NOAEL Studies
Cosmetic Ingredient
Lauryl Alcohol NOAEL Studies
INCI: LAURYL ALCOHOL
CAS: 112-53-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 3324 | mg/kg bw/day | rat | oral | 60 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
NTP_ICE_acute_inhalation 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | >0.7 | mg/L | - | Inhalation | Duration=6 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2937; Record_ID=acute_inhalation_2431; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5026918; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.7; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15424/7/3/3/?documentUUID=8020e1b2-e4e1-4d0c-9a4e-1ffee78da26b; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026918 |
| NTP_ICE_acute_inhalation | LC50 | >1.5 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2940; Record_ID=acute_inhalation_2436; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5026918; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=1.5; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15424/7/3/3/?documentUUID=1d19f03d-0fc7-4c27-b443-3cc40bfd085d; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026918 |
| NTP_ICE_acute_inhalation | LC50 | >2.05 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2938; Record_ID=acute_inhalation_2440; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5026918; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=2.05; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15424/7/3/3/?documentUUID=d201c54c-4d3e-47d5-9f87-3e30d8c858bd; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026918 |
| NTP_ICE_acute_inhalation | LC50 | >21 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2939; Record_ID=acute_inhalation_2442; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5026918; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=21; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15424/7/3/3/?documentUUID=599198c1-86bb-494c-b8c0-bb4a4656ec3e; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026918 |
| NTP_ICE_acute_inhalation | LC50 | >71 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2936; Record_ID=acute_inhalation_2433; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5026918; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=71; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15424/7/3/3/?documentUUID=ddc86c1d-7a52-494c-8011-3f6f19ba3449; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026918 |
NTP_ICE_acute_oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | >2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_1206; row=8938; data_type=In Vivo; mixture=Chemical; chemical_name=1-Dodecanol; preferred_name=1-Dodecanol; dtxsid=DTXSID5026918; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026918; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >12800 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_1207; row=8937; data_type=In Vivo; mixture=Chemical; chemical_name=1-Dodecanol; preferred_name=1-Dodecanol; dtxsid=DTXSID5026918; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026918; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >26530 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_1209; row=8939; data_type=In Vivo; mixture=Chemical; chemical_name=1-Dodecanol; preferred_name=1-Dodecanol; dtxsid=DTXSID5026918; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026918; source_file=acute_oral.xlsx |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=1082; RecordID=ARPathway2016_612; DatasetName=ARPathway2016; DTXSID=DTXSID5026918; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026918 |
NTP_ICE_skin_irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_irritation | Positive reaction | 0 | % | Human | Dermal | - | In Vivo; Four-hour Human Patch Test | sheet=Data_invivo; excel_row=1051; Record_ID=skin_irritation_invivo_7; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5026918; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=0; Response_Unit=%; Species=Human; Reference=Basketter et al. 2004; 15291823; 10.1111/j.0105-1873.2004.00385.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026918 |
NTP_ICE_skin_sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=3820; Record_ID=skin_sensitization_invivo_948; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5026918; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90071-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026918 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 2592 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=3818; Record_ID=skin_sensitization_invivo_948; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5026918; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2592; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90071-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026918 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=3824; Record_ID=skin_sensitization_invivo_948; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5026918; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90071-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026918 |
ToxValDB_ECHA_IUCLID 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | =300 | mg/kg bw/day | Mouse | dermal | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c7fce4b0a7c65d215f4a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12502/7/8?documentUUID=9e7a73fb-6b82-4dda-87ff-d0443fcda40d; YEAR=1973; ORIGINAL_YEAR=1973; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816775_15817575_15817917_15818185_15819114_15819933:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ae3bd724b607725128ced971352e9fd1 |
| ToxValDB_ECHA_IUCLID | NOAEL | =800 | mg/kg bw/day | Mouse | dermal | - | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c841e4b0a7c65d2179ab; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2008/7/8?documentUUID=41ec3767-330f-4e0a-afb5-8f19d03196f3; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816122_15817256_15817275_15817597_15817798_15819687:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a8e862bc8f7ef2c184ba64bff6c7b75b |
| ToxValDB_ECHA_IUCLID | NOAEL | =2000 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac86e4b0a7c65d1bf7e9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2008/7/9/3?documentUUID=41ec3767-330f-4e0a-afb5-8f19d03196f3; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15824025_15824026_15824027_15824028:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1443361a7a3628ca6c7c3b494ad1a6f1 |
| ToxValDB_ECHA_IUCLID | NOEL | <100 | mg/kg bw/day | Rat | oral | subchronic; 45 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc19e4b0a7c65d228dfc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12191/7/6/2?documentUUID=c82d5362-2f7c-4431-9b76-442523b8abb6; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847317_15847368_15847600_15848205_15848867_15848948_15849040:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_69c3c91379c188a7e3a9dc2c69ad0904 |
ToxValDB_GESTIS_DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =155 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631789_15631790:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_652b9e46339c5f34566aed35299a53f6 |
| ToxValDB_GESTIS_DNEL | DNEL systemic | =313 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15631789_15631790:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a3d91a388fc3607ac7a780768a343129 |
ToxValDB_HPVIS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HPVIS | NOAEL | =100 | mg/kg bw/day | Rat | oral | subchronic; 37 days | reproduction developmental | LONG_REF=Hansen, E., "Combined Repeat Dose and Reproductive /Developmental Toxicity Screening Test on 1 -Dodecanol in Rats", lnstitut of Toxicology, Danish National Food Agency, IT 9211105 (1992)Posting dates of documents from HPV Challenge web site from which data have been entered into the HPVIS: Final revised submission posted June 12, 2006; First test plan revision posted April 26, 2004; initial submission posted February 6, 2002.; EXTERNAL_SOURCE_ID=63306; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; STUDY_GROUP=HPVIS:15640005:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_37b8c5dc1b5a0885cd84ecc3f8202fbc |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 178A96NLP2 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C12H26O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"178A96NLP2"} |
| openFDA substances | FDA UNII substance identifier | 178A96NLP2 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C12H26O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"178A96NLP2"} |
| openFDA substances | FDA UNII substance identifier | 178A96NLP2 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C12H26O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"178A96NLP2"} |
| openFDA substances | FDA UNII substance identifier | 178A96NLP2 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C12H26O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"178A96NLP2"} |