1W UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H16","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"GFD7C86Q1W"}
openFDA substances FDA UNII substance identifier GFD7C86Q1W UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H16","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"GFD7C86Q1W"}
openFDA substances FDA UNII substance identifier GFD7C86Q1W UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H16","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"GFD7C86Q1W"}