Is Lawsonia Inermis Cera safe in cosmetics?
Lawsonia Inermis Cera has a safety rating of "GOOD" in our database. EU status: restricted. US status: restricted. 10 toxicological study endpoint(s) are available in our database.
Lawsonia Inermis Cera
Also known as: Henna
INCI: LAWSONIA INERMIS CERA
Lawsonia Inermis Cera (CAS 84988-66-9) is a cosmetic cosmetic ingredient functioning as Skin conditioning (wax from leaves of Lawsonia inermis L., Lythraceae). Reported NOAEL =40 mg/kg bw (SCCNFP Opinion); EU Regulation 1223/2009 status: restricted, max 1.4%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 84988-66-9 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning (wax from leaves of Lawsonia inermis L., Lythraceae)
Safety Rating
GOOD
Chemistry & Identifiers
EC Number
284-854-1
Regulatory Status
EU EU Status
restricted
EU Max Conc.
1.4%
US US Status
restricted
US Notes
Henna (Lawsonia inermis) is approved for hair dye use only per 21 CFR 73.2190; not approved for use in area of the eye
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Lawsonia Inermis Cera.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Lawsonia Inermis Cera. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =40 mg/kg bw | - | - | irritation | SCCNFP Opinion |
| NOAEL | =40 mg/kg/day | oral | rat | repeated dose toxicity | SCCNFP Opinion |
| NOAEL | =40 mg/kg bw | - | - | irritation | SCCNFP Opinion |
| NOAEL | =40 mg/kg/day | oral | rat | repeated dose toxicity | SCCNFP Opinion |
| NOAEL | =40 mg/kg bw | - | - | irritation | SCCNFP Opinion |
| NOAEL | =40 mg/kg/day | oral | rat | repeated dose toxicity | SCCNFP Opinion |
| NOAEL | =40 mg/kg bw | - | - | irritation | SCCNFP Opinion |
| NOAEL | =40 mg/kg/day | oral | rat | repeated dose toxicity | SCCNFP Opinion |
| NOAEL | =200 mg/kg/day | - | rat | dermal absorption | SCCNFP Opinion |
| NOAEL | =200 mg/kg/day | - | rat | dermal absorption | SCCNFP Opinion |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (5 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.2% | - | - | SCCP/0034 |
| measured | 0.28% | in_vitro | - | SCCP/0034 |
| measured | 1.4% | - | - | SCCP/0034 |
| measured | 0.34% | - | - | SCCP/0034 |
| measured | 3.1% | - | - | SCCP/0034 |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Biocide
Deodorizer
Dye
Filler
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Lawsonia Inermis Cera.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Lawsonia Inermis Cera by CAS number or substance name.
Studies
44
Lowest NOAEL
0.00833
Highest NOAEL
200
Units vary across source rows: mg/kg bw/d, mg/kg bw, mg/kg bw/day
SCCS Opinion
SCCNFP Opinion
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 0.2% | - | - |
| 0.28% | in_vitro | - |
| 1.4% | - | - |
| 0.34% | - | - |
| 3.1% | - | - |
Known Synonyms
Henna
Chemical Function
Biocide
Antioxidant
Deodorizer
Softener and conditioner
Dye
Filler
Regulatory Lists
Personal care
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Lawsonia Inermis Cera allowed in the EU?
Lawsonia Inermis Cera EU regulatory status: restricted. Maximum allowed concentration: 1.4%. This is based on EU Regulation 1223/2009 and its amendments.
What does Lawsonia Inermis Cera do in cosmetics?
Lawsonia Inermis Cera functions as: Skin conditioning (wax from leaves of Lawsonia inermis L., Lythraceae). It is classified as a cosmetic ingredient in our database. CAS number: 84988-66-9.
What is the NOAEL for Lawsonia Inermis Cera?
The NOAEL (No Observed Adverse Effect Level) for Lawsonia Inermis Cera is =40 mg/kg bw based on a irritation study via oral route in rat. A total of 10 study endpoints are available. Source: SCCNFP Opinion.
Is Lawsonia Inermis Cera used outside cosmetics?
Lawsonia Inermis Cera also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Lawsonia Inermis Cera compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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