Is Lawsonia Inermis Wax safe in cosmetics?
Lawsonia Inermis Wax has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Lawsonia Inermis Wax
Also known as: Henna
INCI: LAWSONIA INERMIS WAX
Lawsonia Inermis Wax (CAS 84988-66-9) is a cosmetic cosmetic ingredient functioning as Skin conditioning, emollient. Reported NOAEL =40 mg/kg bw (SCCNFP Opinion); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 84988-66-9 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning, emollient
Safety Rating
GOOD
Chemistry & Identifiers
EC Number
284-854-1
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific restriction for purified wax
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Lawsonia Inermis Wax.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Lawsonia Inermis Wax. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =40 mg/kg bw | - | - | irritation | SCCNFP Opinion |
| NOAEL | =40 mg/kg/day | oral | rat | repeated dose toxicity | SCCNFP Opinion |
| NOAEL | =40 mg/kg bw | - | - | irritation | SCCNFP Opinion |
| NOAEL | =40 mg/kg/day | oral | rat | repeated dose toxicity | SCCNFP Opinion |
| NOAEL | =40 mg/kg bw | - | - | irritation | SCCNFP Opinion |
| NOAEL | =40 mg/kg/day | oral | rat | repeated dose toxicity | SCCNFP Opinion |
| NOAEL | =40 mg/kg bw | - | - | irritation | SCCNFP Opinion |
| NOAEL | =40 mg/kg/day | oral | rat | repeated dose toxicity | SCCNFP Opinion |
| NOAEL | =200 mg/kg/day | - | rat | dermal absorption | SCCNFP Opinion |
| NOAEL | =200 mg/kg/day | - | rat | dermal absorption | SCCNFP Opinion |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (5 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.2% | - | - | SCCP/0034 |
| measured | 0.28% | in_vitro | - | SCCP/0034 |
| measured | 1.4% | - | - | SCCP/0034 |
| measured | 0.34% | - | - | SCCP/0034 |
| measured | 3.1% | - | - | SCCP/0034 |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Biocide
Deodorizer
Dye
Filler
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Lawsonia Inermis Wax.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Lawsonia Inermis Wax by CAS number or substance name.
Studies
44
Lowest NOAEL
0.00833
Highest NOAEL
200
Units vary across source rows: mg/kg bw/d, mg/kg bw, mg/kg bw/day
SCCS Opinion
SCCNFP Opinion
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 0.2% | - | - |
| 0.28% | in_vitro | - |
| 1.4% | - | - |
| 0.34% | - | - |
| 3.1% | - | - |
Known Synonyms
Henna
Chemical Function
Biocide
Antioxidant
Deodorizer
Softener and conditioner
Dye
Filler
Regulatory Lists
Personal care
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Lawsonia Inermis Wax allowed in the EU?
Lawsonia Inermis Wax EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Lawsonia Inermis Wax do in cosmetics?
Lawsonia Inermis Wax functions as: Skin conditioning, emollient. It is classified as a cosmetic ingredient in our database. CAS number: 84988-66-9.
What is the NOAEL for Lawsonia Inermis Wax?
The NOAEL (No Observed Adverse Effect Level) for Lawsonia Inermis Wax is =40 mg/kg bw based on a irritation study via oral route in rat. A total of 10 study endpoints are available. Source: SCCNFP Opinion.
Is Lawsonia Inermis Wax used outside cosmetics?
Lawsonia Inermis Wax also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Lawsonia Inermis Wax compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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