Is Lactoperoxidase safe in cosmetics?
Lactoperoxidase has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Lactoperoxidase
INCI: LACTOPEROXIDASE
Lactoperoxidase (CAS 9003-99-0) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent; antimicrobial enzyme for oral care and skin care. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 9003-99-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Lactoperoxidase is classified GHS Danger (H317, H334) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin conditioning agent; antimicrobial enzyme for oral care and skin care applications
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
N-(2-aminophenyl)-4-[[(4-pyridin-3-ylpyrimidin-2-yl)amino]methyl]benzamide
InChIKey
HRNLUBSXIHFDHP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted under 21 CFR 700; GRAS enzyme in food applications; considered safe as used in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Lactoperoxidase.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
3 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "antioxidant-protection, antimicrobial", "mechanism_of_action": "Enzymatic activity, targeted protein modification", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Moderate", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "6-12", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "No", "placebo_controlled": "Yes", "publis…
anti_pollution
{"cas_number": "9003-99-0", "ingredient_class": "antioxidant_pollution_shield", "primary_mechanism": "direct_scavenging", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "n…
baby_pediatric
{"cas_number": "CAS-FUNC-41", "ingredient_class": "other", "pediatric_safety_rating": "good", "minimum_age_months": "3", "neonatal_safe": "no", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Functional ingredient - generally safe", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Softener and conditioner
Stabilizing agent
Regulatory List Membership (1)
EU Restricted for Children (Cosmetics)
Expert Verdict
Expert safety assessment and concern-level summary for Lactoperoxidase.
Regulatory Flags
eu_children_restricted
Chemical Function
Antioxidant
Softener and conditioner
Stabilizing agent
Regulatory Lists
children; Europe; Personal care - dental care - toothpaste
children; Europe; Personal care
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Lactoperoxidase allowed in the EU?
Lactoperoxidase EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Lactoperoxidase do in cosmetics?
Lactoperoxidase functions as: Skin conditioning agent; antimicrobial enzyme for oral care and skin care applications. It is classified as a cosmetic ingredient in our database. CAS number: 9003-99-0.
Is Lactoperoxidase used outside cosmetics?
Lactoperoxidase also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Lactoperoxidase have different safety status in cosmetics vs industrial chemicals?
Lactoperoxidase is classified GHS Danger (H317, H334) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Lactoperoxidase compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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